Association between serotonin transporter gene and borderline personality disorder

Journal of Psychiatric Research

Volumn 40, Issue 5, 2006, Pages 448-453

  Ni, Xingqun ^a   Chan, Kirsten ^a   Bulgin, Natalie ^a   Sicard, Tricia ^a   Bismil, Ramprasad ^a   McMain, Shelley ^a   Kennedy, James L ^a  

^a CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Association study; Borderline personality disorder; Candidate gene; Genetics; Serotonin transporter gene

Indexed keywords

BIOLOGICAL MARKER; SEROTONIN TRANSPORTER;

ADULT; ALLELE; ARTICLE; BORDERLINE STATE; CAUCASIAN; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; TANDEM REPEAT;

ADULT; BORDERLINE PERSONALITY DISORDER; CASE-CONTROL STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC MARKERS; HUMANS; MALE; MINISATELLITE REPEATS; PROMOTER REGIONS (GENETICS); REFERENCE VALUES; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 33744541972     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2006.03.010     Document Type: Article

References (51)

1. Ansorge M.S., Zhou M., Lira A., Hen R., and Gingrich J.A. Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice. Science 306 (2004) 879-881
2. APA (American Psychiatric Association). Practice guideline for the treatment of patients with borderline personality disorder. American Journal of Psychiatry 158 (2001) 1-52
3. Arango V., Underwood M.D., Gubbi A.V., and Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Research 688 (1995) 121-133
4. Battersby S., Ogilvie A.D., Smith C.A., Blackwood D.H., Muir W.J., Quinn J.P., et al. Structure of a variable number tandem repeat of the serotonin transporter gene and association with affective disorder. Psychiatric Genetics 6 (1996) 177-181
5. Bender D.S., Dolan R.T., Skodol A.E., Sanislow C.A., Dyck I.R., McGlashan T.H., et al. Treatment utilization by patients with personality disorders. American Journal of Psychiatry 158 (2001) 295-302
6. Bland J.M., and Altman D.G. Statistics notes. The odds ratio. British Medical Journal 320 (2000) 1468
7. Bondy B., Erfurth A., de Jonge S., Kruger M., and Meyer H. Possible association of the short allele of the serotonin transporter promoter gene polymorphism (5-HTTLPR) with violent suicide. Molecular Psychiatry 5 (2000) 193-195
8. Cadoret R.J., Langbehn D., Caspers K., Troughton E.P., Yucuis R., Sandhu H.K., et al. Associations of the serotonin transporter promoter polymorphism with aggressivity, attention deficit, and conduct disorder in an adoptee population. Comprehensive Psychiatry 44 (2003) 88-101
9. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., et al. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 301 (2003) 386-389
10. Cho H.J., Meira-Lima I., Cordeiro Q., Michelon L., Sham P., Vallada H., et al. Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis. Molecular Psychiatry 10 (2005) 771-781
11. Coccaro E.F., Kavoussi R.J., Sheline Y.I., Lish J.D., and Csernansky J.G. Impulsive aggression in personality disorder correlates with tritiated paroxetine binding in the platelet. Archives of General Psychiatry 53 (1996) 531-536
12. Collier D.A., Stober G., Li T., Heils A., Catalano M., Di Bella D., et al. A novel functional polymorphism within the promoter of the serotonin transporter gene: possible role in susceptibility to affective disorders. Molecular Psychiatry 1 (1996) 453-460
13. de Lara C.L., Dumais A., Rouleau G., Lesage A., Dumont M., Chawky N., et al. STin2 variant and family history of suicide as significant predictors of suicide completion in major depression. Biological Psychiatry 59 (2006) 114-120
14. De Luca V, Zai G, Tharmalingam S, de Bartolomeis A., Wong G, Kennedy JL. Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia. Eur Neuropsychopharmacol 2005.
15. Donegan N.H., Sanislow C.A., Blumberg H.P., Fulbright R.K., Lacadie C., Skudlarski P., et al. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biological Psychiatry 54 (2003) 1284-1293
16. Dudbridge F. Pedigree disequilibrium tests for multilocus haplotypes. Genetic Epidemiology 25 (2003) 115-121
17. Ebner-Priemer U.W., Badeck S., Beckmann C., Wagner A., Feige B., Weiss I., et al. Affective dysregulation and dissociative experience in female patients with borderline personality disorder: a startle response study. Journal of Psychiatric Research 39 (2005) 85-92
18. Fiskerstrand C.E., Lovejoy E.A., and Quinn J.P. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Letters 458 (1999) 171-174
19. Frankle W.G., Lombardo I., New A.S., Goodman M., Talbot P.S., Huang Y., et al. Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652. American Journal of Psychiatry 162 (2005) 915-923
20. Goldman D, Hu X, Zhu G, Lipsky R, Murphy D. The serotonin transporter: new alleles, function and phenotype. In: 3rd annual pharmacogenetics in psychiatry meeting, New York; 2004. p. 16-17.
21. Gutierrez B., Arranz M.J., Collier D.A., Valles V., Guillamat R., Bertranpetit J., et al. Serotonin transporter gene and risk for bipolar affective disorder: an association study in Spanish population. Biological Psychiatry 43 (1998) 843-847
22. Gutierrez B., Pintor L., Gasto C., Rosa A., Bertranpetit J., Vieta E., et al. Variability in the serotonin transporter gene and increased risk for major depression with melancholia. Human Genetics 103 (1998) 319-322
23. Hariri A.R., Drabant E.M., Munoz K.E., Kolachana B.S., Mattay V.S., Egan M.F., et al. A susceptibility gene for affective disorders and the response of the human amygdala. Archives of General Psychiatry 62 (2005) 146-152
24. Heils A., Teufel A., Petri S., Stober G., Riederer P., Bengel D., et al. Allelic variation of human serotonin transporter gene expression. Journal of Neurochemistry 66 (1996) 2621-2624
25. Hoefgen B., Schulze T.G., Ohlraun S., von Widdern O., Hofels S., Gross M., et al. The power of sample size and homogenous sampling: association between the 5-HTTLPR serotonin transporter polymorphism and major depressive disorder. Biological Psychiatry 57 (2005) 247-251
26. Hranilovic D., Stefulj J., Schwab S., Borrmann-Hassenbach M., Albus M., Jernej B., et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biological Psychiatry 55 (2004) 1090-1094
27. Lahiri D.K., and Nurnberger Jr. J.I. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Research 19 (1991) 5444
28. Lauder J.M. Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Annals of the New York Academy of Sciences 600 (1990) 297-313 [discussion 314]
29. Lesch K.P., Balling U., Gross J., Strauss K., Wolozin B.L., Murphy D.L., et al. Organization of the human serotonin transporter gene. Journal of Neural Transmission-General Section 95 (1994) 157-162
30. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274 (1996) 1527-1531
31. Lesch K.P., and Gutknecht L. Pharmacogenetics of the serotonin transporter. Progress in Neuro-Psychopharmacology & Biological Psychiatry 29 (2005) 1062-1073
32. Lesch K.P., and Mossner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?. Biological Psychiatry 44 (1998) 179-192
33. Lieb K., Zanarini M.C., Schmahl C., Linehan M.M., and Bohus M. Borderline personality disorder. Lancet 364 (2004) 453-461
34. Lovejoy E.A., Scott A.C., Fiskerstrand C.E., Bubb V.J., and Quinn J.P. The serotonin transporter intronic VNTR enhancer correlated with a predisposition to affective disorders has distinct regulatory elements within the domain based on the primary DNA sequence of the repeat unit. European Journal of Neuroscience 17 (2003) 417-420
35. Luo X., Kranzler H.R., Zuo L., Wang S., Blumberg H.P., and Gelernter J. CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study. Human Molecular Genetics 14 (2005) 2421-2434
36. MacKenzie A., and Quinn J. A serotonin transporter gene intron 2 polymorphic region, correlated with affective disorders, has allele-dependent differential enhancer-like properties in the mouse embryo. Proceedings of the National Academy of Sciences of the United States of America 96 (1999) 15251-15255
37. Mann J.J., Huang Y.Y., Underwood M.D., Kassir S.A., Oppenheim S., Kelly T.M., et al. A serotonin transporter gene promoter polymorphism (5-HTTLPR) and prefrontal cortical binding in major depression and suicide. Archives of General Psychiatry 57 (2000) 729-738
38. Nigg J.T., and Goldsmith H.H. Genetics of personality disorders: perspectives from personality and psychopathology research. Psychological Bulletin 115 (1994) 346-380
39. Parsey R.V., Hastings R.S., Oquendo M.A., Hu X., Goldman D., Huang Y.Y., et al. Effect of a triallelic functional polymorphism of the serotonin-transporter-linked promoter region on expression of serotonin transporter in the human brain. American Journal of Psychiatry 163 (2006) 48-51
40. Schloss P., and Williams D.C. The serotonin transporter: a primary target for antidepressant drugs. Journal of Psychopharmacology 12 (1998) 115-121
41. Sen S., Villafuerte S., Nesse R., Stoltenberg S.F., Hopcian J., Gleiberman L., et al. Serotonin transporter and GABAA alpha 6 receptor variants are associated with neuroticism. Biological Psychiatry 55 (2004) 244-249
42. Simeon D., Stanley B., Frances A., Mann J.J., Winchel R., and Stanley M. Self-mutilation in personality disorders: psychological and biological correlates. American Journal of Psychiatry 149 (1992) 221-226
43. Skodol A.E., Siever L.J., Livesley W.J., Gunderson J.G., Pfohl B., and Widiger T.A. The borderline diagnosis II: biology, genetics, and clinical course. Biological Psychiatry 51 (2002) 951-963
44. Steiger H., Joober R., Israel M., Young S.N., Ng Ying Kin N.M., Gauvin L., et al. The 5HTTLPR polymorphism, psychopathologic symptoms, and platelet [3H-] paroxetine binding in bulimic syndromes. International Journal of Eating Disorders 37 (2005) 57-60
45. Tamminga C.A., Nemeroff C.B., Blakely R.D., Brady L., Carter C.S., Davis K.L., et al. Developing novel treatments for mood disorders: accelerating discovery. Biological Psychiatry 52 (2002) 589-609
46. Torgersen S. Genetics of patients with borderline personality disorder. Psychiatric Clinics of North America 23 (2000) 1-9
47. Torgersen S., Kringlen E., and Cramer V. The prevalence of personality disorders in a community sample. Archives of General Psychiatry 58 (2001) 590-596
48. Torgersen S., Lygren S., Oien P.A., Skre I., Onstad S., Edvardsen J., et al. A twin study of personality disorders. Comprehensive Psychiatry 41 (2000) 416-425
49. Williams R.B. Neurobiology, cellular and molecular biology, and psychosomatic medicine. Psychosomatic Medicine 56 (1994) 308-315
50. Williams R.B. Lower socioeconomic status and increased mortality: early childhood roots and the potential for successful interventions. Journal of the American Medical Association 279 (1998) 1745-1746
51. Zanarini M.C., Frankenburg F.R., Khera G.S., and Bleichmar J. Treatment histories of borderline inpatients. Comprehensive Psychiatry 42 (2001) 144-150