메뉴 건너뛰기




Volumn 21, Issue 2, 2008, Pages 189-206

Recent advances in predictive understanding of respiratory tract deposition

Author keywords

aerosol deposition; computational; empirical correlation; extrathoracic; larynx; lung; model; mouth throat; nasal; numerical; oral; oropharyngeal; simulation

Indexed keywords

AEROSOL; BIOLOGICAL MODEL; COMPUTER SIMULATION; DRUG DELIVERY SYSTEM; HUMAN; INHALATIONAL DRUG ADMINISTRATION; INTRANASAL DRUG ADMINISTRATION; METABOLISM; NEBULIZER; RESPIRATORY SYSTEM; REVIEW;

EID: 48249139478     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2007.0645     Document Type: Article
Times cited : (100)

References (93)
  • 2
    • 33645467769 scopus 로고    scopus 로고
    • Ultrafine particle-lung interactions: Does size matter?
    • Kreyling WG, Semmler-Behnke M, and Moller W: Ultrafine particle-lung interactions: does size matter? J Aerosol Med. 2006;19:74-83.
    • (2006) J Aerosol Med. , vol.19 , pp. 74-83
    • Kreyling, W.G.1    Semmler-Behnke, M.2    Moller, W.3
  • 3
    • 13544253826 scopus 로고    scopus 로고
    • Device selection and outcomes of aerosol therapy: Evidence-based guidelines
    • American College of Chest Physicians/American College of Asthma, Allergy, and Immunology
    • Dolovich MB, Ahrens RC, Hess DR, Anderson P, Dhand R, Rau JL, Smaldone GC, and Guyatt G: Device selection and outcomes of aerosol therapy: evidence-based guidelines: American College of Chest Physicians/American College of Asthma, Allergy, and Immunology. Chest 2005;127:335-371.
    • (2005) Chest , vol.127 , pp. 335-371
    • Dolovich, M.B.1    Ahrens, R.C.2    Hess, D.R.3    Anderson, P.4    Dhand, R.5    Rau, J.L.6    Smaldone, G.C.7    Guyatt, G.8
  • 4
    • 85010181389 scopus 로고
    • Intercomparison of experimental regional aerosol deposition data
    • Stahlhofen W, Rudolf G, and James AC: Intercomparison of experimental regional aerosol deposition data. J Aerosol Med. 1989;2:285-308.
    • (1989) J Aerosol Med. , vol.2 , pp. 285-308
    • Stahlhofen, W.1    Rudolf, G.2    James, A.C.3
  • 6
    • 0003438430 scopus 로고
    • ICRP, Human Respiratory Tract Model for Radiological Protection. Annals of the ICRP, Elsevier, New York
    • ICRP (International Commission on Radiological Protection) Publication 66. 1994. Human Respiratory Tract Model for Radiological Protection. Annals of the ICRP, Elsevier, New York.
    • (1994) International Commission on Radiological Protection) Publication , vol.66
  • 7
    • 33746761056 scopus 로고    scopus 로고
    • Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: Empirical equations for sex and breathing pattern
    • DOI 10.1152/japplphysiol.00026.2006
    • Kim CS, and Hu SC: Total respiratory tract deposition of fine micrometer-sized particles in healthy adults: empirical equations for gender and breathing pattern. J Appl Physiol. 2006;101:401-412. (Pubitemid 44162347)
    • (2006) Journal of Applied Physiology , vol.101 , Issue.2 , pp. 401-412
    • Kim, C.S.1    Hu, S.-C.2
  • 8
    • 0031468326 scopus 로고    scopus 로고
    • Effect of microgravity and hypergravity on deposition of 0.5- to 3-μm- diameter aerosol in the human lung
    • Darquenne C, Paiva M, West JB, and Prisk GK: Effect of microgravity and hypergravity on deposition of 0.5- to 3-m-diameter aerosol in the human lung. J Appl Physiol. 1997;83:2029-2036. (Pubitemid 28006505)
    • (1997) Journal of Applied Physiology , vol.83 , Issue.6 , pp. 2029-2036
    • Darquenne, C.1    Paiva, M.2    West, J.B.3    Prisk, G.K.4
  • 9
    • 0026973474 scopus 로고
    • Total deposition of aerosol particles in the respiratory tract of children during spontaneous and controlled mouth breathing
    • Schiller-Scotland CHF, Hlawa R, Gebhart J, Wönne R, and Heyder J: Total deposition of aerosol particles in the respiratory tract of children during spontaneous and controlled mouth breathing. J Aerosol Sci. 1992;23(Suppl. 1):S457-S460. (Pubitemid 23634507)
    • (1992) Journal of Aerosol Science , vol.23 , Issue.SUPPL 1
    • Schiller-Scotland, C.H.F.1    Hlawa, R.2    Gebhart, J.3    Wonne, R.4    Heyder, J.5
  • 11
    • 33846213659 scopus 로고    scopus 로고
    • A general, algebraic equation for predicting total respiratory tract deposition of micrometer-sized aerosol particles in humans
    • DOI 10.1016/j.jaerosci.2006.11.002, PII S0021850206002059
    • Martin AR, and Finlay WH: A general, algebraic equation for predicting total respiratory tract deposition of micron-sized aerosol particles in humans. J Aerosol Sci. 2007;38:246-253. (Pubitemid 46096513)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.2 , pp. 246-253
    • Martin, A.R.1    Finlay, W.H.2
  • 12
    • 0022889862 scopus 로고
    • Deposition of particles in the human respiratory tract in the size range 0. 005-15 mu m
    • DOI 10.1016/0021-8502(86)90035-2
    • Heyder J, Gebhart J, Rudolf G, Schiller CF, and Stahlhofen W: Deposition of particles in the human respiratory tract in the size range 0.005-15 μm. J Aerosol Sci. 1986;17:811-825. (Pubitemid 17492310)
    • (1986) Journal of Aerosol Science , vol.17 , Issue.5 , pp. 811-825
    • Heyder, J.1    Gebhart, J.2    Rudolf, G.3    Schiller, C.F.4    Stahlhofen, W.5
  • 14
    • 0029171054 scopus 로고
    • Association of particulate air pollution and acute mortality: Involvement of ultrafine particles?
    • Oberdorster G, Gelein RM, Ferin J, and Weiss B: Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhal Toxicol. 1995;7:111-124.
    • (1995) Inhal Toxicol. , vol.7 , pp. 111-124
    • Oberdorster, G.1    Gelein, R.M.2    Ferin, J.3    Weiss, B.4
  • 15
    • 3843144255 scopus 로고    scopus 로고
    • Analysis of total respiratory deposition of inhaled ultrafine particles in adult subjects at various breathing patterns
    • DOI 10.1080/02786820490465513
    • Kim CS, and Jaques PA: Analysis of total respiratory deposition of inhaled ultrafine particles in adult subjects at various breathing patterns. Aerosol Sci Technol. 2004;38:525-540. (Pubitemid 39045232)
    • (2004) Aerosol Science and Technology , vol.38 , Issue.6 , pp. 525-540
    • Kim, C.S.1    Jaques, P.A.2
  • 16
    • 21344448618 scopus 로고    scopus 로고
    • Total lung deposition of ultrafine particles in elderly subjects during controlled breathing
    • DOI 10.1080/08958370590929493
    • Kim CS, and Jaques PA: Total lung deposition of ultrafine particles in elderly subjects during controlled breathing. Inhal Toxicol. 2005;17:387-399. (Pubitemid 40909585)
    • (2005) Inhalation Toxicology , vol.17 , Issue.7-8 , pp. 387-399
    • Kim, C.S.1    Jaques, P.A.2
  • 17
    • 33845571480 scopus 로고    scopus 로고
    • Computational investigation of particle inertia effects on submicron aerosol deposition in the respiratory tract
    • DOI 10.1016/j.jaerosci.2006.09.007, PII S0021850206001765
    • Longest PW, and Xi J: Computational investigation of particle inertia effects on submicron aerosol deposition in the respiratory tract. J Aerosol Sci. 2007;38: 111-130. (Pubitemid 44937250)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.1 , pp. 111-130
    • Longest, P.W.1    Xi, J.2
  • 18
    • 0016720795 scopus 로고
    • Total deposition of aerosol particles in the human respiratory tract for nose and mouth breathing
    • Heyder J, Armbruster L, Gebhart J, Grein E, and Stahlhofen W: Total deposition of aerosol particles in the human respiratory tract for nose and mouth breathing. J Aerosol Sci. 1975;6:311-328.
    • (1975) J Aerosol Sci. , vol.6 , pp. 311-328
    • Heyder, J.1    Armbruster, L.2    Gebhart, J.3    Grein, E.4    Stahlhofen, W.5
  • 19
    • 0002909819 scopus 로고    scopus 로고
    • Deposition and clearance of inhaled aerosols
    • H. Witschi and PN Nettesheim (eds), CRC Press Inc., Boca Raton, FL
    • Raabe OG: Deposition and clearance of inhaled aerosols. In H. Witschi and PN Nettesheim (eds). Mechanisms of Respiratory Toxicology. CRC Press Inc., Boca Raton, FL; pp. 27-76.
    • Mechanisms of Respiratory Toxicology , pp. 27-76
    • Raabe, O.G.1
  • 21
    • 4644324201 scopus 로고    scopus 로고
    • Aerosol deposition in the extrathoracic region
    • Cheng Y-S: Aerosol deposition in the extrathoracic region. Aerosol Sci Technol. 2003;37:659-671.
    • (2003) Aerosol Sci Technol. , vol.37 , pp. 659-671
    • Cheng, Y.-S.1
  • 23
    • 3242722612 scopus 로고    scopus 로고
    • In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries
    • DOI 10.1016/j.jaerosci.2004.03.003, PII S0021850204000473
    • Grgic B, Heenan AF, Burnell PKP, and Finlay WH: In vitro intersubject and intrasubject deposition measurements in realistic mouth-throat geometries. J Aerosol Sci. 2004;35:1025-1040. (Pubitemid 38993745)
    • (2004) Journal of Aerosol Science , vol.35 , Issue.8 , pp. 1025-1040
    • Grgic, B.1    Finlay, W.H.2    Burnell, P.K.P.3    Heenan, A.F.4
  • 24
    • 0025596608 scopus 로고
    • Modelling and algebraic formulation of regional and aerosol deposition in man
    • Rudolf G, Kobrich R, and Stahlhofen W: Modelling and algebraic formulation of regional and aerosol deposition in man. J Aerosol Sci. 1990;21(Suppl 1): S403-S406.
    • (1990) J Aerosol Sci. , vol.21 , Issue.SUPPL. 1
    • Rudolf, G.1    Kobrich, R.2    Stahlhofen, W.3
  • 25
    • 17644387588 scopus 로고    scopus 로고
    • Suitability of the upper airway models obtained from MRI studies in simulating drug lung deposition from inhalers
    • DOI 10.1007/s11095-004-9023-1
    • Ehtezazi T, Southern KW, Allanson D, Jenkinson I, and O'Callaghan C: Suitability of the upper airway models obtained from MRI studies in simulating drug lung deposition from inhalers. Pharm Res. 2005;22: 166-170. (Pubitemid 40558160)
    • (2005) Pharmaceutical Research , vol.22 , Issue.1 , pp. 166-170
    • Ehtezazi, T.1    Southern, K.W.2    Allanson, D.3    Jenkinson, I.4    O'Callaghan, C.5
  • 26
    • 33745261802 scopus 로고    scopus 로고
    • Dynamics of oropharyngeal aerosol transport and deposition with the realistic flow pattern
    • Sosnowski TR, Moskal A, and Gradon L: Dynamics of oropharyngeal aerosol transport and deposition with the realistic flow pattern. Inhal Toxicol. 2006;18: 773-780.
    • (2006) Inhal Toxicol. , vol.18 , pp. 773-780
    • Sosnowski, T.R.1    Moskal, A.2    Gradon, L.3
  • 27
    • 33847638121 scopus 로고    scopus 로고
    • Large eddy simulation of inhaled particle deposition within the human upper respiratory tract
    • DOI 10.1016/j.jaerosci.2006.09.008, PII S0021850206001698
    • Jin HH, Fan JR, Zeng MJ, and Cen KF: Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. J Aerosol Sci. 2007;38: 257-268. (Pubitemid 46365707)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.3 , pp. 257-268
    • Jin, H.H.1    Fan, J.R.2    Zeng, M.J.3    Cen, K.F.4
  • 28
    • 33748971376 scopus 로고    scopus 로고
    • The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses
    • DOI 10.1016/j.jaerosci.2006.01.003, PII S0021850206000164
    • Grgic B, Martin AR, and Finlay WH: The effect of unsteady flow rate increase on in vitro mouth-throat deposition of inhaled boluses. J Aerosol Sci. 2006;37: 1222-1233. (Pubitemid 44442198)
    • (2006) Journal of Aerosol Science , vol.37 , Issue.10 , pp. 1222-1233
    • Grgic, B.1    Martin, A.R.2    Finlay, W.H.3
  • 30
    • 0000321379 scopus 로고
    • The effect on regional lung deposition of coupled heat and mass transfer between hygroscopic droplets and their surrounding phase
    • Finlay WH, and Stapleton KW: The effect on regional lung deposition of coupled heat and mass transfer between hygroscopic droplets and their surrounding phase. J Aerosol Sci. 1995;26:655-670.
    • (1995) J Aerosol Sci. , vol.26 , pp. 655-670
    • Finlay, W.H.1    Stapleton, K.W.2
  • 32
    • 33845586500 scopus 로고    scopus 로고
    • Hygroscopic growth and evaporation in an aerosol with boundary heat and mass transfer
    • DOI 10.1016/j.jaerosci.2006.07.008, PII S0021850206001455
    • Saleh R, and Shihadeh A: Hygroscopic growth and evaporation in an aerosol with boundary heat and mass transfer. J Aerosol Sci. 2007;38:1-16. (Pubitemid 44937244)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.1 , pp. 1-16
    • Saleh, R.1    Shihadeh, A.2
  • 33
    • 1542291134 scopus 로고    scopus 로고
    • Predicting extrathoracic deposition from dry powder inhalers
    • DOI 10.1016/j.jaerosci.2003.09.002, PII S0021850203004336
    • DeHaan WH, and Finlay WH: Predicting extrathoracic deposition from dry powder inhalers. J Aerosol Sci. 2004;35:309-331. (Pubitemid 38294375)
    • (2004) Journal of Aerosol Science , vol.35 , Issue.3 , pp. 309-331
    • DeHaan, W.H.1    Finlay, W.H.2
  • 34
    • 85010181389 scopus 로고
    • Intercomparison of experimental regional aerosol deposition data
    • Stahlhofen W, Rudolf G, and James AC: Intercomparison of experimental regional aerosol deposition data. J Aerosol Med. 1989;2:285-308.
    • (1989) J Aerosol Med. , vol.2 , pp. 285-308
    • Stahlhofen, W.1    Rudolf, G.2    James, A.C.3
  • 35
    • 34247611311 scopus 로고    scopus 로고
    • Modeling of aerosol deposition with interface devices
    • Finlay WH, and Martin AR: Modeling of aerosol deposition with interface devices. J Aerosol Med Suppl. 2006;1:S19-S28.
    • (2006) J Aerosol Med Suppl. , vol.1
    • Finlay, W.H.1    Martin, A.R.2
  • 36
    • 0030201039 scopus 로고    scopus 로고
    • In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways
    • DOI 10.1016/0021-8502(96)00029-8
    • Cheng K.-H, Cheng YS, Yeh Y-C, Guilmette RA, Simpson SQ, Yang Y-H, and Swift DL: In vivo measurements of nasal airway dimensions and ultrafine aerosol deposition in the human nasal and oral airways. J Aerosol Sci. 1996;27:785-801. (Pubitemid 26234319)
    • (1996) Journal of Aerosol Science , vol.27 , Issue.5 , pp. 785-801
    • Cheng, K.-H.1    Cheng, Y.-S.2    Yeh, H.-C.3    Guilmette, R.A.4    Simpson, S.Q.5    Yang, Y.-H.6    Swift, D.L.7
  • 37
    • 0029380412 scopus 로고
    • Deposition of ultrafine aerosols in the head airways during natural breathing and during simulated breath holding using replicate human upper airway casts
    • Cheng KH, Cheng YS, Yeh H-C, and Swift DL: Deposition of ultrafine aerosols in the head airways during natural breathing and during simulated breath holding using replicate human upper airway casts. Aerosol Sci Technol. 1995;23:465-474.
    • (1995) Aerosol Sci Technol. , vol.23 , pp. 465-474
    • Cheng, K.H.1    Cheng, Y.S.2    Yeh, H.-C.3    Swift, D.L.4
  • 38
    • 34548564546 scopus 로고    scopus 로고
    • Effects of oral airway geometry on the diffusional deposition of inhaled nanoparticles
    • Xi J, and Longest PW: Effects of oral airway geometry on the diffusional deposition of inhaled nanoparticles. ASME J Biomech Eng. 2007.
    • (2007) ASME J Biomech Eng.
    • Xi, J.1    Longest, P.W.2
  • 39
    • 0345256446 scopus 로고    scopus 로고
    • Regional aerosol deposition and flow measurements in an idealized mouth and throat
    • DOI 10.1016/S0021-8502(03)00387-2
    • Grgic B, Finlay WH, and Heenan AF: Regional aerosol deposition and flow measurements in an idealized mouth and throat. J Aerosol Sci. 2004;35:21-32. (Pubitemid 37476252)
    • (2004) Journal of Aerosol Science , vol.35 , Issue.1 , pp. 21-32
    • Grgic, B.1    Finlay, W.H.2    Heenan, A.F.3
  • 40
    • 0034019232 scopus 로고    scopus 로고
    • On the suitability of k-ε turbulence modeling for aerosol deposition in the mouth and throat: A comparison with experiment
    • DOI 10.1016/S0021-8502(99)00547-9, PII S0021850299005479
    • Stapleton KW, Guentsch E, Hoskinson MK, and Finlay WH: On the suitability of k-e turbulence modelling for aerosol deposition in the mouth and throat: a comparison with experiment. J Aerosol Sci. 2000;31: 739-749. (Pubitemid 30173204)
    • (2000) Journal of Aerosol Science , vol.31 , Issue.6 , pp. 739-749
    • Stapleton, K.W.1    Guentsch, E.2    Hoskinson, M.K.3    Finlay, W.H.4
  • 41
    • 0037323228 scopus 로고    scopus 로고
    • Laminar-to-turbulent fluid-particle flows in a human airway model
    • DOI 10.1016/S0301-9322(02)00131-3, PII S0301932202001313
    • Kleinstreuer C, and Zhang Z: Laminar-to-turbulent fluid-particle flows in a human airway model. Int J Multiphase Flow. 2003;29:271-289. (Pubitemid 36230269)
    • (2003) International Journal of Multiphase Flow , vol.29 , Issue.2 , pp. 271-289
    • Kleinstreuer, C.1    Zhang, Z.2
  • 42
    • 34247611172 scopus 로고    scopus 로고
    • Experimental measurement and numerical study of particle deposition in highly idealized mouth-throat models
    • Zhang Y, Chia TZ, and Finlay WH: Experimental measurement and numerical study of particle deposition in highly idealized mouth-throat models. Aerosol Sci Technol. 2006;40:361-372.
    • (2006) Aerosol Sci Technol. , vol.40 , pp. 361-372
    • Zhang, Y.1    Chia, T.Z.2    Finlay, W.H.3
  • 43
    • 84880294418 scopus 로고    scopus 로고
    • In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers
    • Zhang Y, and Finlay WH: In vivo-in vitro comparison of deposition in three mouth-throat models with Qvar and Turbuhaler inhalers. J Aerosol Med.
    • J Aerosol Med
    • Zhang, Y.1    Finlay, W.H.2
  • 44
    • 33847771467 scopus 로고    scopus 로고
    • Transport and deposition of micro-aerosols in realistic and simplified models of the oral airway
    • DOI 10.1007/s10439-006-9245-y
    • Xi J, and Longest PW: Transport and deposition of micro-aerosols in realistic and simplified models of the oral airways. Ann Biomed Eng. 2007;35:560-581. (Pubitemid 46448162)
    • (2007) Annals of Biomedical Engineering , vol.35 , Issue.4 , pp. 560-581
    • Xi, J.1    Longest, P.W.2
  • 46
    • 0142011486 scopus 로고    scopus 로고
    • Simulation of Particle Deposition in an Idealized Mouth with Different Small Diameter Inlets
    • DOI 10.1080/02786820300932
    • Matida EA, DeHaan W, Finlay WH, and Lange CF: Simulation of particle deposition in an idealized mouth with different small diameter inlets. Aerosol Sci Technol. 2003;37:924-932. (Pubitemid 37267772)
    • (2003) Aerosol Science and Technology , vol.37 , Issue.11 , pp. 924-932
    • Matida, E.A.1    DeHaan, W.H.2    Finlay, W.H.3    Lange, C.F.4
  • 47
    • 0345688026 scopus 로고    scopus 로고
    • Improved numerical simulation of aerosol deposition in an idealized mouth-throat
    • DOI 10.1016/S0021-8502(03)00381-1
    • Matida EA, Finlay WH, Lange CF, and Grgic B: Improved numerical simulation of aerosol deposition in an idealized mouth-throat. J Aerosol Sci. 2004;35:1-19. (Pubitemid 37476251)
    • (2004) Journal of Aerosol Science , vol.35 , Issue.1 , pp. 1-19
    • Matida, E.A.1    Finlay, W.H.2    Lange, C.F.3    Grgic, B.4
  • 48
    • 12344301305 scopus 로고    scopus 로고
    • Comparison of micro- and nano-size particle depositions in a human upper airway model
    • DOI 10.1016/j.jaerosci.2004.08.006, PII S0021850204003325
    • Zhang Z, Kleinsteuer C, Donohue JF, and Kim CS: Comparison of micro- and nano-size particle depositions in a human upper airway model. J Aerosol Sci. 2005;36:211-233. (Pubitemid 40138840)
    • (2005) Journal of Aerosol Science , vol.36 , Issue.2 , pp. 211-233
    • Zhang, Z.1    Kleinstreuer, C.2    Donohue, J.F.3    Kim, C.S.4
  • 49
    • 33847638121 scopus 로고    scopus 로고
    • Large eddy simulation of inhaled particle deposition within the human upper respiratory tract
    • DOI 10.1016/j.jaerosci.2006.09.008, PII S0021850206001698
    • Jin HH, Fan JR, Zeng MJ, and Cen KF: Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. J Aerosol Sci. 2007; 38:257-268. (Pubitemid 46365707)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.3 , pp. 257-268
    • Jin, H.H.1    Fan, J.R.2    Zeng, M.J.3    Cen, K.F.4
  • 51
    • 0035119142 scopus 로고    scopus 로고
    • Effect of flow rate on particle deposition in a replica of a human nasal airway
    • DOI 10.1080/089583701300001050
    • Zwartz GJ, and Guilmette RA: Effect of flow rate on particle deposition in a replica of a human nasal airway. Inhal Toxicol. 2001;13:109-127. (Pubitemid 32179053)
    • (2001) Inhalation Toxicology , vol.13 , Issue.2 , pp. 109-127
    • Zwartz, G.J.1    Guilmette, R.A.2
  • 52
    • 11344277827 scopus 로고    scopus 로고
    • Particle deposition in human nasal airway replicas manufactured by different methods. Part I: Inertial regime particles
    • DOI 10.1080/027868290883360
    • Kelly JT, Asgharian B, Kimbell JS, and Wong BA: Particle deposition in human nasal airway replicas manufactured by different methods. Part I: inertial regime particles. Aerosol Sci Technol. 2004;38:1063-1071. (Pubitemid 40075750)
    • (2004) Aerosol Science and Technology , vol.38 , Issue.11 , pp. 1063-1071
    • Kelly, J.T.1    Asgharian, B.2    Kimbell, J.S.3    Wong, B.A.4
  • 53
    • 34247132661 scopus 로고    scopus 로고
    • Modeling of inertial particle transport and deposition in human nasal cavities with wall roughness
    • DOI 10.1016/j.jaerosci.2007.02.002, PII S0021850207000250
    • Shi H, Kleinstreuer C, and Zhang Z: Modelling of inertial particle transport and deposition in human nasal cavities with wall roughness. J Aerosol Sci. 2007;38:398-419. (Pubitemid 46590147)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.4 , pp. 398-419
    • Shi, H.1    Kleinstreuer, C.2    Zhang, Z.3
  • 54
    • 0030388278 scopus 로고    scopus 로고
    • The anterior human nasal passage as a fibrous filter for particles
    • Swift DL, and Kesavanathan J: The anterior human nasal passage as a fibrous filter for particles. Chem Eng Commun. 1996;151:65-78. (Pubitemid 126605302)
    • (1996) Chemical Engineering Communications , vol.151 , pp. 65-78
    • Swift, D.L.1    Kesavanathan, J.2
  • 55
    • 0034946823 scopus 로고    scopus 로고
    • Deposition of fine and coarse aerosols in a rat nasal mold
    • Kelly JT, Kimbell JS, and Asgharian B: Deposition of fine and coarse aerosols in a rat nasal mold. Inhal Toxicol. 2001;13:577-588. (Pubitemid 32660710)
    • (2001) Inhalation Toxicology , vol.13 , Issue.7 , pp. 577-588
    • Kelly, J.T.1    Kimbell, J.S.2    Asgharian, B.3
  • 57
    • 33847775957 scopus 로고    scopus 로고
    • Effectiveness of direct Lagrangian tracking models for simulating nanoparticle deposition in the upper airways
    • DOI 10.1080/02786820701203223, PII 772553900
    • Longest PW, and Xi J: Effectivenss of direct Lagrangian tracking models for simulation of nanoparticle deposition in the upper airways. Aerosol Sci Technol. 2007;41:380-397. (Pubitemid 46393082)
    • (2007) Aerosol Science and Technology , vol.41 , Issue.4 , pp. 380-397
    • Longest, P.W.1    Xi, J.2
  • 58
    • 0037395340 scopus 로고    scopus 로고
    • Fine particle deposition within human nasal airways
    • DOI 10.1080/08958370304458
    • Martonen TB, Zhang Z, and Musante CJ: Fine particle deposition within human nasal airways. Inhal Toxicol. 2003;15:283-303. (Pubitemid 36458881)
    • (2003) Inhalation Toxicology , vol.15 , Issue.4 , pp. 283-303
    • Martonen, T.B.1    Zhang, Z.2    Yue, G.3    Musante, C.J.4
  • 60
    • 34447633218 scopus 로고    scopus 로고
    • Numerical simulation of aerosol deposition in a 3-D human nasal cavity using RANS, RANS/EIM, and LES
    • DOI 10.1016/j.jaerosci.2007.05.003, PII S0021850207000675
    • Liu Y, Matida EA, Gu J, and Johnson MR: Numerical simulation of aerosol deposition in a 3-D human nasal cavity using RANS, RANS/EIM, and LES. J Aerosol Sci. 2007;38:683-700. (Pubitemid 47087808)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.7 , pp. 683-700
    • Liu, Y.1    Matida, E.A.2    Gu, J.3    Johnson, M.R.4
  • 64
    • 0036301152 scopus 로고    scopus 로고
    • 3-D Particle transport within the human upper respiratory tract
    • DOI 10.1016/S0021-8502(02)00060-5, PII S0021850202000605
    • Martonen TB, Zhang Z, Yue G, and Musante CJ: 3-D particle transport within the human upper respiratory tract. J Aerosol Sci. 2002;33:1095-1110. (Pubitemid 34742027)
    • (2002) Journal of Aerosol Science , vol.33 , Issue.8 , pp. 1095-1110
    • Martonen, T.B.1    Zhang, Z.2    Yue, G.3    Musante, C.J.4
  • 65
    • 0028060673 scopus 로고
    • LUDEP 1.0, a personal computer program to implement the new ICRP respiratory tract model
    • Jarvis NS, and Birchall A: LUDEP-1.0, A personalcomputer program to implement the new ICRP respiratory- tract model. Radiat Protect Dosim. 1994;53: 191-193. (Pubitemid 24239659)
    • (1994) Radiation Protection Dosimetry , vol.53 , Issue.1-4 , pp. 191-193
    • Jarvis, N.S.1    Birchall, A.2
  • 66
    • 33947151893 scopus 로고    scopus 로고
    • Aerosol drug delivery optimization by computational methods for the characterization of total and regional deposition of therapeutic aerosols in the respiratory system
    • DOI 10.2174/157340907780058727
    • Balashazy I, Alföldy B, Molnár AJ, Hofmann W, Szoke I, and Kis E: Aerosol drug delivery optimization by computational methods for the characterization of total and regional deposition of therapeutic aerosols in the respiratory system. Curr Comput Aided Drug Design. 2007;3:13-32. (Pubitemid 46403570)
    • (2007) Current Computer-Aided Drug Design , vol.3 , Issue.1 , pp. 13-32
    • Balashazy, I.1    Alfoldy, B.2    Molnar, A.J.3    Hofmann, W.4    Szoke, I.5    Kis, E.6
  • 67
    • 34249109401 scopus 로고    scopus 로고
    • Particle deposition in the pulmonary region of the human lung: Multiple breath aerosol transport and deposition
    • DOI 10.1016/j.jaerosci.2007.03.005, PII S0021850207000456
    • Park SS, and Wexler AS: Particle deposition in the pulmonary region of the human lung: multiple breath aerosol transport and deposition. J Aerosol Sci. 2007;38:509-519. (Pubitemid 46782837)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.5 , pp. 509-519
    • Park, S.S.1    Wexler, A.S.2
  • 68
    • 33846229718 scopus 로고    scopus 로고
    • Particle deposition in the pulmonary region of the human lung: A semi-empirical model of single breath transport and deposition
    • DOI 10.1016/j.jaerosci.2006.11.009, PII S0021850206002126
    • Park SS, and Wexler AS: Particle deposition in the pulmonary region of the human lung: a semi-empirical model of single breath transport and deposition. J Aerosol Sci. 2007;38:228-245. (Pubitemid 46096516)
    • (2007) Journal of Aerosol Science , vol.38 , Issue.2 , pp. 228-245
    • Park, S.S.1    Wexler, A.S.2
  • 69
    • 33747818361 scopus 로고    scopus 로고
    • A computer program for the simulation of fiber deposition in the human respiratory tract
    • Sturm R, and Hofmann W: A computer program for the simulation of fiber deposition in the human respiratory tract. Comput Biol Med. 2007;36:1252-1267.
    • (2007) Comput Biol Med. , vol.36 , pp. 1252-1267
    • Sturm, R.1    Hofmann, W.2
  • 70
    • 33748970673 scopus 로고    scopus 로고
    • Prediction of particle deposition in the human lung using realistic models of lung ventilation
    • DOI 10.1016/j.jaerosci.2006.01.002, PII S0021850206000152
    • Asgharian B, Price OT, and Hofmann W: Prediction of particle deposition in the human lung using realistic models of lung ventilation. J Aerosol Sci. 2006; 37:1209-1221. (Pubitemid 44442197)
    • (2006) Journal of Aerosol Science , vol.37 , Issue.10 , pp. 1209-1221
    • Asgharian, B.1    Price, O.T.2    Hofmann, W.3
  • 71
    • 33745271052 scopus 로고    scopus 로고
    • Airflow distribution in the human lung and its influence on particle deposition
    • Asgharian B, and Price O: Airflow distribution in the human lung and its influence on particle deposition. Inhal Toxicol. 2006;18:795-801.
    • (2006) Inhal Toxicol. , vol.18 , pp. 795-801
    • Asgharian, B.1    Price, O.2
  • 72
    • 33645787038 scopus 로고    scopus 로고
    • A modeling study of the effect of gravity on airflow distribution and particle deposition in the lung
    • Asgharian B, Price O, and Oberdörster G: A modeling study of the effect of gravity on airflow distribution and particle deposition in the lung. Inhal Toxicol. 2006;18:473-481.
    • (2006) Inhal Toxicol. , vol.18 , pp. 473-481
    • Asgharian, B.1    Price, O.2    Oberdörster, G.3
  • 73
    • 22244445130 scopus 로고    scopus 로고
    • Particle deposition in a cast of human tracheobronchial airways
    • DOI 10.1080/027868291001385
    • Zhou Y, and Cheng Y-S: Particle deposition in a cast of human tracheobronchial airways. Aerosol Sci Technol. 2005;39:492-500. (Pubitemid 40993227)
    • (2005) Aerosol Science and Technology , vol.39 , Issue.6 , pp. 492-500
    • Zhou, Y.1    Cheng, Y.-S.2
  • 75
    • 4544287875 scopus 로고    scopus 로고
    • Integration of computer model of drug delivery with human subject testing
    • Martonen T, Hwang D, and Fleming J: Integration of computer model of drug delivery with human subject testing. Comput Eng. 2003;4:135-145.
    • (2003) Comput Eng. , vol.4 , pp. 135-145
    • Martonen, T.1    Hwang, D.2    Fleming, J.3
  • 76
    • 1542506121 scopus 로고    scopus 로고
    • Theoretical analysis of particle deposition in human lungs considering stochastic variations of airway morphology
    • DOI 10.1016/S0021-8502(03)00024-7, PII S0021850203000247
    • Goo J, and Kim CS: Theoretical analysis of particle deposition in human lungs considering stochastic variations of airway morphology. J Aerosol Sci. 2003;34: 585-602. (Pubitemid 38352545)
    • (2003) Journal of Aerosol Science , vol.34 , Issue.5 , pp. 585-602
    • Goo, J.1    Kim, C.S.2
  • 77
    • 0036132860 scopus 로고    scopus 로고
    • Modeling intersubject variability of particle deposition in human lungs
    • Hofmann W, Asgharian B, and Winkler-Heil R: Modeling intersubject variability of particle deposition in human lungs. J Aerosol Sci. 2002;33:219-235 78.
    • (2002) J Aerosol Sci. , vol.33 , Issue.219-235 , pp. 78
    • Hofmann, W.1    Asgharian, B.2    Winkler-Heil, R.3
  • 80
    • 33645463190 scopus 로고    scopus 로고
    • SPECT imaging for radioaerosol deposition and clearance studies
    • Eberl S, Chan H-K, and Daviskas E: SPECT imaging for radioaerosol deposition and clearance studies. J Aerosol Med. 2006;19:8-20.
    • (2006) J Aerosol Med. , vol.19 , pp. 8-20
    • Eberl, S.1    Chan, H.-K.2    Daviskas, E.3
  • 83
    • 33845600916 scopus 로고    scopus 로고
    • Validating CFD predictions of respiratory aerosol deposition: Effects of upstream transition and turbulence
    • DOI 10.1016/j.jbiomech.2006.01.006, PII S0021929006000285
    • Longest PW, and Vinchurkar S: Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence. J Biomech. 2007; 40:305-316. (Pubitemid 44958582)
    • (2007) Journal of Biomechanics , vol.40 , Issue.2 , pp. 305-316
    • Worth Longest, P.1    Vinchurkar, S.2
  • 85
    • 33745238112 scopus 로고    scopus 로고
    • Challenges in validating CFD-derived inhaled aerosol deposition predictions
    • Oldham M: Challenges in validating CFD-derived inhaled aerosol deposition predictions. Inhal Toxicol. 2006;18:781-786.
    • (2006) Inhal Toxicol. , vol.18 , pp. 781-786
    • Oldham, M.1
  • 87
    • 33646410925 scopus 로고    scopus 로고
    • Experimental and numerical smoke carcinogen deposition in a multi-generation human replica tracheobronchial model
    • Robinson RJ, Oldham MJ, Clinkenbeard RE, and Rai P: Experimental and numerical smoke carcinogen deposition in a multi-generation human replica tracheobronchial model. Ann Biomed Eng. 2006;34:373-383.
    • (2006) Ann Biomed Eng. , vol.34 , pp. 373-383
    • Robinson, R.J.1    Oldham, M.J.2    Clinkenbeard, R.E.3    Rai, P.4
  • 88
    • 3042717634 scopus 로고    scopus 로고
    • Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions
    • DOI 10.1063/1.1724830
    • Shi H, Kleinstreuer C, Zhang Z, and Kim CS: Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions. Phys Fluids. 2004;16:2199-2213. (Pubitemid 38957999)
    • (2004) Physics of Fluids , vol.16 , Issue.7 , pp. 2199-2213
    • Shi, H.1    Kleinstreuer, C.2    Zhang, Z.3    Kim, C.S.4
  • 89
    • 29744460920 scopus 로고    scopus 로고
    • Importance of the bifurcation zone and branch orientation in simulated aerosol deposition in the alveolar zone of the human lung
    • DOI 10.1016/j.mnl.2006.01.001, PII S0021850205000571
    • Harrington L, Prisk GK, and Darquenne C: Importance of the bifurcation zone and branch orientation in simulated aerosol deposition in the alveolar zone of the human lung. J Aerosol Sci. 2006;37:37-62. (Pubitemid 43028497)
    • (2006) Journal of Aerosol Science , vol.37 , Issue.1 , pp. 37-62
    • Harrington, L.1    Kim Prisk, G.2    Darquenne, C.3
  • 90
    • 14144252639 scopus 로고    scopus 로고
    • Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics
    • DOI 10.1152/japplphysiol.00795.2004
    • Van Ertbruggen C, Hirsch C, and Paiva M: Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J Appl Physiol. 2005;98:970-980. (Pubitemid 40283678)
    • (2005) Journal of Applied Physiology , vol.98 , Issue.3 , pp. 970-980
    • Van Ertbruggen, C.1    Hirsch, C.2    Paiva, M.3
  • 91
    • 33751011051 scopus 로고    scopus 로고
    • Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics methods
    • DOI 10.1089/jam.2006.19.329
    • Farkas Á, Balashazy I, and Szocs K: Characterization of regional and local deposition of inhaled aerosol drugs in the respiratory system by computational fluid and particle dynamics. J Aerosol Med. 2006;19:329-343. (Pubitemid 44739780)
    • (2006) Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung , vol.19 , Issue.3 , pp. 329-343
    • Farkas, A.1    Balashazy, I.2    Szocs, K.3
  • 92
    • 34247589969 scopus 로고    scopus 로고
    • Lung deposition simulation
    • A Hickey (ed). 2nd ed. Marcel Dekker, New York
    • Finlay WH: Lung deposition simulation, In: A Hickey (ed). Pharmaceutical Inhalation Aerosol Technology. 2nd ed. Marcel Dekker, New York; pp. 155-170; 2003.
    • (2003) Pharmaceutical Inhalation Aerosol Technology , pp. 155-170
    • Finlay, W.H.1
  • 93
    • 20044374879 scopus 로고    scopus 로고
    • Measurement of the effect of cartilaginous rings on particle deposition in a proximal lung bifurcation model
    • DOI 10.1080/027868290945785
    • Zhang Y, and Finlay WH: Measurement of the effect of cartilaginous rings on particle deposition in a proximal lung bifurcation replica. Aerosol Sci Technol. 2005;39:394-399. (Pubitemid 40770115)
    • (2005) Aerosol Science and Technology , vol.39 , Issue.5 , pp. 394-399
    • Zhang, Y.1    Finlay, W.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.