Inhibition of sonic hedgehog signaling aggravates brain damage associated with the down-regulation of Gli1, Ptch1 and SOD1 expression in acute ischemic stroke

Neuroscience Letters

Volumn 506, Issue 1, 2012, Pages 1-6

  Ji, Hui ^a   Miao, Jiangyong ^a   Zhang, Xiangjian ^a,b,c   Du, Yuanyuan ^a   Liu, Haichao ^a   Li, Shuya ^a,d   Li, Litao ^a,e  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b Hebei Institute of Cardio Cerebral Vascular Diseases   (China)

^c Hebei Key Laboratory for Neurology   (China)

^d CAPITAL MEDICAL UNIVERSITY   (China)

^e HEBEI GENERAL HOSPITAL   (China)

Author keywords

Cyclopamine; Glioma associated oncogene homolog 1; Middle cerebral artery occlusion; Patched 1; Superoxide dismutase 1

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; PROTEIN PATCHED 1; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN CORTEX; BRAIN DAMAGE; BRAIN FUNCTION; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN VENTRICLE; BRAIN WATER; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; LOCOMOTION; MALE; NEUROLOGIC DISEASE; NEUROLOGIC EXAMINATION; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WATER CONTENT; WESTERN BLOTTING;

ANALYSIS OF VARIANCE; ANIMALS; BRAIN EDEMA; BRAIN INFARCTION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; HEDGEHOG PROTEINS; INFARCTION, MIDDLE CEREBRAL ARTERY; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; NEUROLOGIC EXAMINATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STATISTICS, NONPARAMETRIC; SUPEROXIDE DISMUTASE; TETRAZOLIUM SALTS; VERATRUM ALKALOIDS;

EID: 84855187498     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.11.027     Document Type: Note

References (26)

1. Amankulor N.M., Hambardzumyan D., Pyonteck S.M., Becher O.J., Joyce J.A., Holland E.C. Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation. J. Neurosci. 2009, 29:10299-10308.
2. Bijlsma M.F., Leenders P.J., Janssen B.J., Peppelenbosch M.P., Ten Cate H., Spek C.A. Endogenous hedgehog expression contributes to myocardial ischemia-reperfusion-induced injury. Exp. Biol. Med. 2008, 233:989-996.
3. Cao E.H., Liu X.Q., Wang J.J., Xu N.F. Effect of natural antioxidant tanshinoneII-A on DNA damage by lipid peroxidation in liver cells. Free Radic. Biol. Med. 1996, 20:801-806.
4. Cuzzocrea S., Riley D.P., Caputi A.P., Salvemini D. Antioxidant therapy: a new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol. Rev. 2001, 53:135-159.
5. Dirnagl U., Lindauer U., Them A., Schreiber S., Pfister H.W., Koedel U., Reszka R., Freyer D., Villringer A. Global cerebral ischemia in the rat: online monitoring of oxygen free radical production using chemiluminescence in vivo. J. Cereb. Blood Flow Metab. 1995, 15:929-940.
6. Dokucu A.I., Ozturk H., Tuncer M.C., Yilmaz F. The effects of molsidomine on hypoxia inducible factor alpha and sonic hedgehog in testicular ischemia/reperfusion injury in rats. Int. Urol. Nephrol. 2009, 41:101-108.
7. Hatashita S., Hoff J.T., Salamat S.M. Ischemic brain edema and the osomotic gradient between blood and brain. J. Cereb. Blood Flow Metab. 1988, 8:552-559.
8. Hooper J.E., Scott M.P. Communicating with hedgehogs. Nat. Rev. Mol. Cell Biol. 2005, 6:306-317.
9. Ikeda K., Negishi H., Yamori Y. Antioxidant nutrients and hypoxia/ischemia brain injury in rodents. Toxicology 2003, 189:55-61.
10. Kofler J., Hurn P.D., Traystman R.J. SOD1 overexpression and female sex exhibit region-specific neuroprotection after globalcerebral ischemia due to cardiac arrest. J. Cereb. Blood Flow Metab. 2005, 25:1130-1137.
11. Lee B., Butcher G.Q., Hoyt K.R., Impey S., Obrietan K. Activity dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133. J. Neurosci. 2005, 25:1137-1148.
12. Lipton P. Ischemic cell death in brain neurons. Physiol. Rev. 1999, 79:1431-1568.
13. Longa E.Z., Weinstein P.R., Carlson S., Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20:84-91.
14. Marigo V., Johnson R.L., Vortkamp A., Tabin C.J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev. Biol. 1996, 180:273-283.
15. Marigo V., Tabin C. Regulation of patched by sonic hedgehog in the developing neural tube. Proc. Natl. Acad. Sci. U.S.A. 1996, 93:9346-9351.
16. Nishi T., Maier C.M., Hayashi T., Saito A., Chan P.H. Superoxide dismutase 1 overexpression reduces MCP-1 and MIP-1 alpha expression after transient focal cerebral ischemia. J. Cereb. Blood Flow Metab. 2005, 25:1312-1324.
17. Pola R., Ling L.E., Aprahamian T.R., Barban E., Bosch-Marce M., Curry C., Corbley M., Kearney M., Isner J.M., Losordo D.W. Postnatal recapitulation of embryonic hedgehog pathway in response to skeletal muscle ischemia. Circulation 2003, 108:479-485.
18. Riobo N.A., Manning D.R. Pathways of signal transduction employed by vertebrate hedgehogs. Biochem. J. 2007, 403:369-379.
19. Ruiz I.A.A., Mas C., Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol. 2007, 17:438-447.
20. Ruiz I.A.A., Palma V., Dahmane N. Hedgehog-Gli signalling and the growth of the brain. Nat. Rev. Neurosci. 2002, 3:24-33.
21. Ruo L.D., Sheng Y.Z., Yuan P.X., Ling M., Yuan W.M., Yu F.Y., Yu M.X., Bo H. Sonic hedgehog protects cortical neurons against oxidative stress. Neurochem. Res. 2011, 36:67-75.
22. Sims J.R., Lee S.W., Topalkara K., Qiu J., Xu J., Zhou Z., Moskowitz M.A. Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke 2009, 40:3618-3626.
23. Simonyi A., Wan Q., Miller R.L., Yusof M., Shelat P.B., Sun A.Y., Sun G.Y. Polyphenols in cerebral ischemia: novel targets for neuroprotection. Mol. Neurobiol. 2005, 31:135-148.
24. Suwelack D., Hurtado-Lorenzo A., Millan E., Gonzalez-Nicolini V., Wawrowsky K., Lowenstein P.R., Castro M.G. Neuronal expression of the transcription factor Gli1 using the Talpha1 alpha-tubulin promoter is neuroprotective in an experimental model of Parkinson's disease. Gene Ther. 2004, 11:1742-1752.
25. Thibert C., Teillet M.A., Lapointe F., Mazelin L., Le Douarin N.M., Mehlen P. Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog. Science 2003, 301:843-846.
26. Yang C.H., Zhang X.J., Fan H.G., Liu Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res. 2009, 1282:133-141.