Heme oxygenase-1 and NADPH cytochrome P450 reductase expression in experimental allergic encephalomyelitis: An expanded view of the stress response

Journal of Neurochemistry

Volumn 75, Issue 6, 2000, Pages 2555-2562

  Emerson, Mitchell R ^a   LeVine, Steven M ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

Author keywords

Experimental allergic encephalomyelitis; Heat shock protein; Heme oxygenase 1; Multiple sclerosis; NADPH cytochrome P450 reductase; Oxidative stress

Indexed keywords

HEME OXYGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; COMPETITIVE INHIBITION; DISEASE SEVERITY; ENZYME ACTIVITY; FEMALE; MACROPHAGE; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BLOTTING, WESTERN; CEREBELLUM; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; IMMUNOHISTOCHEMISTRY; LEUKODYSTROPHY, GLOBOID CELL; MEDULLA OBLONGATA; MEMBRANE PROTEINS; MICE; MICE, INBRED STRAINS; MICE, NEUROLOGIC MUTANTS; MICROSOMES; NADPH-FERRIHEMOPROTEIN REDUCTASE; OXIDATIVE STRESS; PONS;

ANIMALIA;

EID: 0033773770     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752555.x     Document Type: Article

References (64)

1. Ferritin: A cytoprotective antioxidant stratagem of endothelium
2. Reconstitution of the brain mixed function oxidase system: Purification of NADPH-cytochrome P450 reductase and partial purification of cytochrome P450 from whole rat brain
3. The neuroprotective agent SR 57746A abrogates experimental autoimmune encephalomyelitis and impairs associated blood-brain barrier disruption: Implications for multiple sclerosis treatment
4. Pathways of neurosteroid biosynthesis in cell lines from human brain: Regulation of dehydroepiandrosterone formation by oxidative stress and beta-amyloid peptide
5. Inducible nitric oxide synthase gene expression and enzyme activity correlate with disease activity in murine experimental autoimmune encephalomyelitis
6. Evidence for the production of peroxynitrite in inflammatory CNS demyelination
7. Temporal spatial patterns of expression of metallothionein-I and -III and other stress related genes in rat brain after kainic acid-induced seizures
8. Cyclooxygenases-1 and -2 are differentially located to microglia and endothelium in rat EAE and glioma
9. Bilirubin, formed by activation of heme oxygenase-2, protects neurons against oxidative stress injury
10. Protective properties of tin- and manganese-centered porphyrins against hydrogen peroxide-mediated injury in rat astroglial cells
11. Regulation of ferritin and heme oxygenase synthesis in rat fibroblasts by different forms of iron
12. Heme oxygenase: Recent advances in understanding its regulation and role
13. Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: Heme oxygenase 2 is not a heat shock protein
14. Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain
15. Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: Hyperthermia causes rapid induction of mRNA and protein
16. Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis
17. Effect of interleukin-11 on the levels of mRNAs encoding heme oxygenase and haptoglobin in human HepG2 hepatoma cells
18. Hypothermia due to an ascending impairment of shivering in hyperacute experimental allergic encephalomyelitis in the Lewis rat
19. Murine encephalitogenic lymphoid cells induce nitric oxide synthase in primary astrocytes
20. Demonstration of mRNA for five species of cytochrome P450 in human bone marrow, bone marrow-derived macrophages and human haemopoietic cell lines
21. Propentofylline and iloprost suppress the production of TNF-α by macrophages but fail to ameliorate experimental autoimmune encephalomyelitis in Lewis rats
22. Metabolic reactions: Role of cytochrome P-450 in the formation of reactive oxygen species
23. 2-induced expression of the rat heme oxygenase gene
24. Blood-brain barrier permeability to horseradish peroxidase in twitcher and cuprizone intoxicated mice
25. The effect of acute stress and opioid antagonist on the activity of NADPH-P450 reductase in rat Leydig cells
26. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
27. Identification of binding sites for transcription factors NF-κB and AP-2 in the promoter region of the human heme oxygenase 1 gene
28. Heme oxygenase and oxidative stress. Evidence of involvement of bilirubin as physiological protector against oxidative damage
29. Heme oxygenase: Function, multiplicity, regulatory mechanisms, and clinical applications
30. The heme oxygenase system: A regulator of second messenger gases
31. Metals as regulators of heme metabolism
32. Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible
33. The stress gene response in brain
34. Mediation of inflammation by encephalitogenic cells: Interferon-γ induction of nitric oxide synthase and cyclooxygenase 2
35. Modulation of cytochrome P450 by inflammation in astrocytes
36. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice
37. Desferrioxamine suppresses MBP induced experimental allergic encephalomyelitis in SJL mice
38. IL-6 deficiency causes enhanced pathology in twitcher (globoid cell leukodystrophy) mice
39. Heme oxygenase I is required for mammalian iron reutilization
40. Reduced stress defense in heme oxygenase 1-deficient cells
41. Demyelinating diseases
42. Biology of disease. The analysis of autoimmune demyelination: Its impact on multiple sclerosis
43. Neuropathology of experimental allergic encephalomyelitis in inbred strains of mice
44. Demyelination in primate autoimmune encephalomyelitis and acute multiple sclerosis lesions: A case for antigen-specific antibody mediation
45. Metabolism of xenobiotics in the central nervous system: Implications and challenges
46. Prostaglandins and inhibitors of arachidonate metabolism suppress experimental allergic encephalomyelitis
47. Induction by prostaglandin A1 of haem oxygenase in myoblastic cells: An effect independent of expression of the 70 kDa heat shock protein
48. Mice with an inactivation of the inducible nitric oxide synthase gene are susceptible to experimental autoimmune encephalomyelitis
49. Molecular cloning and expression of cDNA for murine galactocerebrosidase and mutation analysis of the twitcher mouse, a model of Krabbe's disease
50. Mitochondrial iron sequestration in dopamine-challenged astroglia: Role of heme oxygenase-1 and the permeability transition pore
51. Inhibition of rat liver microsomal NADPH cytochrome P450 reductase by glutathione and glutathione disulfide
52. Melatonin administration prevents lipopolysaccharide-induced oxidative damage in phenobarbital-treated animals
53. Cytochrome P450 reductase, antioxidant enzymes and cellular resistance to doxorubicin
54. Induction of stress proteins in rat cardiac myocytes by antimony
55. Bilirubin is an antioxidant of possible physiological importance
56. Interleukin-1 beta induces the expression of hsp70, heme oxygenase and Mn-SOD in FACS-purified rat islet beta-cells, but not in alphacells
57. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase
58. 2 in endothelial cells
59. Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis
60. Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin
61. Heme oxygenase-1 mediates an adaptive response to oxidative stress in human skin fibroblasts
62. Some properties of a detergentsolubilized NADPH-cytochrome c (cytochrome P-450) reductase purified by biospecific affinity chromatography
63. Targeted gene deletion of heme oxygenase 2 reveals neural role for carbon monoxide
64. Neurosteroidogenesis in astrocytes, oligodendrocytes, and neurons of cerebral cortex of rat brain