Arsenic promotes ubiquitinylation and lysosomal degradation of cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels in human airway epithelial cells

Journal of Biological Chemistry

Volumn 287, Issue 21, 2012, Pages 17130-17139

  Bomberger, Jennifer M ^a   Coutermarsh, Bonita A ^b   Barnaby, Roxanna L ^b   Stanton, Bruce A ^b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AIRWAY SURFACE LIQUID; ARSENIC EXPOSURE; BACTERIAL INFECTIONS; CHLORIDE CHANNELS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; DOSE-DEPENDENT; ENVIRONMENTAL MODEL; EPIDEMIOLOGICAL STUDIES; HUMAN AIRWAY; INNATE IMMUNE SYSTEMS; LOW DOSE; LYSOSOMAL DEGRADATION; MUCOCILIARY CLEARANCE; POTENTIAL MECHANISM; UBIQUITIN LIGASES; UBIQUITINYLATION;

CELLS; CHLORINE COMPOUNDS; DEGRADATION; PHOSPHORYLATION; PROTEINS; RESPIRATORY SYSTEM;

ARSENIC;

ARSENIC; CBL PROTEIN; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; RESPIRATORY TRACT INFECTION; UBIQUITINATION;

ARSENIC; CELL LINE; CHLORIDES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HUMANS; ION TRANSPORT; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-CBL; RESPIRATORY MUCOSA; RESPIRATORY TRACT INFECTIONS; TIME FACTORS; UBIQUITIN THIOLESTERASE; UBIQUITINATION;

BACTERIA (MICROORGANISMS); CYPRINODONTOIDEI;

EID: 84861219418     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.338855     Document Type: Article

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