Anti-oxidant, anti-inflammatory and immunomodulating properties of an enzymatic protein hydrolysate from yellow field pea seeds

European Journal of Nutrition

Volumn 51, Issue 1, 2012, Pages 29-37

  Ndiaye, Fatou ^a,b   Vuong, Tri ^a   Duarte, Jairo ^a   Aluko, Rotimi E ^c   Matar, Chantal ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITÉ DE MONCTON   (Canada)

^c UNIVERSITY OF MANITOBA   (Canada)

Author keywords

Anti inflammatory; Anti oxidant; Cytokines; Immunomodulating; Pea proteins

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN A; INTERLEUKIN 10; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; NITRIC OXIDE; PROTEIN HYDROLYSATE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL PHAGOCYTOSIS; CELLULAR DISTRIBUTION; CELLULAR IMMUNITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFECT; DRUG MECHANISM; FEMALE; IMMUNOMODULATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PEA; PLANT SEED; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS INHIBITION; UPREGULATION;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CELL LINE, TRANSFORMED; CELLS, CULTURED; CYTOKINES; FEMALE; IMMUNITY, MUCOSAL; IMMUNOGLOBULIN A; IMMUNOMODULATION; INTESTINE, SMALL; MACROPHAGES; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MUCOUS MEMBRANE; PEAS; PHAGOCYTOSIS; PROTEIN HYDROLYSATES; RANDOM ALLOCATION; SEED STORAGE PROTEINS; TOLL-LIKE RECEPTORS;

BACTERIA (MICROORGANISMS); LATHYRUS APHACA; MURINAE; MUS; PISUM SATIVUM;

EID: 84860670686     PISSN: 14366207     EISSN: 14366215     Source Type: Journal    
DOI: 10.1007/s00394-011-0186-3     Document Type: Article

References (44)

1. De Le Blanc A, Matar C, Le Blanc N et al (2005) Effects of milk fermented by Lactobacillus helveticus R389 on a murine breast cancer model. Breast Cancer Res 7:R477-R486
2. Hernandez-Ledesma B, Hsieh CC, De Lumen BO (2009) Antioxidant and anti-inflammatory properties of cancer preventive peptide lunasin in RAW 264.7 macrophages. Biochem Biophys Res Commun 390:803-808
3. Iqbal A, Khalil IA, Ateeq N et al (2006) Nutritional quality of important food legumes. Food Chem 97:331-335 (Pubitemid 41828322)
4. Cheison SC, Wang Z, Xu SY (2007) Preparation of whey protein hydrolysates using a single-and two-stage enzymatic membrane reactor and their immunological and antioxidant properties: characterization by multivariate data analysis. J Agric Food Chem 55:3896-3904 (Pubitemid 46876396)
5. Xue Z, Yu W, Wu M et al (2009) In vivo antitumor and antioxidative effects of a rapeseed meal protein hydrolysate on an S180 tumor-bearing murine model. Biosci Biotechnol Biochem 73:2412-2415
6. Duarte J, Vinderola G, Ritz B et al (2006) Immunomodulating capacity of commercial fish protein hydrolysate for diet supplementation. Immunobiology 211:341-350
7. Pownall TL, Udenigwe CC, Aluko RE (2010) Amino acid composition and antioxidant properties of pea seed (Pisum sativum L.) enzymatic protein hydrolysate fractions. J Agric Food Chem 58:4712-4718
8. Niehues M, Euler M, Georgi G, et al (2010) Peptides from Pisum sativum L. enzymatic protein digest with anti-adhesive activity against Helicobacter pylori: structure-activity and inhibitory activity against BabA, SabA, HpaA and a fibronectin-binding adhesin. Mol Nutr Food Res. http://www.ncbi.nlm.nih.gov/ pubmed/20540145
9. de Le Blanc A, Matar C, Theriault C et al (2005) Effects of milk fermented by Lactobacillus helveticus R389 on immune cells associated to mammary glands in normal and a breast cancer model. Immunobiology 210:349-358 (Pubitemid 41102642)
10. Rachid M, Matar C, Duarte J et al (2006) Effect of milk fermented with a Lactobacillus helveticus R389 (+) proteolytic strain on the immune system and on the growth of 4T1 breast cancer cells in mice. FEMS Immunol Med Microbiol 47:242-253 (Pubitemid 43881744)
11. Vinderola G, Matar C, Palacios J et al (2007) Mucosal immunomodulation by the non-bacterial fraction of milk fermented by Lactobacillus helveticus R389. Int J Food Microbiol 115:180-186 (Pubitemid 46367331)
12. Vinderola G, Perdigon G, Duarte J et al (2006) Effects of kefir fractions on innate immunity. Immunobiology 211:149-156 (Pubitemid 43337755)
13. Vinderola G, Perdigon G, Duarte J et al (2006) Effects of the oral administration of the products derived from milk fermentation by kefir microflora on immune stimulation. J Dairy Res 73:472-479 (Pubitemid 44624077)
14. Vinderola G, Perdigon G, Duarte J et al (2006) Effects of the oral administration of the exopolysaccharide produced by Lactobacillus kefiranofaciens on the gut mucosal immunity. Cytokine 36:254-260 (Pubitemid 46529477)
15. Wetzler C, Kampfer H, Pfeilschifter J et al (2000) Keratinocytederived chemotactic cytokines: expressional modulation by nitric oxide in vitro and during cutaneous wound repair in vivo. Biochem Biophys Res Commun 274:689-696 (Pubitemid 30663680)
16. Hofseth LJ, Saito S, Hussain SP et al (2003) Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc Natl Acad Sci USA 100:143-148 (Pubitemid 36078042)
17. Krieglstein CF, Cerwinka WH, Laroux FS et al (2001) Regulation of murine intestinal inflammation by reactive metabolites of oxygen and nitrogen: divergent roles of superoxide and nitric oxide. J Exp Med 194:1207-1218 (Pubitemid 33055040)
18. Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB et al (2010) Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 9:3256-3276
19. Baritaki S, Huerta-Yepez S, Sahakyan A et al (2010) Mechanisms of nitric oxide-mediated inhibition of EMT in cancer: inhibition of the metastasis-inducer snail and induction of the metastasissuppressor RKIP. Cell Cycle 9:4931-4940
20. Tsai TH, Tsai PJ, Ho SC (2005) Antioxidant and anti-inflammatory activities of several commonly used species. J Food Sci 70:C93-C97
21. Villegas I, Sanchez-Fidalgo S, Alarcon de la Lastra C (2008) New mechanisms and therapeutic potential of curcumin for colorectal cancer. Mol Nutr Food Res 52:1040-1061
22. Vinderola CG, Duarte J, Thangavel D et al (2005) Immunomodulating capacity of kefir. J Dairy Res 72:195-202 (Pubitemid 40689748)
23. Wang J, Mazza G (2002) Inhibitory effects of anthocyanins and other phenolic compounds on nitric oxide production in LPS/IFN-gamma-activated RAW 264.7 macrophages. J Agric Food Chem 50:850-857 (Pubitemid 34163634)
24. Sainte-Marie GA (1962) A paraffin embedding technic for studies employing immunofluorescence. J Histochem Cytochem 10:250-256
25. Perdigon G, de Macias ME, Alvarez S et al (1986) Effect of perorally administered lactobacilli on macrophage activation in mice. Infect Immun 53:404-410 (Pubitemid 16073873)
26. Vinderola G, Matar C, Perdigon G (2005) Role of intestinal epithelial cells in immune effects mediated by gram-positive probiotic bacteria: involvement of toll-like receptors. Clin Diagn Lab Immunol 12:1075-1084 (Pubitemid 41324539)
27. Arwert EN, Lal R, Quist S et al (2010) Tumor formation initiated by nondividing epidermal cells via an inflammatory infiltrate. Proc Natl Acad Sci USA 107:19903-19908
28. de Mejia EG, Dia VP (2009) Lunasin and lunasin-like peptides inhibit inflammation through suppression of NF-kappaB pathway in the macrophage. Peptides 30:2388-2398
29. Jeong JB, Jeong HJ, Park JH et al (2007) Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb). J Agric Food Chem 55:10707-10713
30. Jeong HJ, Lee JR, Jeong JB et al (2009) The cancer preventive seed peptide lunasin from rye is bioavailable and bioactive. Nutr Cancer 61:680-686
31. Hernandez-Ledesma B, Hsieh CC, de Lumen BO (2009) Lunasin, a novel seed peptide for cancer prevention. Peptides 30:426-430
32. Perdigon G, Vintini E, Alvarez S et al (1999) Study of the possible mechanisms involved in the mucosal immune system activation by lactic acid bacteria. J Dairy Sci 82:1108-1114 (Pubitemid 129552387)
33. Vinderola CG, Medici M, Perdigon G (2004) Relationship between interaction sites in the gut, hydrophobicity, mucosal immunomodulating capacities and cell wall protein profiles in indigenous and exogenous bacteria. J Appl Microbiol 96:230-243 (Pubitemid 38223549)
34. Kunder CA, St John AL, Li G et al (2009) Mast cell-derived particles deliver peripheral signals to remote lymph nodes. J Exp Med 206:2455-2467
35. Rumbo M, Anderle P, Didierlaurent A et al (2004) How the gut links innate and adaptive immunity. Ann NY Acad Sci 1029:16-21 (Pubitemid 40298511)
36. de Le Blanc A, Matar C, Farnworth E et al (2006) Study of cytokines involved in the prevention of a murine experimental breast cancer by kefir. Cytokine 34:1-8 (Pubitemid 44177432)
37. Levi RS, Sanderson IR (2004) Dietary regulation of gene expression. Curr Opin Gastroenterol 20:139-142 (Pubitemid 38297401)
38. Sanderson IR, Naik S (2000) Dietary regulation of intestinal gene expression. Annu Rev Nutr 20:311-338
39. Goodrich ME, McGee DW (1999) Effect of intestinal epithelial cell cytokines on mucosal B-cell IgA secretion: enhancing effect of epithelial-derived IL-6 but not TGF-beta on IgA+ B cells. Immunol Lett 67:11-14 (Pubitemid 29143429)
40. Hirano T (2010) Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir. Proc Jpn Acad Ser B Phys Biol Sci 86:717-730
41. Ng EK, Panesar N, Longo WE et al (2003) Human intestinal epithelial and smooth muscle cells are potent producers of IL-6. Mediat Inflamm 12:3-8 (Pubitemid 36566698)
42. Miller TL, McGee DW (2002) Epithelial cells respond to proteolytic and non-proteolytic detachment by enhancing interleukin-6 responses. Immunology 105:101-110 (Pubitemid 34128045)
43. Bhattacharyya S, Gill R, Chen ML et al (2008) Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells. J Biol Chem 283:10550-10558
44. Frei R, Steinle J, Birchler T et al (2010) MHC class II molecules enhance toll-like receptor mediated innate immune responses. PLoS One 5:e8808