Genetic variation at a Yin-Yang 1 response site regulates the transcription of cyclin-dependent kinase inhibitor p18 INK4C transcript in lupus-prone mice

Journal of Immunology

Volumn 188, Issue 10, 2012, Pages 4992-5002

  Potula, Hari Hara S K ^a   Morel, Laurence ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2C; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; PROTEIN P18; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR YY1;

ALLELE; ANIMAL CELL; ARTICLE; B LYMPHOCYTE; BINDING SITE; CDKN2C GENE; CELL EXPANSION; CHROMATIN IMMUNOPRECIPITATION; COMPUTER MODEL; CONTROLLED STUDY; DISEASE PREDISPOSITION; DNA FLANKING REGION; GENE; GENE ACTIVATION; GENE DELETION; GENE FUNCTION; GENE INTERACTION; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IN VIVO STUDY; LUPUS VULGARIS; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; P18 GENE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; SLE2C1 GENE; T LYMPHOCYTE; TRANSACTIVATION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CYCLIN-DEPENDENT KINASE INHIBITOR P18; DOWN-REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; MICE, INBRED NZB; MOLECULAR SEQUENCE DATA; MUTATION; NIH 3T3 CELLS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; TRANSCRIPTION, GENETIC; YY1 TRANSCRIPTION FACTOR;

EID: 84861157368     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101992     Document Type: Article

References (43)

1. Sherr, C. J. 1994. The ins and outs of RB: coupling gene expression to the cell cycle clock. Trends Cell Biol. 4: 15-18. (Pubitemid 24038742)
2. Sherr, C. J., and J. M. Roberts. 1999. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13: 1501-1512. (Pubitemid 29297917)
3. Schrantz, N., G. E. Beney, M. T. Auffredou, M. F. Bourgeade, G. Leca, and A. Vazquez. 2000. The expression of p18INK4 and p27kip1 cyclin-dependent kinase inhibitors is regulated differently during human B cell differentiation. J. Immunol. 165: 4346-4352.
4. Morse, L., D. Chen, D. Franklin, Y. Xiong, and S. Chen-Kiang. 1997. Induction of cell cycle arrest and B cell terminal differentiation by CDK inhibitor p18 (INK4c) and IL-6. Immunity 6: 47-56. (Pubitemid 27130214)
5. Zhou, J. N., and S. Linder. 1996. Expression of CDK inhibitor genes in immortalized and carcinoma derived breast cell lines. Anticancer Res. 16(4A): 1931-1935. (Pubitemid 26270705)
6. Suzuki, T., T. Narita, M. Uchida-Toita, and M. Yoshida. 1999. Down-regulation of the INK4 family of cyclin-dependent kinase inhibitors by tax protein of HTLV-1 through two distinct mechanisms. Virology 259: 384-391. (Pubitemid 29393388)
7. Forget, A., O. Ayrault, W. den Besten, M. L. Kuo, C. J. Sherr, and M. F. Roussel. 2008. Differential post-transcriptional regulation of two Ink4 proteins, p18 Ink4c and p19 Ink4d. Cell Cycle 7: 3737-3746.
8. Blais, A., D. Monté, F. Pouliot, and C. Labrie. 2002. Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1. J. Biol. Chem. 277: 31679-31693. (Pubitemid 34968972)
9. Xu, Z., B. Duan, B. P. Croker, E. K. Wakeland, and L. Morel. 2005. Genetic dissection of the murine lupus susceptibility locus Sle2: contributions to increased peritoneal B-1a cells and lupus nephritis map to different loci. J. Immunol. 175: 936-943. (Pubitemid 41094977)
10. Xu, Z., H. H. Potula, A. Vallurupalli, D. Perry, H. Baker, B. P. Croker, I. Dozmorov, and L. Morel. 2011. Cyclin-dependent kinase inhibitor Cdkn2c regulates B cell homeostasis and function in the NZM2410-derived murine lupus susceptibility locus Sle2c1. J. Immunol. 186: 6673-6682.
11. Shi, Y., J. S. Lee, and K. M. Galvin. 1997. Everything you have ever wanted to know about Yin Yang 1....... Biochim. Biophys. Acta 1332: F49-F66. (Pubitemid 27211616)
12. Thomas, M. J., and E. Seto. 1999. Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key? Gene 236: 197-208. (Pubitemid 29375109)
13. Shrivastava, A., and K. Calame. 1994. An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1. Nucleic Acids Res. 22: 5151-5155.
14. Austen, M., B. Lüscher, and J. M. Lüscher-Firzlaff. 1997. Characterization of the transcriptional regulator YY1. The bipartite transactivation domain is independent of interaction with the TATA box-binding protein, transcription factor IIB, TAFII55, or cAMP-responsive element-binding protein (CPB)-binding protein. J. Biol. Chem. 272: 1709-1717. (Pubitemid 27043257)
15. Seto, E., B. Lewis, and T. Shenk. 1993. Interaction between transcription factors Sp1 and YY1. Nature 365: 462-464. (Pubitemid 23311045)
16. Hobbs, K., J. Negri, M. Klinnert, L. J. Rosenwasser, and L. Borish. 1998. Interleukin-10 and transforming growth factor-beta promoter polymorphisms in allergies and asthma. Am. J. Respir. Crit. Care Med. 158: 1958-1962. (Pubitemid 29008839)
17. Pulleyn, L. J., R. Newton, I. M. Adcock, and P. J. Barnes. 2001. TGFbeta1 allele association with asthma severity. Hum. Genet. 109: 623-627. (Pubitemid 34051416)
18. de Souza, A. P., P. C. Trevilatto, R. M. Scarel-Caminaga, R. B. de Brito, and S. R. Line. 2003. Analysis of the TGF-beta1 promoter polymorphism (C-509T) in patients with chronic periodontitis. J. Clin. Periodontol. 30: 519-523.
19. Li, J. R., J. G. Li, G. H. Deng, W. L. Zhao, Y. J. Dan, Y. M. Wang, and S. Chen. 2011. A common promoter variant of TBX21 is associated with allele specific binding to Yin-Yang 1 and reduced gene expression. Scand. J. Immunol. 73:449-458.
20. You, Y., W. Zhao, S. Chen, W. Tan, Y. Dan, F. Hao, and G. Deng. 2010. Association of TBX21 gene haplotypes in a Chinese population with systemic lupus erythematosus. Scand. J. Rheumatol. 39: 254-258.
21. Chen, S., W. Zhao, W. Tan, B. Xu, Y. Dan, Q. Mao, X. Kuang, Y. Wang, and G. Deng. 2009. Association of TBX21 T-1993C polymorphism with viral persistence but not disease progression in hepatitis B virus carriers. Hepatol. Res. 39: 716-723.
22. Suttner, K., P. Rosenstiel, M. Depner, M. Schedel, L. A. Pinto, A. Ruether, J. Adamski, N. Klopp, T. Illig, C. Vogelberg, et al. 2009. TBX21 gene variants increase childhood asthma risk in combination with HLX1 variants. J. Allergy Clin. Immunol. 123: 1062-1068, 1068.e1-8.
23. Cameron, L., R. B. Webster, J. M. Strempel, P. Kiesler, M. Kabesch, H. Ramachandran, L. Yu, D. A. Stern, P. E. Graves, I. C. Lohman, et al. 2006. Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C〉T, a polymorphism associated with allergic inflammation. J. Immunol. 177: 8633-8642. (Pubitemid 44893827)
24. Su, K., X. Li, J. C. Edberg, J. Wu, P. Ferguson, and R. P. Kimberly. 2004. A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. II. Differential binding of GATA4 and Yin-Yang1 transcription factors and correlated receptor expression and function. J. Immunol. 172: 7192-7199. (Pubitemid 38669164)
25. Greenbaum, J. A., B. Pang, and T. D. Tullius. 2007. Construction of a genomescale structural map at single-nucleotide resolution. Genome Res. 17: 947-953. (Pubitemid 46919729)
26. Marinescu, V. D., I. S. Kohane, and A. Riva. 2005. MAPPER: a search engine for the computational identification of putative transcription factor binding sites in multiple genomes. BMC Bioinformatics 6: 79.
27. Azizkhan, J. C., D. E. Jensen, A. J. Pierce, and M. Wade. 1993. Transcription from TATA-less promoters: dihydrofolate reductase as a model. Crit. Rev. Eukaryot. Gene Expr. 3: 229-254. (Pubitemid 23350185)
28. Joshi, R., J. M. Passner, R. Rohs, R. Jain, A. Sosinsky, M. A. Crickmore, V. Jacob, A. K. Aggarwal, B. Honig, and R. S. Mann. 2007. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell 131: 530-543. (Pubitemid 350007697)
29. Parker, S. C., L. Hansen, H. O. Abaan, T. D. Tullius, and E. H. Margulies. 2009. Local DNA topography correlates with functional noncoding regions of the human genome. Science 324: 389-392.
30. Balasubramanian, B., W. K. Pogozelski, and T. D. Tullius. 1998. DNA strand breaking by the hydroxyl radical is governed by the accessible surface areas of the hydrogen atoms of the DNA backbone. Proc. Natl. Acad. Sci. USA 95: 9738-9743. (Pubitemid 28415239)
31. Courey, A. J., and R. Tjian. 1988. Analysis of Sp1 in vivo reveals multiple transcriptional domains, including a novel glutamine-rich activation motif. Cell 55: 887-898.
32. Liu, H., M. Schmidt-Supprian, Y. Shi, E. Hobeika, N. Barteneva, H. Jumaa, R. Pelanda, M. Reth, J. Skok, K. Rajewsky, and Y. Shi. 2007. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 21: 1179-1189. (Pubitemid 46789876)
33. Pan, X., M. Jones, J. Jiang, K. Zaprazna, D. Yu, W. Pear, I. Maillard, and M. L. Atchison. 2012. Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells. PLoS ONE 7: e30656.
34. Soutto, M., F. Zhang, B. Enerson, Y. Tong, M. Boothby, and T. M. Aune. 2002. A minimal IFN-gamma promoter confers Th1 selective expression. J. Immunol. 169: 4205-4212. (Pubitemid 35178191)
35. Ma, Q., L. Battelli, and A. F. Hubbs. 2006. Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2. Am. J. Pathol. 168: 1960-1974. (Pubitemid 43825316)
36. Li, J., T. D. Stein, and J. A. Johnson. 2004. Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol. Genomics 18: 261-272. (Pubitemid 39319509)
37. Yoh, K., K. Itoh, A. Enomoto, A. Hirayama, N. Yamaguchi, M. Kobayashi, N. Morito, A. Koyama, M. Yamamoto, and S. Takahashi. 2001. Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int. 60: 1343-1353. (Pubitemid 32960028)
38. Córdova, E. J., R. Velázquez-Cruz, F. Centeno, V. Baca, and L. Orozco. 2010. The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus. Lupus 19: 1237-1242.
39. Palko, L., H. W. Bass, M. J. Beyrouthy, and M. M. Hurt. 2004. The Yin Yang-1 (YY1) protein undergoes a DNA-replication-associated switch in localization from the cytoplasm to the nucleus at the onset of S phase. J. Cell Sci. 117: 465-476. (Pubitemid 38181208)
40. Wang, X., Y. Feng, L. Xu, Y. Chen, Y. Zhang, D. Su, G. Ren, J. Lu, and B. Huang. 2008. YY1 restrained cell senescence through repressing the transcription of p16. Biochim. Biophys. Acta 1783: 1876-1883.
41. Griffin, D. O., N. E. Holodick, and T. L. Rothstein. 2011. Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-. J. Exp. Med. 208: 67-80.
42. Griffin, D. O., and T. L. Rothstein. 2011. A small CD11b(+) human B1 cell subpopulation stimulates T cells and is expanded in lupus. J. Exp. Med. 208: 2591-2598.
43. Duan, B., and L. Morel. 2006. Role of B-1a cells in autoimmunity. Autoimmun. Rev. 5: 403-408. (Pubitemid 44143033)