The Five-Factor Model of Personality and Borderline Personality Disorder: A Genetic Analysis of Comorbidity

Biological Psychiatry

Volumn 66, Issue 12, 2009, Pages 1131-1138

  Distel, Marijn A ^a   Trull, Timothy J ^b   Willemsen, Gonneke ^a   Vink, Jacqueline M ^a   Derom, Catherine A ^c   Lynskey, Michael ^d   Martin, Nicholas G ^e   Boomsma, Dorret I ^a  

^a VU UNIVERSITY AMSTERDAM   (Netherlands)

^b UNIVERSITY OF MISSOURI   (United States)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

Author keywords

Borderline personality disorder; five factor model; genetics; personality; twin study

Indexed keywords

ADULT; AGED; AGREEABLENESS; ARTICLE; AUSTRALIA; BELGIUM; BORDERLINE STATE; COMORBIDITY; CONSCIENTIOUSNESS; CONTROLLED STUDY; DIZYGOTIC TWINS; ENVIRONMENTAL FACTOR; EXPERIENCE; EXTRAVERSION; FEMALE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HEREDITY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MODEL; MONOZYGOTIC TWINS; NETHERLANDS; NEUROSIS; OPENNESS TO EXPERIENCE; PERSONALITY; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; SIBLING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BORDERLINE PERSONALITY DISORDER; DISEASES IN TWINS; FEMALE; HUMANS; INTERNATIONAL COOPERATION; MALE; MIDDLE AGED; MODELS, GENETIC; PERSONALITY; PERSONALITY INVENTORY; PHENOTYPE; REGRESSION (PSYCHOLOGY); SIBLINGS; TWINS, DIZYGOTIC; TWINS, MONOZYGOTIC; YOUNG ADULT;

EID: 70450278666     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2009.07.017     Document Type: Article

References (71)

1. Livesley W.J., and Jang K.L. Differentiating normal, abnormal, and disordered personality. Eur J Pers 19 (2005) 257-268
2. Clark L.A. Assessment and diagnosis of personality disorder: Perennial issues and an emerging reconceptualization. Annu Rev Psychol 58 (2007) 227-257
3. Widiger T.A., and Lowe J.R. A dimensional model of personality disorder: Proposal for DSM-V. Psychiatr Clin North Am 31 (2008) 363-378
4. Trull T.J., and Durrett C.A. Categorical and dimensional models of personality disorder. Annu Rev Clin Psychol 1 (2005) 355-380
5. Trull T.J., Tragesser S.L., Solhan M., and Schwartz-Mette R. Dimensional models of personality disorder: Diagnostic and Statistical Manual of Mental Disorders fifth edition and beyond. Curr Opin Psychiatr 20 (2007) 52-56
6. Livesley W.J. The dimensional assessment of personality pathology (DAPP) approach to personality disorder. In: Strack S. (Ed). Differentiating Normal and Abnormal Personality. 2nd ed. (2006), Springer, New York 401-425
7. Clark L.A. Manual for the Schedule for Nonadaptive and Adaptive Personality (1993), University of Minnesota Press, Minneapolis
8. Cloninger C.R., Svrakic D.M., and Przybeck T.R. A psychobiological model of temperament and character. Arch Gen Psychiatry 50 (1993) 975-990
9. Costa P.T., and McCrae R.R. Professional manual: Revised Neo Personality Inventory (Neo-PI-R) and NEO Five-Factor-Inventory (Neo-FFI) (1992), Psychological Assessment Resources, Odessa, FL
10. Widiger T.A., and Lowe J.R. A dimensional model of personality disorder: Proposal for DSM-V. Psychiatr Clin North Am 31 (2008) 363-378
11. Widiger T.A., and Costa P.T. Five-factor model personality disorder research. In: Costa P.T., and Widiger T.A. (Eds). Personality Disorders and the Five Factor Model of Personality. 2nd ed. (2002), American Psychological Association, Washington, DC 59-87
12. Saulsman L.M., and Page A.C. The five-factor model and personality disorder empirical literature: A meta-analytic review. Clin Psychol Rev 23 (2004) 1055-1085
13. Samuel D.B., and Widiger T.A. A meta-analytic review of the relationships between the five-factor model and DSM-IV-TR personality disorders: A facet level analysis. Clin Psychol Rev 28 (2008) 1326-1342
14. Jang K.L., Livesley W.J., Vernon P.A., and Jackson D.N. Heritability of personality disorder traits: A twin study. Acta Psychiatr Scand 94 (1996) 438-444
15. Riemann R., Angleitner A., and Strelau J. Genetic and environmental influences on personality: A study of twins reared together using the self- and peer report NEO-FFI scales. J Pers 65 (1997) 449-475
16. Vernon P.A., Martin R.A., Schermer J.A., and Mackie A. A behavioral genetic investigation of humor styles and their correlations with the big-5 personality dimensions. Pers Individ Dif 44 (2008) 1116-1125
17. Loehlin J.C., McCrae R.R., Costa P.T., and John O.P. Heritabilities of common and measure-specific components of the big five personality factors. J Res Pers 32 (1998) 431-453
18. Waller N.G. Evaluating the structure of personality. In: Cloninger C.R. (Ed). Personality and Psychopathology (1999), American Psychiatric Association, Washington, DC 155-197
19. Eaves L.J., Heath A.C., Martin N.G., Maes H.H., Neale M.C., Kendler K.S., et al. Comparing the biological and cultural inheritance of personality and social attitudes in the Virginia 30 000 study of twins and their relatives. Twin Res 2 (1999) 62-80
20. Lake R.I.E., Eaves L.J., Maes H.H.M., Heath A.C., and Martin N.G. Further evidence against the environmental transmission of individual differences in neuroticism from a collaborative study of 45,850 twins and relatives on two continents. Behav Genet 30 (2000) 223-233
21. Rettew D.C., Rebollo-Mesa I., Hudziak J.J., Willemsen G., and Boomsma D.I. Non-additive and additive genetic effects on extraversion in 3314 Dutch adolescent twins and their parents. Behav Genet 38 (2008) 223-233
22. Keller M.C., Coventry W.L., Heath A.C., and Martin N.G. Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design. Behav Genet 35 (2005) 707-721
23. Distel M.A., Trull T.J., Derom C.A., Thiery E.W., Grimmer M.A., Martin N.G., et al. Heritability of borderline personality disorder features is similar across three countries. Psychol Med 38 (2008) 1219-1229
24. Distel M.A., Rebollo-Mesa I., Willemsen G., Derom C.A., Trull T.J., Martin N.G., et al. Familial resemblance of borderline personality disorder features: Genetic or cultural transmission?. PLoS ONE 4 (2009) e5334 doi:10.1371/journal.pone.0005334.
25. Torgersen S., Czajkowski N., Jacobson K., Reichborn-Kjennerud T., Roysamb E., Neale M.C., et al. Dimensional representations of DSM-IV cluster B personality disorders in a population-based sample of Norwegian twins: A multivariate study. Psychol Med 38 (2008) 1617-1625
26. Martin N.G., and Eaves L.J. Genetic analysis of covariance structure. Heredity 38 (1977) 79-95
27. Boomsma D.I., and Molenaar P.C.M. Using LISREL to analyze genetic and environmental covariance structure. Behav Genet 16 (1986) 237-250
28. Middeldorp C.M., Cath D.C., van Dyck R., and Boomsma D.I. The co-morbidity of anxiety and depression in the perspective of genetic epidemiology. A review of twin and family studies. Psychol Med 35 (2005) 611-624
29. Kendler K.S., Aggen S.H., Czajkowski N., Roysamb E., Tambs K., Torgersen S., et al. The structure of genetic and environmental risk factors for DSM-IV personality disorders a multivariate twin study. Arch Gen Psychiatry 65 (2008) 1438-1446
30. Posthuma D., and Boomsma D.I. Adding nontwin siblings to increase power. Behav Genet 29 (1999) 366
31. Boomsma D.I., de Geus E.J.C., Vink J.M., Stubbe J.H., Distel M.A., Hottenga J.J., et al. Netherlands twin register: From twins to twin families. Twin Res Hum Genet 9 (2006) 849-857
32. Derom C.A., Vlietinck R.F., Thiery E.W., Leroy F.O.G., Fryns J.P., and Derom R.M. The East Flanders prospective twin survey (EFPTS). Twin Res Hum Genet 9 (2006) 733-738
33. Jardine R., Martin N.G., and Henderson A.S. Genetic covariation between neuroticism and the symptoms of anxiety and depression. Genet Epidemiol 1 (1984) 89-107
34. Nyholt D.R. On the probability of dizygotic twins being concordant for two alleles at multiple polymorphic loci. Twin Res Hum Genet 9 (2006) 194-197
35. Distel M.A., Ligthart L., Willemsen G., Nyholt D.R., Trull T.J., and Boomsma D.I. Personality, health and lifestyle in a questionnaire family study: A comparison between highly cooperative and less cooperative families. Twin Res Hum Genet 10 (2007) 348-353
36. Derom C., and Derom R. The East Flanders prospective twin survey. In: Blickstein I., and Keith L.G. (Eds). Multiple Pregnancy: Epidemiology, Gestation and Perinatal Outcome. 2nd ed. (2005), Taylor and Francis, Oxford, England 39-47
37. Morey L.C. The Personality Assessment Inventory: Professional manual (1991), Psychological Assessment Resources, Odessa, FL
38. Morey L.C. Essentials of PAI Assessment (2003), Wiley, Hoboken, NJ
39. Stein M.B., Pinkster-Aspen J.H., and Hilsenroth M.J. Borderline pathology and the personality assessment inventory (PAI): An evaluation of criterion and concurrent validity. J Pers Assess 88 (2007) 81-89
40. Trull T.J. Borderline personality disorder features in nonclinical young adults. 1. Identification and validation. Psychol Assess 7 (1995) 33-41
41. Distel M.A., Hottenga J.J., Trull T.J., and Boomsma D.I. Chromosome 9: Linkage for borderline personality disorder features. Psychiatr Genet 18 (2008) 302-307
42. De Moor M.H.M., Distel M.A., Trull T.J., and Boomsma D.I. Assessment of borderline personality disorder features in population samples: Is the personality assessment inventory-borderline scale measurement invariant across sex and age?. Psychol Assess 21 (2009) 125-130
43. Boomsma D.I., Busjahn A., and Peltonen L. Classical twin studies and beyond. Nat Rev Genet 3 (2002) 872-882
44. Neale M.C., Boker S.M., Xie G., and Maes H.H. Mx: Statistical Modeling. 7th ed. (2006), Department of Psychiatry, Virginia Commonwealth University, Richmond, VA
45. Neale M.C., and Cardon L. Methodology for Genetic Studies of Twins and Families (1992), Kluwer Academic, Dordrecht, The Netherlands
46. Eaves L.J., Heath A.C., Neale M.C., Hewitt J.K., and Martin N.G. Sex differences and non-additivity in the effects of genes on personality. Twin Res 1 (1998) 131-137
47. Crowell S.E., Beauchaine T.P., and Linehan M.M. A biosocial developmental model of borderline personality: Elaborating and extending Linehan's theory. Psychol Bull 135 (2009) 495-510
48. Kendler K.S., Neale M.C., Kessler R.C., Heath A.C., and Eaves L.J. A longitudinal twin study of personality and major depression in women. Arch Gen Psychiatry 50 (1993) 853-862
49. Kendler K.S., Gatz M., Gardner C.O., and Pedersen N.L. Personality and major depression-A Swedish longitudinal, population-based twin study. Arch Gen Psychiatry 63 (2006) 1113-1120
50. Hettema J.M., Neale M.C., Myers J.M., Prescott C.A., and Kendler K.S. A population-based twin study of the relationship between neuroticism and internalizing disorders. Am J Psychiatry 163 (2006) 857-864
51. Sanna S., Jackson A.U., Nagaraja R., Willer C.J., Chen W.M., Bonnycastle L.L., et al. Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet 40 (2008) 198-203
52. Willer C.J., Sanna S., Jackson A.U., Scuteri A., Bonnycastle L.L., Clarke R., et al. Newly identified loci that influence lipid concentrations and risk of coronary artery disease. Nat Genet 40 (2008) 161-169
53. Wang K., Zhang H., Kugathasan S., Annese V., Bradfield J.R., Russell R.K., et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn's disease. Am J Hum Genet 84 (2009) 399-405
54. Welcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 447 (2007) 661-678
55. Shifman S., Bhomra A., Smiley S., Wray N.R., James M.R., Martin N.G., et al. A whole genome association study of neuroticism using DNA pooling. Mol Psychiatry 13 (2008) 302-312
56. Terracciano A., Sanna S., Uda M., Deiana B., Usala G., Busonero F., et al. Genome-wide association scan for five major dimensions of personality. Mol Psychiatry (2009) [published online ahead of print October 28].
57. Osensand A., Catsicas M., Staple J.K., Jones K.A., Ayala G., Knowles J., et al. Inhibition of axonal growth by snap-25 antisense oligonucleotides in-vitro and in-vivo. Nature 364 (1993) 445-448
58. Scarr E., Gray L., Keriakous D., Robinson P.J., and Dean B. Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefrontal cortex in bipolar I disorder. Bipolar Disord 8 (2006) 133-143
59. Fatemi S.H., Earle J.A., Stary J.M., Lee S., and Sedgewick J. Altered levels of the synaptosomal associated protein SNAP-25 in hippocampus of subjects with mood disorders and schizophrenia. Neuroreport 12 (2001) 3257-3262
60. Steeves T.D.L., King D.P., Zhao Y.L., Sangoram A.M., Du F.H., Bowcock A.M., et al. Molecular cloning and characterization of the human CLOCK gene: Expression in the suprachiasmatic nuclei. Genomics 57 (1999) 189-200
61. Benedetti F., Serretti A., Colombo C., Barbini B., Lorenzi C., Campori E., et al. Influence of CLOCK gene polymorphism on circadian mood fluctuation and illness recurrence in bipolar depression. Am J Med Genet B 123B (2003) 23-26
62. Benedetti F., Dallaspezia S., Fulgosi M.C., Lorenzi C., Serretti A., Barbini B., et al. Actimetric evidence that CLOCK 3111 T/C SNP influences sleep and activity patterns in patients affected by bipolar depression. Am J Med Genet B 144B (2007) 631-635
63. Takao T., Tachikawa H., Kawanishi Y., Mizukami K., and Asada T. CLOCK gene T3111C polymorphism is associated with Japanese schizophrenics: A preliminary study. Eur Neuropsychopharmacol 17 (2007) 273-276
64. Nash M.W., Huezo-Diaz P., Sterne A., Purcell S., Hoda F., Cherny S.S., et al. Genome-wide linkage analysis of a composite index of neuroticism and mood-related scales in extreme selected sibships. Hum Mol Genet 13 (2004) 2173-2182
65. Kuo P.H., Neale M.C., Riley B.P., Patterson D.G., Walsh D., Prescott C.A., et al. A genome-wide linkage analysis for the personality trait neuroticism in the Irish affected sib-pair study of alcohol dependence. Am J Med Genet B 144B (2007) 463-468
66. Gillespie N.A., Zhu G., Evans D.M., Medland S.E., Wright M.J., and Martin N.G. A genome-wide scan for Eysenckian personality dimensions in adolescent twin sibships: Psychoticism, extraversion, neuroticism, and lie. J Pers 76 (2008) 1415-1445
67. Wray N.R., Middeldorp C.M., Birley A.J., Gordon S.D., Sullivan P.F., Visscher P.M., et al. Genome-wide linkage analysis of multiple measures of neuroticism of 2 large cohorts from Australia and the Netherlands. Arch Gen Psychiatry 65 (2008) 649-658
68. Neale B.M., Sullivan P.F., and Kendler K.S. A genome scan of neuroticism in nicotine dependent smokers. Am J Med Genet B 132B (2005) 65-69
69. Fullerton J., Cubin M., Tiwari H., Wang C., Bomhra A., Davidson S., et al. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. Am J Hum Genet 72 (2003) 879-890
70. Widiger T.A., and Trull T.J. Further comments toward a dimensional classification of personality disorder. Am Psychol 63 (2008) 62-63
71. Craddock N., O'Donovan M.C., and Owen M.J. Genome-wide association studies in psychiatry: Lessons from early studies of non-psychiatric and psychiatric phenotypes. Mol Psychiatry 13 (2008) 649-653