-
1
-
-
0025978216
-
A phase I clinical, plasma, and cellular pharmacology study of gemcitabine
-
JL Abbruzzese R Grunewald EA Weeks D Gravel T Adams B Nowak S Mineishi P Tarassoff W Satterlee MN Raber 1991 A phase I clinical, plasma, and cellular pharmacology study of gemcitabine J Clin Oncol 9 491 498
-
(1991)
J Clin Oncol
, vol.9
, pp. 491-498
-
-
Abbruzzese, J.L.1
Grunewald, R.2
Weeks, E.A.3
Gravel, D.4
Adams, T.5
Nowak, B.6
Mineishi, S.7
Tarassoff, P.8
Satterlee, W.9
Raber, M.N.10
-
2
-
-
2042532694
-
Population pharmacokinetic analyses: Effect of age, gender, duration of infusion, body surface area on gemcitabine pharmacokinetics
-
Suppl 1
-
S Allerheiligen B Patel P Dhahir R Johnson B Hatcher B Cerimele T Rugg P Tarassoff A Dorr 1995 Population pharmacokinetic analyses: effect of age, gender, duration of infusion, body surface area on gemcitabine pharmacokinetics Pharm Res 12 Suppl 1 S327
-
(1995)
Pharm Res
, vol.12
, pp. 327
-
-
Allerheiligen, S.1
Patel, B.2
Dhahir, P.3
Johnson, R.4
Hatcher, B.5
Cerimele, B.6
Rugg, T.7
Tarassoff, P.8
Dorr, A.9
-
4
-
-
33744839368
-
A formula to estimate the approximate surface area if height, weight be known
-
D Du Bois EF Du Bois 1916 A formula to estimate the approximate surface area if height, weight be known Arch Intern Med 17 863 871
-
(1916)
Arch Intern Med
, vol.17
, pp. 863-871
-
-
Du Bois, D.1
Du Bois, E.F.2
-
6
-
-
3843141820
-
What is the best size descriptor to use for pharmacokinetic studies in the obese?
-
B Green SB Duffull 2004 What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol 58 119 133
-
(2004)
Br J Clin Pharmacol
, vol.58
, pp. 119-133
-
-
Green, B.1
Duffull, S.B.2
-
7
-
-
0025089191
-
Pharmacologically directed design of the dose rate and schedule of 2′,2′-difluorodeoxycytidine (Gemcitabine) administration in leukemia
-
R Grunewald H Kantarjian MJ Keating J Abbruzzese P Tarassoff W Plunkett 1990 Pharmacologically directed design of the dose rate and schedule of 2′,2′-difluorodeoxycytidine (Gemcitabine) administration in leukemia Cancer Res 50 6823 6826
-
(1990)
Cancer Res
, vol.50
, pp. 6823-6826
-
-
Grunewald, R.1
Kantarjian, H.2
Keating, M.J.3
Abbruzzese, J.4
Tarassoff, P.5
Plunkett, W.6
-
8
-
-
0026101039
-
Saturation of 2′,2′-difluorodeoxycytidine 5′-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine
-
R Grunewald JL Abbruzzese P Tarassoff W Plunkett 1991 Saturation of 2′,2′-difluorodeoxycytidine 5′-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine Cancer Chemother Pharmacol 27 258 262
-
(1991)
Cancer Chemother Pharmacol
, vol.27
, pp. 258-262
-
-
Grunewald, R.1
Abbruzzese, J.L.2
Tarassoff, P.3
Plunkett, W.4
-
9
-
-
0026550270
-
Gemcitabine in leukemia: A phase I clinical, plasma, and cellular pharmacology study
-
R Grunewald H Kantarjian M Du K Faucher P Tarassoff W Plunkett 1992 Gemcitabine in leukemia: a phase I clinical, plasma, and cellular pharmacology study J Clin Oncol 10 406 413
-
(1992)
J Clin Oncol
, vol.10
, pp. 406-413
-
-
Grunewald, R.1
Kantarjian, H.2
Du, M.3
Faucher, K.4
Tarassoff, P.5
Plunkett, W.6
-
10
-
-
0026571795
-
Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: A mechanism of self-potentiation
-
V Heinemann YZ Xu S Chubb A Sen LW Hertel GB Grindey W Plunkett 1992 Cellular elimination of 2′,2′-difluorodeoxycytidine 5′-triphosphate: a mechanism of self-potentiation Cancer Res 52 533 539
-
(1992)
Cancer Res
, vol.52
, pp. 533-539
-
-
Heinemann, V.1
Xu, Y.Z.2
Chubb, S.3
Sen, A.4
Hertel, L.W.5
Grindey, G.B.6
Plunkett, W.7
-
11
-
-
0023783698
-
Comparison of the cellular pharmacokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-beta-d-arabinofuranosylcytosine
-
V Heinemann LW Hertel GB Grindey W Plunkett 1988 Comparison of the cellular pharmacokinetics and toxicity of 2′,2′- difluorodeoxycytidine and 1-beta-d-arabinofuranosylcytosine Cancer Res 48 4024 4031
-
(1988)
Cancer Res
, vol.48
, pp. 4024-4031
-
-
Heinemann, V.1
Hertel, L.W.2
Grindey, G.B.3
Plunkett, W.4
-
12
-
-
0025325071
-
Evaluation of the antitumor activity of gemcitabine (2′,2′- difluoro-2′-deoxycytidine)
-
LW Hertel GB Boder JS Kroin SM Rinzel GA Poore GC Todd GB Grindey 1990 Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro- 2′-deoxycytidine) Cancer Res 50 4417 4422
-
(1990)
Cancer Res
, vol.50
, pp. 4417-4422
-
-
Hertel, L.W.1
Boder, G.B.2
Kroin, J.S.3
Rinzel, S.M.4
Poore, G.A.5
Todd, G.C.6
Grindey, G.B.7
-
13
-
-
0029951033
-
A size standard for pharmacokinetics
-
NH Holford 1996 A size standard for pharmacokinetics Clin Pharmacokinet 30 329 332
-
(1996)
Clin Pharmacokinet
, vol.30
, pp. 329-332
-
-
Holford, N.H.1
-
16
-
-
0031763639
-
Assumption testing in population pharmacokinetic models: Illustrated with an analysis of moxonidine data from congestive heart failure patients
-
2
-
MO Karlsson NE Jonsson CG Wiltse JR Wade 1998 Assumption testing in population pharmacokinetic models: illustrated with an analysis of moxonidine data from congestive heart failure patients J Pharmacokinet Biopharm 26 2 207 246
-
(1998)
J Pharmacokinet Biopharm
, vol.26
, pp. 207-246
-
-
Karlsson, M.O.1
Jonsson, N.E.2
Wiltse, C.G.3
Wade, J.R.4
-
17
-
-
0032983664
-
Gemcitabine and paclitaxel: Pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer
-
JR Kroep G Giaccone DA Voorn EF Smit JH Beijnen H Rosing CJ van Moorsel CJ van Groeningen PE Postmus HM Pinedo GJ Peters 1999 Gemcitabine and paclitaxel: pharmacokinetic and pharmacodynamic interactions in patients with non-small-cell lung cancer J Clin Oncol 17 2190 2197
-
(1999)
J Clin Oncol
, vol.17
, pp. 2190-2197
-
-
Kroep, J.R.1
Giaccone, G.2
Voorn, D.A.3
Smit, E.F.4
Beijnen, J.H.5
Rosing, H.6
Van Moorsel, C.J.7
Van Groeningen, C.J.8
Postmus, P.E.9
Pinedo, H.M.10
Peters, G.J.11
-
18
-
-
0037087585
-
Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors
-
BC Kuenen L Rosen EF Smit MR Parson M Levi R Ruijter H Huisman MA Kedde P Noordhuis WJ van der Vijgh GJ Peters GF Cropp P Scigalla K Hoekman HM Pinedo G Giaccone 2002 Dose-finding and pharmacokinetic study of cisplatin, gemcitabine, and SU5416 in patients with solid tumors J Clin Oncol 20 1657 1667
-
(2002)
J Clin Oncol
, vol.20
, pp. 1657-1667
-
-
Kuenen, B.C.1
Rosen, L.2
Smit, E.F.3
Parson, M.R.4
Levi, M.5
Ruijter, R.6
Huisman, H.7
Kedde, M.A.8
Noordhuis, P.9
Van Der Vijgh, W.J.10
Peters, G.J.11
Cropp, G.F.12
Scigalla, P.13
Hoekman, K.14
Pinedo, H.M.15
Giaccone, G.16
-
19
-
-
0030870485
-
Gemcitabine. a review of its pharmacology, clinical potential in non-small cell lung cancer and pancreatic cancer
-
S Noble KL Goa 1997 Gemcitabine. A review of its pharmacology, clinical potential in non-small cell lung cancer and pancreatic cancer Drugs 54 447 472
-
(1997)
Drugs
, vol.54
, pp. 447-472
-
-
Noble, S.1
Goa, K.L.2
-
20
-
-
34247892237
-
Clinical phase I and pharmacology study of gemcitabine (2′, 2′-difluorodeoxycytidine) administered in a two-weekly schedule
-
GJ Peters M Clavel P Noordhuis GJ Geyssen AC Laan J Guastalla HT Edzes JB Vermorken 2007 Clinical phase I and pharmacology study of gemcitabine (2′, 2′-difluorodeoxycytidine) administered in a two-weekly schedule J Chemother 19 212 221
-
(2007)
J Chemother
, vol.19
, pp. 212-221
-
-
Peters, G.J.1
Clavel, M.2
Noordhuis, P.3
Geyssen, G.J.4
Laan, A.C.5
Guastalla, J.6
Edzes, H.T.7
Vermorken, J.B.8
-
22
-
-
0029809541
-
Gemcitabine: Preclinical pharmacology and mechanisms of action
-
Suppl 10
-
W Plunkett P Huang CE Searcy V Gandhi 1996 Gemcitabine: preclinical pharmacology and mechanisms of action Semin Oncol 23 Suppl 10 3 15
-
(1996)
Semin Oncol
, vol.23
, pp. 3-15
-
-
Plunkett, W.1
Huang, P.2
Searcy, C.E.3
Gandhi, V.4
-
23
-
-
0028799108
-
Gemcitabine: Metabolism, mechanisms of action, and self-potentiation
-
Suppl 11
-
W Plunkett P Huang YZ Xu V Heinemann R Grunewald V Gandhi 1995 Gemcitabine: metabolism, mechanisms of action, and self-potentiation Semin Oncol 22 Suppl 11 3 10
-
(1995)
Semin Oncol
, vol.22
, pp. 3-10
-
-
Plunkett, W.1
Huang, P.2
Xu, Y.Z.3
Heinemann, V.4
Grunewald, R.5
Gandhi, V.6
-
24
-
-
0035015115
-
Body surface area as a determinant of pharmacokinetics and drug dosing
-
M Sawyer MJ Ratain 2001 Body surface area as a determinant of pharmacokinetics and drug dosing Invest New Drugs 19 171 177
-
(2001)
Invest New Drugs
, vol.19
, pp. 171-177
-
-
Sawyer, M.1
Ratain, M.J.2
-
25
-
-
53149096898
-
A multicentre randomised phase II study of carboplatin in combination with gemcitabine at standard rate or fixed dose rate infusion in patients with advanced stage non-small-cell lung cancer
-
RA Soo LZ Wang LS Tham WP Yong M Boyer HL Lim HS Lee M Millward S Liang P Beale SC Lee BC Goh 2006 A multicentre randomised phase II study of carboplatin in combination with gemcitabine at standard rate or fixed dose rate infusion in patients with advanced stage non-small-cell lung cancer Ann Oncol 52 153 158
-
(2006)
Ann Oncol
, vol.52
, pp. 153-158
-
-
Soo, R.A.1
Wang, L.Z.2
Tham, L.S.3
Yong, W.P.4
Boyer, M.5
Lim, H.L.6
Lee, H.S.7
Millward, M.8
Liang, S.9
Beale, P.10
Lee, S.C.11
Goh, B.C.12
-
26
-
-
0031114142
-
Preclinical, pharmacologic, and phase I studies of gemcitabine
-
Suppl 7
-
AM Storniolo SR Allerheiligen HL Pearce 1997 Preclinical, pharmacologic, and phase I studies of gemcitabine Semin Oncol 24 Suppl 7 S7-2 S77
-
(1997)
Semin Oncol
, vol.24
-
-
Storniolo, A.M.1
Allerheiligen, S.R.2
Pearce, H.L.3
-
27
-
-
23944515735
-
A novel model for prediction of human drug clearance by allometric scaling
-
H Tang M Mayersohn 2005 A novel model for prediction of human drug clearance by allometric scaling Drug Metab Dispos 33 1297 1303
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1297-1303
-
-
Tang, H.1
Mayersohn, M.2
-
28
-
-
23944475573
-
Accuracy of allometrically predicted pharmacokinetic parameters in humans: Role of species selection
-
H Tang M Mayersohn 2005 Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection Drug Metab Dispos 33 1288 1293
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 1288-1293
-
-
Tang, H.1
Mayersohn, M.2
-
29
-
-
0142121290
-
Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
-
M Tempero W Plunkett V Van Ruiz Haperen J Hainsworth H Hochster R Lenzi J Abbruzzese 2003 Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma J Clin Oncol 21 3402 3408
-
(2003)
J Clin Oncol
, vol.21
, pp. 3402-3408
-
-
Tempero, M.1
Plunkett, W.2
Van Ruiz Haperen, V.3
Hainsworth, J.4
Hochster, H.5
Lenzi, R.6
Abbruzzese, J.7
-
30
-
-
0032939255
-
Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors
-
CJ van Moorsel JR Kroep HM Pinedo G Veerman DA Voorn PE Postmus JB Vermorken CJ van Groeningen WJ van der Vijgh GJ Peters 1999 Pharmacokinetic schedule finding study of the combination of gemcitabine and cisplatin in patients with solid tumors Ann Oncol 10 441 448
-
(1999)
Ann Oncol
, vol.10
, pp. 441-448
-
-
Van Moorsel, C.J.1
Kroep, J.R.2
Pinedo, H.M.3
Veerman, G.4
Voorn, D.A.5
Postmus, P.E.6
Vermorken, J.B.7
Van Groeningen, C.J.8
Van Der Vijgh, W.J.9
Peters, G.J.10
-
31
-
-
0032958512
-
Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines
-
CJ van Moorsel HM Pinedo G Veerman AM Bergman CM Kuiper JB Vermorken WJ van der Vijgh GJ Peters 1999 Mechanisms of synergism between cisplatin and gemcitabine in ovarian and non-small-cell lung cancer cell lines Br J Cancer 80 981 990
-
(1999)
Br J Cancer
, vol.80
, pp. 981-990
-
-
Van Moorsel, C.J.1
Pinedo, H.M.2
Veerman, G.3
Bergman, A.M.4
Kuiper, C.M.5
Vermorken, J.B.6
Van Der Vijgh, W.J.7
Peters, G.J.8
-
32
-
-
18344416952
-
Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: Cancer and leukemia group B 9565
-
AP Venook MJ Egorin GL Rosner D Hollis S Mani M Hawkins J Byrd R Hohl D Budman NJ Meropol MJ Ratain 2000 Phase I and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysfunction: cancer and leukemia group B 9565 J Clin Oncol 18 2780 2787
-
(2000)
J Clin Oncol
, vol.18
, pp. 2780-2787
-
-
Venook, A.P.1
Egorin, M.J.2
Rosner, G.L.3
Hollis, D.4
Mani, S.5
Hawkins, M.6
Byrd, J.7
Hohl, R.8
Budman, D.9
Meropol, N.J.10
Ratain, M.J.11
-
34
-
-
0141923077
-
An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography
-
LZ Wang BC Goh HS Lee P Noordhuis GJ Peters 2003 An expedient assay for determination of gemcitabine and its metabolite in human plasma using isocratic ion-pair reversed-phase high-performance liquid chromatography Ther Drug Monit 25 552 557
-
(2003)
Ther Drug Monit
, vol.25
, pp. 552-557
-
-
Wang, L.Z.1
Goh, B.C.2
Lee, H.S.3
Noordhuis, P.4
Peters, G.J.5
-
35
-
-
0030932272
-
A general model for the origin of allometric scaling laws in biology
-
GB West JH Brown BJ Enquist 1997 A general model for the origin of allometric scaling laws in biology Science 276 122 126
-
(1997)
Science
, vol.276
, pp. 122-126
-
-
West, G.B.1
Brown, J.H.2
Enquist, B.J.3
-
36
-
-
1242269757
-
Simultaneous vs. sequential analysis for population PK/PD data I: Best-case performance
-
L Zhang SL Beal LB Sheiner 2003 Simultaneous vs. sequential analysis for population PK/PD data I: best-case performance J Pharmacokinet Pharmacodyn 30 387 404
-
(2003)
J Pharmacokinet Pharmacodyn
, vol.30
, pp. 387-404
-
-
Zhang, L.1
Beal, S.L.2
Sheiner, L.B.3
|