Evaluation of in vivo mutagenicity by 2,4-diaminotoluene and 2,6-diaminotoluene in liver of F344 gpt delta transgenic rat dosed for 28 days: A collaborative study of the gpt delta transgenic rat mutation assay

Genes and Environment

Volumn 34, Issue 1, 2012, Pages 25-33

  Sui, Hajime ^a   Ohta, Ryo ^a   Shiragiku, Toshiyuki ^b   Akahori, Ayaka ^c   Suzuki, Kenichiro ^c   Nakajima, Madoka ^c   Hayashi, Hiroyuki ^d   Masumura, Kenichi ^e   Nohmi, Takehiko ^e  

^a HATANO RESEARCH INSTITUTE   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

^c Biosafety Research Center   (Japan)

^d MEIJI SEIKA KAISHA LTD   (Japan)

^e NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

Author keywords

28 consecutive daily treatment; Diaminotoluenes; F344 gpt delta transgenic rat; Gpt assay

Indexed keywords

2,4 DIAMINOTOLUENE; 2,6 DIAMINOTOLUENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL EVALUATION; CLINICAL PROTOCOL; CONTROLLED STUDY; FISCHER 344 RAT; GENE MUTATION; GENOTOXICITY; IN VIVO STUDY; LIVER; MALE; MUTAGENICITY; MUTATION RATE; MUTATIONAL ANALYSIS; NONHUMAN; RAT; TRANSGENIC RAT; VALIDITY;

RATTUS; RODENTIA;

EID: 84860651298     PISSN: 18807046     EISSN: 18807062     Source Type: Journal    
DOI: 10.3123/jemsge.34.25     Document Type: Article

References (31)

1. Heddle JA, Dean S, Nohmi T, Boerrigter M, Casciano D, Douglas GR, Glickman BW, Gorelick NJ, Mirsalis JC, Martus HJ, Skopek TR, Thybaud V, Tindall KR, Yajima N. In vivo transgenic mutation assays. Environ Mol Mutagen. 2000; 35: 253-9. (Pubitemid 30196668)
2. Thybaud V, Dean S, Nohmi T, de Boer J, Douglas GR, Glickman BW, Gorelick NJ, Heddle JA, Heflich RH, Lambert I, Martus HJ, Mirsalis JC, Suzuki T, Yajima N. In vivo transgenic mutation assays. Mutat Res. 2003; 540: 141-51. (Pubitemid 37204938)
3. International Programme on Chemical Safety: Transgenic animal mutagenicity assays. Environmental Health Criteria 233, World Health Organization (WHO), Geneva: 2006.
4. - and 6-thioguanine selections. Environ Mol Mutagen. 1996; 28: 465-70. (Pubitemid 126450192)
5. - selection. Environ Mol Mutagen. 2003; 41: 253-9. (Pubitemid 36529772)
6. Toyoda-Hokaiwado N, Inoue T, Masumura K, Hayashi H, Kawamura Y, Kurata Y, Takamune M, Yamada M, Sanada H, Umemura T, Nishikawa A, Nohmi T. Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: In vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers. Toxicol Sci. 2010; 114: 71-8.
7. National Toxicology Program. Bioassay of 2,4-diaminotoluene for possible carcinogenicity. Natl Cancer Inst Carcinog Tech Rep Ser. 1979; 162: 1-139.
8. National Toxicology Program. Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity. Natl Cancer Inst Carcinog Tech Rep Ser. 1980; 200: 1-123.
9. Haworth S, Lawlor T, Mortelmans K, Speck W, Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ Mutagen. 1983; 1 Suppl 1: 3-142. (Pubitemid 14168891)
10. Cunningham ML, Burka LT, Matthews HB. Metabolism, disposition, and mutagenicity of 2,6-diaminotoluene, a mutagenic noncarcinogen. Drug Metab Dispos. 1989; 17: 612-6.
11. Furlong BB, Weaver RP, Goldstein JA. Covalent binding to DNA and mutagenicity of 2,4-diaminotoluene metabolites produced by isolated hepatocytes and 9000 g supernatant from Fischer 344 rats. Carcinogenesis. 1987; 8: 247-51.
12. Cunningham ML, Matthews HB. Evidence for an acetoxyarylamine as the ultimate mutagenic reactive intermediate of the carcinogenic aromatic amine 2,4-diaminotoluene. Mutat Res. 1990; 242: 101-10. (Pubitemid 20327712)
13. Seá verin I, Jondeau A, Dahbi L, Chagnon MC. 2,4-Diaminotoluene (2,4-DAT)-induced DNA damage, DNA repair and micronucleus formation in the human hepatoma cell line HepG2. Toxicology. 2005; 213: 138-46. (Pubitemid 41191289)
14. Bermudez E, Tillery D, Butterworth BE. The effect of 2,4-diaminotoluene and isomers of dinitrotoluene on unscheduled DNA synthesis in primary rat hepatocytes. Environ Mutagen. 1979; 1: 391-8. (Pubitemid 10060815)
15. Butterworth BE, Earle LL, Strom S, Jirtle R, Michalopoulos G. Measurement of chemically induced DNA repair in human hepatocytes. Proc Am Assoc Cancer Res. 1983; 24: 69.
16. Sina JF, Bean CL, Dysart GR, Taylor VI, Bradley MO. Evaluation of the alkaline elution/rat hepatocyte assay as a predictor of carcinogenic/mutagenic potential. Mutat Res. 1983; 113: 357-91.
17. Mirsalis JC, Tyson CK, Butterworth BE. Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay. Environ Mutagen. 1982; 4: 553-62 (Pubitemid 13212912)
18. Sasaki YF, Fujikawa K, Ishida K, Kawamura N, Nishikawa Y, Ohta S, Satoh M, Madarame H, Ueno S, Susa N, Matsusaka N, Tsuda S. The alkaline single cell gel electrophoresis assay with mouse multiple organs: results with 30 aromatic amines evaluated by the IARC and U.S. NTP. Mutat Res. 1999; 440: 1-18. (Pubitemid 29129522)
19. Suter W, Ahiabor R, Blanco B, Locher F, Mantovani F, Robinson M, Sreenan G, Staedtler F, Swingler T, Vignutelli A, Perentes E. Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue™ transgenic mouse mutation assay. Environ Mol Mutagen. 1996; 28: 354-62. (Pubitemid 126450177)
20. Cunningham ML, Hayward JJ, Shane BS, Tindall KR. Distinction of mutagenic carcinogens from a mutagenic noncarcinogen in the big blue transgenic mouse. Environ Health Perspect. 1996; 104 Suppl 3: 683-6. (Pubitemid 26196425)
21. Kirkland D, Beevers C. Induction of LacZ mutations in Muta™ Mouse can distinguish carcinogenic from noncarcinogenic analogues of diaminotoluenes and nitronaphthalenes. Mutat Res. 2006; 608: 88-96. (Pubitemid 44280046)
22. George E, Westmoreland C. Evaluation of the in vivo genotoxicity of the structural analogues 2,6-diaminotoluene and 2,4-diaminotoluene using the rat micronucleus test and rat liver UDS assay. Carcinogenesis. 1991; 12: 2233-7.
23. Sambrook J, Russell DW. Molecular cloning, a laboratory manual. 3rd ed. Vol. 1. New York: Cold Spring Harbor Laboratory Press; 1989.
24. Nohmi T, Suzuki T, Masumura K. Recent advances in the protocols of transgenic mouse mutation assays. Mutat Res. 2000; 455: 191-215.
25. Dunnett CW. A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc. 1955; 50: 1096-121.
26. Dunnett CW. New tables for multiple comparisons with a control. Biometrics. 1964; 20: 482-91.
27. Steel RGD. A multiple comparison rank sum test: Treatments versus control. Biometrics. 1959; 15: 560-72.
28. Masumura K. Spontaneous and induced gpt and Spimutant frequencies in gpt delta transgenic rodent. Genes Environ. 2009; 31: 105-18.
29. Swiger RR, Cosentino L, Masumura KI, Nohmi T, Heddle JA. Further characterization and validation of gpt delta transgenic mice for quantifying somatic mutations in vivo. Environ Mol Mutagen. 2001; 37: 297-303. (Pubitemid 32642725)
30. Yoshimura I. IV 8. Explorative data analysis with diagrammatic representation. In: Yoshimura I, editor. Statistical methods for toxicological and medical data. Tokyo: Scientist Press; 2008. p. 182-6 (in Japanese).
31. Thybaud V, Dean S, Nohmi T, de Boer J, Douglas GR, Glickman BW, Gorelick NJ, Heddle JA, Heflich RH, Lambert I, Martus HJ, Mirsalis JC, Suzuki T, Yajima N. In vivo transgenic mutation assays. Environ Mol Mutagen. 2000; 35: 253-9. (Pubitemid 30196668)