-
1
-
-
78649346692
-
The heat shock response: Life on the verge of death
-
Richter K, Haselbeck M, Buchner J. The heat shock response: Life on the verge of death. Mol. Cell 40(2), 253-266 (2010
-
(2010)
Mol. Cell
, vol.40
, Issue.2
, pp. 253-266
-
-
Richter, K.1
Haselbeck, M.2
Buchner, J.3
-
2
-
-
79960430517
-
Molecular chaperones: Toward new therapeutic tools
-
Almeida M, Nascimento JL, Herculano AM, Crespo-Lopez ME. Molecular chaperones: Toward new therapeutic tools. Biomed. Pharmacother. 65, 239-243 (2011
-
(2011)
Biomed. Pharmacother.
, vol.65
, pp. 239-243
-
-
Almeida, M.1
Nascimento, J.L.2
Herculano, A.M.3
Crespo-Lopez, M.E.4
-
3
-
-
5044239107
-
Pathways of chaperone-mediated protein folding in the cytosol
-
Young D, Agashe VR, Siegers K, Hartl F. Pathways of chaperone-mediated protein folding in the cytosol. Nat. Rev. Mol. Cell Biol. 5, 781-791 (2004
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 781-791
-
-
Young, D.1
Agashe, V.R.2
Siegers, K.3
Hartl, F.4
-
4
-
-
2442445139
-
Role of plant heat-shock proteins and molecular chaperones in the abiotic stress response
-
Wang W, Vinocur B, Shoseyov O, Altman A. Role of plant heat-shock proteins and molecular chaperones in the abiotic stress response. Trends Plant Sci. 9(5), 244-252 (2004
-
(2004)
Trends Plant Sci.
, vol.9
, Issue.5
, pp. 244-252
-
-
Wang, W.1
Vinocur, B.2
Shoseyov, O.3
Altman, A.4
-
5
-
-
27744517366
-
Heat shock proteins as emerging therapeutic targets
-
Soti C, Nagy E, Giricz Z, Vigh L, Csermely P, Ferdinandy P. Heat shock proteins as emerging therapeutic targets. Br. J. Pharmacol. 146(6), 769-780 (2005
-
(2005)
Br. J. Pharmacol.
, vol.146
, Issue.6
, pp. 769-780
-
-
Soti, C.1
Nagy, E.2
Giricz, Z.3
Vigh, L.4
Csermely, P.5
Ferdinandy, P.6
-
6
-
-
33747512168
-
The distinctive role of small heat shockproteins in oncogenesis
-
Laudanski K, Wyczechowska D. The distinctive role of small heat shockproteins in oncogenesis. Arch. Immunol. Ther. Exp. (Warsz). 54(2), 103-111 (2006
-
(2006)
Arch. Immunol. Ther. Exp. (Warsz
, vol.54
, Issue.2
, pp. 103-111
-
-
Laudanski, K.1
Wyczechowska, D.2
-
8
-
-
33746364784
-
Structure and mechanism of the Hsp90 molecular chaperone machinery
-
Pearl LH, Prodromou C. Structure and mechanism of the Hsp90 molecular chaperone machinery. Annu. Rev. Biochem. 75, 271-294 (2006
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 271-294
-
-
Pearl, L.H.1
Prodromou, C.2
-
9
-
-
0034282104
-
Hsp27 negatively regulates cell death by interacting with cytochrome c
-
Bruey JM, Ducasse C, Bonniaud P et al. Hsp27 negatively regulates cell death by interacting with cytochrome c. Nat. Cell Biol. 2, 645-652 (2000
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 645-652
-
-
Bruey, J.M.1
Ducasse, C.2
Bonniaud, P.3
-
10
-
-
33751203833
-
Heat shock proteins 27 and 70: Anti-Apoptotic proteins with tumorigenic properties
-
Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G. Heat shock proteins 27 and 70: Anti-Apoptotic proteins with tumorigenic properties. Cell Cycle 5, 2592-2601(2006
-
(2006)
Cell Cycle
, vol.5
, pp. 2592-2601
-
-
Garrido, C.1
Brunet, M.2
Didelot, C.3
Zermati, Y.4
Schmitt, E.5
Kroemer, G.6
-
11
-
-
17944366977
-
Heat-shock protein 70 antagonizes apoptosis- inducing factor
-
Ravagnan L, Gurbuxani S, Susin SA et al. Heat-shock protein 70 antagonizes apoptosis- inducing factor. Nat. Cell Biol. 3, 839-843 (2001
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 839-843
-
-
Ravagnan, L.1
Gurbuxani, S.2
Susin, S.A.3
-
12
-
-
62349088789
-
Apoptosis versus cell differentiation: Role of heat shock proteins Hsp90, Hsp70 and Hsp27
-
Lanneau D, de Thonel A, Maurel S, Didelot C, Garrido C. Apoptosis versus cell differentiation: Role of heat shock proteins Hsp90, Hsp70 and Hsp27. Prion 1(1), 53-60 (2007
-
(2007)
Prion
, vol.1
, Issue.1
, pp. 53-60
-
-
Lanneau, D.1
De Thonel, A.2
Maurel, S.3
Didelot, C.4
Garrido, C.5
-
13
-
-
34548658230
-
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis
-
Dai C, Whitesell L, Rogers AB, Lindquist S. Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 130(6) 1005-1018 (2007
-
(2007)
Cell
, vol.130
, Issue.6
, pp. 1005-1018
-
-
Dai, C.1
Whitesell, L.2
Rogers, A.B.3
Lindquist, S.4
-
14
-
-
0033890818
-
Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents
-
Bagatell R, Paine-Murrieta GD, Taylor CW et al. Induction of a heat shock factor 1-dependent stress response alters the cytotoxic activity of hsp90-binding agents. Clin. Can. Res. 6(8), 3312-3318 (2000
-
(2000)
Clin. Can. Res.
, vol.6
, Issue.8
, pp. 3312-3318
-
-
Bagatell, R.1
Paine-Murrieta, G..D.2
Taylor, C.W.3
-
15
-
-
0030112452
-
Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells
-
Baler R, Zou J, Voellmy R. Evidence for a role of Hsp70 in the regulation of the heat shock response in mammalian cells. Cell Stress Chaperones 1(1), 33-39(1996
-
(1996)
Cell Stress Chaperones
, vol.1
, Issue.1
, pp. 33-39
-
-
Baler, R.1
Zou, J.2
Voellmy, R.3
-
16
-
-
0027202273
-
The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by Hsp70
-
Mosser DD, Duchaine J, Massie B. The DNA-binding activity of the human heat shock transcription factor is regulated in vivo by Hsp70. Mol. Cell. Biol. 13(9), 5427-5438 (1993
-
(1993)
Mol. Cell. Biol.
, vol.13
, Issue.9
, pp. 5427-5438
-
-
Mosser, D..D.1
Duchaine, J.2
Massie, B.3
-
17
-
-
0026786349
-
Authentic temperature-regulation of a heat shock gene inserted into yeast on a high copy number vector. Influences of overexpression of Hsp90 protein on high temperature growth and thermotolerance
-
Cheng L, Hirst K, Piper PW. Authentic temperature-regulation of a heat shock gene inserted into yeast on a high copy number vector. Influences of overexpression of Hsp90 protein on high temperature growth and thermotolerance. Biochim. Biophys. Acta 1132(1), 26-34 (1992
-
(1992)
Biochim. Biophys. Acta
, vol.1132
, Issue.1
, pp. 26-34
-
-
Cheng, L.1
Hirst, K.2
Piper, P.W.3
-
18
-
-
0035110553
-
Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins
-
Hjorth-Sorensen B, Hoffmann ER, Lissin NM, Sewell AK, Jakobsen BK. Activation of heat shock transcription factor in yeast is not influenced by the levels of expression of heat shock proteins. Mol. Microbiol. 39(4), 914-923(2001
-
(2001)
Mol. Microbiol.
, vol.39
, Issue.4
, pp. 914-923
-
-
Hjorth-Sorensen, B.1
Hoffmann, E.R.2
Lissin, N.M.3
Sewell, A.K.4
Jakobsen, B.K.5
-
19
-
-
0142186172
-
Aging and molecular chaperones
-
Soti C, Csermely P. Aging and molecular chaperones. Exp. Gerontol. 38(10), 1037-1040 (2003
-
(2003)
Exp. Gerontol.
, vol.38
, Issue.10
, pp. 1037-1040
-
-
Soti, C.1
Csermely, P.2
-
20
-
-
0035053046
-
Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological aging of nondividing cells
-
HarrisN, MacLean M, Hatzianthis K, Panaretou B, Piper PW. Increasing Saccharomyces cerevisiae stress resistance, through the overactivation of the heat shock response resulting from defects in the Hsp90 chaperone, does not extend replicative life span but can be associated with slower chronological aging of nondividing cells. Mol. Genet. Genomics 265(2), 258-263(2001
-
(2001)
Mol. Genet. Genomics
, vol.265
, Issue.2
, pp. 258-263
-
-
HarrisN MacLean, M.1
Hatzianthis, K.2
Panaretou, B.3
Piper, P.W.4
-
21
-
-
0033575998
-
Hot-Tub therapy for Type 2 diabetes mellitus
-
Hooper PL. Hot-Tub therapy for Type 2 diabetes mellitus. N. Engl. J. Med. 341(12), 924-925 (1999
-
(1999)
N. Engl. J. Med.
, vol.341
, Issue.12
, pp. 924-925
-
-
Hooper, P.L.1
-
22
-
-
64049105985
-
Inflammation, heat shock proteins, and Type 2 diabetes
-
Hooper PL, Hooper PL. Inflammation, heat shock proteins, and Type 2 diabetes. Cell Stress Chaperones 14(2), 113-115 (2009
-
(2009)
Cell Stress Chaperones
, vol.14
, Issue.2
, pp. 113-115
-
-
Hooper, P.L.1
Hooper, P.L.2
-
23
-
-
53149094022
-
Heat shock proteins in animal neoplasms and human tumors - A comparison
-
Romanucci M, Bastow T,Della Salda L. Heat shock proteins in animal neoplasms and human tumors - A comparison. Cell Stress Chaperones 13(3), 253-262(2008
-
(2008)
Cell Stress Chaperones
, vol.13
, Issue.3
, pp. 253-262
-
-
Romanucci, M.1
Bastow, T.2
Della Salda, L.3
-
24
-
-
84855860803
-
Takimoto
-
CH. Heat shock proteins: A potential anticancer target
-
Sankhala KK, Mita MM, Mita AC, Takimoto CH. Heat shock proteins: A potential anticancer target. Curr. Drug Targets 12(14), 2001-2008 (2011
-
(2011)
Curr. Drug Targets
, vol.12
, Issue.14
, pp. 2001-2008
-
-
Sankhala, K.K.1
Mita, M.M.2
Mita, A.C.3
-
25
-
-
21744445069
-
Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications
-
Ciocca DR, Calderwood SK. Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10(2), 86-103 (2005
-
(2005)
Cell Stress Chaperones
, vol.10
, Issue.2
, pp. 86-103
-
-
Ciocca, D.R.1
Calderwood, S.K.2
-
26
-
-
46049094024
-
Heat shock proteins as novel therapeutic targets in cancer
-
Soo ET, Yip GW, Lwin ZM, Kumar SD, Bay BH. Heat shock proteins as novel therapeutic targets in cancer. In Vivo 22(3), 311-315 (2008
-
(2008)
Vivo
, vol.22
, Issue.3
, pp. 311-315
-
-
Soo, E.T.1
Yip, G.W.2
Lwin, Z.M.3
Kumar, S..D.4
Bay, B.H.5
-
27
-
-
33644835965
-
CioccaDR. Heat shock proteins in cancer: Chaperones of tumorigenesis
-
Calderwood SK, Khaleque MA, Sawyer DB, CioccaDR. Heat shock proteins in cancer: Chaperones of tumorigenesis. Trends Biochem. Sci. 31(3), 164-172 (2006
-
(2006)
Trends Biochem. Sci.
, vol.31
, Issue.3
, pp. 164-172
-
-
Calderwood, S.K.1
Khaleque, M.A.2
Sawyer, D.B.3
-
28
-
-
0037315208
-
Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery
-
Pratt WB, Toft DO. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med.228(2), 111-133 (2003
-
(2003)
Exp. Biol. Med.
, vol.228
, Issue.2
, pp. 111-133
-
-
Pratt, W.B.1
Toft, D.O.2
-
29
-
-
77649147755
-
Heat shock cognate protein 70 is essential for Akt signaling in endothelial function
-
Shiota M, Kusakabe H ,Yzumi Y,et al. Heat shock cognate protein 70 is essential for Akt signaling in endothelial function. Arterioscler. Thromb. Vasc. Biol. 30(3), 491-497 (2010
-
(2010)
Arterioscler. Thromb. Vasc. Biol.
, vol.30
, Issue.3
, pp. 491-497
-
-
Shiota, M.1
Kusakabe H Yzumi, Y.2
-
30
-
-
0027423102
-
Biological and clinical implications of heat shock protein 27,000 (Hsp27): A review
-
Ciocca DR, Oesterreich S, Chamness GC, McGuire WL, Fuqua SA. Biological and clinical implications of heat shock protein 27,000 (Hsp27): A review. J. Natl Cancer Inst. 85, 1558-1570 (1993
-
(1993)
J. Natl Cancer Inst.
, vol.85
, pp. 1558-1570
-
-
Ciocca, D.R.1
Oesterreich, S.2
Chamness, G.C.3
McGuire, W.L.4
Fuqua, S.A.5
-
31
-
-
33751203833
-
Heat shock proteins 27 and 70: Anti-Apoptotic proteins with tumorigenic properties
-
Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E, Kroemer G. Heat shock proteins 27 and 70: Anti-Apoptotic proteins with tumorigenic properties. Cell Cycle 5, 2592-2601 (2006
-
(2006)
Cell Cycle
, vol.5
, pp. 2592-2601
-
-
Garrido, C.1
Brunet, M.2
Didelot, C.3
Zermati, Y.4
Schmitt, E.5
Kroemer, G.6
-
32
-
-
1642471825
-
Heat-shock proteins as regulators of apoptosis
-
Takayama S, Reed JCand Homma S. Heat-shock proteins as regulators of apoptosis. Oncogene 22, 9041-9047 (2003
-
(2003)
Oncogene
, vol.22
, pp. 9041-9047
-
-
Takayama, S.1
Reed, J.C.2
Homma, S.3
-
33
-
-
77954945333
-
Targeting the dynamic Hsp90 complex in cancer
-
Trepel J, Mollapour M, Giaccone G, Neckers L. Targeting the dynamic Hsp90 complex in cancer. Nat. Rev. Cancer. 10(8), 537-549 (2010
-
(2010)
Nat. Rev. Cancer.
, vol.10
, Issue.8
, pp. 537-549
-
-
Trepel, J.1
Mollapour, M.2
Giaccone, G.3
Neckers, L.4
-
34
-
-
11244337455
-
Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2- dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts
-
Eiseman JL, Lan J, Lagattuta TF et al. Pharmacokinetics and pharmacodynamics of 17-demethoxy 17-[[(2- dimethylamino)ethyl]amino]geldanamycin (17DMAG, NSC 707545) in C.B-17 SCID mice bearing MDA-MB-231 human breast cancer xenografts. Cancer Chemother. Pharmacol. 55, 21-32 (2005
-
(2005)
Cancer Chemother. Pharmacol.
, vol.55
, pp. 21-32
-
-
Eiseman, J.L.1
Lan, J.2
Lagattuta, T.F.3
-
35
-
-
75149123144
-
Inhibitors of Hsp90 block p95-HER2 signaling in trastuzumab-resistant tumors and suppress their growth
-
Chandarlapaty S, Scaltriti M, Angelini P et al. Inhibitors of Hsp90 block p95-HER2 signaling in trastuzumab-resistant tumors and suppress their growth. Oncogene 29, 325-334 (2010
-
(2010)
Oncogene
, vol.29
, pp. 325-334
-
-
Chandarlapaty, S.1
Scaltriti, M.2
Angelini, P.3
-
36
-
-
74249085361
-
Update of Hsp90 inhibitors in clinical trial
-
Kim YS, Alarcon SV, Lee S et al. Update of Hsp90 inhibitors in clinical trial. Curr. Top. Med. Chem. 9(15), 1479-1492 (2009
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, Issue.15
, pp. 1479-1492
-
-
Kim, Y.S.1
Alarcon, S.V.2
Lee, S.3
-
37
-
-
77950189338
-
Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy
-
Landriscina M, Amoroso MR, Piscazzi A, Esposito F. Heat shock proteins, cell survival and drug resistance: The mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy. Gynecol. Oncol. 117(2), 177-182 (2010
-
(2010)
Gynecol. Oncol.
, vol.117
, Issue.2
, pp. 177-182
-
-
Landriscina, M.1
Amoroso, M.R.2
Piscazzi, A.3
Esposito, F.4
-
38
-
-
1642268986
-
Hsp90 isoforms: Functions, expression and clinical importance
-
Sreedhar AS, Kalmár E, Csermely P, Shen YF. Hsp90 isoforms: Functions, expression and clinical importance. FEBS Lett. 562, 11-15 (2004
-
(2004)
FEBS Lett.
, vol.562
, pp. 11-15
-
-
Sreedhar, A.S.1
Kalmár, E.2
Csermely, P.3
Shen, Y.F.4
-
39
-
-
34848926209
-
Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches
-
McClellan AJ, Xia Y, Deutschbauer AM, Davis RW, Gerstein M, Frydman J. Diverse cellular functions of the Hsp90 molecular chaperone uncovered using systems approaches. Cell 131, 121-135 (2007
-
(2007)
Cell
, vol.131
, pp. 121-135
-
-
McClellan, A.J.1
Xia, Y.2
Deutschbauer, A.M.3
Davis, R.W.4
Gerstein, M.5
Frydman, J.6
-
40
-
-
2942716692
-
Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness
-
Eustace BK, Sakurai T, Stewart JK et al. Functional proteomic screens reveal an essential extracellular role for hsp90 alpha in cancer cell invasiveness. Nat. Cell Biol. 6, 507-514 (2004
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 507-514
-
-
Eustace, B.K.1
Sakurai, T.2
Stewart, J.K.3
-
42
-
-
34248195608
-
High Hsp90 expression is associated with decreased survival in breast cancer
-
Pick E, Kluger Y, Giltnane JM et al. High Hsp90 expression is associated with decreased survival in breast cancer. Cancer Res. 67, 2932-2937 (2007
-
(2007)
Cancer Res.
, vol.67
, pp. 2932-2937
-
-
Pick, E.1
Kluger, Y.2
Giltnane, J.M.3
-
43
-
-
21144432950
-
The heat shock protein 90 inhibitor, 17-Allylamino-17- demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line
-
Price JT, Quinn JM, Sims NA et al. The heat shock protein 90 inhibitor, 17-Allylamino-17-demethoxygeldanamycin, enhances osteoclast formation and potentiates bone metastasis of a human breast cancer cell line. Cancer Res. 65, 4929-4938 (2005
-
(2005)
Cancer Res.
, vol.65
, pp. 4929-4938
-
-
Price, J.T.1
Quinn, J.M.2
Sims, N.A.3
-
44
-
-
0032959590
-
Structural basis for inhibition of the Hsp90 molecular chaperone by antitumor antibiotic radicicol and geldanamycin
-
Roe S, Prodromou C, O'Brien R,Ladbury JE, Piper PW, Pearl LH. Structural basis for inhibition of the Hsp90 molecular chaperone by antitumor antibiotic radicicol and geldanamycin. J. Med. Chem. 42(2), 260-266 (1999
-
(1999)
J. Med. Chem.
, vol.42
, Issue.2
, pp. 260-266
-
-
Roe, S.1
Prodromou, C.2
O'Brien, R.3
Ladbury, J.E.4
Piper, P.W.5
Pearl, L.H.6
-
45
-
-
0029056501
-
Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent
-
Supko JG, Hickman RL, Grever MR, Malspeis L. Preclinical pharmacologic evaluation of geldanamycin as an antitumor agent. Cancer Chemother. Pharmacol. 36, 305-315 (1995
-
(1995)
Cancer Chemother. Pharmacol.
, vol.36
, pp. 305-315
-
-
Supko, J.G.1
Hickman, R.L.2
Grever, M.R.3
Malspeis, L.4
-
46
-
-
0031005361
-
Crystal structure of an Hsp90-geldanamycin complex
-
Stebbins CE, Russo AA, Schneider C et al. Crystal structure of an Hsp90-geldanamycin complex. Cell 89(2), 239-250 (1997
-
(1997)
Cell
, vol.89
, Issue.2
, pp. 239-250
-
-
Stebbins, C.E.1
Russo, A.A.2
Schneider, C.3
-
47
-
-
61649098007
-
Novobiocin and additional inhibitors of the Hsp90 C-Terminal nucleotide binding pocket
-
Donnelly A, Blagg BS. Novobiocin and additional inhibitors of the Hsp90 C-Terminal nucleotide binding pocket. Curr. Med. Chem. 15(26), 2702-2717 (2009
-
(2009)
Curr. Med. Chem.
, vol.15
, Issue.26
, pp. 2702-2717
-
-
Donnelly, A.1
Blagg, B.S.2
-
48
-
-
77950929054
-
Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia
-
Lancet E, Gojo I, Burton M et al. Phase I study of the heat shock protein 90 inhibitor alvespimycin (KOS-1022, 17-DMAG) administered intravenously twice weekly to patients with acute myeloid leukemia. Leukemia 24, 699-705 (2010
-
(2010)
Leukemia
, vol.24
, pp. 699-705
-
-
Lancet, E.1
Gojo, I.2
Burton, M.3
-
49
-
-
72449185268
-
Phase I trial of 17-dimethylaminoethylamino- 17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies
-
Kummar S, Gutierrez ME, Gardner ER et al. Phase I trial of 17-dimethylaminoethylamino- 17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced malignancies. Eur. J. Cancer 46, 340-347 (2010
-
(2010)
Eur. J. Cancer
, vol.46
, pp. 340-347
-
-
Kummar, S.1
Gutierrez, M.E.2
Gardner, E.R.3
-
50
-
-
68849101479
-
Retaspimycin hydrochloride (IPI-504): A novel heat shock protein inhibitor as an anticancer agent
-
Hanson BE, Vesole DH. Retaspimycin hydrochloride (IPI-504): A novel heat shock protein inhibitor as an anticancer agent. Expert Opin. Investig. Drugs 18, 1375-1383 (2009
-
(2009)
Expert Opin. Investig. Drugs
, vol.18
, pp. 1375-1383
-
-
Hanson, B.E.1
Vesole, D.H.2
-
51
-
-
73149102557
-
A novel Novobiocin-derived C-Terminal inhibitor of the 90-kDa heat shock protein exerts potent antiproliferative effects in human leukemic cells
-
Shelton S.N. Shawgo ME, Matthews SB et al. A novel Novobiocin-derived C-Terminal inhibitor of the 90-kDa heat shock protein exerts potent antiproliferative effects in human leukemic cells. Mol. Pharmacol. 76(6), 1314-1322 (2009
-
(2009)
Mol. Pharmacol.
, vol.76
, Issue.6
, pp. 1314-1322
-
-
Shelton, S.N.1
Shawgo, M.E.2
Matthews, S.B.3
-
52
-
-
66449094961
-
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90
-
Lundgren K, Zhang H, Brekken J et al. BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Mol. Cancer Ther. 8, 921-929 (2009
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 921-929
-
-
Lundgren, K.1
Zhang, H.2
Brekken, J.3
-
53
-
-
74049091229
-
BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy
-
Yin X, Zhang H, Lundgren K, Wilson L, Burrows F, Shores CG. BIIB021, a novel Hsp90 inhibitor, sensitizes head and neck squamous cell carcinoma to radiotherapy. Int. J. Cancer 126, 1216-1225 (2010
-
(2010)
Int. J. Cancer
, vol.126
, pp. 1216-1225
-
-
Yin, X.1
Zhang, H.2
Lundgren, K.3
Wilson, L.4
Burrows, F.5
Shores, C.G.6
-
54
-
-
74049114496
-
BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance
-
Zhang H, Neely L, Lundgren K et al. BIIB021, a synthetic Hsp90 inhibitor, has broad application against tumors with acquired multidrug resistance. Int. J. Cancer 126, 1226-1234 (2010
-
(2010)
Int. J. Cancer
, vol.126
, pp. 1226-1234
-
-
Zhang, H.1
Neely, L.2
Lundgren, K.3
-
55
-
-
55249118494
-
BIIB021, an oral, synthetic non-Ansamycin Hsp90 inhibitor: Phase I experience
-
Elfiky A, Saif MW, Beeram M et al. BIIB021, an oral, synthetic non-Ansamycin Hsp90 inhibitor: Phase I experience. J. Clin. Oncol. 26, 127-129 (2008
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 127-129
-
-
Elfiky, A.1
Saif, M.W.2
Beeram, M.3
-
56
-
-
71549121697
-
A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6 dependent B cell lymphomas
-
Cerchietti LC, Lopes EC, Yang SN et al. A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6 dependent B cell lymphomas. Nat. Med. 15(12), 1369-1376 (2009
-
(2009)
Nat. Med.
, vol.15
, Issue.12
, pp. 1369-1376
-
-
Cerchietti, L.C.1
Lopes, E.C.2
Yang, S.N.3
-
57
-
-
34248166042
-
Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylicpyrazole/isoxazole amide analogues
-
Sharp SY, Prodromou C, Boxall K et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylicpyrazole/isoxazole amide analogues. Mol. Cancer Ther. 6, 1198-1211 (2007
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 1198-1211
-
-
Sharp, S.Y.1
Prodromou, C.2
Boxall, K.3
-
58
-
-
42349084306
-
NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
-
Eccles SA, Massey A, Raynaud FI et al. NVP-AUY922: A novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis. Cancer Res. 68, 2850-2860 (2008
-
(2008)
Cancer Res.
, vol.68
, pp. 2850-2860
-
-
Eccles, S.A.1
Massey, A.2
Raynaud, F.I.3
-
59
-
-
48949119477
-
NVP-AUY922: A small molecule Hsp90 inhibitor with potent antitumor activity in preclinical breast cancer models
-
Jensen MR, Schoepfer J, Radimerski T et al. NVP-AUY922: A small molecule Hsp90 inhibitor with potent antitumor activity in preclinical breast cancer models. Breast Cancer Res. 10(2), R33 (2008
-
(2008)
Breast Cancer Res.
, vol.10
, Issue.2
-
-
Jensen, M.R.1
Schoepfer, J.2
Radimerski, T.3
-
60
-
-
40749103835
-
SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers
-
Chandarlapaty S, Sawai A, Ye Q et al. SNX2112, a synthetic heat shock protein 90 inhibitor, has potent antitumor activity against HER kinase-dependent cancers. Clin. Cancer Res. 14, 240-248 (2008
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 240-248
-
-
Chandarlapaty, S.1
Sawai, A.2
Ye, Q.3
-
61
-
-
79952752856
-
STA-9090, a small-mulecule Hsp90 inhibitor for the potential treatment of cancer
-
Wang Y, Trepel JB, Neckers LM, Giaccone G. STA-9090, a small-mulecule Hsp90 inhibitor for the potential treatment of cancer. Curr. Opin. Investig. Drugs. 11(12), 1466-1476 (2010
-
(2010)
Curr. Opin. Investig. Drugs.
, vol.11
, Issue.12
, pp. 1466-1476
-
-
Wang, Y.1
Trepel, J.B.2
Neckers, L.M.3
Giaccone, G.4
-
62
-
-
79955044159
-
Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling
-
Proia DA, Foley KP, Korbut T et al. Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling. PLoS ONE 6(4), e18552 (2011
-
(2011)
PLoS ONE
, vol.6
, Issue.4
-
-
Proia, D.A.1
Foley, K.P.2
Korbut, T.3
-
63
-
-
84861054767
-
MPC-3100, a fully synthetic, orally bioavailable Hsp90 inhibitor, in cancer patients
-
Presented at: Chicago, IL, USA, 4-8 June
-
Yu MK, Samlowski WE, Baichwal V. MPC-3100, a fully synthetic, orally bioavailable Hsp90 inhibitor, in cancer patients. Presented at: American Society of Clinical Oncology Annual Meeting. Chicago, IL, USA, 4-8 June 2010.
-
(2010)
American Society of Clinical Oncology Annual Meeting
-
-
Yu, M.K.1
Samlowski, W.E.2
Baichwal, V.3
-
65
-
-
0024975155
-
A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
-
Chiang HL, Terlecky SR, Plant CP, Dice JF. A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins. Science 246, 382-385 (1989
-
(1989)
Science
, vol.246
, pp. 382-385
-
-
Chiang, H.L.1
Terlecky, S.R.2
Plant, C.P.3
Dice, J.F.4
-
67
-
-
34547159774
-
Proteome analysis and tissue micro array for profiling protein markers associated with lymph node metastasis in colorectal cancer
-
Pei H, Zhu H, Zeng S, Li Y, Yang H. Proteome analysis and tissue micro array for profiling protein markers associated with lymph node metastasis in colorectal cancer. J. Proteome Res. 6(7), 2495-2501 (2007
-
(2007)
J. Proteome Res.
, vol.6
, Issue.7
, pp. 2495-2501
-
-
Pei, H.1
Zhu, H.2
Zeng, S.3
Li, Y.4
Yang, H.5
-
68
-
-
0028961801
-
Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells
-
Jaattela M. Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells. Int. J. Cancer 60, 689-693 (1995
-
(1995)
Int. J. Cancer
, vol.60
, pp. 689-693
-
-
Jaattela, M.1
-
69
-
-
16644362403
-
Radioresistance is associated to increased Hsp70 content in human glioblastoma cell lines
-
Brondani Da Rocha A, Regner A, Grivicich I et al. Radioresistance is associated to increased Hsp70 content in human glioblastoma cell lines. Int. J. Oncol. 25, 777-785 (2004
-
(2004)
Int. J. Oncol.
, vol.25
, pp. 777-785
-
-
Brondani Da Rocha, A.1
Regner, A.2
Grivicich, I.3
-
70
-
-
10744227948
-
Chemosensitization by a non-Apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant
-
Schmitt E, Parcellier A, Gurbuxani S et al. Chemosensitization by a non-Apoptogenic heat shock protein 70-binding apoptosis-inducing factor mutant. Cancer Res. 63, 8233-8240 (2003
-
(2003)
Cancer Res.
, vol.63
, pp. 8233-8240
-
-
Schmitt, E.1
Parcellier, A.2
Gurbuxani, S.3
-
71
-
-
0032582562
-
Role of Hsp70 in regulation of stress-kinase JNK: Implications in apoptosis and aging
-
Gabai VL, Meriin AB, Yaglom JA, Volloch VZ, Sherman MY. Role of Hsp70 in regulation of stress-kinase JNK: Implications in apoptosis and aging. FEBS Lett. 438, 1-4 (1998
-
(1998)
FEBS Lett.
, vol.438
, pp. 1-4
-
-
Gabai, V.L.1
Meriin, A.B.2
Yaglom, J.A.3
Volloch, V.Z.4
Sherman, M.Y.5
-
72
-
-
70449589907
-
Proteomic profiling of heat shock proteins: An emerging molecular approach with direct pathophysiological and clinical implications
-
Bottoni P, Giardina B, Scatena R. Proteomic profiling of heat shock proteins: An emerging molecular approach with direct pathophysiological and clinical implications. Proteomics Clin Appl. 3, 636-653 (2009
-
(2009)
Proteomics Clin Appl.
, vol.3
, pp. 636-653
-
-
Bottoni, P.1
Giardina, B.2
Scatena, R.3
-
73
-
-
50349096803
-
Dual targeting of HSC70 and Hsp72 inhibits Hsp90 function and induces tumor-specific apoptosis
-
Powers MV, Clarke PA, Workman P. Dual targeting of HSC70 and Hsp72 inhibits Hsp90 function and induces tumor-specific apoptosis. Cancer Cell. 14, 250-262 (2008
-
(2008)
Cancer Cell.
, vol.14
, pp. 250-262
-
-
Powers, M.V.1
Clarke, P.A.2
Workman, P.3
-
74
-
-
61449261930
-
Death by chaperone,Hsp90, Hsp70 or both?
-
Powers MV, Clarke PA, Workman P. Death by chaperone,Hsp90, Hsp70 or both? Cell Cycle 8, 518-526 (2009
-
(2009)
Cell Cycle
, vol.8
, pp. 518-526
-
-
Powers, M.V.1
Clarke, P.A.2
Workman, P.3
-
75
-
-
81555207195
-
Antimyeloma effects of the heat shock protein 70 molecular chaperone inhibitor MAL3-101
-
Braunstein MJ, Scott SS,Scott CM et al.Antimyeloma effects of the heat shock protein 70 molecular chaperone inhibitor MAL3-101. J. Oncol. 201, 232037 (2011
-
(2011)
J. Oncol.
, vol.201
, pp. 232037
-
-
Braunstein, M.J.1
Scott, S.S.2
Scott, C.M.3
-
76
-
-
0043133793
-
Hsp27 is a ubiquitin-binding protein involved in I-kBa proteasomal degradation
-
Parcellier A, Schmitt E, Gurbuxani S et al. Hsp27 is a ubiquitin-binding protein involved in I-kBa proteasomal degradation. Mol. Cell. Biol. 23, 5790-5802 (2003
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5790-5802
-
-
Parcellier, A.1
Schmitt, E.2
Gurbuxani, S.3
-
77
-
-
4644237335
-
Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer
-
Rocchi P, Kojima S, Signaevsky M et al. Heat shock protein 27 increases after androgen ablation and plays a cytoprotective role in hormone-refractory prostate cancer. Cancer Res. 64, 6595-6602 (2004
-
(2004)
Cancer Res.
, vol.64
, pp. 6595-6602
-
-
Rocchi, P.1
Kojima, S.2
Signaevsky, M.3
-
78
-
-
0032404094
-
Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones
-
Garrido C, Fromentin A, Bonnotte B et al. Heat shock protein 27 enhances the tumorigenicity of immunogenic rat colon carcinoma cell clones. Cancer Res. 58, 5495-5499 (1998
-
(1998)
Cancer Res.
, vol.58
, pp. 5495-5499
-
-
Garrido, C.1
Fromentin, A.2
Bonnotte, B.3
-
79
-
-
0031911082
-
Analysis of differential protein expression in normal and neoplastic human breast epithelial cell lines
-
Williams K, Chubb C, Huberman E, Giometti CS. Analysis of differential protein expression in normal and neoplastic human breast epithelial cell lines. Electrophoresis. 19, 333-343 (1998
-
(1998)
Electrophoresis.
, vol.19
, pp. 333-343
-
-
Williams, K.1
Chubb, C.2
Huberman, E.3
Giometti, C.S.4
-
80
-
-
38449118227
-
Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine
-
Mori-Iwamoto S, Kuramitsu Y, Ryozawa S et al. Proteomics finding heat shock protein 27 as a biomarker for resistance of pancreatic cancer cells to gemcitabine. Int. J. Oncol. 31, 1345-1350 (2007
-
(2007)
Int. J. Oncol.
, vol.31
, pp. 1345-1350
-
-
Mori-Iwamoto, S.1
Kuramitsu, Y.2
Ryozawa, S.3
-
81
-
-
34047132772
-
Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells
-
Choi DH, Ha JS, Lee WH et al. Heat shock protein 27 is associated with irinotecan resistance in human colorectal cancer cells. FEBS Lett. 581, 1649-1656 (2007
-
(2007)
FEBS Lett.
, vol.581
, pp. 1649-1656
-
-
Choi, D.H.1
Ha, J.S.2
Lee, W.H.3
-
82
-
-
0032747966
-
Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells
-
Hansen RK, Parra I, Lemieux P, Oesterreich S, Hilsenbeck SG, Fuqua SA. Hsp27 overexpression inhibits doxorubicin-induced apoptosis in human breast cancer cells. Breast Cancer Res. Treat. 56, 187-196 (1999
-
(1999)
Breast Cancer Res. Treat.
, vol.56
, pp. 187-196
-
-
Hansen, R.K.1
Parra, I.2
Lemieux, P.3
Oesterreich, S.4
Hilsenbeck, S.G.5
Fuqua, S.A.6
-
83
-
-
0032555685
-
Repression of heat shock transcription factor HSF1 activation by Hsp90 (Hsp90 complex) that forms a stress-sensitive complex with HSF1
-
Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R. Repression of heat shock transcription factor HSF1 activation by Hsp90 (Hsp90 complex) that forms a stress-sensitive complex with HSF1. Cell 94, 471-480 (1998
-
(1998)
Cell
, vol.94
, pp. 471-480
-
-
Zou, J.1
Guo, Y.2
Guettouche, T.3
Smith, D.F.4
Voellmy, R.5
-
84
-
-
80455131276
-
Mechanisms of resistance to Hsp90 inhibitor drugs: A complex mosaic emerges
-
Piper PW,MillsonSH. Mechanisms of resistance to Hsp90 inhibitor drugs: A complex mosaic emerges. Pharmaceuticals 4, 1400-1422 (2011
-
(2011)
Pharmaceuticals
, vol.4
, pp. 1400-1422
-
-
Piper, P.W.1
Millson, S.H.2
-
85
-
-
77958019101
-
Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma
-
Davenport EL, Zeisig A, Aronson LI et al. Targeting heat shock protein 72 enhances Hsp90 inhibitor-induced apoptosis in myeloma. Leukemia 24, 1804-1807 (2010
-
(2010)
Leukemia
, vol.24
, pp. 1804-1807
-
-
Davenport, E.L.1
Zeisig, A.2
Aronson, L.I.3
-
86
-
-
33747875267
-
Targeting the heat shock factor 1 by RNA interference: A potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer
-
Rossi A, Ciafrè S, Balsamo M, Pierimarchi P, Santoro MG. Targeting the heat shock factor 1 by RNA interference: A potent tool to enhance hyperthermochemotherapy efficacy in cervical cancer. Cancer Res. 66(15), 7678-7685 (2006
-
(2006)
Cancer Res.
, vol.66
, Issue.15
, pp. 7678-7685
-
-
Rossi, A.1
Ciafrè, S.2
Balsamo, M.3
Pierimarchi, P.4
Santoro, M.G.5
-
87
-
-
78649721996
-
Protein kinase A binds and activates heat shock factor 1
-
Murshid A, Chou SD, Prince T, Zhang Y, Bharti A, Calderwood SK. Protein kinase A binds and activates heat shock factor 1. PLoS ONE 5, e13830 (2010
-
(2010)
PLoS ONE
, vol.5
-
-
Murshid, A.1
Chou, S..D.2
Prince, T.3
Zhang, Y.4
Bharti, A.5
Calderwood, S.K.6
-
88
-
-
77954955686
-
Heat shock factors: Integrators of cell stress, development and lifespan
-
Akerfelt M, Morimoto RI, Sistonen L. Heat shock factors: Integrators of cell stress, development and lifespan. Nat. Rev. Mol Cell. Biol. 11, 545-555 (2010
-
(2010)
Nat. Rev. Mol Cell. Biol.
, vol.11
, pp. 545-555
-
-
Akerfelt, M.1
Morimoto, R.I.2
Sistonen, L.3
-
89
-
-
70350568650
-
Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones
-
Kang BH, Altieri DC. Compartmentalized cancer drug discovery targeting mitochondrial Hsp90 chaperones. Oncogene 28, 3681-3688 (2009
-
(2009)
Oncogene
, vol.28
, pp. 3681-3688
-
-
Kang, B.H.1
Altieri, D.C.2
-
90
-
-
65649128567
-
Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90
-
Kang BH, Plescia J, Song HY et al. Combinatorial drug design targeting multiple cancer signaling networks controlled by mitochondrial Hsp90. J. Clin. Invest. 119(3), 454-464 (2009
-
(2009)
J. Clin. Invest.
, vol.119
, Issue.3
, pp. 454-464
-
-
Kang, B.H.1
Plescia, J.2
Song, H.Y.3
-
91
-
-
0141484615
-
A high-Affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
Kamal A, Thao L, Sensintaffar J et al. A high-Affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425, 407-410 (2003
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
-
92
-
-
80051935829
-
The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress
-
Gallo LI, Lagadari M, Piwien-Pilipuk G, Galigniana MD. The 90-kDa heat-shock protein (Hsp90)-binding immunophilin FKBP51 is a mitochondrial protein that translocates to the nucleus to protect cells against oxidative stress. J. Biol. Chem. 286(34), 30152-30160 (2011
-
(2011)
J. Biol. Chem.
, vol.286
, Issue.34
, pp. 30152-30160
-
-
Gallo, L.I.1
Lagadari, M.2
Piwien-Pilipuk, G.3
Galigniana, M.D.4
-
93
-
-
33845913216
-
Intracellular and extracellular functions of heat shock proteins: Repercussions in cancer therapy
-
Schmitt E, Gehrmann M, Brunet M, Multhoff G, Garrido C. Intracellular and extracellular functions of heat shock proteins: Repercussions in cancer therapy. J. Leukoc. Biol. 81, 15-27 (2007
-
(2007)
J. Leukoc. Biol.
, vol.81
, pp. 15-27
-
-
Schmitt, E.1
Gehrmann, M.2
Brunet, M.3
Multhoff, G.4
Garrido, C.5
-
94
-
-
10744233222
-
Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer
-
Mazzaferro V, Coppa J, Carrabba MG et al. Vaccination with autologous tumor-derived heat-shock protein gp96 after liver resection for metastatic colorectal cancer. Clin. Cancer Res. 9, 3235-3245 (2003
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3235-3245
-
-
Mazzaferro, V.1
Coppa, J.2
Carrabba, M.G.3
-
95
-
-
12144290005
-
Heat shock proteins: Biological functions and clinical application as personalized vaccines for human cancer
-
Castelli C, Rivoltini L, Rini F et al. Heat shock proteins: Biological functions and clinical application as personalized vaccines for human cancer. Cancer Immunol. Immunother. 53, 227-233 (2004).
-
(2004)
Cancer Immunol. Immunother.
, vol.53
, pp. 227-233
-
-
Castelli, C.1
Rivoltini, L.2
Rini, F.3
|