-
1
-
-
34250561475
-
A new puffing pattern induced by temperature shock and DNP in Drosophila
-
Ritossa F: A new puffing pattern induced by temperature shock and DNP in Drosophila. Cell Mol Life Sci 18: 571-573, 1962.
-
(1962)
Cell Mol Life Sci
, vol.18
, pp. 571-573
-
-
Ritossa, F.1
-
2
-
-
0016373748
-
Protein synthesis in salivary glands of Drosophila melanogaster: Relation to chromosome puffs
-
Tissieres A, Mitchell HK and Tracy UM: Protein synthesis in salivary glands of Drosophila melanogaster: relation to chromosome puffs. J Mol Biol 84: 389-398, 1974.
-
(1974)
J Mol Biol
, vol.84
, pp. 389-398
-
-
Tissieres, A.1
Mitchell, H.K.2
Tracy, U.M.3
-
4
-
-
7744230895
-
Global transcriptome analysis of the heat shock response of Shewanella oneidensis
-
Gao H, Wang Y, Liu X, Yan T, Wu L, Alm E, Arkin A, Thompson D and Zhou J: Global transcriptome analysis of the heat shock response of Shewanella oneidensis. J Bacteriol 186: 7796-7803, 2004.
-
(2004)
J Bacteriol
, vol.186
, pp. 7796-7803
-
-
Gao, H.1
Wang, Y.2
Liu, X.3
Yan, T.4
Wu, L.5
Alm, E.6
Arkin, A.7
Thompson, D.8
Zhou, J.9
-
5
-
-
33751203833
-
Heat shock proteins 27 and 70: Anti-apoptotic proteins with tumorigenic properties
-
Garrido C, Brunet M, Didelot C, Zermati Y, Schmitt E and Kroemer G: Heat shock proteins 27 and 70: anti-apoptotic proteins with tumorigenic properties. Cell Cycle 5: 2592-2601, 2006.
-
(2006)
Cell Cycle
, vol.5
, pp. 2592-2601
-
-
Garrido, C.1
Brunet, M.2
Didelot, C.3
Zermati, Y.4
Schmitt, E.5
Kroemer, G.6
-
6
-
-
0042235547
-
Heat shock proteins as regulators of the immune response
-
Pockley AG: Heat shock proteins as regulators of the immune response. Lancet 362: 469-476, 2003.
-
(2003)
Lancet
, vol.362
, pp. 469-476
-
-
Pockley, A.G.1
-
7
-
-
33646004634
-
Feedback regulation of the heat shock response
-
Voellmy R: Feedback regulation of the heat shock response. Handb Exp Pharmacol 172: 43-68, 2006.
-
(2006)
Handb Exp Pharmacol
, vol.172
, pp. 43-68
-
-
Voellmy, R.1
-
8
-
-
0029992278
-
Molecular chaperones in cellular protein folding
-
Hartl FU: Molecular chaperones in cellular protein folding. Nature 381: 571-579, 1996.
-
(1996)
Nature
, vol.381
, pp. 571-579
-
-
Hartl, F.U.1
-
9
-
-
0030907672
-
Proteins, RNAs and chaperones in enzyme evolution: A folding perspective
-
Csermely P: Proteins, RNAs and chaperones in enzyme evolution: a folding perspective. Trends Biochem Sci 22: 147-149, 1997.
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 147-149
-
-
Csermely, P.1
-
10
-
-
0036883535
-
Chaperones and aging: Role in neurodegeneration and in other civilizational diseases
-
Soti C and Csermely P: Chaperones and aging: role in neurodegeneration and in other civilizational diseases. Neurochem Int 41: 383-389, 2002.
-
(2002)
Neurochem Int
, vol.41
, pp. 383-389
-
-
Soti, C.1
Csermely, P.2
-
11
-
-
34447507818
-
Inhibitors of the heat shock response: Biology and pharmacology
-
Powers MV and Workman P: Inhibitors of the heat shock response: biology and pharmacology. FEBS Lett 581: 3758-3769, 2007.
-
(2007)
FEBS Lett
, vol.581
, pp. 3758-3769
-
-
Powers, M.V.1
Workman, P.2
-
12
-
-
0142186172
-
Aging and molecular chaperones
-
Soti C and Csermely P: Aging and molecular chaperones. Exp Gerontol 38: 1037-1040, 2003.
-
(2003)
Exp Gerontol
, vol.38
, pp. 1037-1040
-
-
Soti, C.1
Csermely, P.2
-
13
-
-
0032489016
-
The Hsp70 and Hsp60 chaperone machines
-
Bukau B and Horwich AL: The Hsp70 and Hsp60 chaperone machines. Cell 92: 351-366, 1998.
-
(1998)
Cell
, vol.92
, pp. 351-366
-
-
Bukau, B.1
Horwich, A.L.2
-
14
-
-
25844519550
-
HSP90 and the chaperoning of cancer
-
Whitesell L and Lindquist SL: HSP90 and the chaperoning of cancer. Nat Rev Cancer 5: 761-772, 2005.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 761-772
-
-
Whitesell, L.1
Lindquist, S.L.2
-
15
-
-
1642471825
-
Heat-shock proteins as regulators of apoptosis
-
Takayama S, Reed JC and Homma S: Heat-shock proteins as regulators of apoptosis. Oncogene 22: 9041-9047, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 9041-9047
-
-
Takayama, S.1
Reed, J.C.2
Homma, S.3
-
16
-
-
34248187981
-
Heat shock protein 90: The cancer chaperone
-
Neckers L: Heat shock protein 90: the cancer chaperone. J Biosci 32: 517-530, 2007.
-
(2007)
J Biosci
, vol.32
, pp. 517-530
-
-
Neckers, L.1
-
17
-
-
0027251913
-
Correlation of the survival of ovarian cancer patients with mRNA expression of the 60-kD heat-shock protein HSP-60
-
Kimura E, Enns RE, Alcaraz JE, Arboleda J, Slamon DJ and Howell SB: Correlation of the survival of ovarian cancer patients with mRNA expression of the 60-kD heat-shock protein HSP-60. J Clin Oncol 11: 891-898, 1993.
-
(1993)
J Clin Oncol
, vol.11
, pp. 891-898
-
-
Kimura, E.1
Enns, R.E.2
Alcaraz, J.E.3
Arboleda, J.4
Slamon, D.J.5
Howell, S.B.6
-
18
-
-
0027503365
-
Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: Prognostic implications
-
Ciocca DR, Clark GM, Tandon AK, Fuqua SA, Welch WJ and McGuire WL: Heat shock protein hsp70 in patients with axillary lymph node-negative breast cancer: prognostic implications. J Nad Cancer Inst 85: 570-574, 1993.
-
(1993)
J Nad Cancer Inst
, vol.85
, pp. 570-574
-
-
Ciocca, D.R.1
Clark, G.M.2
Tandon, A.K.3
Fuqua, S.A.4
Welch, W.J.5
McGuire, W.L.6
-
19
-
-
0028970484
-
Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix
-
Ralhan R and Kaur J: Differential expression of Mr 70,000 heat shock protein in normal, premalignant, and malignant human uterine cervix. Clin Cancer Res 1: 1217-1222, 1995.
-
(1995)
Clin Cancer Res
, vol.1
, pp. 1217-1222
-
-
Ralhan, R.1
Kaur, J.2
-
20
-
-
0029011834
-
Analysis of heat-shock protein expression in myeloid leukaemia cells by flow cytometry
-
Chant ID, Rose PE and Morris AG: Analysis of heat-shock protein expression in myeloid leukaemia cells by flow cytometry. Br J Haematol 90: 163-168, 1995.
-
(1995)
Br J Haematol
, vol.90
, pp. 163-168
-
-
Chant, I.D.1
Rose, P.E.2
Morris, A.G.3
-
21
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D and Weinberg RA: The hallmarks of cancer. Cell 100: 57-70, 2000.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
24
-
-
15744402283
-
Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ cells sensitive and resistant to STI571 (imatinib mesylate) in association with downregulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change
-
Rahmani M, Reese E, Dai Y, Bauer C, Kramer LB, Huang M, Jove R, Dent P and Grant S: Cotreatment with suberanoylanilide hydroxamic acid and 17-allylamino 17-demethoxygeldanamycin synergistically induces apoptosis in Bcr-Abl+ cells sensitive and resistant to STI571 (imatinib mesylate) in association with downregulation of Bcr-Abl, abrogation of signal transducer and activator of transcription 5 activity, and Bax conformational change. Mol Pharmacol 67: 1166-1176, 2005.
-
(2005)
Mol Pharmacol
, vol.67
, pp. 1166-1176
-
-
Rahmani, M.1
Reese, E.2
Dai, Y.3
Bauer, C.4
Kramer, L.B.5
Huang, M.6
Jove, R.7
Dent, P.8
Grant, S.9
-
26
-
-
0022637380
-
Specific interaction between the p53 cellular tumour antigen and major heat shock proteins
-
Pinhasi-Kimhi O, Michalovitz D, Ben-Zeev A and Oren M: Specific interaction between the p53 cellular tumour antigen and major heat shock proteins. Nature 320: 182-184, 1986.
-
(1986)
Nature
, vol.320
, pp. 182-184
-
-
Pinhasi-Kimhi, O.1
Michalovitz, D.2
Ben-Zeev, A.3
Oren, M.4
-
27
-
-
0025894713
-
-
Hollstein M, Sidransky D. Vogelstein B and Harris CC: p53 mutations in human cancers. Science 253: 49-53, 1991.
-
Hollstein M, Sidransky D. Vogelstein B and Harris CC: p53 mutations in human cancers. Science 253: 49-53, 1991.
-
-
-
-
28
-
-
1542718628
-
Heat shock proteins in the regulation of apoptosis: New strategies in tumor therapy: a comprehensive review
-
Sreedhar AS and Csermely P: Heat shock proteins in the regulation of apoptosis: new strategies in tumor therapy: a comprehensive review. Pharmacol Ther 101: 227-257, 2004.
-
(2004)
Pharmacol Ther
, vol.101
, pp. 227-257
-
-
Sreedhar, A.S.1
Csermely, P.2
-
29
-
-
0141805544
-
Stressed to death: Regulation of apoptotic signaling pathways by the heat shock proteins
-
Beere HM: Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins. Sci STKE 9: RE1, 2001.
-
(2001)
Sci STKE
, vol.9
-
-
Beere, H.M.1
-
30
-
-
1142273472
-
Altered states: Selectively drugging the Hsp90 cancer chaperone
-
Workman P: Altered states: selectively drugging the Hsp90 cancer chaperone. Trends Mol Med 10: 47-51, 2004.
-
(2004)
Trends Mol Med
, vol.10
, pp. 47-51
-
-
Workman, P.1
-
31
-
-
0036666032
-
An Hsp70 family chaperone, mortalin/ mthsp70/PBP74/Grp75: What, when, and where?
-
Wadhwa R, Taira K and Kaul SC: An Hsp70 family chaperone, mortalin/ mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones 7: 309-316, 2002.
-
(2002)
Cell Stress Chaperones
, vol.7
, pp. 309-316
-
-
Wadhwa, R.1
Taira, K.2
Kaul, S.C.3
-
32
-
-
1842691021
-
PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation
-
Zhou J, Schmid T, Frank R and Brune B: PI3K/Akt is required for heat shock proteins to protect hypoxia-inducible factor 1alpha from pVHL-independent degradation. J Biol Chem 279: 13506-13513, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 13506-13513
-
-
Zhou, J.1
Schmid, T.2
Frank, R.3
Brune, B.4
-
33
-
-
10644261537
-
Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase
-
Sun J and Liao JK: Induction of angiogenesis by heat shock protein 90 mediated by protein kinase Akt and endothelial nitric oxide synthase. Arterioscler Thromb Vasc Biol 24: 2238-2244, 2004.
-
(2004)
Arterioscler Thromb Vasc Biol
, vol.24
, pp. 2238-2244
-
-
Sun, J.1
Liao, J.K.2
-
34
-
-
21744445069
-
Heat shock proteins in cancer: Diagnostic, prognostic, predictive, and treatment implications
-
Ciocca DR and Calderwood SK: Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones 10: 86-103, 2005.
-
(2005)
Cell Stress Chaperones
, vol.10
, pp. 86-103
-
-
Ciocca, D.R.1
Calderwood, S.K.2
-
35
-
-
11344280957
-
Extracellular roles for the molecular chaperone, hsp9O
-
Eustace BK and Jay DG: Extracellular roles for the molecular chaperone, hsp9O. Cell Cycle 3: 1098-1100, 2004.
-
(2004)
Cell Cycle
, vol.3
, pp. 1098-1100
-
-
Eustace, B.K.1
Jay, D.G.2
-
37
-
-
0034715919
-
Shape-dependent control of cell growth, differentiation, and apoptosis: Switching between attractors in cell regulatory networks
-
Huang S and Ingber DE: Shape-dependent control of cell growth, differentiation, and apoptosis: switching between attractors in cell regulatory networks. Exp Cell Res 261: 91-103, 2000.
-
(2000)
Exp Cell Res
, vol.261
, pp. 91-103
-
-
Huang, S.1
Ingber, D.E.2
-
38
-
-
0033520946
-
Mammalian HSP60 is a major target for an immunosuppressant mizoribine
-
Itoh H, Komatsuda A, Wakui H, Miura AB and Tashima. Y: Mammalian HSP60 is a major target for an immunosuppressant mizoribine. J Biol Chem 274: 35147-35151, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 35147-35151
-
-
Itoh, H.1
Komatsuda, A.2
Wakui, H.3
Miura, A.B.4
Tashima, Y.5
-
39
-
-
0026526303
-
Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins
-
Nadler SG, Tepper MA, Schacter B and Mazzucco CE: Interaction of the immunosuppressant deoxyspergualin with a member of the Hsp70 family of heat shock proteins. Science 258: 484-486, 1992.
-
(1992)
Science
, vol.258
, pp. 484-486
-
-
Nadler, S.G.1
Tepper, M.A.2
Schacter, B.3
Mazzucco, C.E.4
-
40
-
-
0034671731
-
Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function
-
Wadhwa R, Sugihara T, Yoshida A, Nomura H, Reddel RR, Simpson R, Maruta H and Kaul SC: Selective toxicity of MKT-077 to cancer cells is mediated by its binding to the hsp70 family protein mot-2 and reactivation of p53 function. Cancer Res 60: 6818-6821, 2000.
-
(2000)
Cancer Res
, vol.60
, pp. 6818-6821
-
-
Wadhwa, R.1
Sugihara, T.2
Yoshida, A.3
Nomura, H.4
Reddel, R.R.5
Simpson, R.6
Maruta, H.7
Kaul, S.C.8
-
41
-
-
33749507014
-
Effectiveness of hsp90 inhibitors as anti-cancer drugs
-
Xiao L, Lu X and Ruden DM: Effectiveness of hsp90 inhibitors as anti-cancer drugs. Mini Rev Med Chem 6: 1137-1143, 2006.
-
(2006)
Mini Rev Med Chem
, vol.6
, pp. 1137-1143
-
-
Xiao, L.1
Lu, X.2
Ruden, D.M.3
-
42
-
-
1842713109
-
Enhancement of complement-induced cell lysis: A novel mechanism for the anticancer effects of Hsp90 inhibitors
-
Sreedhar AS, Nardai G and Csermely P: Enhancement of complement-induced cell lysis: a novel mechanism for the anticancer effects of Hsp90 inhibitors. Immunol Lett 92: 157-161, 2004.
-
(2004)
Immunol Lett
, vol.92
, pp. 157-161
-
-
Sreedhar, A.S.1
Nardai, G.2
Csermely, P.3
-
43
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell L, Minmaugh EG, De CB, Myers CE and Neckers LM: Inhibition of heat shock protein HSP90-pp60v-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc Natl Acad Sci USA 91: 8324-8318, 1994.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 8324-8318
-
-
Whitesell, L.1
Minmaugh2
EG, D.C.3
Myers, C.E.4
Neckers, L.M.5
-
46
-
-
0031875042
-
The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin
-
Schulte TW and Neckers LM: The benzoquinone ansamycin 17-allylamino-17-demethoxygeldanamycin binds to HSP90 and shares important biologic activities with geldanamycin. Cancer Chemother Pharmacol 42: 273-279, 1998.
-
(1998)
Cancer Chemother Pharmacol
, vol.42
, pp. 273-279
-
-
Schulte, T.W.1
Neckers, L.M.2
-
47
-
-
0141484615
-
A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
-
Kamal A, Thao L, Sensintaffar J, Zhang L, Boehm MF, Fritz LC and Burrows FJ: A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425: 407-410, 2003.
-
(2003)
Nature
, vol.425
, pp. 407-410
-
-
Kamal, A.1
Thao, L.2
Sensintaffar, J.3
Zhang, L.4
Boehm, M.F.5
Fritz, L.C.6
Burrows, F.J.7
-
48
-
-
0036606332
-
Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′-kinase-AKT-dependent pathway
-
Munster PN, Marchion DC, Basso AD and Rosen N: Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3′-kinase-AKT-dependent pathway. Cancer Res 62: 3132-3137, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 3132-3137
-
-
Munster, P.N.1
Marchion, D.C.2
Basso, A.D.3
Rosen, N.4
-
49
-
-
0142027766
-
Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/ neu-dependent breast tumors
-
De Candia P, Solit DB, Giri D, Brogi E, Siegel PM, Olshen AB, Muller WJ, Rosen N and Benezra R: Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/ neu-dependent breast tumors. Proc Nad Acad Sci USA 100: 12337-12342, 2003.
-
(2003)
Proc Nad Acad Sci USA
, vol.100
, pp. 12337-12342
-
-
De Candia, P.1
Solit, D.B.2
Giri, D.3
Brogi, E.4
Siegel, P.M.5
Olshen, A.B.6
Muller, W.J.7
Rosen, N.8
Benezra, R.9
-
50
-
-
33746417580
-
Hsp90: A novel target for cancer therapy
-
Solit DB and Rosen N: Hsp90: a novel target for cancer therapy. Curr Top Med Chem 6: 1205-1214, 2006.
-
(2006)
Curr Top Med Chem
, vol.6
, pp. 1205-1214
-
-
Solit, D.B.1
Rosen, N.2
-
51
-
-
0037075232
-
Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2
-
Basso AD, Solit DB, Munster PN and Rosen N: Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2. Oncogene 21: 1159-1166, 2002.
-
(2002)
Oncogene
, vol.21
, pp. 1159-1166
-
-
Basso, A.D.1
Solit, D.B.2
Munster, P.N.3
Rosen, N.4
-
52
-
-
0036219609
-
Hsp90 inhibitors as novel cancer chemotherapeutic agents
-
Neck-ers L: Hsp90 inhibitors as novel cancer chemotherapeutic agents. Trends Mol Med 8: S55-S61, 2002.
-
(2002)
Trends Mol Med
, vol.8
-
-
Neck-ers, L.1
-
53
-
-
27744517366
-
Heat shock proteins as emerging therapeutic targets
-
Soti C, Nagy E, Giricz Z, Vigh L, Csermely P and Ferdinandy P: Heat shock proteins as emerging therapeutic targets. Br J Pharmacol 146: 769-780, 2005.
-
(2005)
Br J Pharmacol
, vol.146
, pp. 769-780
-
-
Soti, C.1
Nagy, E.2
Giricz, Z.3
Vigh, L.4
Csermely, P.5
Ferdinandy, P.6
-
54
-
-
0034771555
-
The Hsp90 inhibitor geldanamycin selectively sensitizes BcrAbl-expressing leukemia cells to cytotoxic chemotherapy
-
Blagosklonny MV, Fojo T, Bhalla KN, Kim JS, Trepel JB, Figg WD, Rivera Y and Neckers LM: The Hsp90 inhibitor geldanamycin selectively sensitizes BcrAbl-expressing leukemia cells to cytotoxic chemotherapy. Leukemia 15: 1537-1543, 2001.
-
(2001)
Leukemia
, vol.15
, pp. 1537-1543
-
-
Blagosklonny, M.V.1
Fojo, T.2
Bhalla, K.N.3
Kim, J.S.4
Trepel, J.B.5
Figg, W.D.6
Rivera, Y.7
Neckers, L.M.8
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