The key role of transforming growth factor-beta receptor i and 15-lipoxygenase in hypoxia-induced proliferation of pulmonary artery smooth muscle cells

International Journal of Biochemistry and Cell Biology

Volumn 44, Issue 7, 2012, Pages 1184-1202

  Liu, Yun ^a   Ma, Cui ^a   Zhang, Qianlong ^a   Yu, Lei ^a   Ma, Jun ^a   Zhang, Lei ^a   Hao, Xuewei ^a   Cao, Fangyuan ^a   Wang, Lin ^a   Zhu, Daling ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Biopharmaceutical Key Laboratory of Heilongjiang Province   (China)

Author keywords

15 Lipoxygenase; Proliferation; Pulmonary arterial hypertension; Transforming growth factor beta1

Indexed keywords

15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; BETA ACTIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 3; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE PROGRESSION; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; GENE SILENCING; HISTOLOGY; HYPOXIA; IMMUNOHISTOCHEMISTRY; NONHUMAN; PULMONARY ARTERY; PULMONARY ARTERY SMOOTH MUSCLE CELL; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; ARACHIDONATE 15-LIPOXYGENASE; CELL GROWTH PROCESSES; CELL HYPOXIA; CELL SURVIVAL; CELLS, CULTURED; FEMALE; MALE; MYOCYTES, SMOOTH MUSCLE; PROTEIN-SERINE-THREONINE KINASES; PULMONARY ARTERY; RATS; RATS, WISTAR; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFECTION;

RATTUS;

EID: 84861231371     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2012.04.009     Document Type: Article

References (28)

1. A. Agrotis, N. Kalinina, and A. Bobik Transforming growth factor-beta, cell signaling and cardiovascular disorders Current Vascular Pharmacology 3 2005 55 61
2. S.S. Arcot, D.W. Lipke, M.N. Gillespie, and J.W. Olson Alterations of growth factor transcripts in rat lungs during development of monocrotaline-induced pulmonary hypertension Biochemical Pharmacology 46 1993 1086 1091
3. U. Bartram, and C.P. Speer The role of transforming growth factor beta in lung development and disease Chest 125 2004 754 765
4. S.Y. Chan, and J. Loscalzo Pathogenic mechanisms of pulmonary arterial hypertension Journal of Molecular and Cellular Cardiology 44 2008 14 30
5. + channels in human pulmonary artery smooth muscle cells American Journal of Physiology. Lung, Cellular and Molecular Physiology 291 2006 L993 L1004
6. H.W. Farber, and J. Loscalzo Pulmonary arterial hypertension New England Journal of Medicine 351 2004 1655 1665
7. F. Girard, U. Strausfeld, A. Fernandez, and N.J. Lamb Cyclin A is required for the onset of DNA replication in mammalian fibroblasts Cell 67 1991 1169 1179
8. + currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells European Journal of Pharmacology 587 2008 187 195
9. M. Humbert, O. Sitbon, and G. Simonneau Treatment of pulmonary arterial hypertension New England Journal of Medicine 351 2004 1425 1436
10. T. Ito, T. Okada, H. Miyashita, T. Nomoto, M. Nonaka-Sarukawa, and R. Uchibori Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats Circulation Research 101 2007 734 741
11. Y.S. Kim, Z.G. Xu, M.A. Reddy, S.L. Li, L. Lanting, and K. Sharma Novel interactions between TGF-{beta}1 actions and the 12/15-lipoxygenase pathway in mesangial cells Journal of the American Society of Nephrology 16 2005 352 362
12. J.A. Knoblich, K. Sauer, L. Jones, H. Richardson, R. Saint, and C.F. Lehner Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation Cell 77 1994 107 120
13. C. Ma, Y. Li, J. Ma, Y. Liu, Q. Li, and S. Niu Key role of 15-lipoxygenase/15-hydroxyeicosatetraenoic acid in pulmonary vascular remodeling and vascular angiogenesis associated with hypoxic pulmonary hypertension Hypertension 58 2011 679 688
14. J. Ma, S. Liang, Z. Wang, L. Zhang, J. Jiang, and J. Zheng ROCK pathway participates in the processes that 15-hydroxyeicosatetraenoic acid (15-HETE) mediated the pulmonary vascular remodeling induced by hypoxia in rat Journal of Cellular Physiology 222 2010 82 94
15. M.S. McMurtry, S. Bonnet, X. Wu, J.R. Dyck, A. Haromy, and K. Hashimoto Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis Circulation Research 95 2004 830 840
16. N.W. Morrell, X. Yang, P.D. Upton, K.B. Jourdan, N. Morgan, and K.K. Sheares Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins Circulation 104 2001 790 795
17. H. Nakano, K. Namatame, A. Nakayoshi, and K. Kumada The evaluation of cellular proliferating activity in gastric carcinoma with the proliferating cell nuclear antigen (PCNA) expressive rate: its fundamental examination of the immunohistochemical procedures and its clinical applications Nihon Geka Gakkai Zasshi 94 1993 580 592
18. M. Ohtsubo, and J.M. Roberts Cyclin-dependent regulation of G1 in mammalian fibroblasts Science 259 1993 1908 1912
19. M. Pagano, R. Pepperkok, F. Verde, W. Ansorge, and G. Draetta Cyclin A is required at two points in the human cell cycle EMBO Journal 11 1992 961 971
20. P. Paterlini, A.M. Suberville, F. Zindy, J. Melle, M. Sonnier, and J.P. Marie Cyclin A expression in human hematological malignancies: a new marker of cell proliferation Cancer Research 53 1993 235 238
21. G.G. Pietra, F. Capron, S. Stewart, O. Leone, M. Humbert, and I.M. Robbins Pathologic assessment of vasculopathies in pulmonary hypertension Journal of the American College of Cardiology 43 2004 25S 32S
22. M. Rabinovitch The mouse through the looking glass: a new door into the pathophysiology of pulmonary hypertension Circulation Research 94 2004 1001 1004
23. A.B. Roberts, and M.B. Sporn Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta) Growth Factors 8 1993 1 9
24. K.K. Sheares, T.K. Jeffery, L. Long, X. Yang, and N.W. Morrell Differential effects of TGF-beta1 and BMP-4 on the hypoxic induction of cyclooxygenase-2 in human pulmonary artery smooth muscle cells American Journal of Physiology. Lung, Cellular and Molecular Physiology 287 2004 L919 L927
25. K.R. Stenmark, K.A. Fagan, and M.G. Frid Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms Circulation Research 99 2006 675 691
26. Y.D. Xu, J. Hua, A. Mui, R. O'Connor, G. Grotendorst, and N. Khalil Release of biologically active TGF-beta1 by alveolar epithelial cells results in pulmonary fibrosis American Journal of Physiology. Lung, Cellular and Molecular Physiology 285 2003 L527 L539
27. S. Zhang, I. Fantozzi, D.D. Tigno, E.S. Yi, O. Platoshyn, and P.A. Thistlethwaite Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells American Journal of Physiology. Lung, Cellular and Molecular Physiology 285 2003 L740 L754
28. D. Zhu, M. Medhora, W.B. Campbell, N. Spitzbarth, J.E. Baker, and E.R. Jacobs Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries Circulation Research 92 2003 992 1000