Subacute hypoxia suppresses Kv3.4 channel expression and whole-cell K+ currents through endogenous 15-hydroxyeicosatetraenoic acid in pulmonary arterial smooth muscle cells

European Journal of Pharmacology

Volumn 587, Issue 1-3, 2008, Pages 187-195

  Guo, Lei ^a   Tang, Xiaobo ^a   Tian, Hua ^c   Liu, Ye ^a   Wang, Zhigang ^a   Wu, Hong ^a,d   Wang, Jing ^a   Guo, Sholi ^a   Zhu, Daling ^a,b  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b Bio pharmaceutical Key Laboratory of Heilongjiang Province   (China)

^c Qiqihaer Medical University   (China)

^d MUDANJIANG MEDICAL UNIVERSITY   (China)

Author keywords

15 hydroxyeicosatetraenoic acid; 15 lipoxygenase; Kv3.4; Pulmonary arterial smooth muscle cells; Subacute hypoxia

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; ARACHIDONATE 15 LIPOXYGENASE; ARACHIDONIC ACID; CINNAMIC ACID DERIVATIVE; CINNAMYL 3,4 DIHYDROXY[ALPHA]CYANOCINNAMATE; MESSENGER RNA; NORDIHYDROGUAIARETIC ACID; POTASSIUM CHANNEL; POTASSIUM CHANNEL KV3.4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG INHIBITION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HYPOXIA; NONHUMAN; PATCH CLAMP; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PULMONARY ARTERY; RAT; SMOOTH MUSCLE FIBER; WESTERN BLOTTING; WHOLE CELL;

ANIMALS; ANOXIA; ARACHIDONATE 15-LIPOXYGENASE; BLOTTING, WESTERN; CALCIUM; CELL SEPARATION; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYDROXYEICOSATETRAENOIC ACIDS; INDICATORS AND REAGENTS; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; PULMONARY ARTERY; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SHAW POTASSIUM CHANNELS;

EID: 44149086360     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.02.031     Document Type: Article

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