The NRF2 gene variant, -653G/A, is associated with nephritis in childhood-onset systemic lupus erythematosus

Lupus

Volumn 19, Issue 10, 2010, Pages 1237-1242

  Cordova E J ^a   Velazquez Cruz R ^a   Centeno, F ^a   Baca, V ^b   Orozco, L ^a,c  

^a INSTITUTO NACIONAL DE MEDICINA GENÓMICA   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c UNIVERSIDAD AUTÓNOMA DE LA CIUDAD DE MÉXICO   (Mexico)

Author keywords

lupus; nephritis; Nrf2; polymorphism

Indexed keywords

TRANSCRIPTION FACTOR NRF2;

ADOLESCENT; ARTICLE; ASSAY; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISEASE SEVERITY; FEMALE; GENETIC VARIABILITY; GENOTYPE; HUMAN; KIDNEY DYSFUNCTION; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; MEXICO; ONSET AGE; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS;

AGE OF ONSET; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; MEXICO; NF-E2-RELATED FACTOR 2; POLYMORPHISM, SINGLE NUCLEOTIDE; SEVERITY OF ILLNESS INDEX; SEX FACTORS;

EID: 77956252901     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/0961203310367917     Document Type: Article

References (32)

1. Zhang DD, Hannink M. Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress. Mol Cell Biol 2003 ; 23: 8137-8151.
2. Osburn WO, Kensler TW Nrf2 signaling; an adaptive response pathway for protection against environmental toxic insults. Mutat Res 2008 ; 659: 31-39.
3. Surh YJ, Kundu JK, Na HK Nrf2 as a master redox switch in turning on the cellular signaling involved in the induction of cytoprotective genes by some chemopreventive phytochemicals. Planta Med 2008 ; 74: 1526-1539.
4. Li YJ, Takizawa H., Azuma A., et al. Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice. Clin Immunol 2008 ; 128: 366-373.
5. Ramos-Gomez M., Dolan PM, Itoh K., Yamamoto M., Kensler TW Interactive effects of nrf2 genotype and oltipraz on benzo[a]-pyrene-DNA adducts and tumor yield in mice. Carcinogenesis 2003 ; 24: 461-467.
6. Rangasamy T., Cho CY, Thimmulappa RK, et al. Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke-induced emphysema in mice. J Clin Invest 2004 ; 114: 1248-1259.
7. Cho HY, Reddy SP, Yamamoto M., Kleeberger SR The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004 ; 18: 1258-1260.
8. Calkins MJ, Johnson DA, Townsend JA, et al. The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease. Antioxid Redox Signal 2009 ; 11: 497-508.
9. Lau A., Villeneuve NF, Sun Z., Wong PK, Zhang DD Dual roles of Nrf2 in cancer. Pharmacol Res 2008 ; 58: 262-270.
10. Suh JH, Shenvi SV, Dixon BM, et al. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proc Natl Acad Sci U S A 2004 ; 101: 3381-3386.
11. Fukushima-Uesaka H., Saito Y., Maekawa K., et al. Genetic variations and haplotype structures of transcriptional factor Nrf2 and its cytosolic reservoir protein Keap1 in Japanese. Drug Metab Pharmacokinet 2007 ; 22: 212-219.
12. Marzec JM, Christie JD, Reddy SP, et al. Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury. FASEB J 2007 ; 21: 2237-2246.
13. Guan CP, Zhou MN, Xu AE, et al. The susceptibility to vitiligo is associated with NF-E2-related factor2 (Nrf2) gene polymorphisms; a study on Chinese Han population. Exp Dermatol 2008 ; 17: 1059-1062.
14. Arisawa T., Tahara T., Shibata T., et al. The relationship between Helicobacter pylori infection and promoter polymorphism of the Nrf2 gene in chronic gastritis. Int J Mol Med 2007 ; 19: 143-148.
15. Arisawa T., Tahara T., Shibata T., et al. Nrf2 gene promoter polymorphism and gastric carcinogenesis. Hepatogastroenterology 2008 ; 55: 750-754.
16. Chen XL, Dodd G., Thomas S., et al. Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression. Am J Physiol Heart Circ Physiol 2006 ; 290: H1862 - H1870.
17. Rahman I., Biswas SK, Kirkham PA Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 2006 ; 72: 1439-1452.
18. Thimmulappa RK, Lee H., Rangasamy T., et al. Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis. J Clin Invest 2006 ; 116: 984-995.
19. Lin W., Wu RT, Wu T., Khor TO, Wang H., Kong AN Sulforaphane suppressed LPS-induced inflammation in mouse peritoneal macrophages through Nrf2 dependent pathway. Biochem Pharmacol 2008 ; 76: 967-973.
20. Ma Q., Battelli L., Hubbs AF Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2. Am J Pathol 2006 ; 168: 1960-1974.
21. Li J., Stein TD, Johnson JA Genetic dissection of systemic autoimmune disease in Nrf2-deficient mice. Physiol Genomics 2004 ; 18: 261-272.
22. Yoh K., Itoh K., Enomoto A., et al. Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int 2001 ; 60: 1343-1353.
23. Xing C., Sestak AL, Kelly JA, et al. Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. Hum Genet 2007 ; 120: 623-631.
24. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982 ; 25: 1271-1277.
25. Thimmulappa RK, Scollick C., Traore K., et al. Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun 2006 ; 351: 883-889.
26. Liu H., Dinkova-Kostova AT, Talalay P. Coordinate regulation of enzyme markers for inflammation and for protection against oxidants and electrophiles. Proc Natl Acad Sci U S A 2008 ; 105: 15926-15931.
27. Manandhar S., You A., Lee ES, Kim JA, Kwak MK Activation of the Nrf2-antioxidant system by a novel cyclooxygenase-2 inhibitor furan-2-yl-3-pyridin-2-yl-propenone; implication in anti-inflammatory function by Nrf2 activator. J Pharm Pharmacol 2008 ; 60: 879-887.
28. Comings DE, MacMurray JP Molecular heterosis: a review. Mol Genet Metab 2000 ; 71: 19-31.
29. Yamamoto T., Yoh K., Kobayashi A., et al. Identification of polymorphisms in the promoter region of the human NRF2 gene. Biochem Biophys Res Commun 2004 ; 321: 72-79.
30. Jimenez-Morales S., Velazquez-Cruz R., Ramirez-Bello J., et al. Tumor necrosis factor-alpha is a common genetic risk factor for asthma, juvenile rheumatoid arthritis, and systemic lupus erythematosus in a Mexican pediatric population. Hum Immunol 2009 ; 70: 251-256.
31. Fisher SA, Hampe J., Macpherson AJ, et al. Sex stratification of an inflammatory bowel disease genome search shows male-specific linkage to the HLA region of chromosome 6. Eur J Hum Genet 2002 ; 10: 259-265.
32. Akkad DA, Arning L., Ibrahim SM, Epplen JT Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels. Genes Immun 2007 ; 8: 703-706.