Lipid alterations in human colon epithelial cells induced to differentiation and/or apoptosis by butyrate and polyunsaturated fatty acids

Journal of Nutritional Biochemistry

Volumn 23, Issue 6, 2012, Pages 539-548

  Hofmanová, Jiřina ^a   Ciganek, Miroslav ^b   Slavík, Josef ^b   Kozubík, Alois ^a   Stixová, Lenka ^a   Vaculová, Alena ^a   Dušek, Ladislav ^c   Machala, Miroslav ^b  

^a INSTITUTE OF BIOPHYSICS   (Czech Republic)

^b VETERINARY RESEARCH INSTITUTE   (Czech Republic)

^c MASARYK UNIVERSITY   (Czech Republic)

Author keywords

Apoptosis; Butyrate; Colon cancer; Differentiation; Lipid analyses; Polyunsaturated fatty acids

Indexed keywords

ARACHIDONIC ACID; BUTYRIC ACID; DOCOSAHEXAENOIC ACID; LIPID; PHOSPHOLIPID; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DIET SUPPLEMENTATION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; LIPID COMPOSITION; LIPID STORAGE; MITOCHONDRIAL MEMBRANE POTENTIAL;

APOPTOSIS; ARACHIDONIC ACID; BUTYRATES; CELL DIFFERENTIATION; CHROMATOGRAPHY, LIQUID; COLON; DOCOSAHEXAENOIC ACIDS; EPITHELIAL CELLS; HCT116 CELLS; HUMANS; PHOSPHOLIPIDS; REACTIVE OXYGEN SPECIES; TANDEM MASS SPECTROMETRY; TRIGLYCERIDES;

EID: 84860881089     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2011.02.010     Document Type: Article

References (41)

1. Augenlicht L.H., Heerdt B.G., Mariadason J.M., Yang W., Wilson A.J., Fragale A., et al. Environment-gene interactions in intestinal cancer. Eur J Cancer Prev 2002, 11(Suppl 2):S12-S17.
2. Calder P.C. Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases. Mol Nutr Food Res 2008, 52:885-897.
3. Reddy B.S. Omega-3 fatty acids in colorectal cancer prevention. Int J Cancer 2004, 112:1-7.
4. Arterburn L.M., Hall E.B., Oken H. Distribution, interconversion, and dose response of n-3 fatty acids in humans. Am J Clin Nutr 2006, 83:1467S-1476S.
5. Stillwell W., Shaikh S.R., Zerouga M., Siddiqui R., Wassall S.R. Docosahexaenoic acid affects cell signaling by altering lipid rafts. Reprod Nutr Dev 2005, 45:559-579.
6. Calviello G., Serini S., Piccioni E. n-3 polyunsaturated fatty acids and the prevention of colorectal cancer: molecular mechanisms involved. Curr Med Chem 2007, 14:3059-3069.
7. Hennig B., Lei W., Arzuaga X., Ghosh D.D., Saraswathi V., Toborek M. Linoleic acid induces proinflammatory events in vascular endothelial cells via activation of PI3K/Akt and ERK1/2 signaling. J Nutr Biochem 2006, 17:766-772.
8. Calviello G., Palozza P., Maggiano N., Piccioni E., Franceschelli P., Frattucci A., et al. Cell proliferation, differentiation, and apoptosis are modified by n-3 polyunsaturated fatty acids in normal colonic mucosa. Lipids 1999, 34:599-604.
9. Hofmanová J., Vaculová A., Kozubík A. Polyunsaturated fatty acids sensitize human colon adenocarcinoma HT-29 cells to death receptor-mediated apoptosis. Cancer Lett 2005, 218:33-41.
10. Lupton J.R. Microbial degradation products influence colon cancer risk: the butyrate controversy. J Nutr 2004, 134:479-482.
11. Chapkin R.S., Seo J., McMurray D.N., Lupton J.R. Mechanisms by which docosahexaenoic acid and related fatty acids reduce colon cancer risk and inflammatory disorders of the intestine. Chem Phys Lipids 2008, 153:14-23.
12. Hofmanová J., Vaculová A., Lojek A., Kozubík A. Interaction of polyunsaturated fatty acids and sodium butyrate during apoptosis in HT-29 human colon adenocarcinoma cells. Eur J Nutr 2005, 44:40-51.
13. Hofmanová J., Vaculová A., Koubková Z., Hyžd'alová M., Kozubík A. Human fetal colon cells and colon cancer cells respond differently to butyrate and PUFAs. Mol Nutr Food Res 2009, 53(Suppl 1):S102-S113.
14. Seidner D.L., Lashner B.A., Brzezinski A., Banks P.L., Goldblum J., Fiocchi C., et al. An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial. Clin Gastroenterol Hepatol 2005, 3:358-369.
15. Dobrzynska I., Szachowicz-Petelska B., Sulkowski S., Figaszewski Z. Changes in electric charge and phospholipids composition in human colorectal cancer cells. Mol Cell Biochem 2005, 276:113-119.
16. Bligh E.G., Dyer W.J. A rapid method of total lipid extraction and purification. Can J Biochem Physiol 1959, 37:911-917.
17. Kang J.X., Wang J. A simplified method for analysis of polyunsaturated fatty acids. BMC Biochem 2005, 6:5-8.
18. Bodennec J., Koul O., Aguado I., Brichon G., Zwingelstein G., Portoukalian J. A procedure for fractionation of sphingolipid classes by solid-phase extraction on aminopropyl cartridges. J Lipid Res 2000, 41:1524-1531.
19. Taguchi R., Houjou T., Nakanishi H., Yamazaki T., Ishida M., Imagawa M., et al. Focused lipidomics by tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2005, 823:26-36.
20. Stillwell W., Wassall S.R., Dumaual A.C., Ehringer W.D., Browning C.W., Jenski L.J. Use of merocyanine (MC540) in quantifying lipid domains and packing in phospholipid vesicles and tumor cells. Biochim Biophys Acta 1993, 1146:136-144.
21. Hyžďalová M., Hofmanová J., Pacherník J., Vaculová A., Kozubík A. The interaction of butyrate with TNF-alpha during differentiation and apoptosis of colon epithelial cells: role of NF-kappaB activation. Cytokine 2008, 44:33-43.
22. Sprecher H. Metabolism of highly unsaturated n-3 and n-6 fatty acids. Biochim Biophys Acta 2000, 1486:219-231.
23. Kaur J., Sanyal S.N. Alterations in membrane fluidity and dynamics in experimental colon cancer and its chemoprevention by diclofenac. Mol Cell Biochem 2010, 341:99-108.
24. Schonberg S.A., Lundemo A.G., Fladvad T., Holmgren K., Bremseth H., Nilsen A., et al. Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1. FEBS J 2006, 273:2749-2765.
25. Habermann N., Christian B., Luckas B., Pool-Zobel B.L., Lund E.K., Glei M. Effects of fatty acids on metabolism and cell growth of human colon cell lines of different transformation state. Biofactors 2009, 35:460-467.
26. Kim W., McMurray D.N., Chapkin R.S. n-3 polyunsaturated fatty acids-physiological relevance of dose. Prostaglandins Leukot Essent Fatty Acids 2010, 82:155-158.
27. Rusca A., Di Stefano A.F., Doig M.V., Scarsi C., Perucca E. Relative bioavailability and pharmacokinetics of two oral formulations of docosahexaenoic acid/eicosapentaenoic acid after multiple-dose administration in healthy volunteers. Eur J Clin Pharmacol 2009, 65:503-510.
28. Senkal M., Haaker R., Linseisen J., Wolfram G., Homann H.H., Stehle P. Preoperative oral supplementation with long-chain omega-3 fatty acids beneficially alters phospholipid fatty acid patterns in liver, gut mucosa, and tumor tissue. JPEM J Parenter Enteral Nutr 2005, 29:236-240.
29. Zambell K.L., Fitch M.D., Fleming S.E. Acetate and butyrate are the major substrates for de novo lipogenesis in rat colonic epithelial cells. J Nutr 2003, 133:3509-3515.
30. Marcil V., Delvin E., Seidman E., Poitras L., Zoltowska M., Garofalo C., et al. Modulation of lipid synthesis, apolipoprotein biogenesis, and lipoprotein assembly by butyrate. Am J Physiol Gastrointest Liver Physiol 2002, 283:G340-G346.
31. Mariadason J.M., Arango D., Corner G.A., Aranes M.J., Hotchkiss K.A., Yang W., et al. A gene expression profile that defines colon cell maturation in vitro. Cancer Res 2002, 62:4791-4804.
32. Visca P., Alo P.L., Del Nonno F., Botti C., Trombetta G., Marandino F., et al. Immunohistochemical expression of fatty acid synthase, apoptotic-regulating genes, proliferating factors, and ras protein product in colorectal adenomas, carcinomas, and adjacent nonneoplastic mucosa. Clin Cancer Res 1999, 5:4111-4118.
33. Menendez J.A., Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer 2007, 7:763-777.
34. Gaposchkin D.P., Zoeller R.A., Broitman S.A. Incorporation of polyunsaturated fatty acids into CT-26, a transplantable murine colonic adenocarcinoma. Lipids 2000, 35:181-186.
35. Accioly M.T., Pacheco P., Maya-Monteiro C.M., Carrossini N., Robbs B.K., Oliveira S.S., et al. Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Cancer Res 2008, 68:1732-1740.
36. Hong M.Y., Chapkin R.S., Barhoumi R., Burghardt R.C., Turner N.D., Henderson C.E., et al. Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes. Carcinogenesis 2002, 23:1919-1925.
37. Ng Y., Barhoumi R., Tjalkens R.B., Fan Y.Y., Kolar S., Wang N., et al. The role of docosahexaenoic acid in mediating mitochondrial membrane lipid oxidation and apoptosis in colonocytes. Carcinogenesis 2005, 26:1914-1921.
38. Wassall S.R., Brzustowicz M.R., Shaikh S.R., Cherezov V., Caffrey M., Stillwell W. Order from disorder, corralling cholesterol with chaotic lipids. The role of polyunsaturated lipids in membrane raft formation. Chem Phys Lipids 2004, 132:79-88.
39. Rebillard A., Tekpli X., Meurette O., Sergent O., LeMoigne-Muller G., Vernhet L., et al. Cisplatin-induced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells. Cancer Res 2007, 67:7865-7874.
40. Courtney E.D., Matthews S., Finlayson C., Di Pierro D., Belluzzi A., Roda E., et al. Eicosapentaenoic acid (EPA) reduces crypt cell proliferation and increases apoptosis in normal colonic mucosa in subjects with a history of colorectal adenomas. Int J Colorectal Dis 2007, 22:765-776.
41. Pot G.K., Geelen A., van Heijningen E.M., Siezen C.L., van Kranen H.J., Kampman E. Opposing associations of serum n-3 and n-6 polyunsaturated fatty acids with colorectal adenoma risk: an endoscopy-based case-control study. Int J Cancer 2008, 123:1974-1977.