Macroscopic to microscopic scales of particle dosimetry: From source to fate in the body

Air Quality, Atmosphere and Health

Volumn 5, Issue 2, 2012, Pages 169-187

  Solomon, Paul A ^a   Gehr, Peter ^b   Bennett, Deborah H ^c   Phalen, Robert F ^d   Méndez, Loyda B ^d,e,f   Rothen Rutishauser, Barbara ^g   Clift, Martin ^b   Brandenberger, Christina ^b   Mühlfeld, Christian ^h  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

^f Pacific Southwest Regional Center of Excellence   (United States)

^g UNIVERSITY OF FRIBOURG   (Switzerland)

^h HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Cell particle interaction; Dosimetric modeling; Intake fraction; Lungs; Particle clearance; Particle deposition; Respiratory tract; Translocation; Ultrafine particles

Indexed keywords

ATMOSPHERIC DEPOSITION; ATMOSPHERIC POLLUTION; BIOACCUMULATION; BIOLOGICAL UPTAKE; COMPUTATIONAL FLUID DYNAMICS; CYTOLOGY; DIGITAL IMAGE; DOSE-RESPONSE RELATIONSHIP; HEALTH IMPACT; MICROSCOPY; NEUROLOGY; NUMERICAL MODEL; PARTICLE SIZE; PARTICULATE MATTER; POLICY MAKING; POLLUTANT SOURCE; RESPIRATION; TRANSLOCATION; UNCERTAINTY ANALYSIS;

EID: 84861229113     PISSN: 18739318     EISSN: 18739326     Source Type: Journal    
DOI: 10.1007/s11869-011-0167-y     Document Type: Article

References (113)

1. Ayala A, Brauer M, Mauderly JL, Samet JM (2011) Air pollutants and sources associated with health effects. Air Qual Atmos Health. doi: 10. 1007/s11869-011-0155-2.
2. Alexander DJ, Collins CJ, Coombs DW, Gilkison IS, Hardy CJ, Healey G, Karantabias G, Johnson N, Karlsson A, Kilgour JD, McDonald P (2008) Association of Inhalation Toxicologists (AIT) working party recommendation for standard delivered dose calculation and expression in nonclinical aerosol inhalation toxicology studies with pharmaceuticals. Inhal Toxicol 20: 1179-1189.
3. Aschner M, Erikson KM, Dorman DC (2005) Manganese dosimetry: species differences and implications for neurotoxicity. Crit Rev Toxicol 35: 1-32.
4. Asgharian B, Hoffmann W, Bergmann R (2001) Particle deposition in a multiple-path model of the human lung. Aerosol Sci Technol 34: 332-339.
5. Balásházy I, Hofmann W, Heistracher T (1999) Computation of local enhancement factors for the quantification of particles deposition patterns in airway bifurcations. J Aerosol Sci 30: 185-203.
6. Balásházy I, Hofmann W, Heistracher T (2003) Local particle deposition patterns may play a key role in the development of lung cancer. J Appl Physiol 94: 1719-1725.
7. Bennett WD, Zeman KL (1998) Deposition of fine particles in children spontaneously breathing at rest. Inhal Toxicol 10: 831-842.
8. Bennett WD, Zeman KL (2004) Effect of body size on breathing pattern and fine-particle deposition in children. J Appl Physiol 97: 821-826.
9. Bennett WD, Zeman KL, Kim C, Mascarella J (1997) Enhanced deposition of fine particles in COPD patients spontaneously breathing at rest. Inhal Toxicol 9: 1-14.
10. Bennett DH, Mckone T, Evans J, Nazaroff W, Margni M, Jolliet O, Smith K (2002a) Defining intake fraction. Environ Sci Technol 36(9): 207A-211A.
11. Bennett DH, Margni M, McKone TE, Jolliet O (2002b) Intake fraction for multimedia pollutants: a tool for life cycle analysis and comparative risk assessment. Risk Anal 22(5): 905-918.
12. Brandenberger C, Mühlfeld C, Zulqurnain A, Lenz AG, Schmit O, Parak WJ, Gehr P, Rothen-Rutishauser B (2010) Quantitative evaluation of cellular uptake and trafficking of plain and polyethylene glycol-coated gold nanoparticles. Small 6: 1669-1678.
13. Brodie M, Elvidge AR (1934) The portal of entry and transmissions of the virus of poliomyelitis. Science 79(2045): 235-236.
14. Brook RD, Rajagopalan S, Pope CA III, Brook JR, Bhatnagar A, Diez-Roux AV, Holguin F, Hong Y, Luepker RV, Mittleman MA, Peters A, Siscovick D, Smith SC Jr, Whitsel L, Kaufman JD, In behalf of the American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Council on Nutrition, Physical Activity and Metabolism (2010) Particulate matter air pollution and cardiovascular disease: an update TCBRSO the scientific statement from the American Heart Association. Circulation 121: 2331-2378.
15. Brown JS, Zeman KL, Bennett WD (2002) Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med 166: 1240-1247.
16. Brown JS, Wilson WE, Grant LD (2005) Dosimetric comparisons of particle deposition and retention in rats and humans. Inhal Toxicol 17: 355-385.
17. Chang L-Y, Crapo JD, Gehr P, Rothen-Rutishauser B, Mühlfeld C, Blank F (2010) Alveolar epithelium in lung toxicology. In: Yost GS (ed) Comprehensive toxicology, vol 8, respiratory toxicology. Elsevier, Amsterdam, pp 59-91.
18. Chen LC, Lippmann M (2009) Effects of metals within ambient air particulate matter (PM) on human health. Inhal Toxicol 21: 1-31.
19. De Haar C, Hassing I, Bol M, Bleumink R, Pieters R (2006) Ultrafine but not fine particulate matter causes airway inflammation and allergic airway sensitization to co-administered antigen in mice. Clin Exp Allergy 36: 1469-1479.
20. Donaldson K, Stone V, Borm PJ, Jimenez LA, Gilmour PS, Schins RPF, Knaapen AM, Rahman I, Faux SP, Brown DM, MacNee W (2003) Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med 34: 1369-1382.
21. Donaldson K, Aitken R, Tran L, Stone V, Duffin R, Forrest G, Alexander A (2006) Carbon nanotubes: a review of their properties in relation to pulmonary toxicology and workplace safety. Toxicol Sci 92: 5-22.
22. Doty RL (2008) The olfactory vector hypothesis of neurodegenerative disease: is it viable? Annals Neurol 63: 7-15.
23. Doty RL (2009) Do environmental agents enter the brain via the olfactory mucosa to induce neurodegenerative diseases? NY Acad Sci 1170: 610-614.
24. Eisenberg D, Schwarz E, Komaromy M, Wall R (1984) Analysis of membrane and surface protein sequences with the hydrophobic moment plot. J Mol Biol 179: 125-142.
25. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G (2006) Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect 114: 1172-1178.
26. EPA (1996) Air quality criteria for particulate matter. U. S. Environmental Protection Agency, National Center for Environmental Assessment. Research Triangle Park, NC, EPA/600/P-95/001aF-cF. http://www. epa. gov/nheerl/research/pm/references. html (accessed 8-23-11).
27. EPA (2004) Air quality criteria for particulate matter (Final Report, Oct 2004). U. S. Environmental Protection Agency, Washington, DC, EPA/600/P-99/002aF-bF. http://cfpub. epa. gov/si/si_public_record_report. cfm?dirEntryId=87903 (Accessed 8-23-11).
28. EPA (2009) Integrated science assessment for particulate matter (Final Report). U. S. Environmental Protection Agency, National Center for Environmental Assessment. Washington, DC, EPA/600/R-08/139F. http://cfpub. epa. gov/ncea/isa/recordisplay. cfm?deid=216546 (Accessed 8-23-11).
29. Farkas A, Balásházy I (2008) Quantification of particle deposition in asymmetrical tracheobronchial model geometry. Comput Biol Med 38: 508-518.
30. Ferin J, Oberdörster G, Penney DP (1992) Pulmonary retention of ultrafine and fine particles in rats. Am J Respir Cell Mol Biol 6: 535-542.
31. Finlay WH, Martin AR (2008) Recent advances in predictive understanding of respiratory tract deposition. J Aerosol Med Pulm Drug Deliv 21: 189-206.
32. Finlayson-Pitts BJ, Pitts JN Jr (2000) Chemistry of the upper and lower atmosphere, theory, experiments, and applications. Academic, San Diego, p 969.
33. Foos B, Marty M, Schwartz J, Bennett W, Moya J, Jarabek AM, Salmon AG (2008) Focusing on children's inhalation dosimetry and health effects for risk assessment: an introduction. J Toxicol Environ Health A 71: 149-165.
34. Gallo MA (2008) History and scope of toxicology. In: Klassen CD (ed) Casarett & Doull's toxicology: the basic science of poisons, 7th edn. McGraw Hill, New York, pp 3-10.
35. Gehr P, Bachofen H, Weibel ER (1978) The normal human lung: ultrastructure and morphometric estimation of diffusion capacity. Respir Physiol 32: 121-140.
36. Gehr P, Schürch S, Berthiaume Y, Im Hof V, Geiser M (1990) Particle retention in airways by surfactant. J Aerosol Med 3: 27-43.
37. Gehr P, Green FH, Geiser M, Im Hof V, Lee MM, Schurch S (1996) Airway surfactant, a primary defense barrier: mechanical and immunological aspects. J Aerosol Med 9: 163-181.
38. Gehr P, Muhfeld C, Rothen-Ruthishhauser B, Blank F, eds. (2010) Particle-lung interactions, 2nd edn., Informa Healthcare, New York, NY, 319 pp.
39. Geiser M, Kreyling WG (2010) Deposition and biokinetics of inhaled nanoparticles. Part Fibre Toxicol 7: 2. doi: 10. 1186/1743-8977-7-2.
40. Geiser M, Rothen-Rutishauser B, Kapp N, Schürch S, Kreyling W, Schulz H, Semmler M, Im Hof V, Heyder J, Gehr P (2005) Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ Health Perspect 113: 1555-1560.
41. Gerde P (2008) How do we compare dose to cells in vitro with dose to live animals and humans? Some experiences with inhaled substances. Exp Toxicol Pathol 60: 181-184.
42. Gil J, Weibel ER (1971) Extracellular lining of bronchioles after perfusion-fixation of rat lungs for electron microscopy. Anat Rec 169: 185-199.
43. Ginsberg GL, Foos BP, Firestone MP (2005) Review and analysis of inhalation dosimetry methods for application to children's risk assessment. J Toxicol Environ Health A 68: 573-615.
44. Greco SL, Wilson AM, Hanna SR, Levy JI (2007a) Factors influencing mobile source particulate matter emissions-to-exposure relationships in the Boston urban area. Environ Sci Technol 41: 7675-7682.
45. Greco SL, Wilson AM, Spengler JD, Levy JI (2007b) Spatial patterns of mobile source particulate matter emissions-to-exposure relationships across the United States. Atmos Environ 41: 1011-1025.
46. Hao J, Wang L, Shen M, Li L, Hu J (2007) Air quality impacts of power plant emissions in Beijing. Environ Pollut 147: 401-408.
47. 2. 5 exposure and the time course of impaired heart rate variability: the APACR study. J Expo Sci Environ Epidemiol 21: 65-73.
48. Heath GA, Granvold PW, Hoats AS, Nazaroff WW (2006) Intake fraction assessment of the air pollutant exposure implications of a shift toward distributed electricity generation. Atmos Environ 40: 7164-7177.
49. Holt PG, Stumbles PA (2000) Characterization of dendritic cell populations in the respiratory tract. J Aerosol Med 13: 361-367.
50. Humbert S, Marshall JD, Shaked S, Spadaro JV, Nishioka Y, Preiss P, McKone TE, Horvath A, Jolliet O (2011) Intake fraction for particulate matter: recommendations for life cycle impact assessment. Environ Sci Technol 45: 4808-4816.
51. ICRP (International Commission on Radiological Protection) (1994) Human respiratory tract model for radiological protection. ICRP Publication No. 66. Tarrytown, NY: Elsevier Science Ltd.
52. ICRP (1995) Human respiratory tract model for radiological protection: a report of a task group of the international commission on radiological protection. Ann ICRP 24: 482.
53. Isaacs KK, Martonen TB (2005) Particle deposition in children's lungs: theory and experiment. J Aerosol Med 18: 337-353.
54. Kendall M (2007) Fine airborne urban particles (PM2. 5) sequester lung surfactant and amino acids from human lung lavage. Am J Physiol Lung Cell Mol Physiol 293: L1053-L1058.
55. Kilburn KH (1968) A hypothesis for pulmonary clearance and its implications. Am Rev Respir Dis 98: 449-463.
56. Kleinstreuer C, Zhang Z (2010) Airflow and particle transport in the human respiratory system. Ann Rev Fluid Mech 42: 301-334.
57. Klepeis NE, Nazaroff WW (2006) Modeling residential exposure to secondhand tobacco smoke. Atmos Environ 40(23): 4393-4407.
58. Kreyling WG, Semmler M, Erbe F, Mayer P, Takenaka S, Schulz H, Oberdörster G, Ziesenis A (2002) Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low. J Toxicol Environ Health A 65: 1513-1530.
59. Kreyling WG, Sammler-Behnke M, Möller W (2006a) Health implication of nanoparticles. J Nanoparticle Rsh 8: 543-562.
60. Kreyling WG, Sammler-Behnke M, Möller W (2006b) Ultrafine particle-lung interactions: does size matter? J Aerosol Med 19: 74-83.
61. Künzli N, Jerrett M, Mach WJ, Beckerman B, LaBree L, Gilliland F, Thomas D, Peters J, Hodis HN (2005) Ambient air pollution and atherosclerosis in Los Angeles. Environ Health Perspect 113: 201-206.
62. Lay JC, Stang MR, Fisher PE, Yankaskas JR, Bennett WD (2003) Airway retention of materials of different solubility following local intrabronchial deposition in dogs. J Aerosol Med 16: 153-166.
63. Levy JI, Baxter LK, Schwartz J (2009) Uncertainty and variability in health-related damages from coal-fired power plants in the United States. Risk Ana 29: 1000-1014.
64. Li J, Hao JM (2003) Application of intake fraction to population exposure estimates in Hunan Province of China. J Environ Sci Health A Tox Hazard Subst Environ Eng 38(6): 1041-1054.
65. Luo Z, Li Y, Nazaroff WW (2010) Intake fraction of nonreactive motor vehicle exhaust in Hong Kong. Atmos Environ 44: 1913-1918.
66. MacNee W (2001) Oxidative stress and lung inflammation in airways disease. Eur J Pharmacol 429: 195-207.
67. Marshall JD, Behrentz E (2005) Vehicle self-pollution intake fraction: children's exposure to school bus emissions. Environ Sci Technol 39: 2559-2563.
68. Méndez LB, Gookin G, Phalen RF (2010) Inhaled aerosol particle dosimetry in mice: a review. Inhal Toxicol 22(S2): 15-20.
69. Mills NL, Amin N, Robinson SD, Anand A, Davies J, Patel D, de la Fuente JM, Cassee FR, Boon NA, Macnee W, Millar AM, DE DonaldsonK N (2006) Do inhaled carbon UF particles translocate directly into the circulation in humans? Am J Respir Crit Care Med 173: 426-431.
70. Mühlfeld C, Geiser M, Kapp N, Gehr P, Rothen-Rutishauser B (2007) Re-evaluation of pulmonary titanium dioxide nanoparticle distribution using the "relative deposition index": evidence for clearance through microvasculature. Part Fibre Toxicol 4: 7. doi: 10. 1186/1743-8977-4-7.
71. Nemmar A, Hoet PH, Vanquickenborne B, Dinsdale D, Thomeer M, Hoylaerts MF, Vanbilloen H, Mortelmans L, Nemery B (2002) Passage of inhaled particles into the blood circulation in humans. Circulation 105: 411-414.
72. NRC Research Priorities for Airborne Particulate Matter (1998) I. Immediate priorities and a long-range research portfolio. National Research Council, National Academies Press, Washington, p 195.
73. O'Neill MS, Breton CV, Devlin RB, Utell MJ (2011) Air pollution and health: emerging information on susceptible populations. Air Qual Atmos Health. doi: 10. 1007/s11869-011-0150-7.
74. Oberdörster G (1988) Lung clearance of inhaled insoluble and soluble particles. J Aerosol Med 1: 289-330.
75. Oberdörster G (2010) Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med 267: 89-105.
76. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C (2004) Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol 16: 437-445.
77. Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H (2005) Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol 2: 8. doi: 10. 1186/1743-8977-2-8.
78. Oldham MJ (2006) Challenges in validating CFD-derived inhaled aerosol deposition predictions. Inhal Toxicol 18: 781-786.
79. Peters A, Wichmann HE, Tuch T, Heinrich J, Heyder J (1997) Respiratory effects are associated with the number of ultrafine particles. Am J Respir Crit Care Med 155: 1376-1383.
80. Peters A, Dockery DW, Muller JE, Mittleman MA (2001) Increased particulate air pollution and the triggering of myocardial infarction. Circulation 103: 2810-2815.
81. Peters-Golden M (2004) The alveolar macrophage: the forgotten cell in asthma. Am J Respir Cell Mol Biol 31: 3-7.
82. Phalen RF, Méndez LB (2009) Dosimetry considerations for animal inhalation studies. Biomarkers 14(S1): 63-66.
83. Phalen RF, Oldham MJ, Nel AE (2006) Tracheobronchial particle dose considerations for in-vitro toxicology studies. Toxocol Sci 92: 126-132.
84. Phalen RF, Méndez LB, Oldham MJ (2010) New developments in aerosol dosimetry. Inhal Toxicol 22(S2): 6-14.
85. Poland CA, Duffin R, Kinloch I, Maynard A, Wallace WA, Seaton A, Stone V, Brown S, MacNee W, Donaldson K (2008) Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study. Nat Nanotechnol 3: 423-428.
86. Pope CA III, Dockery DW, Schwartz J (1995) Review of epidemiological evidence of health effects of particulate air pollution. Inhal Toxicol 7: 1-18.
87. Pope CA III, Ezzati M, Dockery DW (2009) Fine-particulate air pollution and life expectancy in the United States. N Engl J Med 360: 376-386.
88. Puett RC, Hart JE, Yanosky JD, Paciorek C, Schwartz J, Suh H, Speizer FE, Laden F (2009) Chronic fine and coarse particulate exposure, mortality, and coronary heart disease in the Nurses' Health Study. Environ Health Perspect 117: 1697-1701.
89. Renwick LC, Brown D, Clouter A, Donaldson K (2004) Increased inflammation and altered macrophage chemotactic responses caused by two ultrafine particle types. Occup Environ Med 61: 442-447.
90. Ries FJ, Marshall JD, Brauer M (2009) IF of urban wood smoke. Environ Sci Technol 43: 4701-4706.
91. Rostami AA (2009) Computational modeling of aerosol deposition in (the) respiratory tract: a review. Inhal Toxicol 21: 262-290.
92. Rothen-Rutishauser B, Mühlfeld C, Blank F, Musso C, Gehr P (2007a) Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Part Fibre Toxicol 4: 9. doi: 10. 1186/1743-8977-4-9.
93. Rothen-Rutishauser B, Schürch S, Gehr P (2007b) Interaction of particles with membranes. In: Donaldson K, Borm P (eds) Particle toxicology. Taylor & Francis Group, LLC, CRC Press, Boca Raton, pp 139-160.
94. Scheuch G, Kohlhäufl M, Möller W, Brand P, Meyer T, Häussinger K, Sommerer K, Heyder J (2008) Particle clearance from the airways of subjects with bronchial hyperresponsiveness and with chronic obstructive pulmonary disease. Exp Lung Res 34: 531-549.
95. Schultz H, Harder V, Ibald-Mulli A, Khandoga A, Koenig W, Krombach F, Radykewicz R, Stampfl A, Thorand B, Peters A (2005) Cardiovascular effects of fine and ultrafine particles. J Aerosol Med 18: 1-22.
96. Schürch S, Gehr P, Im Hof V, Geiser M, Green F (1990) Surfactant displaces particles toward the epithelium in airways and alveoli. Respir Physiol 80: 17-32.
97. Seinfeld JH, Pandis SN (1998) Atmospheric chemistry and physics from air pollution to climate change. Wiley, New York, p 1326.
98. Semmler M, Seitz J, Erbe F, Mayer P, Heyder J, Oberdörster G, Kreyling WG (2004) Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal Toxicol 16: 453-459.
99. Sheppard L, Burnett RT, Szpiro AA, Kim S-Y, Jerrett M, Pope CA III, Brunekreef B (2011) Confounding and exposure measurement error in air pollution epidemiology. Air Qual Atmos Health. doi: 10. 1007/s11869-011-0140-9.
100. Singer SJ, Nicolson GL (1972) The fluid mosaic model of the structure of cell membranes. Science 175: 720-731.
101. Smaldone GC, Foster WM, O'Riordan TG, Messina MS, Perry RJ, Langenback EG (1993) Regional impairment of mucociliary clearance in chronic obstructive pulmonary disease. Chest 103: 1390-1396.
102. Smith JRH, Bailey MR, Etherington G, Shutt AC, Youngmann MJ (2008) Effect of particle size on slow particle clearance from the bronchial tree. Exp Lung Res 34: 287-312.
103. Snipes MB, McClellan RO, Mauderly JL, Wolff RK (1989) Retention patterns for inhaled particles in the lung: comparisons between laboratory animals and humans for chronic exposures. Health Phys 57(S1): 69-78.
104. Solomon PA, Costantini M, Grahame TJ, Gerlofs-Nijland ME, Cassee F, Russell AG, Brook JR, Hopke PK, Hidy G, Phalen RF, Saldiva P, Ebelt Sarnat S, Balmes JR, Tager IB, Özkaynak H, Vedal S, Wierman SSG, Costa DL (2011) Air pollution and health: bridging the gap from sources to health outcomes: conference summary. Air Qual Atmos Health doi: 10. 1007/s11869-011-0161-4.
105. Stevens G, de Foy B, West JJ, Levy JI (2007) Developing intake fraction estimates with limited data: comparison of methods in Mexico City. Atmos Environ 41: 3672-3683.
106. Tainio M, Sofiev M, Hujo M, Tuomisto JT, Loh M, Jantunen MJ, Karppinen A, Kangas L, Karvosenoja N, Kupiainen K, Porvari P, Kukkonen J (2009) Evaluation of the European population intake fractions for European and Finnish anthropogenic primary fine particulate matter emissions. Atmos Environ 43: 3052-3059.
107. van Erp AM, Kelly FJ, Demerjian KD, Pope CA III, Cohen AJ (2011) Progress in research to assess the effectiveness of air quality interventions towards improving public health. Air Qual Atmos Health doi: 10. 1007/s11869-010-0127-y.
108. Vermaelen K, Pauwels R (2005) Pulmonary dendritic cells. Am J Respir Crit Care Med 172: 530-551.
109. Wallenborn JG, McKee JK, Schladweiler MC, Ledbetter AD, Kodavanti UP (2007) Systemic translocation of particulate matter-associated metals following a single intratracheal instillation in rats. Toxicol Sci 98: 231-239.
110. Wang SX, Hao J, Ho MS, Li J, Lu Y (2006) Intake fractions of industrial air pollutants in China: estimation and application. Sci Total Environ 354: 127-141.
111. Wichmann HE, Spix C, Tuch T, Wolke G, Peters A, Heinrich J, Kreyling WG, Heyder J (2000) Daily mortality and fine and ultrafine particles in Erfurt, Germany, part I: role of particle number and particle mass. Res Rep Health Eff Inst 98: 5-94.
112. Wiebert P, Sanchez-Crespo A, Falk R, Philipson K, Lundin A, Larsson S, Möller W, Kreyling WG, Svartengren M (2006) No significant translocation of inhaled 35-nm carbon particles to the circulation in humans. Inhal Toxicol 18: 741-747.
113. Zhou Y, Levy JI (2008) The impact of urban street canyons on population exposure to traffic-related primary pollutants. Atmos Environ 42: 3087-3098.