100 genes for IBD... Whatever next!?

Inflammatory Bowel Disease Monitor

Volumn 11, Issue 3, 2011, Pages 103-111

  Lee, James C ^a,b   Parkes, Miles ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR6; INDUCIBLE T CELL COSTIMULATOR LIGAND; INTERLEUKIN 23; INTERLEUKIN 23 RECEPTOR; JANUS KINASE 2; STAT3 PROTEIN;

CROHN DISEASE; DISEASE COURSE; ENTERITIS; ENVIRONMENTAL EXPOSURE; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE FREQUENCY; GENE FUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HERITABILITY; HUMAN; NONHUMAN; PATHOGENESIS; POSTTRANSCRIPTIONAL GENE SILENCING; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; ULCERATIVE COLITIS;

EID: 84860845743     PISSN: 14667401     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (29)

1. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
2. Duerr RH, Taylor KD, Brant SR et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006;314:1461-3. (Pubitemid 44871953)
3. Libioulle C, Louis E, Hansoul S et al. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4. PLoS Genet 2007;3:e58.
4. Barrett JC, Lee JC, Lees CW et al. Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region. Nat Genet 2009;41:1330-4.
5. Franke A, Balschun T, Karlsen TH et al. Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility. Nat Genet 2008;40:1319-23.
6. Silverberg MS, Cho JH, Rioux JD et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet 2009;41:216-20.
7. McGovern DP, Gardet A, Torkvist L et al. Genome-wide association identifies multiple ulcerative colitis susceptibility loci. Nat Genet 2010;42:332-7.
8. Imielinski M, Baldassano RN, Griffiths A et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet 2009;41:1335-40.
9. Barrett JC, Hansoul S, Nicolae DL et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008;40:955-62.
10. Franke A, McGovern DP, Barrett JC et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci. Nat Genet 2010;42:1118-25.
11. Anderson CA, Boucher G, Lees CW et al. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. Nat Genet 2011; [Epub ahead of print].
12. Wang K, Zhang H, Kugathasan S et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet 2009;84:399-405.
13. Y u R, Gallagher G. The Crohn's disease protective SNP rs11209026 allele "A"mediates alternative splicing in human IL23R transcription. Gastroenterology 2010;138(5 Suppl. 1):S-52-S-3.
14. Nejentsev S, Walker N, Riches D et al. Rare variants of IFIH1, a gene implicated in antiviral responses, protect against type 1 diabetes. Science 2009;324:387-9.
15. McCarroll SA, Huett A, Kuballa P et al. Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet 2008;40:1107-12.
16. Lyons PA, McKinney EF, Rayner TF et al. Novel expression signatures identified by transcriptional analysis of separated leucocyte subsets in systemic lupus erythematosus and vasculitis. Ann Rheum Dis 2010;69:1208-13.
17. Kaser A, Lee AH, Franke A et al. XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 2008;134:743-56.
18. Dendrou CA, Plagnol V, Fung E et al. Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource. Nat Genet 2009;41:1011-5.
19. Massey DC, Bredin F, Parkes M. Use of sirolimus (rapamycin) to treat refractory Crohn's disease. Gut 2008;57:1294-6.
20. Sandborn WJ, Feagan BG, Fedorak RN et al. A randomized trial of ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology 2008;135:1130-41.
21. Frank DN, St Amand AL, Feldman RA et al. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A 2007;104:13780-5. (Pubitemid 350003397)
22. Sartor RB. Microbial influences in inflammatory bowel diseases. Gastroenterology 2008;134:577-94. (Pubitemid 351173057)
23. Willing B, Halfvarson J, Dicksved J et al. Twin studies reveal specific imbalances in the mucosa-associated microbiota of patients with ileal Crohn's disease. Inflamm Bowel Dis 2009;15:653-60.
24. Lapaquette P, Glasser AL, Huett A et al. Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol 2010;12:99-113.
25. Cadwell K, Patel KK, Maloney NS et al. Virus-plus-susceptibility gene interaction determines Crohn's disease gene Atg16L1 phenotypes in intestine. Cell 2010;141:1135-45.
26. Ivanov II, Atarashi K, Manel N et al. Induction of intestinal Th17 cells by segmented filamentous bacteria. Cell 2009;139:485-98.
27. Salzman NH, Hung K, Haribhai D et al. Enteric defensins are essential regulators of intestinal microbial ecology. Nat Immunol 2010;11:76-83.
28. Veldhoen M, Hirota K, Westendorf AM et al. The aryl hydrocarbon receptor links Th17-cell-mediated autoimmunity to environmental toxins. Nature 2008;453:106-9. (Pubitemid 351630329)
29. Lee JC, Anderson CA, Vermeire S. Genetic variants that predispose to early complications in Crohn's disease identified by re-analysing genome-wide association study data from 3 consortia. Journal of Crohn's and Colitis 2010;4:S5.