Chronic hypoxia activates lung 15-lipoxygenase, which catalyzes production of 15-HETE and enhances constriction in neonatal rabbit pulmonary arteries

Circulation Research

Volumn 92, Issue 9, 2003, Pages 992-1000

  Zhu, Daling ^a,b   Medhora, Meetha ^a   Campbell, William B ^a   Spitzbarth, Nancy ^a   Baker, John E ^a   Jacobs, Elizabeth R ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

15 hydroxyeicosatetraenoic acid; 15 lipoxygenase; Eicosanoids; Hypoxic pulmonary vasoconstriction; Trihydroxyeicosatrienoic acid

Indexed keywords

11,12,15 TRIHYDROXYEICOSATRIENOIC ACID; 11,14,15 TRIHYDROXYEICOSATRIENOIC ACID; 15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 15 HYDROXYICOSATETRAENOIC ACID; 17 OCTADECYNOIC ACID; ACETYLCHOLINE; ALPHA NAPHTHOFLAVONE; ARACHIDONATE 15 LIPOXYGENASE; CINNAMIC ACID DERIVATIVE; CINNAMYL 3,4 DIHYDROXYCYANOCINNAMATE; CYTOCHROME P450 INHIBITOR; DISULFIRAM; ICOSATRIENOIC ACID; INDOMETACIN; LIPOXYGENASE INHIBITOR; MICROSOME ENZYME; NORDIHYDROGUAIARETIC ACID; PHENYLEPHRINE; PROSTAGLANDIN SYNTHASE INHIBITOR; SECOBARBITAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; CATALYSIS; CELL MEMBRANE; CELL TRANSPORT; CELLULAR DISTRIBUTION; CHRONICITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ASSAY; GAS CHROMATOGRAPHY; HYPOXIC LUNG VASOCONSTRICTION; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG; MASS SPECTROMETRY; MICROSOME; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; PULMONARY ARTERY; PULMONARY ARTERY OCCLUSION; QUANTITATIVE ANALYSIS; RABBIT; SIBLING; SMOOTH MUSCLE FIBER; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; ARACHIDONATE 15-LIPOXYGENASE; ARACHIDONIC ACID; CATALYSIS; CELL HYPOXIA; ENZYME ACTIVATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HYDROXYEICOSATETRAENOIC ACIDS; INTRACELLULAR MEMBRANES; LUNG; MICROSOMES; PROTEIN TRANSPORT; PULMONARY ARTERY; RABBITS; TIME FACTORS; VASOCONSTRICTION;

EID: 0037687982     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000070881.65194.8F     Document Type: Article

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