[ 11C]DAC-PET for noninvasively monitoring neuroinflammation and immunosuppressive therapy efficacy in rat experimental autoimmune encephalomyelitis model

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 1, 2012, Pages 231-242

  Xie, Lin ^a,b   Yamasaki, Tomoteru ^d   Ichimaru, Naotsugu ^b   Yui, Joji ^c   Kawamura, Kazunori ^c   Kumata, Katsushi ^c   Hatori, Akiko ^c   Nonomura, Norio ^b   Zhang, Ming Rong ^c   Li, Xiao Kang ^a   Takahara, Shiro ^b  

^a NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d TOHOKU UNIVERSITY   (Japan)

Author keywords

Experimental autoimmune encephalomyelitis; Macrophage; Microglia; Multiple sclerosis; Neuroinflammation; Positron emission tomography; T cells; Translocator protein 18 kDa

Indexed keywords

CARBON 11; CARRIER PROTEIN; CD11B ANTIGEN; CD68 ANTIGEN; FINGOLIMOD; MESSENGER RNA; N BENZYL N METHYL 2(7 METHYL 8 OXO 2 PHENYL 7,8 DIHYDRO 9H PURIN 9 YL) ACETAMIDE C 11; UNCLASSIFIED DRUG;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG DISTRIBUTION; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL MONITORING; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATORY CELL; MACROPHAGE; MECHANICAL PROBE; MICROGLIA; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NEUROMONITORING; NON INVASIVE PROCEDURE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOACTIVITY; RAT; SPINAL CORD;

ACETAMIDES; ANIMALS; AUTORADIOGRAPHY; CARBON RADIOISOTOPES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; RATS; RATS, INBRED LEW; RECEPTORS, GABA; SPINAL CORD; TISSUE DISTRIBUTION;

EID: 84860714958     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-011-9322-3     Document Type: Article

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