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Volumn 7, Issue 2, 2012, Pages 247-255

Apolipoprotein E genotype affects tissue metallothionein levels: Studies in targeted gene replacement mice

Author keywords

Ageing; APOE; Metallothionein; Mice; Nrf1

Indexed keywords

ALLYL ISOTHIOCYANATE; APOLIPOPROTEIN E3; APOLIPOPROTEIN E4; CHOLESTEROL; MESSENGER RNA; METALLOTHIONEIN I; METALLOTHIONEIN II; TRANSCRIPTION FACTOR NRF1;

EID: 84860757652     PISSN: 15558932     EISSN: 18653499     Source Type: Journal    
DOI: 10.1007/s12263-012-0282-x     Document Type: Article
Times cited : (19)

References (55)
  • 1
    • 0033990794 scopus 로고    scopus 로고
    • Regulation of metallothionein gene expression by oxidative stress and metal ions
    • Andrews GK (2000) Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochem Pharmacol 59(1):95-104
    • (2000) Biochem Pharmacol , vol.59 , Issue.1 , pp. 95-104
    • Andrews, G.K.1
  • 2
    • 77952875418 scopus 로고    scopus 로고
    • Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity
    • Bahadorani S, Mukai S, Egli D, Hilliker AJ (2010) Overexpression of metal-responsive transcription factor (MTF-1) in Drosophila melanogaster ameliorates life-span reductions associated with oxidative stress and metal toxicity. Neurobiol Aging 31(7):1215-1226
    • (2010) Neurobiol Aging , vol.31 , Issue.7 , pp. 1215-1226
    • Bahadorani, S.1    Mukai, S.2    Egli, D.3    Hilliker, A.J.4
  • 4
    • 78649773966 scopus 로고    scopus 로고
    • Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion
    • Bhattacharya A, Li Y, Wade KL, Paonessa JD, Fahey JW, Zhang Y (2010) Allyl isothiocyanate-rich mustard seed powder inhibits bladder cancer growth and muscle invasion. Carcinogenesis 31(12):2105-2110
    • (2010) Carcinogenesis , vol.31 , Issue.12 , pp. 2105-2110
    • Bhattacharya, A.1    Li, Y.2    Wade, K.L.3    Paonessa, J.D.4    Fahey, J.W.5    Zhang, Y.6
  • 5
    • 77649275112 scopus 로고    scopus 로고
    • Role of Nrf1 in antioxidant response element-mediated gene expression and beyond
    • Biswas M, Chan JY (2010) Role of Nrf1 in antioxidant response element-mediated gene expression and beyond. Toxicol Appl Pharmacol 244(1):16-20
    • (2010) Toxicol Appl Pharmacol , vol.244 , Issue.1 , pp. 16-20
    • Biswas, M.1    Chan, J.Y.2
  • 6
    • 0032549517 scopus 로고    scopus 로고
    • The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals
    • DOI 10.1074/jbc.273.12.7127
    • Bittel D, Dalton T, Samson SL, Gedamu L, Andrews GK (1998) The DNA binding activity of metal response element-binding transcription factor-1 is activated in vivo and in vitro by zinc, but not by other transition metals. J Biol Chem 273(12):7127-7133 (Pubitemid 28160385)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.12 , pp. 7127-7133
    • Bittel, D.1    Dalton, T.2    Samson, S.L.-A.3    Gedamu, L.4    Andrews, G.K.5
  • 8
    • 0025369383 scopus 로고
    • Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: A new approach for the identification of inducing xenobiotics
    • DOI 10.1016/0278-6915(90)90014-E
    • Bogaards JJ, van Ommen B, Falke HE, Willems MI, van Bladeren PJ (1990) Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics. Food Chem Toxicol 28(2):81-88 (Pubitemid 20170904)
    • (1990) Food and Chemical Toxicology , vol.28 , Issue.2 , pp. 81-88
    • Bogaards, J.J.P.1    Van Ommen, B.2    Falke, H.E.3    Willems, M.I.4    Van Bladeren, P.J.5
  • 9
    • 79954504166 scopus 로고    scopus 로고
    • Basic principles and emerging concepts in the redox control of transcription factors
    • Brigelius-Flohe R, Flohe L (2011) Basic principles and emerging concepts in the redox control of transcription factors. Antioxid Redox Signal 15(8):2335-2381
    • (2011) Antioxid Redox Signal , vol.15 , Issue.8 , pp. 2335-2381
    • Brigelius-Flohe, R.1    Flohe, L.2
  • 12
    • 0028593507 scopus 로고
    • Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxidetreated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements
    • Dalton T, Palmiter RD, Andrews GK (1994) Transcriptional induction of the mouse metallothionein-I gene in hydrogen peroxidetreated Hepa cells involves a composite major late transcription factor/antioxidant response element and metal response promoter elements. Nucleic Acids Res 22(23):5016-5023
    • (1994) Nucleic Acids Res , vol.22 , Issue.23 , pp. 5016-5023
    • Dalton, T.1    Palmiter, R.D.2    Andrews, G.K.3
  • 14
    • 34548434021 scopus 로고    scopus 로고
    • Metallothionein prevents high-fat diet-induced cardiac contractile dysfunction: Role of peroxisome proliferator-activated receptor γ coactivator 1α and mitochondrial biogenesis
    • DOI 10.2337/db06-1596
    • Dong F, Li Q, Sreejayan N, Nunn JM, Ren J (2007) Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis. Diabetes 56(9):2201-2212 (Pubitemid 47358226)
    • (2007) Diabetes , vol.56 , Issue.9 , pp. 2201-2212
    • Dong, F.1    Li, Q.2    Sreejayan, N.3    Nunn, J.M.4    Ren, J.5
  • 15
    • 0020455632 scopus 로고
    • Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues
    • DOI 10.1016/0041-008X(82)90068-0
    • Eaton DL, Toal BF (1982) Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol Appl Pharmacol 66(1):134-142 (Pubitemid 13202187)
    • (1982) Toxicology and Applied Pharmacology , vol.66 , Issue.1 , pp. 134-142
    • Eaton, D.L.1    Toal, B.F.2
  • 17
    • 77957916110 scopus 로고    scopus 로고
    • Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver
    • Fischer A, Gaedicke S, Frank J, Doring F, Rimbach G (2010) Dietary vitamin E deficiency does not affect global and specific DNA methylation patterns in rat liver. Br J Nutr 104(7):935-940
    • (2010) Br J Nutr , vol.104 , Issue.7 , pp. 935-940
    • Fischer, A.1    Gaedicke, S.2    Frank, J.3    Doring, F.4    Rimbach, G.5
  • 21
    • 38149125627 scopus 로고    scopus 로고
    • Effect of apoE genotype and vitamin E on biomarkers of oxidative stress in cultured neuronal cells and the brain of targeted replacement mice
    • Huebbe P, Jofre-Monseny L, Boesch-Saadatmandi C, Minihane AM, Rimbach G (2007) Effect of apoE genotype and vitamin E on biomarkers of oxidative stress in cultured neuronal cells and the brain of targeted replacement mice. J Physiol Pharmacol 58(4):683-698
    • (2007) J Physiol Pharmacol , vol.58 , Issue.4 , pp. 683-698
    • Huebbe, P.1    Jofre-Monseny, L.2    Boesch-Saadatmandi, C.3    Minihane, A.M.4    Rimbach, G.5
  • 22
    • 0035859488 scopus 로고    scopus 로고
    • Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: A prospective study
    • DOI 10.1016/S0140-6736(01)05330-2
    • Humphries SE, Talmud PJ, Hawe E, Bolla M, Day IN, Miller GJ (2001) Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet 358(9276): 115-119 (Pubitemid 32709850)
    • (2001) Lancet , vol.358 , Issue.9276 , pp. 115-119
    • Humphries, S.E.1    Talmud, P.J.2    Hawe, E.3    Bolla, M.4    Day, I.N.M.5    Miller, G.J.6
  • 23
    • 67649771693 scopus 로고    scopus 로고
    • Metallothionein as an anti-inflammatory mediator
    • 2009
    • Inoue K, Takano H, Shimada A, Satoh M (2009) Metallothionein as an anti-inflammatory mediator. Med Inflamm 2009:101659
    • (2009) Med Inflamm , pp. 101659
    • Inoue, K.1    Takano, H.2    Shimada, A.3    Satoh, M.4
  • 24
    • 20444438012 scopus 로고    scopus 로고
    • Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells
    • Jeong WS, Keum YS, Chen C, Jain MR, Shen G, Kim JH, Li W, Kong AN (2005) Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells. J Biochem Mol Biol 38(2):167-176 (Pubitemid 43026217)
    • (2005) Journal of Biochemistry and Molecular Biology , vol.38 , Issue.2 , pp. 167-176
    • Jeong, W.-S.1    Keum, Y.-S.2    Chen, C.3    Jain, M.R.4    Shen, G.5    Kim, J.-H.6    Li, W.7    Kong, A.-N.T.8
  • 26
    • 45749140807 scopus 로고    scopus 로고
    • Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice
    • Jofre-Monseny L, Huebbe P, Stange I, Boesch-Saadatmandi C, Frank J, Jackson K, Minihane AM, Rimbach G (2008a) Influence of apolipoprotein E genotype and dietary alpha-tocopherol on redox status and C-reactive protein levels in apolipoprotein E3 and E4 targeted replacement mice. Br J Nutr, 100, 1, 44-53.
    • (2008) Br J Nutr , vol.100 , Issue.1 , pp. 44-53
    • Jofre-Monseny, L.1    Huebbe, P.2    Stange, I.3    Boesch-Saadatmandi, C.4    Frank, J.5    Jackson, K.6    Minihane, A.M.7    Rimbach, G.8
  • 27
    • 38949163967 scopus 로고    scopus 로고
    • Impact of apoE genotype on oxidative stress, inflammation and disease risk
    • DOI 10.1002/mnfr.200700322
    • Jofre-Monseny L, Minihane AM, Rimbach G (2008b) Impact of apoE genotype on oxidative stress, inflammation and disease risk. Mol Nutr Food Res 52(1):131-145 (Pubitemid 351211806)
    • (2008) Molecular Nutrition and Food Research , vol.52 , Issue.1 , pp. 131-145
    • Jofre-Monseny, L.1    Minihane, A.-M.2    Rimbach, G.3
  • 28
    • 0036309574 scopus 로고    scopus 로고
    • Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model
    • Krul C, Humblot C, Philippe C, Vermeulen M, van Nuenen M, Havenaar R, Rabot S (2002) Metabolism of sinigrin (2-propenyl glucosinolate) by the human colonic microflora in a dynamic in vitro large-intestinal model. Carcinogenesis 23(6):1009-1016 (Pubitemid 34752957)
    • (2002) Carcinogenesis , vol.23 , Issue.6 , pp. 1009-1016
    • Krul, C.1    Humblot, C.2    Philippe, C.3    Vermeulen, M.4    Van Nuenen, M.5    Havenaar, R.6    Rabot, S.7
  • 31
    • 66349085616 scopus 로고    scopus 로고
    • Apolipoprotein E: Structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
    • Mahley RW, Weisgraber KH, Huang Y (2009) Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS. J Lipid Res 50(Suppl):S183-S188
    • (2009) J Lipid Res , vol.50 , Issue.SUPPL.
    • Mahley, R.W.1    Weisgraber, K.H.2    Huang, Y.3
  • 32
    • 9744283511 scopus 로고    scopus 로고
    • Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates
    • McWalter GK, Higgins LG, McLellan LI, Henderson CJ, Song L, Thornalley PJ, Itoh K, Yamamoto M, Hayes JD (2004) Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates. J Nutr 134(12 Suppl):3499S-3506S (Pubitemid 39587596)
    • (2004) Journal of Nutrition , vol.134 , Issue.SUPPL.
    • McWalter, G.K.1    Higgins, L.G.2    McLellan, L.I.3    Henderson, C.J.4    Song, L.5    Thornalley, P.J.6    Itoh, K.7    Yamamoto, M.8    Hayes, J.D.9
  • 34
    • 83255192157 scopus 로고    scopus 로고
    • Zinc, metallothioneins and immunosenescence: Effect of zinc supply as nutrigenomic approach
    • doi:10.1007/s10522-10011-19337-10524
    • Mocchegiani E, Costarelli L, Giacconi R, Piacenza F, Basso A, Malavolta M (2011) Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach. Biogerontology. doi:10.1007/s10522-10011-19337-10524
    • (2011) Biogerontology
    • Mocchegiani, E.1    Costarelli, L.2    Giacconi, R.3    Piacenza, F.4    Basso, A.5    Malavolta, M.6
  • 35
    • 0021923648 scopus 로고
    • Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates
    • Newman TC, Dawson PA, Rudel LL, Williams DL (1985) Quantitation of apolipoprotein E mRNA in the liver and peripheral tissues of nonhuman primates. J Biol Chem 260(4):2452-2457 (Pubitemid 15104853)
    • (1985) Journal of Biological Chemistry , vol.260 , Issue.4 , pp. 2452-2457
    • Newman, T.C.1    Dawson, P.A.2    Rudel, L.L.3    Williams, D.L.4
  • 36
    • 57749120460 scopus 로고    scopus 로고
    • Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes
    • Ohtsuji M, Katsuoka F, Kobayashi A, Aburatani H, Hayes JD, Yamamoto M (2008) Nrf1 and Nrf2 play distinct roles in activation of antioxidant response element-dependent genes. J Biol Chem 283(48):33554-33562
    • (2008) J Biol Chem , vol.283 , Issue.48 , pp. 33554-33562
    • Ohtsuji, M.1    Katsuoka, F.2    Kobayashi, A.3    Aburatani, H.4    Hayes, J.D.5    Yamamoto, M.6
  • 37
    • 0023071221 scopus 로고
    • Molecular biology of metallothionein gene expression
    • Palmiter RD (1987) Molecular biology of metallothionein gene expression. Experientia Suppl 52:63-80
    • (1987) Experientia Suppl , vol.52 , pp. 63-80
    • Palmiter, R.D.1
  • 39
    • 0030812747 scopus 로고    scopus 로고
    • Cadmium accumulation, zinc status, and mineral bioavailability of growing rats fed diets high in zinc with increasing amounts of phytic acid
    • Rimbach G, Pallauf J (1997) Cadmium accumulation, zinc status, and mineral bioavailability of growing rats fed diets high in zinc with increasing amounts of phytic acid. Biol Trace Elem Res 57(1):59-70 (Pubitemid 27323565)
    • (1997) Biological Trace Element Research , vol.57 , Issue.1 , pp. 59-70
    • Rimbach, G.1    Pallauf, J.2
  • 40
    • 33750462717 scopus 로고    scopus 로고
    • Changes in glucosinolate concentrations, myrosinase activity, and production of metabolites of glucosinolates in cabbage (Brassica oleracea var. capitata) cooked for different durations
    • DOI 10.1021/jf0607314
    • Rungapamestry V, Duncan AJ, Fuller Z, Ratcliffe B (2006) Changes in glucosinolate concentrations, myrosinase activity, and production of metabolites of glucosinolates in cabbage (Brassica oleracea Var. capitata) cooked for different durations. J Agric Food Chem 54(20):7628-7634 (Pubitemid 44645782)
    • (2006) Journal of Agricultural and Food Chemistry , vol.54 , Issue.20 , pp. 7628-7634
    • Rungapamestry, V.1    Duncan, A.J.2    Fuller, Z.3    Ratcliffe, B.4
  • 42
    • 52149112705 scopus 로고    scopus 로고
    • Gene-environment interaction and oxidative stress in cardiovascular disease
    • Stephens JW, Bain SC, Humphries SE (2008) Gene-environment interaction and oxidative stress in cardiovascular disease. Atherosclerosis 200(2):229-238
    • (2008) Atherosclerosis , vol.200 , Issue.2 , pp. 229-238
    • Stephens, J.W.1    Bain, S.C.2    Humphries, S.E.3
  • 43
    • 78650229303 scopus 로고    scopus 로고
    • Metallothionein and the biology of aging
    • Swindell WR (2011) Metallothionein and the biology of aging. Ageing Res Rev 10(1):132-145
    • (2011) Ageing Res Rev , vol.10 , Issue.1 , pp. 132-145
    • Swindell, W.R.1
  • 44
    • 3543117254 scopus 로고    scopus 로고
    • Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells
    • Tang L, Zhang Y (2004) Dietary isothiocyanates inhibit the growth of human bladder carcinoma cells. J Nutr 134(8):2004-2010 (Pubitemid 39031331)
    • (2004) Journal of Nutrition , vol.134 , Issue.8 , pp. 2004-2010
    • Tang, L.1    Zhang, Y.2
  • 46
    • 74949124720 scopus 로고    scopus 로고
    • Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture
    • Wagner AE, Ernst I, Iori R, Desel C, Rimbach G (2010) Sulforaphane but not ascorbigen, indole-3-carbinole and ascorbic acid activates the transcription factor Nrf2 and induces phase-2 and antioxidant enzymes in human keratinocytes in culture. Exp Dermatol 19(2):137-144
    • (2010) Exp Dermatol , vol.19 , Issue.2 , pp. 137-144
    • Wagner, A.E.1    Ernst, I.2    Iori, R.3    Desel, C.4    Rimbach, G.5
  • 47
    • 84860745555 scopus 로고    scopus 로고
    • Anti-inflammatory potential of allyl-isothiocyanaterole of Nrf2, NFkappaB and microRNA-155
    • doi:10.1111/j.1582-4934.2011.01367.x
    • Wagner AE, Boesch-Saadatmandi C, Dose J, Schultheiss G, Rimbach G (2011) Anti-inflammatory potential of allyl-isothiocyanaterole of Nrf2, NFkappaB and microRNA-155. J Cell Mol Med. doi:10.1111/j.1582-4934.2011.01367.x
    • (2011) J Cell Mol Med.
    • Wagner, A.E.1    Boesch-Saadatmandi, C.2    Dose, J.3    Schultheiss, G.4    Rimbach, G.5
  • 48
    • 0019783892 scopus 로고
    • Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms
    • Weisgraber KH, Rall Jr SC, Mahley RW (1981) Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms. J Biol Chem 256(17):9077-9083 (Pubitemid 12208303)
    • (1981) Journal of Biological Chemistry , vol.256 , Issue.17 , pp. 9077-9083
    • Weisgraber, K.H.1    Rall Jr., S.C.2    Mahley, R.W.3
  • 50
    • 33744456501 scopus 로고    scopus 로고
    • Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: Role of oxidative stress
    • Yang X, Doser TA, Fang CX, Nunn JM, Janardhanan R, Zhu M, Sreejayan N, Quinn MT, Ren J (2006) Metallothionein prolongs survival and antagonizes senescence-associated cardiomyocyte diastolic dysfunction: role of oxidative stress. Faseb J 20(7):1024-1026
    • (2006) Faseb J , vol.20 , Issue.7 , pp. 1024-1026
    • Yang, X.1    Doser, T.A.2    Fang, C.X.3    Nunn, J.M.4    Janardhanan, R.5    Zhu, M.6    Sreejayan, N.7    Quinn, M.T.8    Ren, J.9
  • 51
    • 0035681887 scopus 로고    scopus 로고
    • Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes
    • Ye L, Zhang Y (2001) Total intracellular accumulation levels of dietary isothiocyanates determine their activity in elevation of cellular glutathione and induction of Phase 2 detoxification enzymes. Carcinogenesis 22(12):1987-1992 (Pubitemid 34065393)
    • (2001) Carcinogenesis , vol.22 , Issue.12 , pp. 1987-1992
    • Ye, L.1    Zhang, Y.2
  • 52
    • 27944494853 scopus 로고    scopus 로고
    • Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells
    • Yeh CT, Yen GC (2005) Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells. Carcinogenesis 26(12):2138-2148
    • (2005) Carcinogenesis , vol.26 , Issue.12 , pp. 2138-2148
    • Yeh, C.T.1    Yen, G.C.2
  • 53
    • 0032532317 scopus 로고    scopus 로고
    • Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes
    • Zhang Y, Talalay P (1998) Mechanism of differential potencies of isothiocyanates as inducers of anticarcinogenic Phase 2 enzymes. Cancer Res 58(20):4632-4639 (Pubitemid 28480628)
    • (1998) Cancer Research , vol.58 , Issue.20 , pp. 4632-4639
    • Zhang, Y.1    Talalay, P.2
  • 54
    • 10344243477 scopus 로고    scopus 로고
    • Cancer-preventive isothiocyanates: Dichotomous modulators of oxidative stress
    • DOI 10.1016/j.freeradbiomed.2004.09.033, PII S0891584904008081
    • Zhang Y, Li J, Tang L (2005) Cancer-preventive isothiocyanates: dichotomous modulators of oxidative stress. Free Radic Biol Med 38(1):70-77 (Pubitemid 39626910)
    • (2005) Free Radical Biology and Medicine , vol.38 , Issue.1 , pp. 70-77
    • Zhang, Y.1    Li, J.2    Tang, L.3
  • 55
    • 77952952816 scopus 로고    scopus 로고
    • Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet
    • Zhang YK, Yeager RL, Tanaka Y, Klaassen CD (2010) Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. Toxicol Appl Pharmacol 245(3):326-334
    • (2010) Toxicol Appl Pharmacol , vol.245 , Issue.3 , pp. 326-334
    • Zhang, Y.K.1    Yeager, R.L.2    Tanaka, Y.3    Klaassen, C.D.4


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