메뉴 건너뛰기




Volumn 7, Issue 3, 2012, Pages 309-322

Cografting of carotid body cells improves the long-term survival, fiber outgrowth and functional effects of grafted dopaminergic neurons

Author keywords

carotid body; cell therapy; dopamine; GDNF; neuroprotection; Parkinson; rat; transplantation

Indexed keywords

GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR;

EID: 84861316762     PISSN: 17460751     EISSN: 1746076X     Source Type: Journal    
DOI: 10.2217/rme.12.22     Document Type: Article
Times cited : (12)

References (77)
  • 1
    • 0028911848 scopus 로고
    • Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease
    • Kordower JH, Freeman TB, Snow BJ et al. Neuropathological evidence of graft survival and striatal reinnervation after the transplantation of fetal mesencephalic tissue in a patient with Parkinson's disease. N. Engl. J. Med. 332, 1118-1124 (1995).
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1118-1124
    • Kordower, J.H.1    Freeman, T.B.2    Snow, B.J.3
  • 2
    • 0027977759 scopus 로고
    • Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease
    • Lindvall O, Sawle G, Widner H et al. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann. Neurol. 35, 172-180 (1994).
    • (1994) Ann. Neurol. , vol.35 , pp. 172-180
    • Lindvall, O.1    Sawle, G.2    Widner, H.3
  • 3
    • 0035826089 scopus 로고    scopus 로고
    • Transplantation of embryonic dopamine neurons for severe Parkinson's disease
    • Freed CR, Greene PE, Breeze RE et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344, 710-719 (2001).
    • (2001) N. Engl. J. Med. , vol.344 , pp. 710-719
    • Freed, C.R.1    Greene, P.E.2    Breeze, R.E.3
  • 4
    • 0042837887 scopus 로고    scopus 로고
    • A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease
    • Olanow CW, Goetz CG, Kordower JH et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann. Neurol. 54, 403-414 (2003).
    • (2003) Ann. Neurol. , vol.54 , pp. 403-414
    • Olanow, C.W.1    Goetz, C.G.2    Kordower, J.H.3
  • 5
    • 77957230012 scopus 로고    scopus 로고
    • Neural grafting in Parkinson's disease problems and possibilities
    • Brundin P, Barker RA, Parmar M. Neural grafting in Parkinson's disease problems and possibilities. Prog. Brain Res. 184, 265-294 (2010).
    • (2010) Prog. Brain Res. , vol.184 , pp. 265-294
    • Brundin, P.1    Barker, R.A.2    Parmar, M.3
  • 6
    • 65849389930 scopus 로고    scopus 로고
    • Microtransplantation of dopaminergic cell suspensions: Further characterization and optimization of grafting parameters
    • Nikkhah G, Rosenthal C, Falkenstein G, Roedter A, Papazoglou A, Brandis A. Microtransplantation of dopaminergic cell suspensions: further characterization and optimization of grafting parameters. Cell Transplant. 18, 119-133 (2009).
    • (2009) Cell Transplant. , vol.18 , pp. 119-133
    • Nikkhah, G.1    Rosenthal, C.2    Falkenstein, G.3    Roedter, A.4    Papazoglou, A.5    Brandis, A.6
  • 7
    • 38149126482 scopus 로고    scopus 로고
    • Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in Parkinsonian mice
    • Parish CL, Castelo-Branco G, Rawal N et al. Wnt5a-treated midbrain neural stem cells improve dopamine cell replacement therapy in Parkinsonian mice. J. Clin. Invest. 118, 149-160 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 149-160
    • Parish, C.L.1    Castelo-Branco, G.2    Rawal, N.3
  • 8
    • 23344449323 scopus 로고    scopus 로고
    • Stem cell treatment for Parkinson's disease: An update for 2005
    • Snyder BJ, Olanow CW. Stem cell treatment for Parkinson's disease: an update for 2005. Curr. Opin. Neurol. 18, 376-385 (2005).
    • (2005) Curr. Opin. Neurol. , vol.18 , pp. 376-385
    • Snyder, B.J.1    Olanow, C.W.2
  • 9
    • 77549085774 scopus 로고    scopus 로고
    • Transplantable midbrain dopamine neurons: A moving target
    • Villaescusa JC, Arenas E. Transplantable midbrain dopamine neurons: a moving target. Exp. Neurol. 222, 173-178 (2010).
    • (2010) Exp. Neurol. , vol.222 , pp. 173-178
    • Villaescusa, J.C.1    Arenas, E.2
  • 10
    • 0028795044 scopus 로고
    • Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
    • Beck KD, Valverde J, Alexi T et al. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature 373, 339-344 (1995).
    • (1995) Nature , vol.373 , pp. 339-344
    • Beck, K.D.1    Valverde, J.2    Alexi, T.3
  • 11
    • 0027285510 scopus 로고
    • GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
    • Lin LF, Doherty DH, Lile, JD, Bektesh S, Collins F. GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science 260, 1130-1132 (1993).
    • (1993) Science , vol.260 , pp. 1130-1132
    • Lin, L.F.1    Doherty, D.H.2    Lile, J.D.3    Bektesh, S.4    Collins, F.5
  • 13
    • 0028834063 scopus 로고
    • Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
    • Tomac A, Lindqvist E, Lin LF et al. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo. Nature 373, 335-339 (1995).
    • (1995) Nature , vol.373 , pp. 335-339
    • Tomac, A.1    Lindqvist, E.2    Lin, L.F.3
  • 14
    • 33644833272 scopus 로고    scopus 로고
    • Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease
    • Lang AE, Gill S, Patel NK et al. Randomized controlled trial of intraputamenal glial cell line-derived neurotrophic factor infusion in Parkinson disease. Ann. Neurol. 59, 459-466 (2006).
    • (2006) Ann. Neurol. , vol.59 , pp. 459-466
    • Lang, A.E.1    Gill, S.2    Patel, N.K.3
  • 15
    • 22544461907 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain
    • Love S, Plaha P, Patel NK, Hotton GR, Brooks DJ, Gill SS. Glial cell line-derived neurotrophic factor induces neuronal sprouting in human brain. Nat. Med. 11, 703-704 (2005).
    • (2005) Nat. Med. , vol.11 , pp. 703-704
    • Love, S.1    Plaha, P.2    Patel, N.K.3    Hotton, G.R.4    Brooks, D.J.5    Gill, S.S.6
  • 16
    • 34248570313 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease
    • Yasuhara T, Shingo T, Date I. Glial cell line-derived neurotrophic factor (GDNF) therapy for Parkinson's disease. Acta Med. Okayama 61, 51-56 (2007).
    • (2007) Acta Med. Okayama , vol.61 , pp. 51-56
    • Yasuhara, T.1    Shingo, T.2    Date, I.3
  • 17
    • 0031905828 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells
    • Apostolides C, Sanford E, Hong M, Mendez I. Glial cell line-derived neurotrophic factor improves intrastriatal graft survival of stored dopaminergic cells. Neuroscience 83, 363-372 (1998).
    • (1998) Neuroscience , vol.83 , pp. 363-372
    • Apostolides, C.1    Sanford, E.2    Hong, M.3    Mendez, I.4
  • 18
    • 0031812748 scopus 로고    scopus 로고
    • Enhancement of graft survival and sensorimotor behavioral recovery in rats undergoing transplantation with dopaminergic cells exposed to glial cell line-derived neurotrophic factor
    • Mehta V, Hong M, Spears J, Mendez I. Enhancement of graft survival and sensorimotor behavioral recovery in rats undergoing transplantation with dopaminergic cells exposed to glial cell line-derived neurotrophic factor. J. Neurosurg. 88, 1088-1095 (1998).
    • (1998) J. Neurosurg. , vol.88 , pp. 1088-1095
    • Mehta, V.1    Hong, M.2    Spears, J.3    Mendez, I.4
  • 19
    • 0030298512 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts
    • Rosenblad C, Martinez-Serrano A, Björklund A. Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts. Neuroscience 75, 979-985 (1996).
    • (1996) Neuroscience , vol.75 , pp. 979-985
    • Rosenblad, C.1    Martinez-Serrano, A.2    Björklund, A.3
  • 20
    • 28144438531 scopus 로고    scopus 로고
    • Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors increased yield of dopamine cells is dependent on embryonic donor age
    • Torres EM, Monville C, Lowenstein PR, Castro MG, Dunnett SB. Delivery of sonic hedgehog or glial derived neurotrophic factor to dopamine-rich grafts in a rat model of Parkinson's disease using adenoviral vectors increased yield of dopamine cells is dependent on embryonic donor age. Brain Res. Bull. 68, 31-41 (2005).
    • (2005) Brain Res. Bull. , vol.68 , pp. 31-41
    • Torres, E.M.1    Monville, C.2    Lowenstein, P.R.3    Castro, M.G.4    Dunnett, S.B.5
  • 21
    • 0032192007 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor improves survival of dopaminergic neurons in transplants of fetal ventral mesencephalic tissue
    • Yurek DM. Glial cell line-derived neurotrophic factor improves survival of dopaminergic neurons in transplants of fetal ventral mesencephalic tissue. Exp. Neurol. 153, 195-202 (1998).
    • (1998) Exp. Neurol. , vol.153 , pp. 195-202
    • Yurek, D.M.1
  • 22
    • 75149113700 scopus 로고    scopus 로고
    • Compacted DNA nanoparticle gene transfer of GDNF to the rat striatum enhances the survival of grafted fetal dopamine neurons
    • Yurek DM, Flectcher AM, Kowalczyk TH, Padegimas L, Cooper MJ. Compacted DNA nanoparticle gene transfer of GDNF to the rat striatum enhances the survival of grafted fetal dopamine neurons. Cell Transplant. 18, 1183-1196 (2009).
    • (2009) Cell Transplant. , vol.18 , pp. 1183-1196
    • Yurek, D.M.1    Flectcher, A.M.2    Kowalczyk, T.H.3    Padegimas, L.4    Cooper, M.J.5
  • 23
    • 0037106092 scopus 로고    scopus 로고
    • Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons
    • Ostenfeld T, Tai YT, Martin P, Déglon N, Aebischer P, Svendsen CN. Neurospheres modified to produce glial cell line-derived neurotrophic factor increase the survival of transplanted dopamine neurons. J. Neurosci. Res. 69, 955-965 (2002).
    • (2002) J. Neurosci. Res. , vol.69 , pp. 955-965
    • Ostenfeld, T.1    Tai, Y.T.2    Martin, P.3    Déglon, N.4    Aebischer, P.5    Svendsen, C.N.6
  • 24
    • 0031936437 scopus 로고    scopus 로고
    • Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts
    • Sautter J, Tseng JL, Braguglia D et al. Implants of polymer-encapsulated genetically modified cells releasing glial cell line-derived neurotrophic factor improve survival, growth, and function of fetal dopaminergic grafts. Exp. Neurol. 149, 230-236 (1998).
    • (1998) Exp. Neurol. , vol.149 , pp. 230-236
    • Sautter, J.1    Tseng, J.L.2    Braguglia, D.3
  • 25
    • 10844229392 scopus 로고    scopus 로고
    • Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor
    • Georgievska B, Carlsson T, Lacar B, Winkler C, Kirik D. Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor. Eur. J. Neurosci. 20, 3121-3130 (2004).
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 3121-3130
    • Georgievska, B.1    Carlsson, T.2    Lacar, B.3    Winkler, C.4    Kirik, D.5
  • 26
    • 33749055558 scopus 로고    scopus 로고
    • Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats
    • Winkler C, Georgievska B, Carlsson T, Lacar B, Kirik D. Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats. Neuroscience 141, 521-531 (2006).
    • (2006) Neuroscience , vol.141 , pp. 521-531
    • Winkler, C.1    Georgievska, B.2    Carlsson, T.3    Lacar, B.4    Kirik, D.5
  • 27
    • 0032005461 scopus 로고    scopus 로고
    • Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates
    • Espejo EF, Montoro RJ, Armengol JA, Lápez-Barneo J. Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantation of carotid body cell aggregates. Neuron 20, 197-206 (1998).
    • (1998) Neuron , vol.20 , pp. 197-206
    • Espejo, E.F.1    Montoro, R.J.2    Armengol, J.A.3    Lápez-Barneo, J.4
  • 28
    • 0342308802 scopus 로고    scopus 로고
    • Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen
    • Luquin MR, Montoro RJ, Guillén J et al. Recovery of chronic parkinsonian monkeys by autotransplants of carotid body cell aggregates into putamen. Neuron 22, 743-750 (1999).
    • (1999) Neuron , vol.22 , pp. 743-750
    • Luquin, M.R.1    Montoro, R.J.2    Guillén, J.3
  • 29
    • 0037221429 scopus 로고    scopus 로고
    • Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats
    • Toledo-Aral JJ, Méndez-Ferrer S, Pardal R, Echevarría M, Lápez-Barneo J. Trophic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body-grafted parkinsonian rats. J. Neurosci. 23, 141-148 (2003).
    • (2003) J. Neurosci. , vol.23 , pp. 141-148
    • Toledo-Aral, J.J.1    Méndez-Ferrer, S.2    Pardal, R.3    Echevarría, M.4    Lápez-Barneo, J.5
  • 30
    • 0042125235 scopus 로고    scopus 로고
    • Autotransplantation of human carotid body cell aggregates for treatment of Parkinson's disease
    • Arjona V, Mínguez-Castellanos A, Montoro RJ et al. Autotransplantation of human carotid body cell aggregates for treatment of Parkinson's disease. Neurosurgery 53, 321-328 (2003).
    • (2003) Neurosurgery , vol.53 , pp. 321-328
    • Arjona, V.1    Mínguez-Castellanos, A.2    Montoro, R.J.3
  • 31
    • 34547647081 scopus 로고    scopus 로고
    • Carotid body autotransplantation in Parkinson disease A clinical and positron emission tomography study
    • Mínguez-Castellanos A, Escamilla-Sevilla F, Hotton GR et al. Carotid body autotransplantation in Parkinson disease. A clinical and positron emission tomography study. J. Neurol. Neurosurg. Psychiatry 78, 825-831 (2007).
    • (2007) J. Neurol. Neurosurg. Psychiatry , vol.78 , pp. 825-831
    • Mínguez-Castellanos, A.1    Escamilla-Sevilla, F.2    Hotton, G.R.3
  • 32
    • 5444276658 scopus 로고    scopus 로고
    • Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine- lesioned rats implications for Parkinson's disease
    • Shukla S, Agrawal AK, Chaturvedi RK et al. Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine-lesioned rats. implications for Parkinson's disease. J. Neurochem. 91, 274-284 (2004).
    • (2004) J. Neurochem. , vol.91 , pp. 274-284
    • Shukla, S.1    Agrawal, A.K.2    Chaturvedi, R.K.3
  • 34
    • 17644392790 scopus 로고    scopus 로고
    • Selective glial cell linederived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation
    • Villadiego J, Méndez-Ferrer S, Valdés- Sánchez T et al. Selective glial cell linederived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation. J. Neurosci. 25, 4091-4098 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 4091-4098
    • Villadiego, J.1    Méndez-Ferrer, S.2    Valdés- Sánchez, T.3
  • 35
    • 0027449341 scopus 로고
    • Correlation of apomorphine and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats
    • Hudson JL, Van Horne CG, Stromberg I et al. Correlation of apomorphine and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats. Brain Res. 626, 167-174 (1993).
    • (1993) Brain Res. , vol.626 , pp. 167-174
    • Hudson, J.L.1    Van Horne, C.G.2    Stromberg, I.3
  • 38
    • 0026339976 scopus 로고
    • Unbiased stereological estimation of the total number of neurons of the rat hippocampus using the optical fractionator
    • West MJ, Slomianka L, Gundersen HJG. Unbiased stereological estimation of the total number of neurons of the rat hippocampus using the optical fractionator. Anat. Rec. 231, 482-497 (1991).
    • (1991) Anat. Rec. , vol.231 , pp. 482-497
    • West, M.J.1    Slomianka, L.2    Gundersen, H.J.G.3
  • 39
    • 84985280160 scopus 로고
    • The efficiency of systematic sampling in stereology and its prediction
    • Gundersen HJG, Jensen EB. The efficiency of systematic sampling in stereology and its prediction. J. Microsc. 147, 229-263 (1987).
    • (1987) J. Microsc. , vol.147 , pp. 229-263
    • Gundersen, H.J.G.1    Jensen, E.B.2
  • 40
    • 0023913503 scopus 로고
    • Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
    • Gundersen HJG, Bendsen TF, Korbo L, Marcussen N, Moller A, Nielsen K. Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APIMS 96, 379-394 (1988).
    • (1988) APIMS , vol.96 , pp. 379-394
    • Gundersen, H.J.G.1    Bendsen, T.F.2    Korbo, L.3    Marcussen, N.4    Moller, A.5    Nielsen, K.6
  • 41
    • 0027452902 scopus 로고
    • Dopamine-rich grafts in the neostriatum and/or nucleus accumbens Effects on drug-induced behaviours and skilled paw-reaching
    • Abrous DN, Shaltot AR, Torres EM, Dunnett SB. Dopamine-rich grafts in the neostriatum and/or nucleus accumbens. Effects on drug-induced behaviours and skilled paw-reaching. Neuroscience 53, 187-197 (1993).
    • (1993) Neuroscience , vol.53 , pp. 187-197
    • Abrous, D.N.1    Shaltot, A.R.2    Torres, E.M.3    Dunnett, S.B.4
  • 42
    • 0021954503 scopus 로고
    • Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival
    • Brundin P, Isacson O, Björklund A. Monitoring of cell viability in suspensions of embryonic CNS tissue and its use as a criterion for intracerebral graft survival. Brain Res. 331, 251-259 (1985).
    • (1985) Brain Res. , vol.331 , pp. 251-259
    • Brundin, P.1    Isacson, O.2    Björklund, A.3
  • 43
    • 0036955707 scopus 로고    scopus 로고
    • Intrastriatal grafting of glomus cells ameliorates behavioral defects of Parkinsonian rats
    • Hao G, Yao Y, Wang J, Zhang L, Viroonchatapan N, Wang ZZ. Intrastriatal grafting of glomus cells ameliorates behavioral defects of Parkinsonian rats. Physiol. Behav. 77, 519-525 (2002).
    • (2002) Physiol. Behav. , vol.77 , pp. 519-525
    • Hao, G.1    Yao, Y.2    Wang, J.3    Zhang, L.4    Viroonchatapan, N.5    Wang, Z.Z.6
  • 44
    • 0030725572 scopus 로고    scopus 로고
    • Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
    • Björklund A, Rosenblad C, Winkler C, Kirik D. Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol. Dis. 4, 186-200 (1997).
    • (1997) Neurobiol. Dis. , vol.4 , pp. 186-200
    • Björklund, A.1    Rosenblad, C.2    Winkler, C.3    Kirik, D.4
  • 45
    • 0033526078 scopus 로고    scopus 로고
    • Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts
    • Lápez-Martín E, Caruncho HJ, Rodríguez- Pallares J, Guerra MJ, Labandeira-García JL. Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts. J. Comp. Neurol. 406, 199-206 (1999).
    • (1999) J. Comp. Neurol. , vol.406 , pp. 199-206
    • Lápez-Martín, E.1    Caruncho, H.J.2    Rodríguez-Pallares, J.3    Guerra, M.J.4    Labandeira-García, J.L.5
  • 47
    • 0029053195 scopus 로고
    • Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons
    • Bowenkamp KE, Hoffman AF, Gerhardt GA et al. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. J. Comp. Neurol. 355, 479-388 (1995).
    • (1995) J. Comp. Neurol. , vol.355 , pp. 479-388
    • Bowenkamp, K.E.1    Hoffman, A.F.2    Gerhardt, G.A.3
  • 48
    • 0029803454 scopus 로고    scopus 로고
    • Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease
    • Winkler C, Sauer H, Lee CS, Björklund A. Short-term GDNF treatment provides long-term rescue of lesioned nigral dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 16, 7206-7215 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 7206-7215
    • Winkler, C.1    Sauer, H.2    Lee, C.S.3    Björklund, A.4
  • 49
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower JH, Emborg ME, Bloch J et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290, 767-773 (2000).
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3
  • 50
    • 0036434879 scopus 로고    scopus 로고
    • Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer
    • Georgievska B, Kirik D, Björklund A. Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer. Exp. Neurol. 177, 461-474 (2002).
    • (2002) Exp. Neurol. , vol.177 , pp. 461-474
    • Georgievska, B.1    Kirik, D.2    Björklund, A.3
  • 51
    • 3242762057 scopus 로고    scopus 로고
    • Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system
    • Georgievska B, Kirik D, Björklund A. Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system. J. Neurosci. 24, 6437-6445 (2004).
    • (2004) J. Neurosci. , vol.24 , pp. 6437-6445
    • Georgievska, B.1    Kirik, D.2    Björklund, A.3
  • 52
    • 12844287442 scopus 로고    scopus 로고
    • Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
    • Eslamboli A, Georgievska B, Ridley RM et al. Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease. J. Neurosci. 25, 769-777 (2005).
    • (2005) J. Neurosci. , vol.25 , pp. 769-777
    • Eslamboli, A.1    Georgievska, B.2    Ridley, R.M.3
  • 53
    • 0032850453 scopus 로고    scopus 로고
    • Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease
    • Kordower JH, Palfi S, Chen EY et al. Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease. Ann. Neurol. 46, 419-424 (1999).
    • (1999) Ann. Neurol. , vol.46 , pp. 419-424
    • Kordower, J.H.1    Palfi, S.2    Chen, E.Y.3
  • 54
    • 0037435511 scopus 로고    scopus 로고
    • Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
    • Nutt JG, Burchiel KJ, Comella CL et al. Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD. Neurology 60, 69-73 (2003).
    • (2003) Neurology , vol.60 , pp. 69-73
    • Nutt, J.G.1    Burchiel, K.J.2    Comella, C.L.3
  • 55
    • 13144282676 scopus 로고    scopus 로고
    • Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD A two-year outcome study
    • Patel NK, Bunnage M, Plaha P, Svendsen CN, Heywood P, Gill SS. Intraputamenal infusion of glial cell line-derived neurotrophic factor in PD. A two-year outcome study. Ann. Neurol. 57, 298-302 (2005).
    • (2005) Ann. Neurol. , vol.57 , pp. 298-302
    • Patel, N.K.1    Bunnage, M.2    Plaha, P.3    Svendsen, C.N.4    Heywood, P.5    Gill, S.S.6
  • 56
    • 14844311296 scopus 로고    scopus 로고
    • Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor
    • Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, Young B. Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor. J. Neurosurg. 102, 216-222 (2005).
    • (2005) J. Neurosurg. , vol.102 , pp. 216-222
    • Slevin, J.T.1    Gerhardt, G.A.2    Smith, C.D.3    Gash, D.M.4    Kryscio, R.5    Young, B.6
  • 59
    • 0035863081 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo
    • Erickson JT, Brosenitsch TA, Katz DM. Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo. J. Neurosci. 21, 581-589 (2001).
    • (2001) J. Neurosci. , vol.21 , pp. 581-589
    • Erickson, J.T.1    Brosenitsch, T.A.2    Katz, D.M.3
  • 60
    • 0025876757 scopus 로고
    • BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra
    • Hyman C, Hofer M, Barde YA et al. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350, 230-232 (1991).
    • (1991) Nature , vol.350 , pp. 230-232
    • Hyman, C.1    Hofer, M.2    Barde, Y.A.3
  • 62
    • 79651474103 scopus 로고    scopus 로고
    • Enhanced GDNF expression in dopaminergic cells of monkeys grafted with carotid body cell aggregates
    • Luquin MR, Manrique M, Guillén J, Arbizu J, Ordoñez C, Marcilla I. Enhanced GDNF expression in dopaminergic cells of monkeys grafted with carotid body cell aggregates. Brain Res. 1375, 120-127 (2011).
    • (2011) Brain Res. , vol.1375 , pp. 120-127
    • Luquin, M.R.1    Manrique, M.2    Guillén, J.3    Arbizu, J.4    Ordoñez, C.5    Marcilla, I.6
  • 64
    • 35348906206 scopus 로고    scopus 로고
    • Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body
    • Pardal R, Ortega-Sáenz P, Durán R, Lápez-Barneo J. Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131, 364-377 (2007).
    • (2007) Cell , vol.131 , pp. 364-377
    • Pardal, R.1    Ortega-Sáenz, P.2    Durán, R.3    Lápez-Barneo, J.4
  • 65
    • 0034065380 scopus 로고    scopus 로고
    • Improving the survival of grafted dopaminergic neurons: A review over current approaches
    • Brundin P, Karlsson J, Emgård M et al. Improving the survival of grafted dopaminergic neurons: a review over current approaches. Cell Transplant. 9, 179-195 (2000).
    • (2000) Cell Transplant. , vol.9 , pp. 179-195
    • Brundin, P.1    Karlsson, J.2    Emgård, M.3
  • 66
    • 0037111277 scopus 로고    scopus 로고
    • Comparison between survival of lazaroidtreated embryonic nigral neurons in cell suspensions, cultures and transplants
    • Karlsson J, Emgård M, Brundin P. Comparison between survival of lazaroidtreated embryonic nigral neurons in cell suspensions, cultures and transplants. Brain Res. 955, 268-280 (2002).
    • (2002) Brain Res. , vol.955 , pp. 268-280
    • Karlsson, J.1    Emgård, M.2    Brundin, P.3
  • 67
    • 0028899401 scopus 로고
    • Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease
    • Nakao N, Frodl EM, Widner H et al. Overexpressing Cu/Zn superoxide dismutase enhances survival of transplanted neurons in a rat model of Parkinson's disease. Nat. Med. 1, 226-231 (1995).
    • (1995) Nat. Med. , vol.1 , pp. 226-231
    • Nakao, N.1    Frodl, E.M.2    Widner, H.3
  • 68
    • 0013670016 scopus 로고    scopus 로고
    • Flunarizine improves the survival of grafted dopaminergic neurons
    • Kaminski Schierle GS, Hansson O, Brundin P. Flunarizine improves the survival of grafted dopaminergic neurons. Neuroscience 94, 17-20 (1999).
    • (1999) Neuroscience , vol.94 , pp. 17-20
    • Kaminski Schierle, G.S.1    Hansson, O.2    Brundin, P.3
  • 69
  • 70
    • 2442450540 scopus 로고    scopus 로고
    • Reassessment of caspase inhibition to augment grafted dopamine neuron survival
    • Marchionini DM, Collier TJ, Pitzer MR, Sortwell CE. Reassessment of caspase inhibition to augment grafted dopamine neuron survival. Cell Transplant. 13, 273-282 (2004).
    • (2004) Cell Transplant. , vol.13 , pp. 273-282
    • Marchionini, D.M.1    Collier, T.J.2    Pitzer, M.R.3    Sortwell, C.E.4
  • 72
    • 0028138846 scopus 로고
    • A microtransplantation approach for cell suspension grafting in the rat Parkinson model: A detailed account of the methodology
    • Nikkhah G, Olsson M, Eberhard J, Bentlage C, Cunningham MG, Björklund A. A microtransplantation approach for cell suspension grafting in the rat Parkinson model: a detailed account of the methodology. Neuroscience 63, 57-72 (1994).
    • (1994) Neuroscience , vol.63 , pp. 57-72
    • Nikkhah, G.1    Olsson, M.2    Eberhard, J.3    Bentlage, C.4    Cunningham, M.G.5    Björklund, A.6
  • 73
    • 2442586646 scopus 로고    scopus 로고
    • Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts
    • Alemdar AY, Sadi D, McAlister VC, Mendez I. Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts. Cell Transplant. 13, 263-271 (2004).
    • (2004) Cell Transplant. , vol.13 , pp. 263-271
    • Alemdar, A.Y.1    Sadi, D.2    McAlister, V.C.3    Mendez, I.4
  • 74
    • 34247572561 scopus 로고    scopus 로고
    • Intracerebral co-transplantation of liposomal tacrolimus improves xenograft survival and reduces graft rejection in the hemiparkinsonian rat
    • Alemdar AY, Sadi D, McAlister V, Mendez I. Intracerebral co-transplantation of liposomal tacrolimus improves xenograft survival and reduces graft rejection in the hemiparkinsonian rat. Neuroscience 146, 213-224 (2007).
    • (2007) Neuroscience , vol.146 , pp. 213-224
    • Alemdar, A.Y.1    Sadi, D.2    McAlister, V.3    Mendez, I.4
  • 75
    • 22544444518 scopus 로고    scopus 로고
    • Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient
    • Karlsson J, Petersén A, Gidö G, Wieloch T, Brundin P. Combining neuroprotective treatment of embryonic nigral donor tissue with mild hypothermia of the graft recipient. Cell Transplant. 14, 301-309 (2005).
    • (2005) Cell Transplant. , vol.14 , pp. 301-309
    • Karlsson, J.1    Petersén, A.2    Gidö, G.3    Wieloch, T.4    Brundin, P.5
  • 76
    • 0033586328 scopus 로고    scopus 로고
    • Sertoli cells enhance the survival of co-transplanted dopamine neurons
    • Willing AE, Othberg AI, Saporta S et al. Sertoli cells enhance the survival of co-transplanted dopamine neurons. Brain Res. 822, 246-250 (1999).
    • (1999) Brain Res. , vol.822 , pp. 246-250
    • Willing, A.E.1    Othberg, A.I.2    Saporta, S.3
  • 77
    • 0035696058 scopus 로고    scopus 로고
    • Liposomal tacrolimus administered systemically and within the donor cell suspension improves xenograft survival in hemiparkinsonian rats
    • Alemdar AY, Baker KA, Sadi D, McAlister VC, Mendez I. Liposomal tacrolimus administered systemically and within the donor cell suspension improves xenograft survival in hemiparkinsonian rats. Exp. Neurol. 172, 416-424 (2001).
    • (2001) Exp. Neurol. , vol.172 , pp. 416-424
    • Alemdar, A.Y.1    Baker, K.A.2    Sadi, D.3    McAlister, V.C.4    Mendez, I.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.