Association between 5-HTTLPR and borderline personality disorder traits among youth

Frontiers in Psychiatry

Volumn 2, Issue MAR, 2011, Pages

  Hankin, Benjamin L ^a   Barrocas, Andrea L ^a   Jenness, Jessica ^a   Oppenheimer, Caroline W ^a   Badanes, Lisa S ^a   Abela, John R Z ^b   Young, Jami ^b   Smolen, Andrew ^c  

^a UNIVERSITY OF DENVER   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

Author keywords

Borderline personality disorder; Molecular genetics; Serotonin; Youth

Indexed keywords

SEROTONIN TRANSPORTER;

ADOLESCENT; ALLELE; ARTICLE; BORDERLINE STATE; CHILD; CHILD PSYCHIATRY; DEPRESSION; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; PROMOTER REGION; PSYCHOLOGIC ASSESSMENT; SCHOOL CHILD; SELF REPORT; SEROTONIN TRANSPORTER GENE;

EID: 84861101989     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2011.00006     Document Type: Article

References (53)

1. Achenbach, T. M., McConaughy, S. H., and Howell, C. T. (1987). Child/adolescent behavior and emotional problems: implications of cross-informant correlations for situational specificity. Psychol. Bull. 101, 213-232.
2. Al-Alem, L., and Omar, H. A. (2008). Borderline personality disorder: an overview of history, diagnosis and treatment in adolescents. Int. J. Adolesc. Med. Health 20, 395-404.
3. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders, 4th Edn (Text Revision). Washington, DC: APA Press.
4. Anchordoquy, H. C., McGreary, C., Liping, L., Krauter, K. S., and Smolen, A. (2003). Genotyping of three candidate genes after whole-genome preamplification of DNA collected from buccal cells. Behav. Genet. 33, 73-78.
5. Anguelova, M., Benkelfat, C., and Turecki, G. (2003). A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol. Psychiatry 8, 574-591.
6. Beauchaine, T. P., Klein, D. N., Crowell, S. E., Derbidge, C., and Gatzke-Kopp, L. (2009). Multifinality in the development of personality disorders: a biology × sex × environment interaction model of antisocial and borderline traits. Dev. Psychopathol. 21, 735-770.
7. Beevers, C. G., Wells, T. T., Ellis, A. J., and McGeary, J. E. (2009a). Association of the serotonin transporter gene promoter region (5-HTTLPR) polymorphism with biased attention for emotional stimuli. J. Abnorm. Psychol. 118, 670-681.
8. Beevers, C. G., Wells, T. T., Ellis, A. J., and McGeary, J. E. (2009b). Serotonin transporter gene promoter region polymorphism and selective processing of emotional images. Biol. Psychol. 83, 260-265.
9. Canli, T., and Lesch, K. P. (2007). Long story short: the serotonin transporter in emotion regulation and social cognition. Nat. Neurosci. 10, 1103-1109.
10. Caspi, A., Hariri, A. R., Holmes, A., Uher, R., and Moffitt, T. E. (2010). Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am. J. Psychiatry 167, 509-527.
11. Chen, H., Cohen, P., Crawford, T. N., Kasen, S., Johnson, J. G., and Berenson, K. (2006). Relative impact of young adult personality disorders on subsequent quality of life: findings of a community-based longitudinal study. J. Pers. Disord. 20, 510-523.
12. Cicchetti, D., and Crick, N. R. (2009). Precursors and diverse pathways to personality disorder in children and adolescents. Dev. Psychopathol. 21, 683-685.
13. Cohen, P., and Cohen, J. (1984). The clinician's illusion. Arch. Gen. Psychiatry 41, 1178-1182.
14. Cole, D. A., Truglo, R., and Peeke, L. (1997). Relation between symptoms of anxiety and depression in children: a multitrait-multimethod-multigroup assessment. J. Couns. Clin. Psychol. 65, 110-119.
15. Crawford, T. N., Cohen, P., Johnson, J. G., Kasen, S., First, M. B., Gordon, K., and Brook, J. S. (2005). Self-reported personality disorder in the children in the community sample: convergent and prospective validity in late adolescence and adulthood. J. Pers. Disord. 19, 30-52.
16. Crick, N. R., Murray-Close, D., and Woods, K. (2005). Borderline personality features in childhood: a short-term longitudinal study. Dev. Psychopathol. 17, 1051-1070.
17. Crick, N. R., Woods, K., Murray-Close, D., and Han, G. (2007). " The development of borderline personality disorder: current progress and future directions." in Personality Disorders in Childhood and Adolescence, eds A. Freeman and M. A. Reinecke (Hoboken, NJ: John Wiley and Sons), 341-384.
18. Crowell, S. E., Beauchaine, T. P., and Linehan, M. M. (2009). A biosocial developmental model of borderline personality: elaborating and extending Linehan's theory. Psychol. Bull. 135, 495-510.
19. Distel, M. A., Trull, T. J., Willemsen, G., Vink, J. M., Derom, C. A., Lynskey, M., Martin, N. G., and Boomsma, D. I. (2009). The five-factor model of personality and borderline personality disorder: a genetic analysis of comorbidity. Biol. Psychiatry 66, 1131-1138.
20. Donegan, N. H., Sanislow, C. A., Blumberg, H. P., Fulbright, R., K., Lacadie, D., Skudlarski, P., Gore, J. C., Olson, I. R., McGlashan, T. H., and Wexler, B. E. (2003). Amygdala hyperactivity in borderline personality disorder: implications for emotional dysregulation. Biol. Psychiatry 54, 1284-1293.
21. Ebner-Priemer, U. W., Badeck, S., Beckman, C., Wagner, A., Feige B., Weiss, I., Lieb, K., and Bohus, M. (2005). Affective dysregulation and dissociative experience in female patients with borderline personality disorder: a startle response study. J. Psychiatr. Res. 39, 85-92.
22. Frankle, W. G., Lombardo, I., New, A. S., Goodman, M., Talbot, P. S., Huang, Y., Hwang, D. R., Slifstein, M., Curry, S., Abi-Dargham, A., Laruelle, M., andSiever, L. J. (2005). Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652. Am. J. Psychiatry 162, 915-923.
23. Goodman, M., New, A. S., Triebwasser, J., Collins, K. A., and Sieve, L. (2010). Phenotype, endophenotype, and genotype comparisons between borderline personality disorder and major depressive disorder. J. Pers. Disord. 24, 38-59.
24. Goodman, S. H., Lahey, B. B., Fielding, B., Dulcan, M., Narrow, W., and Regier, D. (1997). Representativeness of clinical samples of youths with mental disorders: a preliminary population-based study. J. Abnorm. Psychol. 106, 3-14.
25. Gotlib, I. H., Joorman, J., Minor, K., and Hallmayer, J. (2008). HPA axis reactivity: a mechanism underlying the association among 5-HTTLPR, stress, and depression. Biol. Psychiatry 63, 847-851.
26. Hariri, A. R., Drabant, E. M., Munoz, K. E., Kolachana, B. S., Mattay, V. S., Egan, M. F., and Weinberger, D. R. (2005). A susceptibility gene for affective disorders and the response of the human amygdala. Arch. Gen. Psychiatry 62, 146-152.
27. Hoefgen, B., Schulze, T. G., Ohlraun, S., von Widdern, O., Hofels, S., Gross, M., Heidmann, V., Kovalenko, S., Eckermann, A., Kolsch, H., Metten, M., Zobel, A., Becker, T., Nothen, M. M., Propping, P., Heun, R., Maier, W., and Rietschel, M. (2005). The power of sample size and homogenous sampling: Association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biol. Psychiatry 57, 247-251.
28. Hu, X., Oroszi, G., Chun, J., Smith, T. L., Goldman, D., and Schuckit, M. A. (2005). An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk. Alcohol Clin. Exp. Res. 29, 8-16.
29. Johnson, J. G., Cohen, P., Kasen, S., and Brook, J. S. (2006a). Personality disorder traits evident by early adulthood and risk for eating and weight problems during middle adulthood. Int. J. Eat. Disord. 39, 184-192.
30. Johnson, J. G., Cohen, P., Kasen, S., and Brook, J. S. (2006b). Personality disorders evident by early adulthood and risk for anxiety disorder during middle adulthood. Anxiety Disord. 20, 408-426.
31. Klein, D. N., Dougherty, L. R., and Olino, T. M. (2005). Toward guidelines for evidence-based assessment of depression in children and adolescents. J. Clin. Child Adolesc. Psychol. 34, 412-432.
32. Kovacs, M. (1985). The Children's Depression Inventory (CDI). Psychopharmachol. Bull. 21, 995-998.
33. Lesch, K. P., Dietmar, B., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Muller, C. R., Hamer, D. H., and Murphy D. L. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531.
34. Lewinsohn, P., Hops, H., Roberts, R., Seeley, J., and Andrews, J. (1993). Adolescent psychopathology: I. Prevalence and incidence of depression and other DSM-III - R disorders in high school students. J. Abnorm. Psychol. 102, 133-144.
35. Lis, E., Greenfiled, B., Henry, M., Guile, J. M., and Dougherty, G. (2007). Neuroimaging and genetics of borderline personality disorder: a review. J. Psychiatry Neurosci. 32, 162-173.
36. New, A. S., Goodman, M., Triebwasser, J., and Siever, L. J. (2008). Recent advances in the biological study of personality disorders. Psychiatr. Clin. N. Am. 31, 441-461.
37. Ni, X., Chan, D., Chan, K., McMain, S., and Kennedy J. L. (2009). Serotonin genes and gene-gene interactions in borderline personality disorder in a matched case-control study. Prog. Neuropsychopharmacol. Biol. Psychiatry 33, 128-133.
38. Ni, X., Chan, K., Bulgin, N., Sicard, T., Bismil, R., McMain, S., and Kennedy J. L. (2006). Association between serotonin transporter gene and borderline personality disorder. J. Psychiatry Res. 40, 448-453.
39. Petersen, A., Compas, B., Brooks-Gunn, J., Stemmler, M., Ey, S., and Grant, K. (1993). Depression in adolescence. Am. Psychol. 48, 155-168.
40. Putnam, K. M., and Silk, K. R. (2005). Emotion dysregulation and the development of borderline personality disorder. Dev. Psychopathol. 17, 899-925.
41. Reichborn-Kjennerud, T. (2008). Genetics of personality disorders. Psychiatr. Clin. N. Am. 31, 421-440.
42. Silk, K. R., Lee, S., Hill, E. M., and Lohr, N. E. (1995). Borderline personality disorder symptoms and severity of sexual abuse. Am. J. Psychiatry 152, 1059-1064.
43. Skodol, A. E., Gunderson, J. G., Pfohl, B., Widiger, T. A., Livesley, W. J., and Siever, L. J. (2002a). The borderline diagnosis I: psychopathology, comorbidity, and personality structure. Biol. Psychiatry 51, 936-950.
44. Skodol, A. E., Siever, L. J., Livesley, W. J., Gunderson, J. G., Pfohl, B., and Widiger, T. A. (2002b). The borderline diagnosis II: biology, genetics,and clinical course. Biol. Psychiatry 51, 951-963.
45. Soloff, P. H., Price, J. C., Meltzer, C. C., Fabio, A., Frank, G. K., and Kaye, W. H. (2007). 5HT [sub]2A[sub] receptor binding is increased in borderline personality disorder. Biol. Psychiatry 62, 580-587.
46. Tadić, A., Baskaya, O., Victor, A., Lieb, K., Höppner, W., and Dahme, N. (2008). Association analysis of SCN9A gene variants with borderline personality disorder. J. Psychiatr. Res. 43, 155-163.
47. Tolonen, H. (2005). Towards the High Quality of Population Health Surveys. Standardization and Quality Control. Helsinki: National Public Health Institute A27/2005. Available at: http://www.ktl.fi/ attachments/suomi/julkaisut/ julkaisusarja_a/2005/2005a27.pdf
48. Tolonen, H., Dobson, A., and Kulathinal, S. (2005). Effect on trend estimates of the difference between survey respondents and non-respondents: Results from 27 populations in the WHO MONICA Project. Eur. J. Epidemiol. 20, 887-898.
49. Wagner, S., Baskaya, O., Anicker, N. J., Dahmen, N., Lieb, K., and Tadić, A. (2010). The catechol o-methyltransferase (COMT) val158met polymorphism modulates the association of serious life events (SLE) and impulsive aggression in female patients with borderline personality disorder (BPD). Acta Psychiatr. Scand. 122, 110-117.
50. Welch, S. S., and Linehan, M. M. (2002). High-risk situations associated with parasuicide and drug use in borderline personality disorder. J. Pers. Disord. 16, 561-569.
51. Wendland, J. R., Martin, B. J., Kruse, M. R., Lesch, K. P., and Murphy D. L. (2006).Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol. Psychiatry 11, 224-226.
52. Winograd, G., Cohen, P., and Chen, H. (2008). Adolescent borderline symptoms in the community: prognosis for functioning over 20 years. Child Psychol. Psychiatry 49, 933-941.
53. Yen, S., Shea, M. T., Sanislow, C. A., Grilo, C. M., Skodol A. E., Gunderson, J. G., McGlashan, T. H., Zanarini, M. C., and Morey, L. C. (2004). Borderline personality disorder criteria associated with prospectively observed suicide behavior. Am. J. Psychiatry 161, 1296-1298