-
1
-
-
0041332751
-
Hierarchy of the beta-cell signals controlling insulin secretion
-
Henquin JC, Ravier MA, Nenquin M, Jonas JC, Gilon P. Hierarchy of the beta-cell signals controlling insulin secretion. Eur J Clin Invest 2003;33:742-50.
-
(2003)
Eur J Clin Invest
, vol.33
, pp. 742-750
-
-
Henquin, J.C.1
Ravier, M.A.2
Nenquin, M.3
Jonas, J.C.4
Gilon, P.5
-
2
-
-
0037023692
-
Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues
-
Antinozzi PA, Ishihara H, Newgard CB, Wollheim CB. Mitochondrial metabolism sets the maximal limit of fuel-stimulated insulin secretion in a model pancreatic beta cell: a survey of four fuel secretagogues. J Biol Chem 2002;277:11746-55.
-
(2002)
J Biol Chem
, vol.277
, pp. 11746-11755
-
-
Antinozzi, P.A.1
Ishihara, H.2
Newgard, C.B.3
Wollheim, C.B.4
-
3
-
-
0032788372
-
Molecular biology of adenosine triphosphate-sensitive potassium channels
-
Aguilar-Bryan L, Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocr Rev 1999;20: 101-35.
-
(1999)
Endocr Rev
, vol.20
, pp. 101-135
-
-
Aguilar-Bryan, L.1
Bryan, J.2
-
4
-
-
0029097424
-
Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion
-
MacDonald MJ. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion. J Biol Chem 1995;270:20051-8.
-
(1995)
J Biol Chem
, vol.270
, pp. 20051-20058
-
-
MacDonald, M.J.1
-
5
-
-
0034072556
-
Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion
-
Farfari S, Schulz V, Corkey B, Prentki M. Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion. Diabetes 2000;49:718-26.
-
(2000)
Diabetes
, vol.49
, pp. 718-726
-
-
Farfari, S.1
Schulz, V.2
Corkey, B.3
Prentki, M.4
-
6
-
-
0037022527
-
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)
-
Lu D, Mulder H, Zhao P, Burgess SC, Jensen MV, Kamzolova S, Newgard CB, Sherry AD. 13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS). Proc Natl Acad Sci USA 2002; 99:2708-13.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2708-2713
-
-
Lu, D.1
Mulder, H.2
Zhao, P.3
Burgess, S.C.4
Jensen, M.V.5
Kamzolova, S.6
Newgard, C.B.7
Sherry, A.D.8
-
7
-
-
7244248787
-
13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells
-
Cline GW, Lepine RL, Papas KK, Kibbey RG, Shulman GI. 13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells. J Biol Chem 2004;279:44370-5.
-
(2004)
J Biol Chem
, vol.279
, pp. 44370-44375
-
-
Cline, G.W.1
Lepine, R.L.2
Papas, K.K.3
Kibbey, R.G.4
Shulman, G.I.5
-
8
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 2001;105:745-55.
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
Grujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
-
9
-
-
0346340042
-
Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction
-
Krauss S, Zhang CY, Scorrano L, Dalgaard LT, St-Pierre J, Grey ST, Lowell BB. Superoxide-mediated activation of uncoupling protein 2 causes pancreatic beta cell dysfunction. J Clin Invest 2003;112:1831-42.
-
(2003)
J Clin Invest
, vol.112
, pp. 1831-1842
-
-
Krauss, S.1
Zhang, C.Y.2
Scorrano, L.3
Dalgaard, L.T.4
St-Pierre, J.5
Grey, S.T.6
Lowell, B.B.7
-
10
-
-
67649641804
-
Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pan creatic beta-cell function
-
Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pan creatic beta-cell function. Endocrinology 2009;150:3040-8.
-
(2009)
Endocrinology
, vol.150
, pp. 3040-3048
-
-
Pi, J.1
Bai, Y.2
Daniel, K.W.3
Liu, D.4
Lyght, O.5
Edelstein, D.6
Brownlee, M.7
Corkey, B.E.8
Collins, S.9
-
11
-
-
67650533760
-
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets
-
Pongratz RL, Kibbey RG, Kirkpatrick CL, Zhao X, Pontoglio M, Yaniv M, Wollheim CB, Shulman GI, Cline GW. Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. J Biol Chem 2009;284: 16808-21.
-
(2009)
J Biol Chem
, vol.284
, pp. 16808-16821
-
-
Pongratz, R.L.1
Kibbey, R.G.2
Kirkpatrick, C.L.3
Zhao, X.4
Pontoglio, M.5
Yaniv, M.6
Wollheim, C.B.7
Shulman, G.I.8
Cline, G.W.9
-
12
-
-
24144496798
-
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes
-
Kjorholt C, Akerfeldt MC, Biden TJ, Laybutt DR. Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes. Diabetes 2005;54:2755-63.
-
(2005)
Diabetes
, vol.54
, pp. 2755-2763
-
-
Kjorholt, C.1
Akerfeldt, M.C.2
Biden, T.J.3
Laybutt, D.R.4
-
13
-
-
1242317666
-
The mitochondrial transporter family (SLC25): physiological and pathological implications
-
Palmieri F. The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch 2004;447:689-709.
-
(2004)
Pflugers Arch
, vol.447
, pp. 689-709
-
-
Palmieri, F.1
-
14
-
-
70349669093
-
Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter
-
Jiang D, Zhao L, Clapham DE. Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter. Science 2009;326:144-7.
-
(2009)
Science
, vol.326
, pp. 144-147
-
-
Jiang, D.1
Zhao, L.2
Clapham, D.E.3
-
15
-
-
60549109221
-
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation
-
Wiederkehr A, Park KS, Dupont O, Demaurex N, Pozzan T, Cline GW, Wollheim CB. Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J 2009;28:417-28.
-
(2009)
EMBO J
, vol.28
, pp. 417-428
-
-
Wiederkehr, A.1
Park, K.S.2
Dupont, O.3
Demaurex, N.4
Pozzan, T.5
Cline, G.W.6
Wollheim, C.B.7
-
16
-
-
0035856942
-
Mitochondrial function in normal and diabetic beta-cells
-
Maechler P, Wollheim CB. Mitochondrial function in normal and diabetic beta-cells. Nature 2001;414:807-12.
-
(2001)
Nature
, vol.414
, pp. 807-812
-
-
Maechler, P.1
Wollheim, C.B.2
-
17
-
-
17644434484
-
Bicarbonate-carbon dioxide buffer system: a determinant of the mitochondrial pH gradient
-
Simpson DP, Hager SR. Bicarbonate-carbon dioxide buffer system: a determinant of the mitochondrial pH gradient. Am J Physiol 1984;247(3 Pt 2):F440-6.
-
(1984)
Am J Physiol
, vol.247
, Issue.3 PT 2
-
-
Simpson, D.P.1
Hager, S.R.2
-
18
-
-
44949196953
-
Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell
-
Wiederkehr A, Wollheim CB. Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell. Cell Calcium 2008;44:64-76.
-
(2008)
Cell Calcium
, vol.44
, pp. 64-76
-
-
Wiederkehr, A.1
Wollheim, C.B.2
-
19
-
-
33846954392
-
Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion
-
Pongratz RL, Kibbey RG, Shulman GI, Cline GW. Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion. J Biol Chem 2007;282:200-7.
-
(2007)
J Biol Chem
, vol.282
, pp. 200-207
-
-
Pongratz, R.L.1
Kibbey, R.G.2
Shulman, G.I.3
Cline, G.W.4
-
20
-
-
0037131246
-
Beta-Cell adaptation to insulin resistance: increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats
-
Liu YQ, Jetton TL, Leahy JL. Beta-Cell adaptation to insulin resistance: increased pyruvate carboxylase and malate-pyruvate shuttle activity in islets of nondiabetic Zucker fatty rats. J Biol Chem 2002;277:39163-8.
-
(2002)
J Biol Chem
, vol.277
, pp. 39163-39168
-
-
Liu, Y.Q.1
Jetton, T.L.2
Leahy, J.L.3
-
21
-
-
0033431775
-
Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells
-
Ishihara H, Wang H, Drewes LR, Wollheim CB. Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest 1999;104:1621-9.
-
(1999)
J Clin Invest
, vol.104
, pp. 1621-1629
-
-
Ishihara, H.1
Wang, H.2
Drewes, L.R.3
Wollheim, C.B.4
-
22
-
-
0018643965
-
Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans
-
Ashcroft SJ, Christie MR. Effects of glucose on the cytosolic ration of reduced/oxidized nicotinamide-adenine dinucleotide phosphate in rat islets of Langerhans. Biochem J 1979;184:697-700.
-
(1979)
Biochem J
, vol.184
, pp. 697-700
-
-
Ashcroft, S.J.1
Christie, M.R.2
-
23
-
-
21344456969
-
Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin
-
't Veld P, Renstrom E, Schuit FC
-
Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renstrom E, Schuit FC. Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes 2005;54:2132-42.
-
(2005)
Diabetes
, vol.54
, pp. 2132-2142
-
-
Ivarsson, R.1
Quintens, R.2
Dejonghe, S.3
Tsukamoto, K.4
-
24
-
-
33845971563
-
The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion
-
Joseph JW, Jensen MV, Ilkayeva O, Palmieri F, Alarcon C, Rhodes CJ, Newgard CB. The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem 2006;281:35624-32.
-
(2006)
J Biol Chem
, vol.281
, pp. 35624-35632
-
-
Joseph, J.W.1
Jensen, M.V.2
Ilkayeva, O.3
Palmieri, F.4
Alarcon, C.5
Rhodes, C.J.6
Newgard, C.B.7
-
25
-
-
33750053271
-
A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion
-
Ronnebaum SM, Ilkayeva O, Burgess SC, Joseph JW, Lu D, Stevens RD, Becker TC, Sherry AD, Newgard CB, Jensen MV. A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem 2006;281:30593-602.
-
(2006)
J Biol Chem
, vol.281
, pp. 30593-30602
-
-
Ronnebaum, S.M.1
Ilkayeva, O.2
Burgess, S.C.3
Joseph, J.W.4
Lu, D.5
Stevens, R.D.6
Becker, T.C.7
Sherry, A.D.8
Newgard, C.B.9
Jensen, M.V.10
-
26
-
-
57349189962
-
Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucosestimulated insulin secretion from rodent islets
-
Ronnebaum SM, Jensen MV, Hohmeier HE, Burgess SC, Zhou YP, Qian S, MacNeil D, Howard A, Thornberry N, Ilkayeva O, Lu D, Sherry AD, Newgard CB. Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucosestimulated insulin secretion from rodent islets. J Biol Chem 2008;283:28909-17.
-
(2008)
J Biol Chem
, vol.283
, pp. 28909-28917
-
-
Ronnebaum, S.M.1
Jensen, M.V.2
Hohmeier, H.E.3
Burgess, S.C.4
Zhou, Y.P.5
Qian, S.6
MacNeil, D.7
Howard, A.8
Thornberry, N.9
Ilkayeva, O.10
Lu, D.11
Sherry, A.D.12
Newgard, C.B.13
-
27
-
-
0003152036
-
-
London: Portland Press Ltd. Chapter 5 Metabolic control analysis
-
Fell D. Understanding the control of metabolism. London: Portland Press Ltd.; 1997. Chapter 5, Metabolic control analysis; p101-33.
-
(1997)
Understanding the control of metabolism
, pp. 101-133
-
-
Fell, D.1
-
28
-
-
72149115136
-
Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line
-
Brown LJ, Longacre MJ, Hasan NM, Kendrick MA, Stoker SW, Macdonald MJ. Chronic reduction of the cytosolic or mitochondrial NAD(P)-malic enzyme does not affect insulin secretion in a rat insulinoma cell line. J Biol Chem 2009;284:35359-67.
-
(2009)
J Biol Chem
, vol.284
, pp. 35359-35367
-
-
Brown, L.J.1
Longacre, M.J.2
Hasan, N.M.3
Kendrick, M.A.4
Stoker, S.W.5
Macdonald, M.J.6
-
30
-
-
0016816729
-
The mitochondrial malic enzymes. I. Submitochondrial localization and purification and properties of the NAD(P)+-dependent enzyme from adrenal cortex
-
Mandella RD, Sauer LA. The mitochondrial malic enzymes. I. Submitochondrial localization and purification and properties of the NAD(P)+-dependent enzyme from adrenal cortex. J Biol Chem 1975;250:5877-84.
-
(1975)
J Biol Chem
, vol.250
, pp. 5877-5884
-
-
Mandella, R.D.1
Sauer, L.A.2
-
31
-
-
0026660577
-
Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme
-
Teller JK, Fahien LA, Davis JW. Kinetics and regulation of hepatoma mitochondrial NAD(P) malic enzyme. J Biol Chem 1992;267:10423-32.
-
(1992)
J Biol Chem
, vol.267
, pp. 10423-10432
-
-
Teller, J.K.1
Fahien, L.A.2
Davis, J.W.3
-
32
-
-
33947592820
-
Mitochondrial GTP regulates glucose-stimulated insulin secretion
-
Kibbey RG, Pongratz RL, Romanelli AJ, Wollheim CB, Cline GW, Shulman GI. Mitochondrial GTP regulates glucose-stimulated insulin secretion. Cell Metab 2007;5:253-64.
-
(2007)
Cell Metab
, vol.5
, pp. 253-264
-
-
Kibbey, R.G.1
Pongratz, R.L.2
Romanelli, A.J.3
Wollheim, C.B.4
Cline, G.W.5
Shulman, G.I.6
-
33
-
-
70350374347
-
Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion
-
Stark R, Pasquel F, Turcu A, Pongratz RL, Roden M, Cline GW, Shulman GI, Kibbey RG. Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion. J Biol Chem 2009;284:26578-90.
-
(2009)
J Biol Chem
, vol.284
, pp. 26578-26590
-
-
Stark, R.1
Pasquel, F.2
Turcu, A.3
Pongratz, R.L.4
Roden, M.5
Cline, G.W.6
Shulman, G.I.7
Kibbey, R.G.8
-
34
-
-
84864805444
-
-
Paper presented at: Keystone Symposia: Islet and Beta Cell Biology; 6-11; Snowbird, UT, USA
-
Pongratz RL, Papas KK, Kibbey RG, Cline GW. Role for anaplerosis and pyruvate cycling in fuel-stimulated insulin secretion from human islets. Paper presented at: Keystone Symposia: Islet and Beta Cell Biology; 2008 Apr 6-11; Snowbird, UT, USA.
-
(2008)
Role for anaplerosis and pyruvate cycling in fuel-stimulated insulin secretion from human islets
-
-
Pongratz, R.L.1
Papas, K.K.2
Kibbey, R.G.3
Cline, G.W.4
-
35
-
-
79956322775
-
Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets
-
MacDonald MJ, Longacre MJ, Stoker SW, Kendrick M, Thonpho A, Brown LJ, Hasan NM, Jitrapakdee S, Fukao T, Hanson MS, Fernandez LA, Odorico J. Differences between human and rodent pancreatic islets: low pyruvate carboxylase, atp citrate lyase, and pyruvate carboxylation and high glucose-stimulated acetoacetate in human pancreatic islets. J Biol Chem 2011;286:18383-96.
-
(2011)
J Biol Chem
, vol.286
, pp. 18383-18396
-
-
MacDonald, M.J.1
Longacre, M.J.2
Stoker, S.W.3
Kendrick, M.4
Thonpho, A.5
Brown, L.J.6
Hasan, N.M.7
Jitrapakdee, S.8
Fukao, T.9
Hanson, M.S.10
Fernandez, L.A.11
Odorico, J.12
-
36
-
-
0032429792
-
Glucose-stimulated insulin secretion is not obligatorily linked to an increase in O2 consumption in betaHC9 cells
-
Papas KK, Jarema MA. Glucose-stimulated insulin secretion is not obligatorily linked to an increase in O2 consumption in betaHC9 cells. Am J Physiol 1998;275(6 Pt 1):E1100-6.
-
(1998)
Am J Physiol
, vol.275
, Issue.6 PT 1
-
-
Papas, K.K.1
Jarema, M.A.2
-
37
-
-
80755175762
-
Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis
-
Epub Oct 7. DOI:10.1016/j.bbrc.2011.09.153
-
Cline GW, Pongratz RL, Zhao X, Papas KK. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis. Biochem Biophys Res Commun. Epub 2011 Oct 7. DOI:10.1016/ j.bbrc.2011.09.153.
-
(2011)
Biochem Biophys Res Commun
-
-
Cline, G.W.1
Pongratz, R.L.2
Zhao, X.3
Papas, K.K.4
|