메뉴 건너뛰기




Volumn 210, Issue 2, 2004, Pages 171-177

Cytotoxicity and pharmacokinetics of cladribine metabolite, 2-chloroadenine in patients with leukemia

Author keywords

Chloroadenine; Cladribine; Leukemia; Metabolism; Pharmacokinetics

Indexed keywords

2 CHLOROADENINE; ANTINEOPLASTIC AGENT; CLADRIBINE; DRUG METABOLITE; UNCLASSIFIED DRUG;

EID: 2942534191     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2004.03.007     Document Type: Article
Times cited : (37)

References (32)
  • 1
    • 3042870116 scopus 로고
    • Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo
    • Carson D., Wasson D., Kaye J., Ullman B., Martin D., Robins R., Montgomery J. Deoxycytidine kinase-mediated toxicity of deoxyadenosine analogs toward malignant human lymphoblasts in vitro and toward murine L1210 leukemia in vivo. Proc. Natl. Acad. Sci. USA. 11:1980;6865-6869
    • (1980) Proc. Natl. Acad. Sci. USA. , vol.11 , pp. 6865-6869
    • Carson, D.1    Wasson, D.2    Kaye, J.3    Ullman, B.4    Martin, D.5    Robins, R.6    Montgomery, J.7
  • 2
    • 0022003367 scopus 로고
    • Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes
    • Seto S., Carrera J., Kubota M., Wasson B., Carson D. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. J. Clin. Invest. 75:1985;377-383
    • (1985) J. Clin. Invest. , vol.75 , pp. 377-383
    • Seto, S.1    Carrera, J.2    Kubota, M.3    Wasson, B.4    Carson, D.5
  • 3
    • 0025274664 scopus 로고
    • Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine
    • Piro L.D., Carrera C.J., Carson D.A., Beutler E. Lasting remissions in hairy-cell leukemia induced by a single infusion of 2-chlorodeoxyadenosine. N. Engl. J. Med. 322:1990;1117-1121
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1117-1121
    • Piro, L.D.1    Carrera, C.J.2    Carson, D.A.3    Beutler, E.4
  • 4
    • 0026803021 scopus 로고
    • A single cycle of 2-chlorodeoxyadenosine results in complete remission in the majority of patients with hairy cell leukemia
    • Tallman M.S., Hakimian D., Variakojis D., Koslow D., Sisney G.A., Rademaker A.W., et al. A single cycle of 2-chlorodeoxyadenosine results in complete remission in the majority of patients with hairy cell leukemia. Blood. 80:1992;2203-2209
    • (1992) Blood , vol.80 , pp. 2203-2209
    • Tallman, M.S.1    Hakimian, D.2    Variakojis, D.3    Koslow, D.4    Sisney, G.A.5    Rademaker, A.W.6
  • 5
    • 0036179221 scopus 로고    scopus 로고
    • Oral cladribine for B-cell chronic lymphocytic leukaemia: Report of a phase II trial with a 3-d, 3-weekly schedule in untreated and pretreated patients, and a long-term follow-up of 126 previously untreated patients, Br
    • Karlsson K., Stromberg M., Liliemark J., Delannoy A., Johnson S.A., Porwit A., et al. Oral cladribine for B-cell chronic lymphocytic leukaemia: report of a phase II trial with a 3-d, 3-weekly schedule in untreated and pretreated patients, and a long-term follow-up of 126 previously untreated patients, Br. J. Haematol. 116:2002;538-548
    • (2002) J. Haematol. , vol.116 , pp. 538-548
    • Karlsson, K.1    Stromberg, M.2    Liliemark, J.3    Delannoy, A.4    Johnson, S.A.5    Porwit, A.6
  • 6
    • 0026347961 scopus 로고
    • Chlorodeoxyadenosine treatment of refractory chronic lymphocytic leukemia
    • Saven A., Carrera C.J., Carson D., Beutler E.J., Piro L. Chlorodeoxyadenosine treatment of refractory chronic lymphocytic leukemia. Leuk. Lymphoma. 5:1991;133-138
    • (1991) Leuk. Lymphoma. , vol.5 , pp. 133-138
    • Saven, A.1    Carrera, C.J.2    Carson, D.3    Beutler, E.J.4    Piro, L.5
  • 7
    • 0029804405 scopus 로고    scopus 로고
    • 2-Chloro-2′-deoxyadenosine: Clinical applications in hematology
    • Delannoy A. 2-Chloro-2′-deoxyadenosine: clinical applications in hematology. Blood Rev. 10:1996;148-166
    • (1996) Blood Rev. , vol.10 , pp. 148-166
    • Delannoy, A.1
  • 10
    • 0028214392 scopus 로고
    • Analysis of 2-chloro-2'-deoxyadenosine in human blood plasma and urine by high-performance liquid chromatography using solid-phase extraction
    • Albertioni F., Pettersson B., Reichelova V., Juliusson G., Liliemark J. Analysis of 2-chloro-2'-deoxyadenosine in human blood plasma and urine by high-performance liquid chromatography using solid-phase extraction. Ther. Drug Monit. 16:1994;413-418
    • (1994) Ther. Drug Monit. , vol.16 , pp. 413-418
    • Albertioni, F.1    Pettersson, B.2    Reichelova, V.3    Juliusson, G.4    Liliemark, J.5
  • 11
    • 0030757255 scopus 로고    scopus 로고
    • Stability and analysis of 2-chloro-2′-deoxyadenosine, 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine and 2-chloroadenine in human blood plasma
    • Lindemalm S., Albertioni F., Liliemark J. Stability and analysis of 2-chloro-2′-deoxyadenosine, 2-chloro-2′-arabino-fluoro-2′- deoxyadenosine and 2-chloroadenine in human blood plasma. Anticancer Drugs. 8:1997;445-453
    • (1997) Anticancer Drugs. , vol.8 , pp. 445-453
    • Lindemalm, S.1    Albertioni, F.2    Liliemark, J.3
  • 12
    • 0026533461 scopus 로고
    • Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabino-fluoro-2′-deoxyadenosine
    • Carson D., Wasson B., Esparza L., Carrera C., Kipps T., Cottam H. Oral antilymphocyte activity and induction of apoptosis by 2-chloro-2′-arabino- fluoro-2′-deoxyadenosine. Proc. Natl. Acad. Sci. USA. 89:1992;2970-2974
    • (1992) Proc. Natl. Acad. Sci. USA. , vol.89 , pp. 2970-2974
    • Carson, D.1    Wasson, B.2    Esparza, L.3    Carrera, C.4    Kipps, T.5    Cottam, H.6
  • 13
    • 0029745011 scopus 로고    scopus 로고
    • 2-Chloro-2′-deoxyadenosine (2CdA) biochemical aspects of antileukemic efficacy
    • Fabianowska-Majewska K., Wyczechowska D. 2-Chloro-2′-deoxyadenosine (2CdA) biochemical aspects of antileukemic efficacy. Acta Pol. Pharm. 53:1996;231-239
    • (1996) Acta Pol. Pharm. , vol.53 , pp. 231-239
    • Fabianowska-Majewska, K.1    Wyczechowska, D.2
  • 14
    • 0034657005 scopus 로고    scopus 로고
    • Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2′-deoxyadenosine, Biochem
    • Bontemps F., Delacauw A., Cardoen S., Van Den Neste E., Van Den Berghe G. Metabolism and cytotoxic effects of 2-chloroadenine, the major catabolite of 2-chloro-2′-deoxyadenosine, Biochem. Pharmacology. 2000;1237-1243
    • (2000) Pharmacology , pp. 1237-1243
    • Bontemps, F.1    Delacauw, A.2    Cardoen, S.3    Van Den Neste, E.4    Van Den Berghe, G.5
  • 15
    • 0029162556 scopus 로고
    • Mammalian deoxyribonucleoside kinases
    • Arner E.S., Eriksson S. Mammalian deoxyribonucleoside kinases. Pharmacol. Ther. 67:1995;155-186
    • (1995) Pharmacol. Ther. , vol.67 , pp. 155-186
    • Arner, E.S.1    Eriksson, S.2
  • 16
    • 0242560897 scopus 로고    scopus 로고
    • Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs
    • Sjoberg A.H., Wang L., Eriksson S. Substrate specificity of human recombinant mitochondrial deoxyguanosine kinase with cytostatic and antiviral purine and pyrimidine analogs. Mol. Pharmacol. 53:1998;270-273
    • (1998) Mol. Pharmacol. , vol.53 , pp. 270-273
    • Sjoberg, A.H.1    Wang, L.2    Eriksson, S.3
  • 17
    • 0024439683 scopus 로고
    • Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice
    • Avery T., Rehg J., Lumm W., Harwood F., Santana V., Blakley R. Biochemical pharmacology of 2-chlorodeoxyadenosine in malignant human hematopoietic cell lines and therapeutic effects of 2-bromodeoxyadenosine in drug combinations in mice. Cancer Res. 49:1989;4972-4978
    • (1989) Cancer Res. , vol.49 , pp. 4972-4978
    • Avery, T.1    Rehg, J.2    Lumm, W.3    Harwood, F.4    Santana, V.5    Blakley, R.6
  • 18
    • 0027505303 scopus 로고
    • Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine
    • Robertson L.E., Chubb S., Meyn R.E., Story M., Ford R., Hittelman W.N., Plunkett W. Induction of apoptotic cell death in chronic lymphocytic leukemia by 2-chloro-2′-deoxyadenosine and 9-beta-D-arabinosyl-2-fluoroadenine. Blood. 81:1993;143-150
    • (1993) Blood , vol.81 , pp. 143-150
    • Robertson, L.E.1    Chubb, S.2    Meyn, R.E.3    Story, M.4    Ford, R.5    Hittelman, W.N.6    Plunkett, W.7
  • 19
    • 0028010849 scopus 로고
    • Newer purine analogues for the treatment of hairy-cell leukemia
    • Saven A., Piro L. Newer purine analogues for the treatment of hairy-cell leukemia. N. Engl. J. Med. 330:1994;691-697
    • (1994) N. Engl. J. Med. , vol.330 , pp. 691-697
    • Saven, A.1    Piro, L.2
  • 20
    • 0032483010 scopus 로고    scopus 로고
    • Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c
    • Leoni L.M., Chao Q., Cottam H.B., Genini D., Rosenbach M., Carrera C.J., et al. Induction of an apoptotic program in cell-free extracts by 2-chloro-2′-deoxyadenosine 5′-triphosphate and cytochrome c. Proc. Natl. Acad. Sci. USA. 95:1998;9567-9571
    • (1998) Proc. Natl. Acad. Sci. USA. , vol.95 , pp. 9567-9571
    • Leoni, L.M.1    Chao, Q.2    Cottam, H.B.3    Genini, D.4    Rosenbach, M.5    Carrera, C.J.6
  • 21
    • 0034669944 scopus 로고    scopus 로고
    • Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria
    • Genini D., Adachi S., Chao Q., Rose D.W., Carrera C.J., Cottam H.B., et al. Deoxyadenosine analogs induce programmed cell death in chronic lymphocytic leukemia cells by damaging the DNA and by directly affecting the mitochondria. Blood. 96:2000;3537-3543
    • (2000) Blood , vol.96 , pp. 3537-3543
    • Genini, D.1    Adachi, S.2    Chao, Q.3    Rose, D.W.4    Carrera, C.J.5    Cottam, H.B.6
  • 22
    • 0037079699 scopus 로고    scopus 로고
    • Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release
    • Chandra J., Mansson E., Gogvadze V., Kaufmann S.H., Albertioni F., Orrenius S. Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. Blood. 99:2002;655-663
    • (2002) Blood , vol.99 , pp. 655-663
    • Chandra, J.1    Mansson, E.2    Gogvadze, V.3    Kaufmann, S.H.4    Albertioni, F.5    Orrenius, S.6
  • 23
    • 0033951610 scopus 로고    scopus 로고
    • 2-Chloro-2′-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4
    • Nomura Y., Inanami O., Takahashi K., Matsuda A., Kuwabara M. 2-Chloro-2′-deoxyadenosine induces apoptosis through the Fas/Fas ligand pathway in human leukemia cell line MOLT-4. Leukemia. 14:2000;299-306
    • (2000) Leukemia , vol.14 , pp. 299-306
    • Nomura, Y.1    Inanami, O.2    Takahashi, K.3    Matsuda, A.4    Kuwabara, M.5
  • 24
    • 0038576220 scopus 로고    scopus 로고
    • A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2′-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells
    • Ceruti S., Beltrami E., Matarrese P., Mazzola A., Cattabeni F., Malorni W., Abbracchio M.P. A key role for caspase-2 and caspase-3 in the apoptosis induced by 2-chloro-2′-deoxy-adenosine (cladribine) and 2-chloro-adenosine in human astrocytoma cells. Mol. Pharmacol. 63:2003;1437-1447
    • (2003) Mol. Pharmacol. , vol.63 , pp. 1437-1447
    • Ceruti, S.1    Beltrami, E.2    Matarrese, P.3    Mazzola, A.4    Cattabeni, F.5    Malorni, W.6    Abbracchio, M.P.7
  • 25
    • 0028918514 scopus 로고
    • Cellular pharmacokinetics of 2-Chloro-2'-Deoxyadenosine Nucleotides: Comparison of intermittent and continuous intravenous infusion and subcutaneous and oral administration in leukemia patients
    • Liliemark J., Juliusson G. Cellular pharmacokinetics of 2-Chloro-2'-Deoxyadenosine Nucleotides: Comparison of intermittent and continuous intravenous infusion and subcutaneous and oral administration in leukemia patients. Clin. Cancer Res. 1:1995;385-390
    • (1995) Clin. Cancer Res. , vol.1 , pp. 385-390
    • Liliemark, J.1    Juliusson, G.2
  • 26
    • 0015366370 scopus 로고
    • Synthesis and biological activity of selected 2, 6-disubstituted-(2- deoxy-a-and-b-D-erythro-pentofuranosyl)purines
    • Christensen L.F., Broom A. Synthesis and biological activity of selected 2, 6-disubstituted-(2-deoxy-a-and-b-D-erythro-pentofuranosyl)purines. J. Med. Chem. 15:1972;735-739
    • (1972) J. Med. Chem. , vol.15 , pp. 735-739
    • Christensen, L.F.1    Broom, A.2
  • 27
    • 0000924071 scopus 로고
    • 2-Chloroadenine and 2-chloroadenosine
    • Brown G., Weliky V. 2-Chloroadenine and 2-chloroadenosine. J. Org. Chem. 23:1958;125-126
    • (1958) J. Org. Chem. , vol.23 , pp. 125-126
    • Brown, G.1    Weliky, V.2
  • 28
    • 0026529184 scopus 로고
    • Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA), Int
    • Larsson R., Kristensen J., Sandberg C., Nygren P. Laboratory determination of chemotherapeutic drug resistance in tumor cells from patients with leukemia, using a fluorometric microculture cytotoxicity assay (FMCA), Int. J. Cancer. 50:1992;177-185
    • (1992) J. Cancer. , vol.50 , pp. 177-185
    • Larsson, R.1    Kristensen, J.2    Sandberg, C.3    Nygren, P.4
  • 29
    • 0027155584 scopus 로고
    • On the bioavailability of 2-chloro-2'-deoxyadenosine (CdA). The influence of food and omeprazole
    • Albertioni F., Juliusson G., Liliemark J. On the bioavailability of 2-chloro-2'-deoxyadenosine (CdA). The influence of food and omeprazole. Eur. J. Clin. Pharmacol. 44:1993;579-582
    • (1993) Eur. J. Clin. Pharmacol. , vol.44 , pp. 579-582
    • Albertioni, F.1    Juliusson, G.2    Liliemark, J.3
  • 30
    • 0027056958 scopus 로고
    • On the bioavailability of oral and subcutaneous 2-chloro-2′- deoxyadenosine in humans: Alternative routes of administration
    • Liliemark J., Albertioni F., Hassan M., Juliusson G. On the bioavailability of oral and subcutaneous 2-chloro-2′-deoxyadenosine in humans: alternative routes of administration. J. Clin. Oncol. 10:1992;1514-1518
    • (1992) J. Clin. Oncol. , vol.10 , pp. 1514-1518
    • Liliemark, J.1    Albertioni, F.2    Hassan, M.3    Juliusson, G.4
  • 31
    • 0029918664 scopus 로고    scopus 로고
    • Pharmacokinetic study of oral and bolus intravenous 2- chlorodeoxyadenosine in patients with malignancy
    • Saven A., Cheung W.K., Smith I., Moyer M., Johannsen T., Rose E., et al. Pharmacokinetic study of oral and bolus intravenous 2-chlorodeoxyadenosine in patients with malignancy. J. Clin. Oncol. 14:1996;978-983
    • (1996) J. Clin. Oncol. , vol.14 , pp. 978-983
    • Saven, A.1    Cheung, W.K.2    Smith, I.3    Moyer, M.4    Johannsen, T.5    Rose, E.6
  • 32
    • 0032969980 scopus 로고    scopus 로고
    • Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2′-deoxyadenosine
    • Van Den Neste E., Bontemps F., Delacauw A., Cardoen S., Louviaux I., Scheiff J.M., et al. Potentiation of antitumor effects of cyclophosphamide derivatives in B-chronic lymphocytic leukemia cells by 2-chloro-2′- deoxyadenosine. Leukemia. 13:1999;918-925
    • (1999) Leukemia , vol.13 , pp. 918-925
    • Van Den Neste, E.1    Bontemps, F.2    Delacauw, A.3    Cardoen, S.4    Louviaux, I.5    Scheiff, J.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.