Interleukin-10 expression mediated by an adeno-associated virus vector prevents monocrotaline-induced pulmonary arterial hypertension in rats

Circulation Research

Volumn 101, Issue 7, 2007, Pages 734-741

  Ito, Takayuki ^a   Okada, Takashi ^b   Miyashita, Hiroshi ^a   Nomoto, Tatsuya ^a   Nonaka Sarukawa, Mutsuko ^a   Uchibori, Ryosuke ^a   Maeda, Yoshikazu ^a   Urabe, Masashi ^a   Mizukami, Hiroaki ^a   Kume, Akihiro ^a   Takahashi, Masafumi ^c   Ikeda, Uichi ^c   Shimada, Kazuyuki ^a   Ozawa, Keiya ^a  

^a JICHI MEDICAL UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

^c SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Gene therapy; Inflammation; Interleukins; Pulmonary hypertension; Vascular smooth muscle cell proliferation

Indexed keywords

HEME OXYGENASE INHIBITOR; INTERLEUKIN 10; MONOCROTALINE; PARVOVIRUS VECTOR; PROTOPORPHYRIN TIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL INFILTRATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HEART VENTRICLE SEPTUM; HUMAN; HUMAN CELL; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; PULMONARY HYPERTENSION; RAT; SMOOTH MUSCLE FIBER; SURVIVAL RATE; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY;

ADENOVIRIDAE; ANIMALS; CELLS, CULTURED; CHICKENS; GENETIC VECTORS; HUMANS; HYPERTENSION, PULMONARY; INTERLEUKIN-10; MALE; MONOCROTALINE; PULMONARY ARTERY; RATS; RATS, WISTAR;

EID: 34848875473     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.107.153023     Document Type: Article

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