Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal histoplasma capsulatum infection

Infection and Immunity

Volumn 78, Issue 5, 2010, Pages 2125-2137

  Szymczak, Wendy A ^a,b,d   Deepe Jr , George S ^a,c  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR2; COMPLEMENTARY DNA; INTERLEUKIN 12; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; BONE MARROW; C57BL 6 MOUSE; CD4+ T LYMPHOCYTE; CELL TRANSFER; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HISTOPLASMA CAPSULATUM; IMMUNITY; LETHALITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; MYCOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; RNA ISOLATION; T CELL DEPLETION; TH2 CELL; YEAST CELL;

ADOPTIVE TRANSFER; ANIMALS; CD4-POSITIVE T-LYMPHOCYTES; COLONY COUNT, MICROBIAL; DENDRITIC CELLS; HISTOPLASMA; HISTOPLASMOSIS; LUNG; LYMPHOCYTE DEPLETION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CCR2; SPLEEN;

EID: 77951223904     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00065-10     Document Type: Article

References (51)

1. Aldridge, J. R., Jr., C. E. Moseley, D. A. Boltz, N. J. Negovetich, C. Reynolds, J. Franks, S. A. Brown, P. C. Doherty, R. G. Webster, and P. G. Thomas. 2009. TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection. Proc. Natl. Acad. Sci. U. S. A. 106:5306-5311.
2. Allen, H. L., and G. S. Deepe, Jr. 2005. Apoptosis modulates protective immunity to the pathogenic fungus Histoplasma capsulatum. J. Clin. Invest. 115:2875-2885.
3. Allendoerfer, R., and G. S. Deepe, Jr. 1998. Blockade of endogenous TNF-α exacerbates primary and secondary pulmonary histoplasmosis by differential mechanisms. J. Immunol. 160:6072-6082. (Pubitemid 28298071)
4. Allendoerfer, R., and G. S. Deepe, Jr. 1997. Intrapulmonary response to Histoplasma capsulatum in gamma interferon knockout mice. Infect. Immun. 65:2564-2569.
5. Allendoerfer, R., and G. S. Deepe, Jr. 2000. Regulation of infection with Histoplasma capsulatum by TNFR1 and -2. J. Immunol. 165:2657-2664.
6. Allendorfer, R., G. D. Brunner, and G. S. Deepe, Jr. 1999. Complex requirements for nascent and memory immunity in pulmonary histoplasmosis. J. Immunol. 162:7389-7396. (Pubitemid 29277716)
7. Brummer, E., and D. A. Stevens. 1995. Antifungal mechanisms of activated murine bronchoalveolar or peritoneal macrophages for Histoplasma capsulatum. Clin. Exp. Immunol. 102:65-70.
8. Deepe, G. S., Jr., R. Gibbons, and E. Woodward. 1999. Neutralization of endogenous granulocyte-macrophage colony-stimulating factor subverts the protective immune response to Histoplasma capsulatum. J. Immunol. 163:4985-4993.
9. Deepe, G. S., Jr., and R. S. Gibbons. 2003. Protective and memory immunity to Histoplasma capsulatum in the absence of IL-10. J. Immunol. 171:5353-5362.
10. Deepe, G. S., Jr., R. S. Gibbons, and A. G. Smulian. 2008. Histoplasma capsulatum manifests preferential invasion of phagocytic subpopulations in murine lungs. J. Leukoc. Biol. 84:669-678.
11. De Smedt, T., B. Pajak, G. G. Klaus, R. J. Noelle, J. Urbain, O. Leo, and M. Moser. 1998. Antigen-specific T lymphocytes regulate lipopolysaccharide- induced apoptosis of dendritic cells in vivo. J. Immunol. 161:4476-4479. (Pubitemid 28492014)
12. + CD8α+ dendritic cells promote protective immunity to respiratory infection with Bordetella pertussis. J. Immunol. 183:400-410.
13. -/- dendritic cells: implications for islet transplantation. Transplantation 85:1030-1038.
14. Frank, K. M., D. K. Hogarth, J. L. Miller, S. Mandal, P. J. Mease, R. J. Samulski, G. A. Weisgerber, and J. Hart. 2009. Investigation of the cause of death in a gene-therapy trial. N. Engl. J. Med. 361:161-169.
15. Gildea, L. A., G. M. Ciraolo, R. E. Morris, and S. L. Newman. 2005. Human dendritic cell activity against Histoplasma capsulatum is mediated via phagolysosomal fusion. Infect. Immun. 73:6803-6811.
16. Gildea, L. A., R. Gibbons, F. D. Finkelman, and G. S. Deepe, Jr. 2003. Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum. Infect. Immun. 71:3787-3793.
17. Gomez, A. M., J. C. Rhodes, and G. S. Deepe, Jr. 1991. Antigenicity and immunogenicity of an extract from the cell wall and cell membrane of Histoplasma capsulatum yeast cells. Infect. Immun. 59:330-336.
18. Herring, A. C., N. R. Falkowski, G. H. Chen, R. A. McDonald, G. B. Toews, and G. B. Huffnagle. 2005. Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells. Infect. Immun. 73:39-49.
19. Izikson, L., R. S. Klein, I. F. Charo, H. L. Weiner, and A. D. Luster. 2000. Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR) 2. J. Exp. Med. 192:1075-1080.
20. Jia, T., N. V. Serbina, K. Brandl, M. X. Zhong, I. M. Leiner, I. F. Charo, and E. G. Pamer. 2008. Additive roles for MCP-1 and MCP-3 in CCR2-mediated recruitment of inflammatory monocytes during Listeria monocytogenes infection. J. Immunol. 180:6846-6853.
21. Kadowaki, N. 2007. Dendritic cells: a conductor of T cell differentiation. Allergol. Int. 56:193-199.
22. Karimi, M. H., P. Ebadi, A. A. Pourfathollah, Z. S. Soheili, S. Samiee, Z. Ataee, S. Z. Tabei, and S. M. Moazzeni. 2009. Immune modulation through RNA interference-mediated silencing of CD40 in dendritic cells. Cell. Immunol. 259:74-81.
23. Kulkarni, H., B. K. Agan, V. C. Marconi, R. J. O'Connell, J. F. Camargo, W. He, J. Delmar, K. R. Phelps, G. Crawford, R. A. Clark, M. J. Dolan, and S. K. Ahuja. 2008. CCL3L1-CCR5 genotype improves the assessment of AIDS risk in HIV-1-infected individuals. PLoS One 3:e3165.
24. Lamhamedi-Cherradi, S. E., R. E. Martin, T. Ito, F. Kheradmand, D. B. Corry, Y. J. Liu, and M. Moyle. 2008. Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12. J. Immunol. 180:6000-6009.
25. + T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6:541-549.
26. Launois, P., K. G. Swihart, G. Milon, and J. A. Louis. 1997. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J. Immunol. 158:3317-3324.
27. Lin, J. S., C. W. Yang, D. W. Wang, and B. A. Wu-Hsieh. 2005. Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum. J. Immunol. 174:6282-6291.
28. + monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. J. Immunol. 180:2562-2572.
29. Liotta, F., F. Frosali, V. Querci, A. Mantei, L. Fili, L. Maggi, B. Mazzinghi, R. Angeli, E. Ronconi, V. Santarlasci, T. Biagioli, L. Lasagni, C. Ballerini, P. Parronchi, A. Scheffold, L. Cosmi, E. Maggi, S. Romagnani, and F. Annunziato. 2008. Human immature myeloid dendritic cells trigger a TH2-polarizing program via Jagged-1/Notch interaction. J. Allergy Clin. Immunol. 121:1000-1005 e1008.
30. + T cells. J. Immunol. 154:5071-5079.
31. Maroof, A., M. Penny, R. Kingston, C. Murray, S. Islam, P. A. Bedford, and S. C. Knight. 2006. Interleukin-4 can induce interleukin-4 production in dendritic cells. Immunology 117:271-279.
32. Marth, T., and B. L. Kelsall. 1997. Regulation of interleukin-12 by complement receptor 3 signaling. J. Exp. Med. 185:1987-1995.
33. Nakano, H., K. L. Lin, M. Yanagita, C. Charbonneau, D. N. Cook, T. Kakiuchi, and M. D. Gunn. 2009. Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. Nat. Immunol. 10:394-402.
34. Osterholzer, J. J., J. L. Curtis, T. Polak, T. Ames, G. H. Chen, R. McDonald, G. B. Huffnagle, and G. B. Toews. 2008. CCR2 mediates conventional dendritic cell recruitment and the formation of bronchovascular mononuclear cell infiltrates in the lungs of mice infected with Cryptococcus neoformans. J. Immunol. 181:610-620.
35. H2 cytokine-dependent immunity. Nat. Immunol. 10:697-705.
36. Peters, W., H. M. Scott, H. F. Chambers, J. L. Flynn, I. F. Charo, and J. D. Ernst. 2001. Chemokine receptor 2 serves an early and essential role in resistance to Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U. S. A. 98:7958-7963.
37. + monocytes is essential for control of acute toxoplasmosis. J. Exp. Med. 201:1761-1769.
38. Sato, N., S. K. Ahuja, M. Quinones, V. Kostecki, R. L. Reddick, P. C. Melby, W. A. Kuziel, and S. S. Ahuja. 2000. CC chemokine receptor (CCR) 2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cytokines, B cell outgrowth, and sustained neutrophilic inflammation. J. Exp. Med. 192:205-218.
39. + T cells. J. Immunol. 169:5818-5826.
40. Serbina, N. V., and E. G. Pamer. 2006. Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2. Nat. Immunol. 7:311-317.
41. Sokol, C. L., N. Q. Chu, S. Yu, S. A. Nish, T. M. Laufer, and R. Medzhitov. 2009. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat. Immunol. 10:713-720.
42. Steinfelder, S., J. F. Andersen, J. L. Cannons, C. G. Feng, M. Joshi, D. Dwyer, P. Caspar, P. L. Schwartzberg, A. Sher, and D. Jankovic. 2009. The major component in schistosome eggs responsible for conditioning dendritic cells for Th2 polarization is a T2 ribonuclease (omega-1). J. Exp. Med. 206:1681-1690.
43. Szymczak, W. A., and G. S. Deepe, Jr. 2009. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity. J. Immunol. 183:1964-1974.
44. Traynor, T. R., A. C. Herring, M. E. Dorf, W. A. Kuziel, G. B. Toews, and G. B. Huffnagle. 2002. Differential roles of CC chemokine ligand 2/monocyte chemotactic protein-1 and CCR2 in the development of T1 immunity. J. Immunol. 168:4659-4666.
45. Traynor, T. R., W. A. Kuziel, G. B. Toews, and G. B. Huffnagle. 2000. CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infection. J. Immunol. 164:2021-2027.
46. Voehringer, D., K. Shinkai, and R. M. Locksley. 2004. Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 production. Immunity 20:267-277. (Pubitemid 38388229)
47. + Th2 cell function. J. Immunol. 178:219-227.
48. Wiethe, C., A. Debus, M. Mohrs, A. Steinkasserer, M. Lutz, and A. Gessner. 2008. Dendritic cell differentiation state and their interaction with NKT cells determine Th1/Th2 differentiation in the murine model of Leishmania major infection. J. Immunol. 180:4371-4381.
49. + T cells: implications for vaccine development in immune-deficient hosts. J. Exp. Med. 197:1405-1416.
50. + T cells. Nat. Immunol. 10:706-712.
51. Zhou, P., M. C. Sieve, J. Bennett, K. J. Kwon-Chung, R. P. Tewari, R. T. Gazzinelli, A. Sher, and R. A. Seder. 1995. IL-12 prevents mortality in mice infected with Histoplasma capsulatum through induction of IFN-γ. J. Immunol. 155:785-795.