Airway retention of materials of different solubility following local intrabronchial deposition in dogs

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 16, Issue 2, 2003, Pages 153-166

  Lay, John C ^a,c   Stang, Mark R ^a   Fisher, Paul E ^b   Yankaskas, James R ^a   Bennett, William D ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

99mTechnetium; Airway particle clearance; Human serum albumin; Mucociliary clearance; Sulfur colloid

Indexed keywords

HUMAN SERUM ALBUMIN; SERUM ALBUMIN TC 99M; SULFUR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CLEARANCE; CONTROLLED STUDY; DOG; DRY DEPOSITION; ENDOTRACHEAL TUBE; LUNG CLEARANCE; MALE; MUCOCILIARY CLEARANCE; NONHUMAN; PARTICLE SIZE; SCINTILLATION CAMERA; SOLID; SOLUBILITY; WATER PERMEABILITY;

ANIMALS; BRONCHI; COLLOIDS; DOGS; GAMMA CAMERAS; LUNG; MALE; MUCOCILIARY CLEARANCE; RADIONUCLIDE IMAGING; RESPIRATORY PHYSIOLOGY; SERUM ALBUMIN; SULFUR; TECHNETIUM;

EID: 0038808963     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/089426803321919915     Document Type: Article

References (44)

1. Lay, J.C., C.R. Berry, C.S. Kim, et al. 1995. Retention of insoluble particles following local intrabronchial deposition in dogs. J. Appl. Physiol. 79:1921-1929.
2. Lippmann, M., D.B. Yeates, and R.E. Albert. 1980. Deposition, retention, and clearance of inhaled particles. Br. J. Ind. Med. 37:337-362.
3. Morrow, P.E. 1977. Clearance kinetics of inhaled particles. In: J.D. Brain, D.F. Proctor, and L.M. Reid, eds. Respiratory Defense Mechanisms (Part II). Marcel Dekker, New York, 491.
4. Stahlhofen, W., R. Koebrich, G. Rudolf, et al. 1990. Short-term and long-term clearance of particles from the upper human respiratory tract as a function of particle size. J. Aerosol Sci. 21(Suppl.1):S407-410.
5. Patrick, G., and C. Stirling. 1977. The retention of particles in large airways of the respiratory tract. Proc. R. Soc. Lond. B. Ser. V 198:455,
6. Gehr, P., V. Im Hof, M. Geiser, et al. 1991. The fate of particles deposited in the intrapulmonary conducting airways. J. Aerosol Med. 4:349-361.
7. Jones, J.G., B.D. Minty, and D. Royston. 1982. The physiology of leaky lungs. Br. J. Anaesth. 54:705-721.
8. Taylor, A.E., and K.A. Gaar, Jr. 1970. Estimation of equivalent pore radii of pulmonary capillary and alveolar membranes. Am. J. Physiol. 218:1133-1140.
9. Johnson, L.G., P.W. Cheng, and R.C. Boucher. 1989. Albumin absorption by canine bronchial epithelium. J. Appl. Physiol. 66:2772-2779.
10. Amis, T.C., and B.C. McKiernan. 1986. Systematic identification of endobronchial anatomy during bronchoscopy in the dog. Am. J. Vet. Res. 47:2649-2657.
11. Hoover, M.D., J.R. Harkema, B.A. Muggenburg, et al. 1993. A microspray nozzle for local administration of liquids or suspensions to lung airways via bronchoscopy. J. Aerosol Med. 6:67-72.
12. Kennedy, S.M., R.K. Elwood, B.J.R. Wiggs, et al. 1984. Increased airway mucosal permeability of smokers. Am. Rev. Respir. Dis. 129:143-148.
13. Huchon, G.J., A.B. Montgomery, A. Lipavsky, et al. 1987. Respiratory clearance of aerosolized radioactive solutes of varying molecular weight. J. Nucl. Med. 5:894-902.
14. Peterson, B.T., H.L. James, and J.W. McLarty. 1988. Effect of lung volume on clearance of solutes from the air spaces of lungs. J. Appl. Physiol. 64:1068-1075.
15. Nemmar, A., H. Vanbilloen, M.F. Hoylaerts, et al. 2001. Passage of intratracheally instilled ultrafine particles from the lung into the systemic circulation in hamster. Am. J. Respir. Crit. Care Med. 164:1665-1668.
16. Bhalla, D.K., R.C. Mannix, M.T. Kleinman, et al. 1986. Relative permeability of nasal, tracheal, and bronchoalveolar mucosa to macromolecules in rats exposed to ozone. J. Toxicol. Environ. Health 17:269-283.
17. Gehr, P., S. Schürch, Y. Berthaiume, et al. 1990. Particle retention in airways by surfactant. J. Aerosol Med. 3:27-43.
18. Matsui, H., S.H. Randell, S.W. Reretti, et al. 1998. Coordinated Clearance of Periciliary liquid and mucus from airway surfaces. J. Clin. Invest. 102:1125-1131.
19. Stirling, C., and G. Patrick. 1980. The localisation of particles retained in the trachea in the rat. J. Pathol. 131:309-320.
20. Geiser, M., L.M. Cruz-Orive, V. Im Hof, et al. 1990. Assessment of particle retention and clearance in the intrapulmonary conducting airways of hamster lungs with the fractionater. J. Microsc. 160:75-88.
21. Geiser, M., M. Baumann, L.M. Cruz-Orive, et al. 1994. The effect of particle inhalation on macrophage number and phagocytic activity in the intrapulmonary conducting airways of hamsters. Am. J. Respir. Cell Mol. Biol. 10:594-603.
22. Sleigh, M.A. 1977. The nature and action of respiratory tract cilia. In J.D. Brain, D.F. Proctor, and L.M. Reid, eds. Respiratory Defense Mechanisms. Part I. Marcel Decker, New York, 247-288.
23. Jeffery, P.K., and L.M. Reid. 1977. The respiratory mucous membrane. In J.D. Brain, D.F. Proctor, and L.M. Reid, eds. Respiratory Defense Mechanisms. Part I. Marcel Dekker, New York, 193-245.
24. Van As, A. 1977. Pulmonary airway clearance mechanisms: a reappraisal. Am. Rev. Respir. Dis. 115:721-726.
25. Kreyling, W.G., and G. Scheuch. 2000. Clearance of particles deposited in the lungs. In P. Gher and J. Heyder, eds. Particle-Lung Interactions. Marcel Dekker, New York, 323-376.
26. Luchtel, D.L. 1982. Mucociliary interactions in rabbit intrapulmonary airways. Cell Motil. Suppl. 1:77-81.
27. Isawa, T., T. Teshima, T. Hirano, et al. 1989. Normal values for quantitative parameters for evaluation of mucociliary clearance in lungs. Tohuku J. Exp. Med. 158:119-131.
28. 99mDTPA from the bronchial mucosa. Am. Rev. Respir. Dis. 139:1132-1138.
29. 99mTc-DTPA in asthma. Am. Rev. Respir. Dis. 139:1139-1143.
30. Weiss, T., P. Dorow, and R. Felix. 1983. Regional mucociliary removal of inhaled particles in smokers with small airways disease. Respiration 44:338-345.
31. Isawa, T., T. Teshima, T. Hirano, et al. 1990. Mucociliary clearance and transport in bronchiectasis: global and regional assessment. J. Nucl. Med. 31:543-548.
32. 99mTc-labeled albumin from lungs in anesthetized guinea pigs. Exp. Lung Res. 19:237-255.
33. 99mTc-human serum albumin clearance and effects of surfactant replacement after lung lavage in rabbits. Crit. Care Med. 24:1518-1523.
34. Peterson, B.T., K.C. Dickerson, H.L. James, et al. 1989. Comparison of three tracers for detecting lung epithelial injury in anesthetized sheep. J. Appl. Physiol. 66:2374-2383.
35. 2-receptor agonists enhances mucociliary clearance in sheep. J. Appl. Physiol. 87:2191-2196.
36. Laurenzi, B.A., S. Yin, and J.J. Guarmeri. 1968. Adverse effect of oxygen on tracheal mucus flow. N. Engl. J. Med. 279:333-339.
37. Forbes, A.R. 1976. Halothane depresses mucociliary flow in the trachea. Anesthesiology 45:59-63.
38. Olivier, K.N., W.D. Bennett, K.W. Hohneker, et al. 1996. Acute safety and effects on mucociliary clearance of aerosolized uridine 5′-triphosphate ± amiloride in normal human adults. Am. J. Respir. Crit. Care Med. 154:217-223.
39. Knowles, M.R., N.L. Church, W.E. Waltner, et al. 1990. A pilot study of aerosolized amiloride for the treatment of lung disease in cystic fibrosis. N. Engl. J. Med. 322:1189-1194.
40. Bennett, W.D., K.N. Olivier, K.L. Zeman, et al. 1996. Effect of uridine 5′-triphosphate plus amiloride on mucociliar clearance in adult cystic fibrosis. Am. J. Respir. Crit. Care Med. 153:1796-1801.
41. Daviskas, E., S.D. Anderson, I. Gonda, et al. 1996. Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects. Eur. Respir. J. 9:725-732.
42. Min, Y., K.S. Lee, J.B. Yun, et al. 2001. Hypertonic saline decreases ciliary movement in human nasal epithelium in vitro. Otolaryngol. Head Neck Surg. 124: 313-316.
43. Boek, W.M., N. Keles, K. Graamans, et al. 1999. Physiologic and hypertonic saline solutions impair ciliary activity in vitro. Laryngoscope 109:396-399.
44. Bennett, W.D., W.F. Chapman, J.C. Lay, et al. 1993. Pulmonary clearance of inhaled particles 24 to 48 hours post deposition: effect of Beta-adrenergic stimulation. J. Aerosol Med. 6:53-62.