Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: In vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers

Toxicological Sciences

Volumn 114, Issue 1, 2009, Pages 71-78

  Toyoda Hokaiwado, Naomi ^a   Inoue, Tomoki ^a   Masumura, Kenichi ^a   Hayashi, Hiroyuki ^b   Kawamura, Yuji ^b   Kurata, Yasushi ^b   Takamune, Makiko ^a   Yamada, Masami ^a   Sanada, Hisakazu ^c   Umemura, Takashi ^a   Nishikawa, Akiyoshi ^a   Nohmi, Takehiko ^a  

^a NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^b MEIJI SEIKA KAISHA LTD   (Japan)

^c KAKEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

3R principle; Carcinogenicity; Diaminotoluenes; Genotoxicity; gpt delta transgenic rat

Indexed keywords

2,4 DIAMINOTOLUENE; 2,6 DIAMINOTOLUENE; CYTOSINE; GLUTATHIONE TRANSFERASE; GUANINE; NUCLEIC ACID;

AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENICITY; CONTROLLED STUDY; FISCHER 344 RAT; GENE MUTATION; GENOTOXICITY; IN VIVO STUDY; ISOMER; LIVER CARCINOGENESIS; LIVER TOXICITY; LIVER TUMOR; MALE; MUTAGENICITY; MUTATION RATE; NEPHROTOXICITY; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PLACENTA; RAT; REPORTER GENE; SHUTTLE VECTOR; TRANSGENIC RAT;

ANIMALIA; RATTUS;

EID: 77951557168     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp306     Document Type: Article

References (40)

1. Aoki, Y., Hashimoto, A.H., Amanuma, K., Matsumoto, M., Hiyoshi, K., Takano, H., Masumura, K., Itoh, K., Nohmi, T., and Yamamoto, M. (2007). Enhanced spontaneous and benzo(a)pyrene-induced mutations in the lung of Nrf2-deficient gpt delta mice. Cancer Res. 67, 5643-5648.
2. Bagnyukova, T.V., Tryndyak, V.P., Montgomery, B., Churchwell, M.I., Karpf, A.R., James, S.R., Muskhelishveli, L., Beland, F.A., and Pogribny, I.P. (2008). Genetic and epigenetic changes in rat preneoplastic liver tissue induced by 2-acetylaminofluorene. Carcinogenesis 29, 638-646.
3. Balls, M. (1997). The three Rs concept of alternatives to animal experimentation. In Animal Alternatives (L. F. M. van Zutphen and M. Balls, Eds.), pp. 27-41. Elsevier, Amsterdam.
4. Cunningham, M.L., Burka, L.T., and Matthews, H.B. (1989). Metabolism, disposition, and mutagenicity of 2,6-diaminotoluene, a mutagenic non-carcinogen. Drug Metab. Dispos. 17, 612-617.
5. Cunningham, M.L., Hayward, J.J., Shane, B.S., and Tindall, K.R. (1996). Distinction of mutagenic carcinogens from a mutagenic noncarcinogen in the big blue transgenic mouse. Environ. Health Perspect. 104(Suppl. 3), 683-686.
6. de Azambuja, E., Cardoso, F., de Castro, G., Jr, Colozza, M., Mano, M.S., Durbecq, V., Sotiriou, C., Larsimont, D., Piccart-Gebhart, M.J., and Paesmans, M. (2007). Ki-67 as prognostic marker in early breast caner: a meta-analysis of published studies involving 12,155 patients. Br. J. Cancer. 96, 1504-1513.
7. Eastmond, D.A., Hartwig, A., Anderson, D., Anwar, W.A., Cimino, M.C., Dobrev, I., Douglas, G.R., Nohmi, T., Phillips, D.H., and Vickers, C. (2009). Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme. Mutagenesis 24, 341-349.
8. Gerdes, J., Schwab, U., Lemke, H., and Stein, H. (1983). Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int. J. Cancer 31, 13-20.
9. Hashimoto, A.H., Amanuma, K., Masumura, K., Nohmi, T., and Aoki, Y. (2009). In vivo mutagenesis caused by diesel exhaust in the testis of gpt delta mouse. Genes Environ. 31, 1-8.
10. -selection. Environ. Mol. Mutagen. 41, 253-259.
11. Hayashi, M. (2008). Update on the maintenance of the ICH S2 genetic toxicology. Pharm. Regul. Sci. 39, 515-521.
12. Heddle, J.A., Dean, S., Nohmi, T., Boerrigter, M., Casciano, D., Douglas, G.R., Glickman, B.W., Gorelick, N.J., Mirsalis, J.C., Martus, H.J., et al. (2000). In vivo transgenic mutation assays. Environ. Mol. Mutagen. 35, 253-259.
13. Horiguchi, M., Masumura, K.I., Ikehata, H., Ono, T., Kanke, Y., and Nohmi, T. (2001). Molecular nature of ultraviolet B light-induced deletions in the murine epidermis. Cancer Res. 61, 3913-3918.
14. Ito, N., Imaida, K., Asamoto, M., and Shirai, T. (2000). Early detection of carcinogenic substances and modifiers in rats. Mutat. Res. 462, 209-217.
15. Kirkland, D., Aardema, M., Henderson, L., and Muller, L. (2005). Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens I. Sensitivity, specificity and relative predictivity. Mutat. Res. 584, 1-256.
16. Kirkland, D., and Beevers, C. (2006). Induction of LacZ mutations in Muta Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes. Mutat. Res. 608, 88-96.
17. Kirsch-Volders, M., Aardema, M., and Elhajouji, A. (2000). Concepts of threshold in mutagenesis and carcinogenesis. Mutat. Res. 464, 3-11.
18. Maron, D.M., and Ames, B.N. (1983). Revised methods for the salmonella mutagenicity test. Mutat. Res. 113, 173-215.
19. Masumura, K., Matsui, M., Katoh, M., Horiya, N., Ueda, O., Tanabe, H., Yamada, M., Suzuki, H., Sofuni, T., and Nohmi, T. (1999). Spectra of gpt mutations in ethylnitrosourea-treated and untreated transgenic mice. Environ. Mol. Mutagen. 34, 1-8.
20. Masumura, K., Matsui, K., Yamada, M., Horiguchi, M., Ishida, K., Watanabe, M., Wakabayashi, K., and Nohmi, T. (2000). Characterization of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in the colon of gpt delta transgenic mouse: novel G: C deletions beside runs of identical bases. Carcinogenesis 21, 2049-2056.
21. Masumura, K., Kuniya, K., Kurobe, T., Fukuoka, M., Yatagai, F., and Nohmi, T. (2002). Heavy-ion-induced mutations in the gpt delta transgenic mouse: comparison of mutation spectra induced by heavy-ion, X-ray, and gamma-ray radiation. Environ. Mol. Mutagen. 40, 207-215.
22. Masumura, K., Totsuka, Y., Wakabayashi, K., and Nohmi, T. (2003). Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse. Carcinogenesis 24, 1985-1993.
23. National Toxicology Program. (1979). Bioassay of 2,4-diaminotoluene for possible carcinogenicity. Natl. Cancer Inst. Carcinog. Tech. Rep. Ser. 162, 1-139.
24. National Toxicology Program. (1980). Bioassay of 2,6-toluenediamine dihydrochloride for possible carcinogenicity (CAS No. 15481-70-6). Natl. Toxicol. Program Tech. Rep. Ser. 200, 1-123.
25. Nohmi, T. (2008). Possible mechanisms of practical thresholds for genotoxicity. Genes Environ. 30, 108-113.
26. Nohmi, T., Katoh, M., Suzuki, H., Matsui, M., Yamada, M., Watanabe, M., Suzuki, M., Horiya, N., Ueda, O., Shibuya, T., et al. (1996). A new transgenic mouse mutagenesis test system using Spi-and 6-thioguanine selections. Environ. Mol. Mutagen. 28, 465-470.
27. Nohmi, T., and Masumura, K. (2005). Molecular nature of intrachromosomal deletions and base substitutions induced by environmental mutagens. Environ. Mol. Mutagen. 45, 150-161.
28. Nohmi, T., Suzuki, T., and Masumura, K. (2000). Recent advances in the protocols of transgenic mouse mutation assays. Mutat. Res. 455, 191-215.
29. Nolte, M., Werner, M., Nasarek, A., Bektas, H., von Wasielewski, R., Klempnauer, J., and Georgii, A. (1998). Expression of proliferation associated antigens and detection of numerical chromosome aberrations in primary human liver tumors: relevance to tumor characteristic and prognosis. J. Clin. Pathol. 51, 47-51.
30. Ogiso, T., Tatematsu, M., Tamano, S., Tsuda, H., and Ito, N. (1985). Comparative effects of carcinogens on the induction of placental glutathione S-transferase-positive liver nodules in a short-term assay and of hepatocellular carcinomas in a long-term assay. Toxicol. Pathol. 13, 257-265.
31. Preston, R.J., and Hoffmann, G.R. (2007). Genetic toxicology. In Casarett and Doull's Toxicology: The Basic Science of Poisons (C. D. Klaassen, Ed.), pp. 381-413. The McGraw-Hill Companies, Inc., New York.
32. Shibata, A., Maeda, D., Ogino, H., Tsutsumi, M., Nohmi, T., Nakagama, H., Sugimura, T., Teraoka, H., and Masutani, M. (2009). Role of Parp-1 in suppressing spontaneous deletion mutation in the liver and brain of mice at adolescence and advanced age. Mutat. Res. 664, 20-27.
33. Takeiri, A., Mishima, M., Tanaka, K., Shioda, A., Ueda, O., Suzuki, H., Inoue, M., Masumura, K., and Nohmi, T. (2003). Molecular characterization of mitomycin C-induced large deletions and tandem-base substitutions in the bone marrow of gpt delta transgenic mice. Chem. Res. Toxicol. 16, 171-179.
34. Taningher, M., Peluso, M., Parodi, S., Ledda-Columbano, G.M., and Columbano, A. (1995). Genotoxic and non-genotoxic activities of 2,4-and 2,6-diaminotoluene, as evaluated in Fischer-344 rat liver. Toxicology 99, 1-10.
35. Thybaud, V., Dean, S., Nohmi, T., de Boer, J., Douglas, G.R., Glickman, B.W., Gorelick, N.J., Heddle, J.A., Heflich, R.H., Lambert, I., et al. (2003).In vivo transgenic mutation assays. Mutat. Res. 540, 141-151.
36. Tsuda, H., Fukushima, S., Wanibuchi, H., Morimura, K., Nakae, D., Imaida, K., Tatematsu, M., Hirose, M., Wakabayashi, K., and Moore, M.A. (2003). Value of GST-P positive preneoplastic hepatic foci in dose-response studies of hepatocarcinogenesis: evidence for practical thresholds with both genotoxic and nongenotoxic carcinogens. A review of recent work. Toxicol. Pathol. 31, 80-86.
37. Umemura, T., Kanki, K., Kuroiwa, Y., Ishii, Y., Okano, K., Nohmi, T., Nishikawa, A., and Hirose, M. (2006). In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate. Cancer Sci. 97, 829-835.
38. Umemura, T., Tasaki, M., Kijima, A., Okamura, T., Inoue, T., Ishii, Y., Suzuki, Y., Masui, N., Nohmi, T., and Nishikawa, A. (2009). Possible participation of oxidative stress in causation of cell proliferation and in vivo mutagenicity in kidneys of gpt delta rats treated with potassium bromate. Toxicology 257, 46-52.
39. Watanabe, M., Igarashi, T., Kaminuma, T., Sofuni, T., and Nohmi, T. (1994). N-hydroxyarylamine O-acetyltransferase of Salmonella typhimurium: proposal for a common catalytic mechanism of arylamine acetyltransferase enzymes. Environ. Health Perspect. 102(Suppl. 6), 83-89.
40. Xu, A., Smilenov, L.B., He, P., Masumura, K., Nohmi, T., Yu, Z., and Hei, T.K. (2007). New insight into intrachromosomal deletions induced by chrysotile in the gpt delta transgenic mutation assay. Environ. Health Perspect. 115, 87-92.