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Volumn 13, Issue 7, 2012, Pages 1306-1316

Nanocarriers to solid tumors: Considerations on tumor penetration and exposure of tumor cells to therapeutic agents

Author keywords

Liposomes; Micelles; Targeted delivery; Triggered release; Tumor penetration

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; DOXORUBICIN; GOLD NANOPARTICLE; LIPOSOME; MALEIC ACID; METHOTREXATE; METHYLPREDNISOLONE SODIUM SUCCINATE; NANOCARRIER; PACLITAXEL;

EID: 84861160747     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920112800624256     Document Type: Review
Times cited : (14)

References (100)
  • 1
    • 0033302303 scopus 로고    scopus 로고
    • Transport of molecules, particles, and cells in solid tumors
    • Jain, K. Transport of molecules, particles, and cells in solid tumors. Ann. Rev. Biomed. Eng., 1999, 1, 241-263.
    • (1999) Ann. Rev. Biomed. Eng. , vol.1 , pp. 241-263
    • Jain, K.1
  • 2
    • 33746491709 scopus 로고    scopus 로고
    • Drug penetration in solid tumours
    • Minchinton, A.; Tannock, I. Drug penetration in solid tumours. Nat. Rev. Cancer, 2006, 6, 583-92.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 583-592
    • Minchinton, A.1    Tannock, I.2
  • 3
    • 84861146750 scopus 로고    scopus 로고
    • Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine
    • Zaidi, H.; Sgouros, G. Therapeutic Applications of Monte Carlo Calculations in Nuclear Medicine. IoP: Bristol, 2003.
    • (2003) IoP: Bristol
    • Zaidi, H.1    Sgouros, G.2
  • 4
    • 46849103828 scopus 로고    scopus 로고
    • Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance
    • Thurber, G. M.; Schmidt, M. M.; Wittrup, K. D. Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance. Adv. Drug Deliv. Rev., 2008, 60(12), 1421-1434.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.12 , pp. 1421-1434
    • Thurber, G.M.1    Schmidt, M.M.2    Wittrup, K.D.3
  • 5
    • 34250380650 scopus 로고    scopus 로고
    • Theoretic criteria for antibody penetration into solid tumors and micrometastases
    • Thurber, G. M.; Zajic, S. C.; Wittrup, K. D. Theoretic criteria for antibody penetration into solid tumors and micrometastases. J. Nucl. Med., 2007, 48(6), 995-999.
    • (2007) J. Nucl. Med. , vol.48 , Issue.6 , pp. 995-999
    • Thurber, G.M.1    Zajic, S.C.2    Wittrup, K.D.3
  • 6
    • 77955251549 scopus 로고    scopus 로고
    • The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles
    • Lee, H.; Fonge, H.; Hoang, B.; Reilly, R. M.; Allen, C. The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Mol. Pharm., 2011, 7(4), 1195-1208.
    • (2011) Mol. Pharm. , vol.7 , Issue.4 , pp. 1195-1208
    • Lee, H.1    Fonge, H.2    Hoang, B.3    Reilly, R.M.4    Allen, C.5
  • 7
    • 37249021356 scopus 로고    scopus 로고
    • Surface-active liposomes for targeted cancer therapy
    • Sofou, S. Surface-active liposomes for targeted cancer therapy. Nanomed., 2007, 2, 711-724
    • (2007) Nanomed. , vol.2 , pp. 711-724
    • Sofou, S.1
  • 8
    • 39749160560 scopus 로고    scopus 로고
    • Antibody-targeted liposomes in cancer therapy and imaging
    • Sofou, S.; Sgouros, G. Antibody-targeted liposomes in cancer therapy and imaging. Expert Opin. Drug Deliv., 2008, 5(2), 189-204.
    • (2008) Expert Opin. Drug Deliv. , vol.5 , Issue.2 , pp. 189-204
    • Sofou, S.1    Sgouros, G.2
  • 9
    • 0036548794 scopus 로고    scopus 로고
    • Dissecting tumor pathophysiology using intravital microscopy
    • Jain, R. K.; Munn, L. L.; Fukumura, D. Dissecting tumor pathophysiology using intravital microscopy. Nat. Rev. Cancer, 2002, 2, 266-276.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 266-276
    • Jain, R.K.1    Munn, L.L.2    Fukumura, D.3
  • 11
    • 0031959490 scopus 로고    scopus 로고
    • Early phase tumor accumulation of macromolecules: A great difference between the tumor vs. normal tissue in their clearance rate
    • Noguchi, Y.; Wu, J.; Duncan, R.; Strohalm, J.; Ulbrich, K.; Akaike, T.; Maeda, H. Early phase tumor accumulation of macromolecules: A great difference between the tumor vs. normal tissue in their clearance rate. Jpn J. Cancer Res., 1998, 89, 307-314.
    • (1998) Jpn J. Cancer Res. , vol.89 , pp. 307-314
    • Noguchi, Y.1    Wu, J.2    Duncan, R.3    Strohalm, J.4    Ulbrich, K.5    Akaike, T.6    Maeda, H.7
  • 12
    • 0001217379 scopus 로고
    • The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit
    • Young, J.; Lumsden, C.; Stalker, A. The significance of the tissue pressure of normal testicular and of neoplastic (Brown-Pearce carcinoma) tissue in the rabbit. J. Pathol. Bacteriol., 1950, 62, 313-33.
    • (1950) J. Pathol. Bacteriol. , vol.62 , pp. 313-333
    • Young, J.1    Lumsden, C.2    Stalker, A.3
  • 13
    • 0023219734 scopus 로고
    • Transport of molecules in the tumor interstitium: A Review
    • Jain, R. Transport of molecules in the tumor interstitium: A Review. Canser Res., 1987, 47, 3039-3051.
    • (1987) Canser Res. , vol.47 , pp. 3039-3051
    • Jain, R.1
  • 14
    • 4944266313 scopus 로고    scopus 로고
    • High intersial fluid pressure-an obstacle in cancer therapy
    • Heldin, C.; Rubin, K.; Pietras, K.; Ostman, A. High intersial fluid pressure-an obstacle in cancer therapy. Nat. Rev. Can., 2004, 4, 806-813.
    • (2004) Nat. Rev. Can. , vol.4 , pp. 806-813
    • Heldin, C.1    Rubin, K.2    Pietras, K.3    Ostman, A.4
  • 15
    • 0034193258 scopus 로고    scopus 로고
    • Role of extracellular matrix assembly in interstitial transport in solid tumors
    • Netti, P.; Berk, D.; Swartz, M.; Grodzinsky, A.; Jain, R. Role of extracellular matrix assembly in interstitial transport in solid tumors. Canser Res., 2000, 60, 2497-2503.
    • (2000) Canser Res. , vol.60 , pp. 2497-2503
    • Netti, P.1    Berk, D.2    Swartz, M.3    Grodzinsky, A.4    Jain, R.5
  • 16
    • 0016277217 scopus 로고
    • Diffusion and convection in normal and neoplastic tissues
    • Swabb, E.; Wei, J.; Gullino, P. Diffusion and convection in normal and neoplastic tissues. Can Res., 1974, 34, 2814-2822.
    • (1974) Can Res. , vol.34 , pp. 2814-2822
    • Swabb, E.1    Wei, J.2    Gullino, P.3
  • 17
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
    • Helmlinger, G.; Yuan, F.; Dellian, M.; Jain, R. K. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat. Med., 1997, 3, 177-182.
    • (1997) Nat. Med. , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    dellian, M.3    Jain, R.K.4
  • 18
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel, P.; Kallinowski, F.; Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review. Cancer Res., 1989, 49(23), 6449-6465.
    • (1989) Cancer Res. , vol.49 , Issue.23 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 20
    • 0000459772 scopus 로고
    • Uber den Stoffwechsel der Carcinomzelle
    • Warburg, O.; Posener, K.; Negelein, E. Uber den Stoffwechsel der Carcinomzelle. Biochem. Z., 1924, 152, 309-344.
    • (1924) Biochem. Z. , vol.152 , pp. 309-344
    • Warburg, O.1    Posener, K.2    Negelein, E.3
  • 21
    • 0031927798 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • Gerwec, L. Causes and consequences of tumour acidity and implications for treatment. Semin. Rad. Oncol., 1998, 8, 176-182.
    • (1998) Semin. Rad. Oncol. , vol.8 , pp. 176-182
    • Gerwec, L.1
  • 22
    • 0033986761 scopus 로고    scopus 로고
    • Causes and consequences of tumour acidity and implications for treatment
    • Stubbs, M.; McSheehy, P.; Griffiths, J.; Bashford, C. Causes and consequences of tumour acidity and implications for treatment. Mol. Med. Today, 2000, 6, 15-19.
    • (2000) Mol. Med. Today , vol.6 , pp. 15-19
    • Stubbs, M.1    McSheehy, P.2    Griffiths, J.3    Bashford, C.4
  • 23
    • 0024379967 scopus 로고
    • Human tumour pH and its variation
    • Tannock, I.; Rotin, D. Human tumour pH and its variation. Cancer Res., 1989, 49, 4373-4384.
    • (1989) Cancer Res. , vol.49 , pp. 4373-4384
    • Tannock, I.1    Rotin, D.2
  • 24
    • 0026568374 scopus 로고
    • Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH
    • Casciari, J.; Sotirchos, S.; Sutherland, R. Variations in tumor cell growth rates and metabolism with oxygen concentration, glucose concentration, and extracellular pH. J. Cell. Phys., 1992, 151, 386-394.
    • (1992) J. Cell. Phys. , vol.151 , pp. 386-394
    • Casciari, J.1    Sotirchos, S.2    Sutherland, R.3
  • 25
    • 0018330397 scopus 로고
    • Tumour cell proliferation in relation to the vasculature
    • Hirst, D.; Denekamp, J. Tumour cell proliferation in relation to the vasculature. Cell Tiss. Kinetics, 1979, 12, 31-42.
    • (1979) Cell Tiss. Kinetics , vol.12 , pp. 31-42
    • Hirst, D.1    Denekamp, J.2
  • 26
    • 0029886833 scopus 로고    scopus 로고
    • Oxygen dependence of the cytotoxicity of the enediyne anti-tumour antibiotic esperamicin A1r
    • Batchelder, R.; Wilson, W.; Hay, M.; Denny, W. Oxygen dependence of the cytotoxicity of the enediyne anti-tumour antibiotic esperamicin A1. Br. J. Cancer. Suppl., 1996, 27, 52-56.
    • (1996) Br. J. Cancer. Suppl. , vol.27 , pp. 52-56
    • Batchelder, R.1    Wilson, W.2    Hay, M.3    Denny, W.4
  • 27
    • 0042411985 scopus 로고    scopus 로고
    • Tumour hypoxia, chemotherapeutic resistance and hypoxiarelated therapies
    • Shannon, A. M.; Bouchier-Hayes, D. J.; Condron, C. M.; Toomey, D. Tumour hypoxia, chemotherapeutic resistance and hypoxiarelated therapies. Cancer Treat Rev., 2003, 29, 297-307.
    • (2003) Cancer Treat Rev. , vol.29 , pp. 297-307
    • Shannon, A.M.1    Bouchier-Hayes, D.J.2    Condron, C.M.3    Toomey, D.4
  • 28
    • 0028307739 scopus 로고
    • Hypoxia and drug resistance
    • Teicher, B. A. Hypoxia and drug resistance. Cancer Metastasis Rev., 1994, 13, 139-168.
    • (1994) Cancer Metastasis Rev. , vol.13 , pp. 139-168
    • Teicher, B.A.1
  • 29
    • 2942590732 scopus 로고    scopus 로고
    • Exploiting tumour hypoxia in cancer treatment
    • Brown, J.; Wilson, W. Exploiting tumour hypoxia in cancer treatment. Nat. Rev. Cancer, 2004, 4, 437-447.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 437-447
    • Brown, J.1    Wilson, W.2
  • 30
    • 85047697737 scopus 로고    scopus 로고
    • Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis
    • Liu, S.; Minton, N.; Giaccia, A.; Brown, J. Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Ther., 2002, 9, 291-296.
    • (2002) Gene Ther. , vol.9 , pp. 291-296
    • Liu, S.1    Minton, N.2    Giaccia, A.3    Brown, J.4
  • 31
    • 34248195085 scopus 로고    scopus 로고
    • Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis
    • Kasinskas, R.; Forbes, N. Salmonella typhimurium lacking ribose chemoreceptors localize in tumor quiescence and induce apoptosis. Cancer Res., 2007, 67, 3201-309.
    • (2007) Cancer Res. , vol.67 , pp. 3201-3309
    • Kasinskas, R.1    Forbes, N.2
  • 32
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman, M.; Fojo, T.; Bates, S. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat. Rev. Cancer, 2002, 2, 48-58.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.1    Fojo, T.2    Bates, S.3
  • 33
    • 0033628853 scopus 로고    scopus 로고
    • Cellular mechanisms of multidrug resistance of tumor cells
    • Stavrovskaya, A. Cellular mechanisms of multidrug resistance of tumor cells. Biochem. (Moscow), 2000, 65, 95-106.
    • (2000) Biochem. (Moscow) , vol.65 , pp. 95-106
    • Stavrovskaya, A.1
  • 34
    • 39649120532 scopus 로고    scopus 로고
    • A review of stimuli-responsive nanocarriers for drug and gene delivery
    • Ganta, S.; Devalapally, H.; Shahiwala, A.; Amij, I. M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Contr Rel., 2008, 126, 187-204.
    • (2008) J. Contr Rel. , vol.126 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amij, I.M.4
  • 36
    • 23144448579 scopus 로고    scopus 로고
    • Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts
    • Eikenes, L.; Tari, M.; Tufto, I.; Bruland, O.; de Lange Davies, C. Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (Caelyx) in human osteosarcoma xenografts. Br. J. Cancer, 2005, 11, 81-88.
    • (2005) Br. J. Cancer , vol.11 , pp. 81-88
    • Eikenes, L.1    Tari, M.2    Tufto, I.3    Bruland, O.4    de Lange Davies, C.5
  • 37
    • 0034671219 scopus 로고    scopus 로고
    • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: Importance of triggered drug release
    • Kong, G.; Anyarambhatla, G.; Petros, W. P.; Braun, R. D.; Colvin, O. M.; Needham, D.; Dewhirst, M. W. Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. Cancer Res., 2000, 60(24), 6950-6957.
    • (2000) Cancer Res. , vol.60 , Issue.24 , pp. 6950-6957
    • Kong, G.1    Anyarambhatla, G.2    Petros, W.P.3    Braun, R.D.4    Colvin, O.M.5    Needham, D.6    Dewhirst, M.W.7
  • 38
    • 0025055743 scopus 로고
    • Enhancement of monoclonal antibody uptake in human colon tumor xenografts following irradiation
    • Kalofonos, H.; Rowlinson, G.; Epenetos, A. Enhancement of monoclonal antibody uptake in human colon tumor xenografts following irradiation. Cancer Res., 1990, 50, 159-163.
    • (1990) Cancer Res. , vol.50 , pp. 159-163
    • Kalofonos, H.1    Rowlinson, G.2    Epenetos, A.3
  • 39
    • 44249123015 scopus 로고    scopus 로고
    • Ultrasound mediated delivery of drugs and genes to solid tumors
    • Frenkel, V., Ultrasound mediated delivery of drugs and genes to solid tumors. Drug Deliv. Rev., 2008, 60, 1193-1208.
    • (2008) Drug Deliv. Rev., , vol.60 , pp. 1193-1208
    • Frenkel, V.1
  • 41
    • 77955251549 scopus 로고    scopus 로고
    • The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles
    • Lee, H.; Fonge, H.; Hoang, B.; Reilly, R. M.; Allen, C. The effects of particle size and molecular targeting on the intratumoral and subcellular distribution of polymeric nanoparticles. Mol. Pharm., 2011, 7(4),1195-1208.
    • (2011) Mol. Pharm., , vol.7 , Issue.4 , pp. 1195-1208
    • Lee, H.1    Fonge, H.2    Hoang, B.3    Reilly, R.M.4    Allen, C.5
  • 42
    • 38949192863 scopus 로고    scopus 로고
    • Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers
    • Torchilin, V. P. Tat peptide-mediated intracellular delivery of pharmaceutical nanocarriers. Adv. Drug Deliv. Rev., 2008, 60(4-5), 548-558.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.4-5 , pp. 548-558
    • Torchilin, V.1
  • 44
    • 34547657290 scopus 로고    scopus 로고
    • Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes
    • Kale, A. A.; Torchilin, V. P. Enhanced transfection of tumor cells in vivo using "Smart" pH-sensitive TAT-modified pegylated liposomes. J. Drug Targeting, 2007, 15(7-8), 538-545.
    • (2007) J. Drug Targeting , vol.15 , Issue.7-8 , pp. 538-545
    • Kale, A.A.1    Torchilin, V.2
  • 45
    • 77949653038 scopus 로고    scopus 로고
    • The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity
    • Karve, S.; Bandekar, A.; Ali, M. R.; Sofou, S. The pH-dependent association with cancer cells of tunable functionalized lipid vesicles with encapsulated doxorubicin for high cell-kill selectivity. Biomat, 2010, 31, 4409-4416.
    • (2010) Biomat , vol.31 , pp. 4409-4416
    • Karve, S.1    Bandekar, A.2    Ali, M.R.3    Sofou, S.4
  • 46
    • 67651091968 scopus 로고    scopus 로고
    • pH-dependent formation of lipid heterogeneities controls surface topography and binding reactivity in functionalized bilayers
    • Bajagur Kempegowda, G.; Karve, S.; Bandekar, A.; Adhikari, A.; Khaimchayev, T.; Sofou, S. pH-dependent formation of lipid heterogeneities controls surface topography and binding reactivity in functionalized bilayers. Langmuir, 2009, 25, 8144-8151.
    • (2009) Langmuir , vol.25 , pp. 8144-8151
    • Bajagur Kempegowda, G.1    Karve, S.2    Bandekar, A.3    Adhikari, A.4    Khaimchayev, T.5    Sofou, S.6
  • 47
    • 23144448579 scopus 로고    scopus 로고
    • Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (CaelyxTM) in human osteosarcoma xenografts
    • Eikenes, L.; Tari, M.; Tufto, I.; Bruland, O. S.; de Lange Davies, C. Hyaluronidase induces a transcapillary pressure gradient and improves the distribution and uptake of liposomal doxorubicin (CaelyxTM) in human osteosarcoma xenografts. Br. J. Cancer, 2005, 93, 81-88.
    • (2005) Br. J. Cancer , vol.93 , pp. 81-88
    • Eikenes, L.1    Tari, M.2    Tufto, I.3    Bruland, O.S.4    de Lange Davies, C.5
  • 48
    • 0031048011 scopus 로고    scopus 로고
    • Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposi's sarcoma
    • Smith, K. J.; Skelton, H. G.; Turiansky, G.; Wagner, K. F. Hyaluronidase enhances the therapeutic effect of vinblastine in intralesional treatment of Kaposi's sarcoma. J. Am. Acad. Dermatol., 1997, 36(2), 239-242.
    • (1997) J. Am. Acad. Dermatol. , vol.36 , Issue.2 , pp. 239-242
    • Smith, K.J.1    Skelton, H.G.2    Turiansky, G.3    Wagner, K.F.4
  • 49
    • 0032738827 scopus 로고    scopus 로고
    • A randomized controlled trial of local injections of hyaluronidase versus placebo in cancer patients receiving subcutaneous hydration
    • Bruera, E.; Neumann, C. M.; Pituskin, E.; Calder, K.; Hanson, J. A randomized controlled trial of local injections of hyaluronidase versus placebo in cancer patients receiving subcutaneous hydration. Ann. Oncol., 1999, 10(10), 1255-1258.
    • (1999) Ann. Oncol. , vol.10 , Issue.10 , pp. 1255-1258
    • Bruera, E.1    Neumann, C.M.2    Pituskin, E.3    Calder, K.4    Hanson, J.5
  • 50
    • 0032974504 scopus 로고    scopus 로고
    • Adjuvant therapy with hyaluronidase prior to excision of dermatofibrosarcoma protuberans
    • Menon, P.; Smith, K. J.; Crittenden, J.; Skelton, H. Adjuvant therapy with hyaluronidase prior to excision of dermatofibrosarcoma protuberans. Dermat. Surg., 1999, 25, 205-209.
    • (1999) Dermat. Surg. , vol.25 , pp. 205-209
    • Menon, P.1    Smith, K.J.2    Crittenden, J.3    Skelton, H.4
  • 51
    • 1642453836 scopus 로고    scopus 로고
    • Radiation improves the distribution and uptake of liposomal Doxorubicin (Caelyx) in human osteosarcoma xenografts
    • Davies, C. L.; Lundstrom, L. M.; J., F.; Eikenes, L.; Bruland, O. S.; Kaalhus, O.; Hjelstuen, M. H. B.; Brekken, C. Radiation improves the distribution and uptake of liposomal Doxorubicin (Caelyx) in human osteosarcoma xenografts. Cancer Res., 2004, 64, 547-553.
    • (2004) Cancer Res. , vol.64 , pp. 547-553
    • Davies, C.L.1    Lundstrom, L.M.J.F.2    Eikenes, L.3    Bruland, O.S.4    Kaalhus, O.5    Hjelstuen, M.H.B.6    Brekken, C.7
  • 52
    • 45749140558 scopus 로고    scopus 로고
    • Heterogeneous domains and membrane permeability in phosphatidylcholinephosphatidic acid rigid vesicles as a function of pH and lipid chain mismatch
    • Karve, S.; Bajagur Kempegowda, G.; Sofou, S. Heterogeneous domains and membrane permeability in phosphatidylcholinephosphatidic acid rigid vesicles as a function of pH and lipid chain mismatch. Langmuir, 2008, 24, 5679-5688.
    • (2008) Langmuir , vol.24 , pp. 5679-5688
    • Karve, S.1    Bajagur Kempegowda, G.2    Sofou, S.3
  • 53
    • 69249210919 scopus 로고    scopus 로고
    • The use of pH-triggered leaky heterogeneities on rigid lipid bilayers to improve intracellular trafficking and therapeutic potential of targeted liposomal immunochemotherapy
    • Karve, S.; Alaouie, A.; Zhou, Y.; Rotolo, J.; Sofou, S. The use of pH-triggered leaky heterogeneities on rigid lipid bilayers to improve intracellular trafficking and therapeutic potential of targeted liposomal immunochemotherapy. Biomat, 2009, 30, 6055-6064.
    • (2009) Biomat , vol.30 , pp. 6055-6064
    • Karve, S.1    Alaouie, A.2    Zhou, Y.3    Rotolo, J.4    Sofou, S.5
  • 54
    • 0035300546 scopus 로고    scopus 로고
    • Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature
    • Kong, G.; Braun, R.; Dewhirst, M. Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. Cancer Res., 2001, 61, 3027-3032.
    • (2001) Cancer Res. , vol.61 , pp. 3027-3032
    • Kong, G.1    Braun, R.2    Dewhirst, M.3
  • 55
    • 0015795402 scopus 로고
    • Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol
    • Papahadjopoulos, D.; Jacobson, K.; Nir, S.; Isac, I. Phase transitions in phospholipid vesicles Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol. BBA-Biomembranes, 1973, 311(3), 330-348.
    • (1973) BBA-Biomembranes , vol.311 , Issue.3 , pp. 330-348
    • Papahadjopoulos, D.1    Jacobson, K.2    Nir, S.3    Isac, I.4
  • 56
    • 0018773111 scopus 로고
    • Liposomes and local hyperthermia: Selective delivery of methotrexate to heated tumors
    • Weinstein, J.; Magin, R.; Yatvin, M.; Zaharko, D. Liposomes and local hyperthermia: selective delivery of methotrexate to heated tumors. Science, 1979, 204, 188-191.
    • (1979) Science , vol.204 , pp. 188-191
    • Weinstein, J.1    Magin, R.2    Yatvin, M.3    Zaharko, D.4
  • 57
    • 0035981024 scopus 로고    scopus 로고
    • The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors
    • Needham, D.; Dewhirst, M. W. The development and testing of a new temperature-sensitive drug delivery system for the treatment of solid tumors. Adv. Drug Deliv. Rev., 2001, 53(3), 285-305.
    • (2001) Adv. Drug Deliv. Rev. , vol.53 , Issue.3 , pp. 285-305
    • Needham, D.1    Dewhirst, M.W.2
  • 59
    • 65149101001 scopus 로고    scopus 로고
    • Thermosensitive liposomes entrapping iron oxide nanoparticles for controllable drug release
    • Tai, L. A.; Tsai, P. J.; Wang, Y. C.; Wang, Y. J.; Lo, L. W.; Yang, C. S. Thermosensitive liposomes entrapping iron oxide nanoparticles for controllable drug release. Nanotechnol., 2009, 20, 135101.
    • (2009) Nanotechnol. , vol.20 , pp. 135101
    • Tai, L.A.1    Tsai, P.J.2    Wang, Y.C.3    Wang, Y.J.4    Lo, L.W.5    Yang, C.S.6
  • 61
    • 3442898460 scopus 로고    scopus 로고
    • Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound
    • Lin, H. Y.; Thomas, J. L. Factors affecting responsivity of unilamellar liposomes to 20 kHz ultrasound. Langmuir., 2004, 20, 6100-6106.
    • (2004) Langmuir. , vol.20 , pp. 6100-6106
    • Lin, H.Y.1    Thomas, J.L.2
  • 63
    • 0035438421 scopus 로고    scopus 로고
    • Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm
    • Berg, O. G.; Gelb, M. H.; Tsai, M.-D.; Jain, M. K. Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm. Chem. Rev., 2001, 101(9), 2613-2654.
    • (2001) Chem. Rev. , vol.101 , Issue.9 , pp. 2613-2654
    • Berg, O.G.1    Gelb, M.H.2    Tsai, M.-D.3    Jain, M.K.4
  • 64
    • 0018909402 scopus 로고
    • Phospholipase A2 activity in 9,10-dimethyl-1,2-benzanthracene-induced mammary tumors of rats
    • Rillema, J. A.; Osmialowski, E. C.; Linebaugh, B. E. Phospholipase A2 activity in 9,10-dimethyl-1,2-benzanthracene-induced mammary tumors of rats. BBA-Lipids and Lipid Metabolism, 1980, 617(1), 150-155.
    • (1980) BBA-Lipids and Lipid Metabolism , vol.617 , Issue.1 , pp. 150-155
    • Rillema, J.A.1    Osmialowski, E.C.2    Linebaugh, B.E.3
  • 66
    • 24644473641 scopus 로고    scopus 로고
    • Triggered activation and release of liposomal prodrugs and drugs in cancer tissue by secretory phospholipase A2
    • Andresen, T. L.; Jensen, S. S.; Kaasgaard, T.; Jørgensen, K. Triggered activation and release of liposomal prodrugs and drugs in cancer tissue by secretory phospholipase A2. Curr. Drug Deliv., 2005, 2, 353-362.
    • (2005) Curr. Drug Deliv. , vol.2 , pp. 353-362
    • Andresen, T.L.1    Jensen, S.S.2    Kaasgaard, T.3    Jørgensen, K.4
  • 69
    • 61349107152 scopus 로고    scopus 로고
    • Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes
    • Zhu, L.; Huo, Z.; Wang, L.; Tong, X.; Xiao, Y.; Ni, K. Targeted delivery of methotrexate to skeletal muscular tissue by thermosensitive magnetoliposomes. Int. J. Pharm., 2009, 370, 136-143.
    • (2009) Int. J. Pharm. , vol.370 , pp. 136-143
    • Zhu, L.1    Huo, Z.2    Wang, L.3    Tong, X.4    Xiao, Y.5    Ni, K.6
  • 71
    • 33847671358 scopus 로고    scopus 로고
    • TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors
    • Sethuraman, V.; Bae, Y. TAT peptide-based micelle system for potential active targeting of anti-cancer agents to acidic solid tumors. J. Contr Rel., 2007, 118, 216-24.
    • (2007) J. Contr Rel. , vol.118 , pp. 216-224
    • Sethuraman, V.1    Bae, Y.2
  • 72
    • 56949105019 scopus 로고    scopus 로고
    • Recent progress in tumor pH targeting nanotechnology
    • Lee, E.; Gao, Z.; Bae, Y. Recent progress in tumor pH targeting nanotechnology. J. Contr. Rel., 2008, 132, 164-70.
    • (2008) J. Contr. Rel. , vol.132 , pp. 164-170
    • Lee, E.1    Gao, Z.2    Bae, Y.3
  • 73
    • 67349269478 scopus 로고    scopus 로고
    • pH-sensitive properties of surface charge-switched multifunctional polymeric micelle
    • Oh, K.; Kim, D.; You, H.; Ahn, Y.; Lee, E. pH-sensitive properties of surface charge-switched multifunctional polymeric micelle. Int. J. Pharm., 2009, 376, 134-140.
    • (2009) Int. J. Pharm. , vol.376 , pp. 134-140
    • Oh, K.1    Kim, D.2    You, H.3    Ahn, Y.4    Lee, E.5
  • 74
    • 0038106270 scopus 로고    scopus 로고
    • Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization
    • Lee, E.; Shin, H.; Na, K.; Bae, Y. Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization. J. Contr Rel., 2003, 90, 363-374.
    • (2003) J. Contr Rel. , vol.90 , pp. 363-374
    • Lee, E.1    Shin, H.2    Na, K.3    Bae, Y.4
  • 75
    • 2442656249 scopus 로고    scopus 로고
    • Combined cancer therapy by micellar-encapsulated drug and ultrasound
    • Rapoport, N. Combined cancer therapy by micellar-encapsulated drug and ultrasound. Int. J. Pharm., 2004, 277, 155-162.
    • (2004) Int. J. Pharm. , vol.277 , pp. 155-162
    • Rapoport, N.1
  • 76
    • 34547561267 scopus 로고    scopus 로고
    • Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery
    • Rapoport, N. Physical stimuli-responsive polymeric micelles for anti-cancer drug delivery. Progr. Polymer. Sci., 2007, 32, 962-990.
    • (2007) Progr. Polymer. Sci. , vol.32 , pp. 962-990
    • Rapoport, N.1
  • 79
    • 3142660422 scopus 로고    scopus 로고
    • Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts
    • Eikenes, L.; Bruland, O. S.; Brekken, C.; Davies, C. L. Collagenase increases the transcapillary pressure gradient and improves the uptake and distribution of monoclonal antibodies in human osteosarcoma xenografts. Cancer Res., 2004, 64, 4768-4773.
    • (2004) Cancer Res. , vol.64 , pp. 4768-4773
    • Eikenes, L.1    Bruland, O.S.2    Brekken, C.3    Davies, C.L.4
  • 80
    • 42249095831 scopus 로고    scopus 로고
    • Increased nano particle penetration in collagenase-treated multicellular spheroids
    • Goodman, T.; Olive, P.; Pun, S. Increased nano particle penetration in collagenase-treated multicellular spheroids. Int. J. Nanomed., 2007, 2, 265-274.
    • (2007) Int. J. Nanomed. , vol.2 , pp. 265-274
    • Goodman, T.1    Olive, P.2    Pun, S.3
  • 81
    • 36348930079 scopus 로고    scopus 로고
    • Matrix metalloproteinases-1 and-8 improve the distribution and efficacy of an oncolytic virus
    • Mok, W.; Boucher, Y.; Jain, R. Matrix metalloproteinases-1 and-8 improve the distribution and efficacy of an oncolytic virus. Cancer Res., 2007, 67, 10664-10668.
    • (2007) Cancer Res. , vol.67 , pp. 10664-10668
    • Mok, W.1    Boucher, Y.2    Jain, R.3
  • 82
    • 0037880675 scopus 로고    scopus 로고
    • Relationship between microvessel density and thermographic hot areas in breast cancer
    • Yahara, T.; Koga, T.; Yoshida, S.; Nakagawa, S.; Deguchi, H.; Shirouzu, K. Relationship between microvessel density and thermographic hot areas in breast cancer. Surg. Today, 2003, 33, 243-248.
    • (2003) Surg. Today , vol.33 , pp. 243-248
    • Yahara, T.1    Koga, T.2    Yoshida, S.3    Nakagawa, S.4    Deguchi, H.5    Shirouzu, K.6
  • 83
    • 43049150432 scopus 로고    scopus 로고
    • Novel super pH-sensitive nanoparticles responsive to tumor extracellular pH
    • Li, F.; Wua, H.; Zhang, H.; Li, F.; Gu, C.; Yang, Q. Novel super pH-sensitive nanoparticles responsive to tumor extracellular pH. Carbohyd. Polymers, 2008, 73, 390-400.
    • (2008) Carbohyd. Polymers , vol.73 , pp. 390-400
    • Li, F.1    Wua, H.2    Zhang, H.3    Li, F.4    Gu, C.5    Yang, Q.6
  • 84
    • 67349221482 scopus 로고    scopus 로고
    • Antitumor drug Paclitaxel-loaded pH-sensitive nanoparticles targeting tumor extracellular pH
    • Li, F.; Wua, H.; Zhang, H.; Li, F.; Gu, C.; Yang, Q. Antitumor drug Paclitaxel-loaded pH-sensitive nanoparticles targeting tumor extracellular pH. Carbohyd. Polymers, 2009, 77, 773-778.
    • (2009) Carbohyd. Polymers , vol.77 , pp. 773-778
    • Li, F.1    Wua, H.2    Zhang, H.3    Li, F.4    Gu, C.5    Yang, Q.6
  • 85
    • 77349090485 scopus 로고    scopus 로고
    • pHresponsive silica nanoparticles for controllable O2 generation
    • Li, Z.; Wang, J.; Chen, J.; Lei, W.; Wang, X.; Zhang, B. pHresponsive silica nanoparticles for controllable O2 generation. Nanotechnol, 2010, 21, 115102-115108.
    • (2010) Nanotechnol , vol.21 , pp. 115102-115108
    • Li, Z.1    Wang, J.2    Chen, J.3    Lei, W.4    Wang, X.5    Zhang, B.6
  • 87
    • 67349169756 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of TATpbearing paclitaxel-loaded micelles in vitro and in vivo
    • Sawant, R. R.; Torchilin, V. P. Enhanced cytotoxicity of TATpbearing paclitaxel-loaded micelles in vitro and in vivo. Int. J. Pharm., 2009, 374(1-2), 114-118.
    • (2009) Int. J. Pharm. , vol.374 , Issue.1-2 , pp. 114-118
    • Sawant, R.R.1    Torchilin, V.2
  • 88
    • 2442692534 scopus 로고    scopus 로고
    • Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles
    • O'Neal, D. P.; Hirsch, L. R.; Halas, N. J.; Payne, J. D.; West, J. L. Photo-thermal tumor ablation in mice using near infrared-absorbing nanoparticles. Cancer Lett., 2004, 209(2), 171-176.
    • (2004) Cancer Lett. , vol.209 , Issue.2 , pp. 171-176
    • O'Neal, D.P.1    Hirsch, L.R.2    Halas, N.J.3    Payne, J.D.4    West, J.L.5
  • 89
    • 31544444415 scopus 로고    scopus 로고
    • The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells
    • Grantab, R.; Sivananthan, S.; Tannock, I. The penetration of anticancer drugs through tumor tissue as a function of cellular adhesion and packing density of tumor cells. Cancer Res., 2006, 66, 1033-1039.
    • (2006) Cancer Res. , vol.66 , pp. 1033-1039
    • Grantab, R.1    Sivananthan, S.2    Tannock, I.3
  • 90
    • 4344578280 scopus 로고    scopus 로고
    • Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture
    • Kyle, A.; Huxham, L.; Chiam, A.; Sim, D.; Minchinton, A. Direct assessment of drug penetration into tissue using a novel application of three-dimensional cell culture. Cancer Res., 2004, 64, 6304-6309.
    • (2004) Cancer Res. , vol.64 , pp. 6304-6309
    • Kyle, A.1    Huxham, L.2    Chiam, A.3    Sim, D.4    Minchinton, A.5
  • 92
    • 72449142109 scopus 로고    scopus 로고
    • Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies
    • Ong, S.; Zhao, Z.; Arooz, T.; Zhao, D.; Zhang, S.; Du, T.; Wasser, M.; van Noort, D.; Yu, H. Engineering a scaffold-free 3D tumor model for in vitro drug penetration studies. Biomat, 2010, 31, 1180-1190.
    • (2010) Biomat , vol.31 , pp. 1180-1190
    • Ong, S.1    Zhao, Z.2    Arooz, T.3    Zhao, D.4    Zhang, S.5    du, T.6    Wasser, M.7    van Noort, D.8    Yu, H.9
  • 93
    • 16544380146 scopus 로고    scopus 로고
    • The use of 3-D cultures for high-throughput screening: The multicellular spheroid model
    • Kunz-Schughart, L.; Freyer, J.; Hofstaedter, F.; Ebner, R. The use of 3-D cultures for high-throughput screening: the multicellular spheroid model. J. Biomol. Screen., 2004, 9, 273-85.
    • (2004) J. Biomol. Screen. , vol.9 , pp. 273-285
    • Kunz-Schughart, L.1    Freyer, J.2    Hofstaedter, F.3    Ebner, R.4
  • 94
    • 0024433856 scopus 로고
    • Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors
    • Fujimori, K.; Covell, D. G.; Fletcher, J. E.; Weinstein, J. N. Modeling analysis of the global and microscopic distribution of immunoglobulin G, F(ab')2, and Fab in tumors. Cancer Res., 1989, 49, 5656-5663.
    • (1989) Cancer Res. , vol.49 , pp. 5656-5663
    • Fujimori, K.1    Covell, D.G.2    Fletcher, J.E.3    Weinstein, J.N.4
  • 95
    • 51649088495 scopus 로고    scopus 로고
    • Spatio-temporal modeling of nanoparticle delivery to multicellular tumor spheroids
    • Goodman, T. T.; Chen, J.; Matveev, K.; Pun, S. H. Spatio-temporal modeling of nanoparticle delivery to multicellular tumor spheroids. Biotech. Bioeng., 2008, 10, 388-399.
    • (2008) Biotech. Bioeng. , vol.10 , pp. 388-399
    • Goodman, T.T.1    Chen, J.2    Matveev, K.3    Pun, S.H.4
  • 96
    • 0037444270 scopus 로고    scopus 로고
    • Theoretical analysis of antibody targeting of tumor spheroids: Importance of dosage for penetration and affinity for retention
    • Graff, C. P.; Wittrup, K. D. Theoretical analysis of antibody targeting of tumor spheroids: Importance of dosage for penetration and affinity for retention. Cancer Res., 2003, 63, 1288-1296.
    • (2003) Cancer Res. , vol.63 , pp. 1288-1296
    • Graff, C.P.1    Wittrup, K.D.2
  • 97
    • 0026425576 scopus 로고
    • An analysis of monoclonal antibody distribution in microscopic tumor nodules: Consequences of a "binding site barrier"
    • van Osdol, W.; Fujimori, K.; Weinstein, J. N. An analysis of monoclonal antibody distribution in microscopic tumor nodules: consequences of a "binding site barrier". Cancer Res., 1991, 51, 4776-4784.
    • (1991) Cancer Res. , vol.51 , pp. 4776-4784
    • van Osdol, W.1    Fujimori, K.2    Weinstein, J.N.3
  • 98
    • 0026747885 scopus 로고
    • Early intervention in cancer using monoclonal antibodies and other biological ligands: Micropharmacology and the "binding site barrier"
    • Weinstein, J. N.; van Osdol, W. Early intervention in cancer using monoclonal antibodies and other biological ligands: micropharmacology and the "binding site barrier". Cancer Res., 1992, 52, 2747-2751.
    • (1992) Cancer Res. , vol.52 , pp. 2747-2751
    • Weinstein, J.N.1    van Osdol, W.2


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