Brain serotonin transporter distribution in subjects with impulsive aggressivity: A positron emission study with [11C]McN 5652

American Journal of Psychiatry

Volumn 162, Issue 5, 2005, Pages 915-923

  Frankle, W Gordon ^a   Lombardo, Ilise ^b   New, Antonia S ^b   Goodman, Marianne ^b   Talbot, Peter S ^b   Huang, Yiyun ^b   Hwang, Dah Ren ^b   Slifstein, Mark ^b   Curry, Susan ^b   Abi Bargham, Anissa ^b   Laruelle, Marc ^b   Siever, Larry J ^b  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE; 1,2,3,5,6,10B HEXAHYDRO 6 (4 METHYLTHIOPHENYL)PYRROLO[2,1 A]ISOQUINOLINE C 11; SEROTONIN TRANSPORTER; TRACER; UNCLASSIFIED DRUG;

ADULT; AGGRESSIVENESS; ARTICLE; BINDING AFFINITY; CINGULATE GYRUS; COMPARTMENT MODEL; CONTROLLED STUDY; HUMAN; IMAGE ANALYSIS; IMPULSIVENESS; NEUROIMAGING; OUTCOMES RESEARCH; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM;

ADULT; AGGRESSION; BRAIN; CARBON RADIOISOTOPES; FEMALE; FUNCTIONAL LATERALITY; GYRUS CINGULI; HUMANS; IMPULSIVE BEHAVIOR; ISOQUINOLINES; MAGNETIC RESONANCE IMAGING; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POSITRON-EMISSION TOMOGRAPHY; SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TISSUE DISTRIBUTION;

EID: 21044443874     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/appi.ajp.162.5.915     Document Type: Article

References (64)

1. Brown GL, Goodwin FK, Ballenger JC, Goyer PF, Major LF: Aggression in humans correlates with cerebrospinal fluid amine metabolites. Psychiatry Res 1979; 1:131-139
2. Brown GL, Ebert MH, Goyer PF, Jimerson DC, Klein WJ, Bunney WE, Goodwin FK: Aggression, suicide, and serotonin: relationships to CSF amine metabolites. Am J Psychiatry 1982; 139: 741-746
3. Linnoila M, Virkkunen M, Scheinin M, Nuutila A, Rimon R, Goodwin FK: Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentration differentiates impulsive from nonimpulsive violent behavior. Life Sci 1983; 33:2609-2614
4. Coccaro EF, Siever LJ, Klar HM, Maurer G, Cochrane K, Cooper TB, Mohs RC, Davis KL: Serotonergic studies in patients with affective and personality disorders: correlates with suicidal and impulsive aggressive behavior. Arch Gen Psychiatry 1989; 46: 587-599
5. Siever L, Trestman RL: The serotonin system and aggressive personality disorder. Int Clin Psychopharmacol 1993; 8(suppl 2):33-39
6. Weiger WA, Bear DM: An approach to the neurology of aggression. J Psychiatr Res 1988; 22:85-98
7. Heinrichs RW: Frontal cerebral lesions and violent incidents in chronic neuropsychiatric patients. Biol Psychiatry 1989; 25: 174-178
8. Grafman J, Schwab K, Warden D, Pridgen A, Brown HR, Salazar AM: Frontal lobe injuries, violence, and aggression: a report of the Vietnam Head Injury Study. Neurology 1996; 46:1231-1238
9. Anderson SW, Bechara A, Damasio H, Tranel D, Damasio AR: Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci 1999; 2:1032-1037
10. Butter CM, Snyder DR, McDonald JA: Effects of orbital frontal lesions on aversive and aggressive behaviors in rhesus monkeys. J Comp Physiol Psychol 1970; 72:132-144
11. Weiger WA, Bear DM: An approach to the neurology of aggression. J Psychiatr Res 1988; 22:85-98
12. Anderson SW, Bechara A, Damasio H, Tranel D, Damasio AR: Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nat Neurosci 1999; 2:1032-1037
13. Siever LJ, Buchsbaum MS, New AS, Spiegel-Cohen J, Wei T, Hazlett EA, Sevin E, Nunn M, Mitropoulou V: d,l-Fenfluramine response in impulsive personality disorder assessed with [18F]fluorodeoxyglucose positron emission tomography. Neuropsychopharmacology 1999; 20:413-423
14. 18fluorodeoxyglucose positron emission tomography response to metachlorophenylpiperazine in impulsive aggression. Arch Gen Psychiatry 2002; 59:621-629
15. 11C](+)McN5652 as a radiotracer for imaging serotonin uptake sites with PET. Life Sci 1993; 53:883-892
16. 11C]McN5652: a serotonin transporter radioligand. J Cereb Blood Flow Metab 1999; 19:967-981
17. 11C]MMcN5652. Synapse 1995; 20:37-43
18. 11C]McN 5652. J Nucl Med 2000; 41:1465-1477
19. 11C](+)McN-5652: assessment of methods. J Cereb Blood Flow Metab 2000; 20:253-262
20. 11C](+)McN5652. Biol Psychiatry 2002; 51:715-722
21. Simpson HB, Lombardo I, Slifstein M, Huang HY, Hwang DR, Abi-Dargham A, Liebowitz MR, Laruelle M: Serotonin transporters in obsessive-compulsive disorder: a positron emission tomography study with [(11)C]McN 5652. Biol Psychiatry 2003; 54:1414-1421
22. McCann UD, Szabo Z, Scheffel U, Dannals RF, Ricaurte GA: Positron emission tomographic evidence of toxic effect of MDMA ("Ecstasy") on brain serotonin neurons in human beings. Lancet 1998; 352:1433-1437
23. Buchert R, Thomasius R, Nebeling B, Petersen K, Obrocki J, Jenicke L, Wilke F, Wartberg L, Zapletalova P, Clausen M: Long-term effects of "Ecstasy" use on serotonin transporters of the brain investigated by PET. J Nucl Med 2003; 44:375-384
24. Coccaro EF, Kavoussi RJ, Berman ME, Lish JD: Intermittent explosive disorder-revised: development, reliability, and validity of research criteria. Compr Psychiatry 1998; 39:368-376
25. Coccaro EF: Intermittent explosive disorder. Curr Psychiatry Rep 2000; 2:67-71
26. Pfohl B, Blum N, Zimmerman M: Structured Interview for DSM-IV Personality: SIDP-IV. Washington, DC, American Psychiatric Press, 1997
27. First MB, Spitzer RL, Gibbon M, Williams JBW: Structured Clinical Interview for DSM-IV Axis I Disorders, version 2.0. New York, New York State Psychiatric Institute, Biometrics Research, 1995
28. 11C]McN-5652 from racemic McN-5652. J Labelled Comp Radiopharm 1999; 42:1301-1312
29. 11C]McN 5652 in healthy humans. J Nucl Med 2004; 45:682-694
30. Mawlawi OM, Weiss R, Shinn A, Pidcock J, Slifstein M, Laruelle M: Performance characteristics of a head immobilization device for PET imaging (abstract). J Nucl Med 1999; 40:281P
31. 11C]NNC 756. Synapse 1999; 32:93-109
32. Abi-Dargham A, Laruelle M, Seibyl, J, Rattner Z, Baldwin RM, Zoghbi SS, Zea-Ponce Y, Bremner JD, Hyde TM, Charney DS, Hoffer PB, Innis RB: SPECT measurement of benzodiazepine receptors in human brain with [123-I]iomazenil: kinetic and equilibrium paradigms. J Nucl Med 1994; 35:228-238
33. Abi-Dargham A, Mawlawi O, Lombardo I, Gil R, Martinez D, Huang Y, Hwang DR, Keilp J, Kochan L, Van Heertum R, Gorman JM, Laruelle M: Prefrontal dopamine D1 receptors and working memory in schizophrenia. J Neurosci 2002; 22:3708-3719
34. 11C]NNC 112 in humans: validation and reproducibility. J Cereb Blood Flow Metab 2000; 20:225-243
35. Woods RP, Cherry SR, Mazziotta JC: Rapid automated algorithm for aligning and reslicing PET images. J Comp Assist Tomogr 1992; 16:620-633
36. Duvernoy H: The Human Brain: Surface, Three-Dimensional Sectional Anatomy and MRI. New York, Springer-Verlag Wien, 1991
37. Talairach J, Tournoux P: Co-Planar Stereotaxic Atlas of the Human Brain: Three-Dimensional Proportional System. New York, Thieme Medical, 1988
38. Killiany RJ, Moss MB, Nicholson T, Jolez F, Sandor T: An interactive procedure for extracting features of the brain from magnetic resonance images: the lobes. Hum Brain Mapp 1997; 5: 355-363
39. Kates WR, Abrams MT, Kaufmann WE, Breiter SN, Reiss AL: Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiatr Res Neuroimaging 1997; 75:31-48
40. Pani L, Gessa GL, Carboni S, Portas CM, Rossetti ZL: Brain dialysis and dopamine: does the extracellular concentration of dopamine reflect synaptic release? Eur J Pharmacol 1990; 180:85-90
41. Mawlawi O, Martinez D, Slifstein M, Broft A, Chatterjee R, Hwang DR, Huang Y, Simpson N, Ngo K, Van Heertum R, Laruelle M: Imaging human mesolimbic dopamine transmission with positron emission tomography, I: accuracy and precision of D2 receptor parameter measurements in ventral striatum. J Cereb Blood Flow Metab 2001; 21:1034-1057
42. Mintun MA, Raichle ME, Kilbourn MR, Woolen GF, Welch MJ: A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann Neurol 1984; 15:217-227
43. Laruelle M, Baldwin RM, Rattner Z, Al-Tikriti MS, Zea-Ponce Y, Zoghbi SS, Charney DS, Price JC, Frost JJ, Hoffer PB, Innis RB: SPECT quantification of [123I]iomazenil binding to benzodiazepine receptors in nonhuman primates, I: kinetic modeling of single bolus experiments. J Cereb Blood Flow Metab 1994; 14: 439-452
44. 11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab 1991; 11:735-744
45. Levenberg K: A method for the solution of certain problems in least squares. Q Applied Mathematics 1944; 2:164-168
46. Laruelle M, Vanisberg M, Maloteaux J: Regional and subcellular localization in human brain of [3H]paroxetine binding, a marker of serotonin uptake sites. Biol Psychiatry 1988; 24: 299-309
47. Backstrom I, Bergstrom M, Marcusson J: High affinity [3H]paroxetine binding to serotonin uptake sites in human brain tissue. Brain Res 1989; 486:261-268
48. Plenge P, Mellerup ET, Laursen H: Regional distribution of the serotonin transport complex in human brain, identified with 3H-paroxetine, 3H-citalopram and 3H-imipramine. Prog Neuropsychopharmacol Biol Psychiatry 1990; 14:61-72
49. Lamelle M, van Dyck C, Abi-Dargham A, Zea-Ponce Y, Zoghbi SS, Charney DS, Baldwin RM, Hoffer PB, Kung HF, Innis RB: Compartmental modeling of iodine-123-iodobenzofuran binding to dopamine D2 receptors in healthy subjects. J Nucl Med 1994; 35:743-754
50. Slifstein M, Laruelle M: Models and methods for derivation of in vivo neuroreceptor parameters with PET and SPECT reversible radiotracers. Nucl Med Biol 2001; 28:595-608
51. Wilson AA, Ginovart N, Schmidt M, Meyer JH, Threlkeld PG, Houle S: Novel radiotracers for imaging the serotonin transporter by positron emission tomography: synthesis, radiosynthesis, and in vitro and ex vivo evaluation of (11)C-labeled 2-(phenylthio)araalkylamines. J Med Chem 2000; 43:3103-3110
52. Huang Y, Bae S-A, Zhu Z, Guo N, Hwang DR, Laruelle M: Fluorinated analogues of ADAM as new PET radioligands for the serotonin transporter: synthesis and pharmacological evaluation. J Labelled Comp Radiopharm 2001; 44:518-520
53. 11C]AFM. J Cereb Blood Flow Metab 2002; 22:1377-1398
54. Asberg M, Traskman L, Thoren P: 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatry 1976; 33:1193-1197
55. Arango V, Underwood MD, Gubbi AV, Mann JJ: Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res 1995; 688:121-133
56. Brown CS, Kent TA, Bryant SG, Gevedon RM, Campbell JL, Felthous AR, Barratt ES, Rose RM: Blood platelet uptake of serotonin in episodic aggression. Psychiatry Res 1989; 27:5-12
57. Davidson RJ, Putnam KM, Larson CL: Dysfunction in the neural circuitry of emotion regulation - a possible prelude to violence. Science 2000; 289:591-594
58. Bush G, Luu P, Posner MI: Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn Sci 2000; 4:215-222
59. Siegel A, Edinger HM: Role of the limbic system in hypothalamically elicited attack behavior. Neurosci Biobehav Rev 1983; 7: 395-407
60. Dougherty DD, Shin LM, Alpert NM, Pitman RK, Orr SP, Lasko M, Macklin ML, Fischman AJ, Rauch SL: Anger in healthy men: a PET study using script-driven imagery. Biol Psychiatry 1999; 46: 466-472
61. Rauch SL, Jenike MA, Alpert NM, Baer L, Breiter HC, Savage CR, Fischman AJ: Regional cerebral blood flow measured during symptom provocation in obsessive-compulsive disorder using oxygen 15-labeled carbon dioxide and positron emission tomography. Arch Gen Psychiatry 1994; 51:62-70
62. Rauch SL, van der Kolk BA, Fisler RE, Alpert NM, Orr SP, Savage CR, Fischman AJ, Jenike MA, Pitman RK: A symptom provocation study of posttraumatic stress disorder using positron emission tomography and script-driven imagery. Arch Gen Psychiatry 1996; 53:380-387
63. Rauch SL, Savage CR, Alpert NM, Miguel EC, Baer L, Breiter HC, Fischman AJ, Manzo PA, Moretti C, Jenike MA: A positron emission tomographic study of simple phobic symptom provocation. Arch Gen Psychiatry 1995; 52:20-28
64. Beauregard M, Levesque J, Bourgouin P: Neural correlates of conscious self-regulation of emotion. J Neurosci 2001; 21:RC165