Novel function of neuron-restrictive silencer factor (NRSF) for posttranscriptional regulation

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 10, 2008, Pages 1835-1846

  Kim, Chun Sung ^a,b   Hwang, Cheol Kyu ^a   Song, Kyu Young ^a   Choi, Hack Sun ^a   Kim, Do Kyung ^b   Law, Ping Yee ^a   Wei, Li Na ^a   Loh, Horace H ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b Chosun University   (South Korea)

Author keywords

eIF4G; Mu opioid receptor; NRSE; NRSF; Translational regulation

Indexed keywords

INITIATION FACTOR 4G; MESSENGER RNA; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR ANTAGONIST; NEURON RESTRICTIVE SILENCER FACTOR; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; FUNCTIONAL PROTEOMICS; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGAND BINDING; NEUROBLASTOMA CELL; NONHUMAN; POLYSOME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; RAT; RNA BINDING; RNA INTERFERENCE; RNA TRANSLATION; TRANSCRIPTION REGULATION;

ANIMALS; CELL LINE, TUMOR; CYTOPLASM; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; LIGANDS; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; RATS; RECEPTORS, OPIOID, MU; REPRESSOR PROTEINS; RNA, MESSENGER;

EID: 50849103324     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.06.019     Document Type: Article

References (55)

1. Wood P.L. The significance of multiple CNS opioid receptor types: a review of critical considerations relating to technical details and anatomy in the study of central opioid actions. Peptides 9 Suppl 1 (1988) 49-55
2. Berrendero F., Kieffer B.L., and Maldonado R. Attenuation of nicotine-induced antinociception, rewarding effects, and dependence in mu-opioid receptor knock-out mice. J. Neurosci. 22 (2002) 10935-10940
3. Bolster D.R., Vary T.C., Kimball S.R., and Jefferson L.S. Leucine regulates translation initiation in rat skeletal muscle via enhanced eIF4G phosphorylation. J. Nutr. 134 (2004) 1704-1710
4. Choi H.S., Hwang C.K., Kim C.S., Song K.Y., Law P.Y., Wei L.N., and Loh H.H. Transcriptional regulation of mouse mu opioid receptor gene: Sp3 isoforms (M1, M2) function as repressors in neuronal cells to regulate the mu opioid receptor gene. Mol. Pharmacol. 67 (2005) 1674-1683
5. Choi H.S., Kim C.S., Hwang C.K., Song K.Y., Law P.Y., Wei L.N., and Loh H.H. Novel function of the poly(C)-binding protein {alpha}CP3 as a transcriptional repressor of the mu opioid receptor gene. Faseb. J. (2007)
6. Coulson J.M., Ahmed S.I., Quinn J.P., and Woll P.J. Detection of small cell lung cancer by RT-PCR for neuropeptides, neuropeptide receptors, or a splice variant of the neuron restrictive silencer factor. Methods. Mol. Med. 75 (2003) 335-352
7. Hwang C.K., Wu X., Wang G., Kim C.S., and Loh H.H. Mouse mu opioid receptor distal promoter transcriptional regulation by SOX proteins. J. Biol. Chem. 278 (2003) 3742-3750
8. Hwang C.K., Song K.Y., Kim C.S., Choi H.S., Guo X.H., Law P.Y., Wei L.N., and Loh H.H. Evidence of endogenous mu opioid receptor regulation by epigenetic control of the promoters. Mol. Cell. Biol. 27 (2007) 4720-4736
9. Hwang C.K., Kim C.S., Choi H.S., McKercher S.R., and Loh H.H. Transcriptional regulation of mouse mu opioid receptor gene by PU.1. J. Biol. Chem. 279 (2004) 19764-19774
10. Kim C.S., Hwang C.K., Choi H.S., Song K.Y., Law P.Y., Wei L.N., and Loh H.H. Neuron-restrictive silencer factor (NRSF) functions as a repressor in neuronal cells to regulate the mu opioid receptor gene. J. Biol. Chem. 279 (2004) 46464-46473
11. Kim C.S., Choi H.S., Hwang C.K., Song K.Y., Lee B.K., Law P.Y., Wei L.N., and Loh H.H. Evidence of the neuron-restrictive silencer factor (NRSF) interaction with Sp3 and its synergic repression to the mu opioid receptor (MOR) gene. Nucleic. Acids. Res. 34 (2006) 6392-6403
12. Ko J.L., Minnerath S.R., and Loh H.H. Dual promoters of mouse mu-opioid receptor gene. Biochem. Biophys. Res. Commun. 234 (1997) 351-357
13. Ko J.L., and Loh H.H. Single-stranded DNA-binding complex involved in transcriptional regulation of mouse mu-opioid receptor gene. J. Biol. Chem. 276 (2001) 788-795
14. Ko J.L., Liu H.C., Minnerath S.R., and Loh H.H. Transcriptional regulation of mouse mu-opioid receptor gene. J. Biol. Chem. 273 (1998) 27678-27685
15. Ko J.L., Liu H.C., and Loh H.H. Role of an AP-2-like element in transcriptional regulation of mouse micro-opioid receptor gene. Brain. Res. Mol. Brain. Res. 112 (2003) 153-162
16. Ko J.L., Chen H.C., and Loh H.H. Differential promoter usage of mouse mu-opioid receptor gene during development. Brain. Res. Mol. Brain. Res. 104 (2002) 184-193
17. Majumder S. REST in good times and bad: roles in tumor suppressor and oncogenic activities. Cell. Cycle. 5 (2006) 1929-1935
18. Westbrook T.F., Martin E.S., Schlabach M.R., Leng Y., Liang A.C., Feng B., Zhao J.J., Roberts T.M., Mandel G., Hannon G.J., Depinho R.A., Chin L., and Elledge S.J. A genetic screen for candidate tumor suppressors identifies REST. Cell 121 (2005) 837-848
19. Bessis A., Champtiaux N., Chatelin L., and Changeux J.P. The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 5906-5911
20. Kallunki P., Edelman G.M., and Jones F.S. The neural restrictive silencer element can act as both a repressor and enhancer of L1 cell adhesion molecule gene expression during postnatal development. Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 3233-3238
21. Seth K.A., and Majzoub J.A. Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. J. Biol. Chem. 276 (2001) 13917-13923
22. Yoo J., Jeong M.J., Lee S.S., Lee K.I., Kwon B.M., Kim D.S., Park Y.M., and Han M.Y. The neuron restrictive silencer factor can act as an activator for dynamin I gene promoter activity in neuronal cells. Biochem. Biophys. Res. Commun. 283 (2001) 928-932
23. Sun Y.M., Greenway D.J., Johnson R., Street M., Belyaev N.D., Deuchars J., Bee T., Wilde S., and Buckley N.J. Distinct profiles of REST interactions with its target genes at different stages of neuronal development. Mol. Biol. Cell. 16 (2005) 5630-5638
24. Nedelec S., Foucher I., Brunet I., Bouillot C., Prochiantz A., and Trembleau A. Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons. Proc. Natl. Acad. Sci. U. S. A. 101 (2004) 10815-10820
25. Park C.Y., and Dolmetsch R. Cell signaling. The double life of a transcription factor takes it outside the nucleus. Science 314 (2006) 64-65
26. Lin H., Huganir R., and Liao D. Temporal dynamics of NMDA receptor-induced changes in spine morphology and AMPA receptor recruitment to spines. Biochem. Biophys. Res. Commun. 316 (2004) 501-511
27. Liao D., Scannevin R.H., and Huganir R. Activation of silent synapses by rapid activity-dependent synaptic recruitment of AMPA receptors. J. Neurosci. 21 (2001) 6008-6017
28. Song K.Y., Hwang C.K., Kim C.S., Choi H.S., Law P.Y., Wei L.N., and Loh H.H. Translational repression of mouse mu opioid receptor expression via leaky scanning. Nucleic. Acids. Res. 35 (2007) 1501-1513
29. Roopra A., Qazi R., Schoenike B., Daley T.J., and Morrison J.F. Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes. Molecular. Cell. 14 (2004) 727-738
30. Choi H.S., Kim C.S., Hwang C.K., Song K.Y., Wang W., Qiu Y., Law P.Y., Wei L.N., and Loh H.H. The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor. Biochem. Biophys. Res. Commun. 343 (2006) 1132-1140
31. Tsai N.P., Bi J., Loh H.H., and Wei L.N. Netrin-1 signaling regulates de novo protein synthesis of kappa opioid receptor by facilitating polysomal partition of its mRNA. J. Neurosci. 20 (2006) 9743-9749
32. Kemp D.M., Lin J.C., and Habener J.F. Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factor. J. Biol. Chem. 278 (2003) 35057-35062
33. Smith R., Chung H., Rundquist S., Maat-Schieman M.L., Colgan L., Englund E., Liu Y.J., Roos R.A., Faull R.L., Brundin P., and Li J.Y. Cholinergic neuronal defect without cell loss in Huntington's disease. Hum. Mol. Genet. 15 (2006) 3119-3131
34. Raynor K., Kong H., Law S., Heerding J., Tallent M., Livingston F., Hines J., and Reisine T. Molecular biology of opioid receptors. NIDA. Res. Monogr. 161 (1996) 83-103
35. Formisano L., Noh K.M., Miyawaki T., Mashiko T., Bennett M.V., and Zukin R.S. Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 4170-4175
36. Schoenherr C.J., and Anderson D.J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267 (1995) 1360-1363
37. Palm K., Belluardo N., Metsis M., and Timmusk T. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J. Neurosci. 18 (1998) 1280-1296
38. Kallunki P., Edelman G.M., and Jones F.S. Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element. J. Cell. Biol. 138 (1997) 1343-1354
39. Kim M.Y., Jeong B.C., Lee J.H., Kee H.J., Kook H., Kim N.S., Kim Y.H., Kim J.K., Ahn K.Y., and Kim K.K. A repressor complex, AP4 transcription factor and geminin, negatively regulates expression of target genes in nonneuronal cells. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 13074-13079
40. Kim S.M., Yang J.W., Park M.J., Lee J.K., Kim S.U., Lee Y.S., and Lee M.A. Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor. Biochem. Biophys. Res. Commun. 346 (2006) 426-435
41. Okamoto S., Sherman K., and Lipton S.A. Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells. Brain. Res. Mol. Brain. Res. 74 (1999) 44-54
42. Qiang M., Rani C.S., and Ticku M.K. Neuron-restrictive silencer factor regulates the N-methyl-d-aspartate receptor 2B subunit gene in basal and ethanol-induced gene expression in fetal cortical neurons. Mol. Pharmacol. 67 (2005) 2115-2125
43. Quinn J.P., Bubb V.J., Marshall-Jones Z.V., and Coulson J.M. Neuron restrictive silencer factor as a modulator of neuropeptide gene expression. Regul. Pept. 108 (2002) 135-141
44. Timmusk T., Palm K., Lendahl U., and Metsis M. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. J. Biol. Chem. 274 (1999) 1078-1084
45. Tsuda L., Kaido M., Lim Y.M., Kato K., Aigaki T., and Hayashi S. An NRSF/REST-like repressor downstream of Ebi/SMRTER/Su(H) regulates eye development in Drosophila. Embo. J. 25 (2006) 3191-3202
46. Wood I.C., Roopra A., and Buckley N.J. Neural specific expression of the m4 muscarinic acetylcholine receptor gene is mediated by a RE1/NRSE-type silencing element. J. Biol. Chem. 271 (1996) 14221-14225
47. Yeo M., Lee S.K., Lee B., Ruiz E.C., Pfaff S.L., and Gill G.N. Small CTD phosphatases function in silencing neuronal gene expression. Science 307 (2005) 596-600
48. Kraner S.D., Chong J.A., Tsay H.J., and Mandel G. Silencing the type II sodium channel gene: a model for neural-specific gene regulation. Neuron 9 (1992) 37-44
49. Mori N., Schoenherr C., Vandenbergh D.J., and Anderson D.J. A common silencer element in the SCG10 and type II Na+ channel genes binds a factor present in nonneuronal cells but not in neuronal cells. Neuron 9 (1992) 45-54
50. Chen Z.F., Paquette A.J., and Anderson D.J. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat. Genet. 20 (1998) 136-142
51. Kuwabara T., Hsieh J., Nakashima K., Taira K., and Gage F.H. A small modulatory dsRNA specifies the fate of adult neural stem cells. Cell 116 (2004) 779-793
52. Zuccato C., Tartari M., Crotti A., Goffredo D., Valenza M., Conti L., Cataudella T., Leavitt B.R., Hayden M.R., Timmusk T., Rigamonti D., and Cattaneo E. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nature. Genet. 35 (2003) 76-83
53. Raught B., Gingras A.C., Gygi S.P., Imataka H., Morino S., Gradi A., Aebersold R., and Sonenberg N. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. EMBO. J. 19 (2000) 434-444
54. Nguyen K.A., Santos S.J., Kreidel M.K., Diaz A.L., Rey R., and Lawson M.A. Acute regulation of translation initiation by gonadotropin-releasing hormone in the gonadotrope cell line LbetaT2. Mol. Endocrinol. 18 (2004) 1301-1312
55. Crozier S.J., Kimball S.R., Emmert S.W., Anthony J.C., and Jefferson L.S. Oral leucine administration stimulates protein synthesis in rat skeletal muscle. J. Nutr. 135 (2005) 376-382