Chronic exposure to arsenic in the drinking water alters the expression of immune response genes in mouse lung

Environmental Health Perspectives

Volumn 117, Issue 7, 2009, Pages 1108-1115

  Kozul, Courtney D ^a,b   Hampton, Thomas H ^a,b   Davey, Jennifer C ^a,b   Gosse, Julie A ^a,b,e   Nomikos, Athena P ^a,b   Eisenhauer, Phillip L ^c   Weiss, Daniel J ^c   Thorpe, Jessica E ^d   Ihnat, Michael A ^d   Hamilton, Joshua W ^a,b,f  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

^b DARTMOUTH COLLEGE   (United States)

^c UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^e UNIVERSITY OF MAINE   (United States)

^f MARINE BIOLOGICAL LABORATORY   (United States)

Author keywords

Arsenic; Inflammation; Innate immune system; Lung; Migration

Indexed keywords

ADAM 10 PROTEIN; ADAM PROTEIN; ARSENIC; CYTOKINE; CYTOKINE RECEPTOR; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1 RECEPTOR TYPE II; INTERLEUKIN 1BETA; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL SUBUNIT 3 BETA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; FLUID INTAKE; FOOD INTAKE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNE RESPONSE GENE; IMMUNOREGULATION; INNATE IMMUNITY; LONG TERM EXPOSURE; LUNG PARENCHYMA; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RISK FACTOR; TRANSCRIPTION REGULATION;

ANIMALS; ARSENIC; BLOTTING, WESTERN; BRONCHOALVEOLAR LAVAGE FLUID; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNE SYSTEM; LUNG; MALE; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; WATER POLLUTANTS, CHEMICAL; WATER SUPPLY;

MUS;

EID: 67650927982     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.0800199     Document Type: Article

References (48)

1. Abernathy CO, Liu YP, Longfellow D, Aposhian HV, Beck B, Fowler B, et al. 1999. Arsenic: health effects, mechanisms of actions, and research issues. Environ Health Perspect 107:593-597.
2. Agency for Toxic Substances and Disease Registry. 1999. Toxicological Profile for Arsenic (Update). Atlanta, GA:Agency for Toxic Substances and Disease Registry.
3. Akira S, Takeda K. 2004. Toll-like receptor signalling. Nat Rev Immunol 4(7):499-511.
4. Andrew AS, Bernardo V, Warnke LA, Davey JC, Hampton T, Mason RA, et al. 2007. Exposure to arsenic at levels found in U.S. drinking water modifies expression in the mouse lung. Toxicol Sci 100(1):75-87.
5. Andrew AS, Jewell DA, Mason RA, Whitfield ML, Moore JH, Karagas MR. 2008. Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect 116:524-531.
6. Andrew AS, Warren AJ, Barchowsky A, Temple KA, Klei L, Soucy NV, et al. 2003. Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect 111:825-835.
7. Blobel CP. 2005. ADAMs: key components in EGFR signalling and development. Nat Rev 6(1):32-43.
8. Bodwell JE, Gosse JA, Nomikos AP, Hamilton JW. 2006. Arsenic disruption of steroid receptor gene activation: complex dose-response effects are shared by several steroid receptors. Chem Res Toxicol 19(12):1619-1629.
9. Bodwell JE, Kingsley LA, Hamilton JW. 2004. Arsenic at very low concentrations alters glucocorticoid receptor (GR)-mediated gene activation but not GR-mediated gene repression: complex dose-response effects are closely correlated with levels of activated GR and require a functional GR DNA binding domain. Chem Res Toxicol 17(8):1064-1076.
10. Breitling R, Armengaud P, Amtmann A, Herzyk P. 2004. Rank products: a simple, yet powerful, new method to detect differentially regulated genes in replicated microarray experiments. FEBS Lett 573(1-3):83-92.
11. Breitling R, Herzyk P. 2005. Rank-based methods as a non-parametric alternative of the T-statistic for the analysis of biological microarray data. J Bioinform Comput Biol. 3(5):1171-1189.
12. Corsini E, Asti L, Viviani B, Marinovich M, Galli CL 1999. Sodium arsenate induces overproduction of interleukin-1alpha in murine keratinocytes: role of mitochondria. J Invest Dermatol 113(5):760-765.
13. Davey JC, Bodwell JE, Gosse JA, Hamilton JW. 2007. Arsenic as an endocrine disruptor: effects of arsenic on estrogen receptor-mediated gene expression in vivo and in cell culture. Toxicol Sci 98(1):75-86.
14. Davey JC, Nomikos AP, Wungjiranirun M, Sherman JR, Ingram L, Batki C, et al. 2008. Arsenic as an endocrine disruptor: arsenic disrupts retinoic acid receptor- and thyroid hormone receptor-mediated gene regulation and thyroid hormone-mediated amphibian tail metamorphosis. Environ Health Perspect 116:165-172.
15. De BK, Majumdar D, Sen S, Guru S, Kundu S. 2004. Pulmonary involvement in chronic arsenic poisoning from drinking contaminated ground-water. J Assoc Phys India 52:395-400.
16. Dinarello CA. 2005, Interleukin-1 beta. Crit Care Med 33(12 suppl): S460-S462.
17. Fry FIC, Navasumrit P, Valiathan C, Svensson JP, Hogan BJ, Luo M, et al. 2007. Activation of inflammation/NF-kappaB signaling in infants born to arsenic-exposed mothers. PLoS Genet 3(11):e207.
18. Ghosh P, Banerjee M, De Chaudhuri S, Chowdhury R, Das JK, Mukherjee A, et al. 2007. Comparison of health effects between individuals with and without skin lesions in the population exposed to arsenic through drinking water in West Bengal, India. J Expo Sci Environ Epidemiol 17(3):215-223.
19. Gosse J, Hampton T, Davey J, Hamilton J. 2008. A new approach to analysis and interpretation of toxicogenomic gene expression data and its importance in examining biological responses to low, environmentally relevant doses of toxicants. In: Toxicogenomics; A Powerful Tool for Toxicity Assessment (Sahu S, ed). Hoboken, NJ:John Wiley and Sons, 27-57.
20. Kamat CD, Green DE, Curilla S, Warnke L, Hamilton JW, Sturup S, et al. 2005. Role of HIF signaling on tumorigenesis in response to chronic low-dose arsenic administration. Toxicol Sci 86(2):248-257.
21. Karagas MR, Stukel TA, Tosteson TD. 2002. Assessment of cancer risk and environmental levels of arsenic in New Hampshire. Int J Hyg Environ Health 205(1-2):85-94.
22. Kozul CD, Nomikos AP, Hampton TH, Wahnke LA, Gosse JA, Davey JC, et al. 2008. Laboratory diet-profoundly alters gene expression and confounds genomic analysis in mouse liver and lung. Chem-Biol Interact 173(2):129-140.
23. Lage CR, Nayak A, Kim CH. 2006. Arsenic ecotoxicology and innate immunity. Integr Comp Biol 46(6):1040-1054.
24. Lantz RC, Lynch BJ, Boitano S, Poplin GS, Littau S, Tsaprailis G, et al. 2007. Pulmonary biomarkers based on alterations in protein, expression after exposure to arsenic. Environ Health Perspect 115:586-591.
25. Lemarie A, Morzadec C, Bourdonnay E, Fardel O, Vernhet L. 2006. Human macrophages constitute targets for immunotoxic inorgqnic arsenic. J Immunol 177(5):3019-3027.
26. Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, et al. 2005. ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc Natl Acad Sci USA 102(26):9182-9187.
27. Marshall G, Ferreccio C, Yuan Y, Bates MN, Steinmaus C, Selvin S, et al. 2007. Fifty-year study of lung and bladder cancer mortality in Chile related to arsenic in drinking water. J Natl Cancer Inst 99(12):920-928.
28. Mazumder DN. 2007. Arsenic and non-malignant lung disease. J Environ Sci Health 42(12):1859-1867.
29. National Research Council. 1999. Arsenic in Drinking Water. Washington, DC:National Research Council.
30. Nayak AS, Lage CR, Kim CH, 2007. Effects of low concentrations of arsenic on the innate immune system of the zebrafish (Danio rerio). Toxicol Sci 98(1):118-124.
31. Olsen CE, Liguori AE, Zong Y, Lantz RC, Burgess JL, Boitano S. 2008. Arsenic upregulates MMP-9 and inhibits wound repair in human airway epithelial cells. Am J Physiol 295(2):L293-302.
32. Patterson R, Vega L, Trouba K, Bortner C, Germolec D. 2004. Arsenic-induced alterations in the contact hypersensitivity response in Balb/c mice. Toxicol Appl Pharmacol 198(3):434-443.
33. Raqib R, Ahmed S, Sultana R, Wagatsuma Y, Mondal D, Hoque AM, et al. 2009. Effects of in utero arsenic exposure on child immunity and morbidity in rural Bangladesh. Toxicol Lett 185(3):197-202.
34. Schottelius AJ, Moldawer LL, Dinarello CA, Asadullah K, Sterry W, Edwards CK III. 2004. Biology of tumor necrosis factor-alpha- implications for psoriasis. Exp Dermatol 13(4):193-222.
35. Selgrade MK. 2007. Immunotoxicity: the risk is real. Toxicol Sci 100:328-332.
36. Smith AH, Hopenhayn-Rich C, Bates MN, Goeden HM, Hertz-Picciotto I, Duggan HM, et al. 1992. Cancer risks from arsenic in drinking water. Environ Health Perspect 97:259-267.
37. Smith AH, Marshall G, Yuan Y, Ferreccio C, Liaw J, von Ehrenstein O, et al. 2006. Increased mortality from lung cancer and bronchiectasis in young adults after exposure to arsenic in utero and in early childhood. Environ Health Perspect 114:1293-1296.
38. Soto-Pena GA, Luna AL, Acosta-Saavedra L, Conde P, Lopez-Carrillo L, Cebrian ME, et al. 2006. Assessment of lymphocyte subpopulations and cytokine secretion in children exposed to arsenic. FASEB J 20(6):779-781.
39. Tapio S, Grosche B. 2006. Arsenic in the aetiology of cancer. Mutat Res 612(3):215-246.
40. U.S. EPA. 2001. National primary drinking water regulations; arsenic and clarifications to compliance and new source contaminants monitoring. Fed Reg 66:6975-7066.
41. Vega L, Styblo M, Patterson R, Cullen W, Wang C, Germolec D. 2001. Differential effects of trivalent and pentavalent arsenicals on cell proliferation and cytokine secretion in normal human epidermal keratinocytes. Toxicol Appl Pharmacol 172(3):225-232.
42. Watanabe C, Inaoka T, Matsui T, Ishigaki K, Murayama N, Ohtsuka R. 2003. Effects of arsenic on younger generations. J Environ Sci Health 38(1):129-139.
43. Wu H, Arron JR. 2003. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Bioessays 25(11):1096-1105.
44. Wu MM, Chiou HY, Ho IC, Chen CJ, Lee TC. 2003. Gene expression of inflammatory molecules in circulating lymphocytes from arsenic-exposed human subjects. Environ Health Perspect 111:1429-1438.
45. Yancy SL, Sheldon EA, Gilmont RR, Welsh MJ. 2005. Sodium arsenite exposure alters cell migration, focal adhesion localization and decreases tyrosine phosphorylation of focal adhesion kinase in H9C2 myoblasts. Toxicol Sci 84(2):278-286.
46. Yu HS, Chang KL, Yu CL, Wu CS, Chen GS, Ho JC. 1998. Defective IL-2 receptor expression in lymphocytes of patients with arsenic-induced Bowen's disease. Arch Dermatol Res 290(12)681-687.
47. Zaldivar R, Ghai GL. 1980. Clinical epidemiological studies on endemic chronic arsenic poisoning in children and adults, including observations on children with high- and low-in-take of dietary arsenic. Zentralbl Bakteriol 170(5-6):409-421.
48. Zhou LF, Zhu Y, Cui XF, Xie WP, Hu AH, Yin KS. 2006. Arsenic trioxide, a potent inhibitor of NF-kappaB, abrogates allergen-induced airway hyperresponsiveness and inflammation. Respir Res 7:146; doi: 10.1186/ 1465-9921-7-146 [Online 20 December 2006].