Role of C3, C5 and anaphylatoxin receptors in acute lung injury and in sepsis

Advances in Experimental Medicine and Biology

Volumn 946, Issue , 2012, Pages 147-159

  Bosmann, Markus ^b   Ward, Peter A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b NONE

Author keywords

Anaphylatoxins; Complement; Endotoxin; Immune complexes; Sepsis; Septic shock

Indexed keywords

C5L2 PROTEIN; CHEMOKINE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT RECEPTOR; CYTOKINE; THROMBIN; UNCLASSIFIED DRUG;

ACUTE LUNG INJURY; ARTICLE; CAPILLARY ENDOTHELIUM; CELL DEATH; COMPLEMENT ACTIVATION; CYTOKINE STORM; ENDOTHELIUM CELL; HUMAN; INFLAMMATION; INNATE IMMUNITY; LEUKOCYTE ACTIVATION; LEUKOCYTE ADHERENCE; LUNG CAPILLARY; NONHUMAN; POLYMICROBIAL SEPSIS; PRIORITY JOURNAL; SEPSIS; TH1 CELL; TH2 CELL; VASCULAR ENDOTHELIUM;

ACUTE LUNG INJURY; ANAPHYLATOXINS; ANIMALS; COMPLEMENT C3; COMPLEMENT C5; HUMANS; RECEPTOR, ANAPHYLATOXIN C5A; RECEPTORS, COMPLEMENT; SEPSIS;

MUS;

EID: 80555154767     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-0106-3_9     Document Type: Article

References (58)

1. Amara, U., Flierl, M.A., Rittirsch, D., Klos, A., Chen, H., Acker, B., Bruckner, U.B., Nilsson, B., Gebhard, F., Lambris, J.D., and Huber-Lang, M.2010).Molecular intercommunication between the complement and coagulation systems. Journal of Immunology, 185, 5628-5636
2. Bamberg, C.E., Mackay, C.R., Lee, H., Zahra, D., Jackson, J., Lim, Y.S., Whitfeld, P.L., Craig, S., Corsini, E., Lu, B., Gerard, C., and Gerard, N.P.2010).The C5a Receptor (C5aR) C5L2 Is a Modulator of C5aR-mediated Signal Transduction. Journal of Biological Chemistry, 285,7633-7644
3. Barton, P.A., and Warren, J.S.1993).Complement component C5 modulates the systemic tumor necrosis factor response in murine endotoxic shock. Infection & Immunity, 61, 1474-1481
4. Cain, S.A., and Monk, P.N.2002).The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74).Journal of Biological Chemistry, 277, 7165-7169
5. Chen, N.J., Mirtsos, C., Suh, D., Lu, Y.C., Lin, W.J., McKerlie, C., Lee, T., Baribault, H., Tian, H., and Yeh, W.C.2007).C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a. Nature, 446, 203-207
6. Collard, C.D., Lekowski, R., Jordan, J.E., Agah, A., and Stahl, G.L.1999).Complement activation following oxidative stress. Molecular Immunology, 36, 941-948
7. Czermak, B.J., Sarma, V., Pierson, C.L., Warner, R.L., Huber-Lang, M., Bless, N.M., Schmal, H., Friedl, H.P., and Ward, P.A.1999).Protective effects of C5a blockade in sepsis. Nature Medicine, 5, 788-792
8. Donnelly, S.C., Haslett, C., Reid, P.T., Grant, I.S., Wallace, W.A., Metz, C.N., Bruce, L.J., and Bucala, R.1997).Regulatory role for macrophage migration inhibitory factor in acute respiratory distress syndrome. Nature Medicine, 3, 320-323
9. Flierl, M.A., Rittirsch, D., Nadeau, B.A., Day, D.E., Zetoune, F.S., Sarma, J.V., Huber-Lang, M.S., and Ward, P.A.2008).Functions of the complement components C3 and C5 during sepsis. Faseb Journal, 22, 3483-3490
10. Gannon, D.E., Varani, J., Phan, S.H., Ward, J.H., Kaplan, J., Till, G.O., Simon, R.H., Ryan, U.S., and Ward, P.A.1987).Source of iron in neutrophil-mediated killing of endothelial cells. Laboratory Investigation, 57, 37-44
11. Gao, H., Neff, T., and Ward, P.A.2006).Regulation of lung inflammation in the model of IgG immune-complex injury. Annual Review Of Pathology, 1, 215-242
12. Gerard, N.P., and Gerard, C.1991).The chemotactic receptor for human C5a anaphylatoxin. Nature, 349, 614-617
13. Gerard, N.P., Lu, B., Liu, P., Craig, S., Fujiwara, Y., Okinaga, S., and Gerard, C.2005).An anti-inflammatory function for the complement anaphylatoxin C5a-binding protein, C5L2. Journal of Biological Chemistry, 280, 39677-39680
14. Hammerschmidt, D.E., Weaver, L.J., Hudson, L.D., Craddock, P.R., and Jacob, H.S.1980).Association ofcomplement activation and elevated plasma-C5a with adult respiratory distress syndrome. Pathophysiological relevance and possible prognostic value. Lancet, 1, 947-949
15. Hawlisch, H., Belkaid, Y., Baelder, R., Hildeman, D., Gerard, C., and Kohl, J.2005).C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity, 22, 415-426
16. Huber-Lang, M., Sarma, J.V., Zetoune, F.S., Rittirsch, D., Neff, T.A., McGuire, S.R., Lambris, J.D., Warner, R.L., Flierl, M.A., Hoesel, L.M., Gebhard, F., Younger, J.G., Drouin, S.M., Wetsel, R.A., and Ward, P.A.2006).Generation of C5a in the absence of C3: a new complement activation pathway. Nature Medicine, 12, 682-687
17. Huber-Lang, M.S., Riedeman, N.C., Sarma, J.V., Younkin, E.M., McGuire, S.R., Laudes, I.J., Lu, K.T., Guo, R.F., Neff, T.A., Padgaonkar, V.A., Lambris, J.D., Spruce, L., Mastellos, D., Zetoune, F.S., and Ward, P.A.2002a).Protection of innate immunity by C5aR antagonist in septic mice. FASEB Journal, 16, 1567-1574
18. Huber-Lang, M.S., Sarma, J.V., McGuire, S.R., Lu, K.T., Guo, R.F., Padgaonkar, V.A., Younkin, E.M., Laudes, I.J., Riedemann, N.C., Younger, J.G., and Ward, P.A.2001).Protective effects of anti-C5a peptide antibodies in experimental sepsis. FASEB Journal, 15, 568-570
19. Huber-Lang, M.S., Younkin, E.M., Sarma, J.V., McGuire, S.R., Lu, K.T., Guo, R.F., Padgaonkar, V.A., Curnutte, J.T., Erickson, R., and Ward, P.A.2002b).Complement-induced impairment of innate immunity during sepsis. Journal of Immunology, 169, 3223-3231
20. Kalant, D., Cain, S.A., Maslowska, M., Sniderman, A.D., Cianflone, K., and Monk, P.N.2003).The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg(77)/acylation-stimulating protein. Journal of Biological Chemistry, 278, 11123-11129
21. Kalant, D., MacLaren, R., Cui, W., Samanta, R., Monk, P.N., Laporte, S.A., and Cianflone, K.2005).C5L2 is a functional receptor for acylation-stimulating protein. Journal of Biological Chemistry, 280, 23936-23944
22. Karp, C.L., Grupe, A., Schadt, E., Ewart, S.L., Keane-Moore, M., Cuomo, P.J., x00F, hl, J., Wahl, L., Kuperman, D., Germer, S., Aud, D., Peltz, G., and Wills-Karp, M.2000).Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nature Immunology, 1, 221-226
23. Kohl, J., Baelder, R., Lewkowich, I.P., Pandey, M.K., Hawlisch, H., Wang, L.H., Best, J., Herman, N.S., Sproles, A.A., Zwirner, J., Whitsett, J.A., Gerard, C., Sfyroera, G., Lambris, J.D., and Wills-Karp, M.2006).A regulatory role for the C5a anaphylatoxin in, type 2 immunity in asthma. Journal of Clinical Investigation, 116, 783-796
24. Lajoie, S., Lewkowich, I.P., Suzuki, Y., Clark, J.R., Sproles, A.A., Dienger, K., Budelsky, A.L., and Wills-Karp, M.2010).Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nature Immunology, 11, 928-935
25. Larsen, G.L., Mitchell, B.C., and Henson, P.M.1981).The pulmonary response of C5 sufficient and deficient mice to immune complexes. American Review of Respiratory Disease, 123, 434-439
26. Laudes, I.J., Chu, J.C., Sikranth, S., Huber-Lang, M., Guo, R.F., Riedemann, N., Sarma, J.V., Schmaier, A.H., and Ward, P.A. (2002). Anti-C5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. American Journal of Pathology, 160, 1867-1875
27. Lee, H., Whitfeld, P.L., and Mackay, C.R.2008).Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Immunology & Cell Biology, 86, 153-160
28. Li, S., Boackle, S.A., Holers, V.M., Lambris, J.D., and Blatteis, C.M.2005).Complement component C5a is integral to the febrile response of mice to lipopolysaccharide. Neuroimmunomodulation, 12, 67-80
29. Lotze, M.T., and Tracey, K.J.2005).High-mobility group box 1 protein (HMGB): Nuclear weapon in the immune arsenal. Nature Reviews Immunology, 5, 331-342
30. Makita, H., Nishimura, M., Miyamoto, K., Nakano, T., Tanino, Y., Hirokawa, J., Nishihira, J., and Kawakami, Y.1998).Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation. American Journal of Respiratory & Critical Care Medicine, 158, 573-579
31. Markiewski, M.M., Nilsson, B., Ekdahl, K.N., Mollnes, T.E., and Lambris, J.D.2007).Complement and coagulation: strangers or partners in crime? Trends in Immunology, 28, 184-192
32. Mulligan, M.S., Schmid, E., Beck-Schimmer, B., Till, G.O., Friedl, H.P., Brauer, R.B., Hugli, T.E., Miyasaka, M., Warner, R.L., Johnson, K.J., and Ward, P.A.1996).Requirement and role of C5a in acute lung inflammatory injury in rats. Journal of Clinical Investigation, 98, 503-512
33. Niederbichler, A.D., Hoesel, L.M., Westfall, M.V., Gao, H.W., Ipaktchi, K.R., Sun, L., Zetoune, F.S., Su, G.L., Arbabi, S., Sarma, J.V., Wang, S.C., Hemmila, M.R., and Ward, P.A.2006).An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. Journal of Experimental Medicine, 203, 53-61
34. Nishihira, J.2000).Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth. Journal of Interferon & Cytokine Research, 20, 751-762
35. Okinaga, S., Slattery, D., Humbles, A., Zsengeller, Z., Morteau, O., Kinrade, M.B., Brodbeck, R.M., Krause, J.E., Choe, H.R., Gerard, N.P., and Gerard, C.2003).C5L2, a nonsignaling C5A binding protein. Biochemistry, 42, 9406-9415
36. Pittet, J.F., Mackersie, R.C., Martin, T.R., and Matthay, M.A.1997).Biological markers of acute lung injury: prognostic and pathogenetic significance. American Journal of Respiratory & Critical Care Medicine, 155, 1187-1205
37. Prodeus, A.P., Zhou, X.N., Maurer, M., Galli, S.J., and Carroll, M.C.1997).Impaired mast celldependent natural immunity in complement C3-deficient mice. Nature, 390, 172-175
38. Kalant, D., Cain, S.A., Maslowska, M., Sniderman, A.D., Cianflone, K., and Monk, P.N.2003).The chemoattractant receptor-like protein C5L2 binds the C3a des-Arg(77)/acylation-stimulating protein. Journal of Biological Chemistry, 278, 11123-11129
39. Kalant, D., MacLaren, R., Cui, W., Samanta, R., Monk, P.N., Laporte, S.A., and Cianflone, K.2005).C5L2 is a functional receptor for acylation-stimulating protein. Journal of Biological Chemistry, 280, 23936-23944
40. Karp, C.L., Grupe, A., Schadt, E., Ewart, S.L., Keane-Moore, M., Cuomo, P.J., x00F, hl, J., Wahl, L., Kuperman, D., Germer, S., Aud, D., Peltz, G., and Wills-Karp, M.2000).Identification of complement factor 5 as a susceptibility locus for experimental allergic asthma. Nature Immunology, 1, 221-226
41. Kohl, J., Baelder, R., Lewkowich, I.P., Pandey, M.K., Hawlisch, H., Wang, L.H., Best, J., Herman, N.S., Sproles, A.A., Zwirner, J., Whitsett, J.A., Gerard, C., Sfyroera, G., Lambris, J.D., and Wills-Karp, M.2006).A regulatory role for the C5a anaphylatoxin in, type 2 immunity in asthma. Journal of Clinical Investigation, 116, 783-796
42. Lajoie, S., Lewkowich, I.P., Suzuki, Y., Clark, J.R., Sproles, A.A., Dienger, K., Budelsky, A.L., and Wills-Karp, M.2010).Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nature Immunology, 11, 928-935
43. Larsen, G.L., Mitchell, B.C., and Henson, P.M.1981).The pulmonary response of C5 sufficient and deficient mice to immune complexes. American Review of Respiratory Disease, 123, 434-439
44. Laudes, I.J., Chu, J.C., Sikranth, S., Huber-Lang, M., Guo, R.F., Riedemann, N., Sarma, J.V., Schmaier,A.H., and Ward, P.A.2002).Anti-C5a ameliorates coagulation/fibrinolytic protein changes in a rat model of sepsis. American Journal of Pathology, 160, 1867-1875
45. Lee, H., Whitfeld, P.L., and Mackay, C.R.2008).Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2. Immunology & Cell Biology, 86, 153-160
46. Li, S., Boackle, S.A., Holers, V.M., Lambris, J.D., and Blatteis, C.M.2005).Complement component C5a is integral to the febrile response of mice to lipopolysaccharide. Neuroimmunomodulation, 12, 67-80
47. Lotze, M.T., and Tracey, K.J.2005).High-mobility group box 1 protein (HMGB): Nuclear weapon in the immune arsenal. Nature Reviews Immunology, 5, 331-342
48. Makita, H., Nishimura, M., Miyamoto, K., Nakano, T., Tanino, Y., Hirokawa, J., Nishihira, J., and Kawakami, Y.1998).Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation. American Journal of Respiratory & Critical Care Medicine, 158, 573-579
49. Markiewski, M.M., Nilsson, B., Ekdahl, K.N., Mollnes, T.E., and Lambris, J.D.2007).Complement and coagulation: strangers or partners in crime? Trends in Immunology, 28, 184-192
50. Mulligan, M.S., Schmid, E., Beck-Schimmer, B., Till, G.O., Friedl, H.P., Brauer, R.B., Hugli, T.E., Miyasaka, M., Warner, R.L., Johnson, K.J., and Ward, P.A.1996).Requirement and role of C5a in acute lung inflammatory injury in rats. Journal of Clinical Investigation, 98, 503-512
51. Niederbichler, A.D., Hoesel, L.M., Westfall, M.V., Gao, H.W., Ipaktchi, K.R., Sun, L., Zetoune, F.S., Su, G.L., Arbabi, S., Sarma, J.V., Wang, S.C., Hemmila, M.R., and Ward, P.A.2006).An essential role for complement C5a in the pathogenesis of septic cardiac dysfunction. Journal of Experimental Medicine, 203, 53-61
52. Nishihira, J.2000).Macrophage migration inhibitory factor (MIF): its essential role in the immune system and cell growth. Journal of Interferon & Cytokine Research, 20, 751-762
53. Okinaga, S., Slattery, D., Humbles, A., Zsengeller, Z., Morteau, O., Kinrade, M.B., Brodbeck, R.M., Krause, J.E., Choe, H.R., Gerard, N.P., and Gerard, C.2003).C5L2, a nonsignaling C5A binding protein. Biochemistry, 42, 9406-9415
54. Pittet, J.F., Mackersie, R.C., Martin, T.R., and Matthay, M.A.1997).Biological markers of acute lung injury: prognostic and pathogenetic significance. American Journal of Respiratory & Critical Care Medicine, 155, 1187-1205
55. Prodeus, A.P., Zhou, X.N., Maurer, M., Galli, S.J., and Carroll, M.C.1997).Impaired mast celldependent natural immunity in complement C3-deficient mice. Nature, 390, 172-175
56. Watford, W.T., Wright, J.R., Hester, C.G., Jiang, H., and Frank, M.M.2001).Surfactant protein A regulates complement activation. Journal of Immunology, 167, 6593-6600
57. Zhang, X., Kimura, Y., Fang, C., Zhou, L., Sfyroera, G., Lambris, J.D., Wetsel, R.A., Miwa, T., and Song, W.-C.2007).Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood, 110, 228-236
58. Zhang, X., Schmudde, I., Laumonnier, Y., Pandey, M.K., Clark, J.R., Konig, P., Gerard, N.P., Gerard, C., Wills-Karp, M., and Kohl, J.2010).A Critical Role for C5L2 in the Pathogenesis of Experimental Allergic Asthma. Journal of Immunology, 185, 6741-6752