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Volumn 28, Issue 4, 2009, Pages 417-428

Matrix alkalinization: A novel mitochondrial signal for sustained pancreatic β-cell activation

Author keywords

cell; ATP synthesis rates; Insulin secretion; Metabolism; mtAlpHi

Indexed keywords

ALKALINIZATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL PH; CONTROLLED STUDY; ENERGY METABOLISM; HUMAN; HUMAN CELL; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NONHUMAN; PANCREAS ISLET BETA CELL; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

EID: 60549109221     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.302     Document Type: Article
Times cited : (60)

References (38)
  • 1
    • 1642483415 scopus 로고    scopus 로고
    • Mitochondrial pH monitored by a new engineered green fluorescent protein mutant
    • Abad MF, Di Benedetto G, Magalhaes PJ, Filippin L, Pozzan T (2004) Mitochondrial pH monitored by a new engineered green fluorescent protein mutant. J Biol Chem 279: 11521-11529
    • (2004) J Biol Chem , vol.279 , pp. 11521-11529
    • Abad, M.F.1    Di Benedetto, G.2    Magalhaes, P.J.3    Filippin, L.4    Pozzan, T.5
  • 2
    • 37549071057 scopus 로고    scopus 로고
    • Measurement of cytosolic and mitochondrial pH in living cells during reversible metabolic inhibition
    • Balut C, vandeVen M, Despa S, Lambrichts I, Ameloot M, Steels P, Smets I (2008) Measurement of cytosolic and mitochondrial pH in living cells during reversible metabolic inhibition. Kidney Int 73: 226-232
    • (2008) Kidney Int , vol.73 , pp. 226-232
    • Balut, C.1    vandeVen, M.2    Despa, S.3    Lambrichts, I.4    Ameloot, M.5    Steels, P.6    Smets, I.7
  • 3
    • 11244311918 scopus 로고    scopus 로고
    • The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets
    • Brun T, Franklin I, St-Onge L, Biason-Lauber A, Schoenle EJ, Wollheim CB, Gauthier BR (2004) The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival in rat and human islets. J Cell Biol 167: 1123-1135
    • (2004) J Cell Biol , vol.167 , pp. 1123-1135
    • Brun, T.1    Franklin, I.2    St-Onge, L.3    Biason-Lauber, A.4    Schoenle, E.J.5    Wollheim, C.B.6    Gauthier, B.R.7
  • 5
  • 7
    • 0037941267 scopus 로고    scopus 로고
    • Regulation of the mitochondrial ATP-synthase in health and disease
    • Das AM (2003) Regulation of the mitochondrial ATP-synthase in health and disease. Mol Genet Metab 79: 71-82
    • (2003) Mol Genet Metab , vol.79 , pp. 71-82
    • Das, A.M.1
  • 8
    • 0029833117 scopus 로고    scopus 로고
    • Stable and diffusible pools of nucleotides in pancreatic islet cells
    • Detimary P, Jonas JC, Henquin JC (1996) Stable and diffusible pools of nucleotides in pancreatic islet cells. Endocrinology 137: 4671-4676
    • (1996) Endocrinology , vol.137 , pp. 4671-4676
    • Detimary, P.1    Jonas, J.C.2    Henquin, J.C.3
  • 9
    • 0027176448 scopus 로고
    • Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells
    • Duchen MR, Smith PA, Ashcroft FM (1993) Substrate-dependent changes in mitochondrial function, intracellular free calcium concentration and membrane channels in pancreatic beta-cells. Biochem J 294 (Part 1): 35-42
    • (1993) Biochem J , vol.294 , Issue.PART 1 , pp. 35-42
    • Duchen, M.R.1    Smith, P.A.2    Ashcroft, F.M.3
  • 10
    • 20044374696 scopus 로고    scopus 로고
    • Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB (2005) {beta}-cell secretory products activate {alpha}-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 54: 1808-1815
    • Franklin I, Gromada J, Gjinovci A, Theander S, Wollheim CB (2005) {beta}-cell secretory products activate {alpha}-cell ATP-dependent potassium channels to inhibit glucagon release. Diabetes 54: 1808-1815
  • 12
    • 0026632641 scopus 로고
    • Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells
    • Gembal M, Gilon P, Henquin JC (1992) Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cells. J Clin Invest 89: 1288-1295
    • (1992) J Clin Invest , vol.89 , pp. 1288-1295
    • Gembal, M.1    Gilon, P.2    Henquin, J.C.3
  • 13
    • 0015975778 scopus 로고
    • The pancreatic beta-cell recognition of insulin secretagogues. Effects of calcium and sodium on glucose metabolism and insulin release
    • Hellman B, Idahl LA, Lernmark A, Sehlin J, Taljedal IB (1974) The pancreatic beta-cell recognition of insulin secretagogues. Effects of calcium and sodium on glucose metabolism and insulin release. Biochem J 138: 33-45
    • (1974) Biochem J , vol.138 , pp. 33-45
    • Hellman, B.1    Idahl, L.A.2    Lernmark, A.3    Sehlin, J.4    Taljedal, I.B.5
  • 14
    • 0018910833 scopus 로고
    • Dynamics of O2 consumption in rat pancreatic islets
    • Hutton JC, Malaisse WJ (1980) Dynamics of O2 consumption in rat pancreatic islets. Diabetologia 18: 395-405
    • (1980) Diabetologia , vol.18 , pp. 395-405
    • Hutton, J.C.1    Malaisse, W.J.2
  • 15
    • 0037385959 scopus 로고    scopus 로고
    • Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells
    • Ishihara H, Maechler P, Gjinovci A, Herrera PL, Wollheim CB (2003) Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells. Nat Cell Biol 5: 330-335
    • (2003) Nat Cell Biol , vol.5 , pp. 330-335
    • Ishihara, H.1    Maechler, P.2    Gjinovci, A.3    Herrera, P.L.4    Wollheim, C.B.5
  • 16
    • 21344456969 scopus 로고    scopus 로고
    • Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renstrom E, Schuit FC (2005) Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes 54: 2132-2142
    • Ivarsson R, Quintens R, Dejonghe S, Tsukamoto K, in 't Veld P, Renstrom E, Schuit FC (2005) Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin. Diabetes 54: 2132-2142
  • 17
    • 33845971563 scopus 로고    scopus 로고
    • The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion
    • Joseph JW, Jensen MV, Ilkayeva O, Palmieri F, Alarcon C, Rhodes CJ, Newgard CB (2006) The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. J Biol Chem 281: 35624-35632
    • (2006) J Biol Chem , vol.281 , pp. 35624-35632
    • Joseph, J.W.1    Jensen, M.V.2    Ilkayeva, O.3    Palmieri, F.4    Alarcon, C.5    Rhodes, C.J.6    Newgard, C.B.7
  • 18
    • 0029808483 scopus 로고    scopus 로고
    • Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells
    • Kennedy ED, Rizzuto R, Theler JM, Pralong WF, Bastianutto C, Pozzan T, Wollheim CB (1996) Glucose-stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin-expressing INS-1 cells. J Clin Invest 98: 2524-2538
    • (1996) J Clin Invest , vol.98 , pp. 2524-2538
    • Kennedy, E.D.1    Rizzuto, R.2    Theler, J.M.3    Pralong, W.F.4    Bastianutto, C.5    Pozzan, T.6    Wollheim, C.B.7
  • 19
    • 0033531951 scopus 로고    scopus 로고
    • Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria
    • Kennedy HJ, Pouli AE, Ainscow EK, Jouaville LS, Rizzuto R, Rutter GA (1999) Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria. J Biol Chem 274: 13281-13291
    • (1999) J Biol Chem , vol.274 , pp. 13281-13291
    • Kennedy, H.J.1    Pouli, A.E.2    Ainscow, E.K.3    Jouaville, L.S.4    Rizzuto, R.5    Rutter, G.A.6
  • 20
    • 0032499784 scopus 로고    scopus 로고
    • Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins
    • Llopis J, McCaffery JM, Miyawaki A, Farquhar MG, Tsien RY (1998) Measurement of cytosolic, mitochondrial, and Golgi pH in single living cells with green fluorescent proteins. Proc Natl Acad Sci USA 95: 6803-6808
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 6803-6808
    • Llopis, J.1    McCaffery, J.M.2    Miyawaki, A.3    Farquhar, M.G.4    Tsien, R.Y.5
  • 21
    • 0030926003 scopus 로고    scopus 로고
    • Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells
    • Maechler P, Kennedy ED, Pozzan T, Wollheim CB (1997) Mitochondrial activation directly triggers the exocytosis of insulin in permeabilized pancreatic beta-cells. EMBO J 16: 3833-3841
    • (1997) EMBO J , vol.16 , pp. 3833-3841
    • Maechler, P.1    Kennedy, E.D.2    Pozzan, T.3    Wollheim, C.B.4
  • 22
    • 0033540037 scopus 로고    scopus 로고
    • Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
    • Maechler P, Wollheim CB (1999) Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis. Nature 402: 685-689
    • (1999) Nature , vol.402 , pp. 685-689
    • Maechler, P.1    Wollheim, C.B.2
  • 23
    • 0033776271 scopus 로고    scopus 로고
    • Changes in intramitochondrial and cytosolic pH: Early events that modulate caspase activation during apoptosis
    • Matsuyama S, Llopis J, Deveraux QL, Tsien RY, Reed JC (2000) Changes in intramitochondrial and cytosolic pH: early events that modulate caspase activation during apoptosis. Nat Cell Biol 2: 318-325
    • (2000) Nat Cell Biol , vol.2 , pp. 318-325
    • Matsuyama, S.1    Llopis, J.2    Deveraux, Q.L.3    Tsien, R.Y.4    Reed, J.C.5
  • 24
    • 33744952060 scopus 로고    scopus 로고
    • Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons
    • Nicholls DG (2006) Simultaneous monitoring of ionophore- and inhibitor-mediated plasma and mitochondrial membrane potential changes in cultured neurons. J Biol Chem 281: 14864-14874
    • (2006) J Biol Chem , vol.281 , pp. 14864-14874
    • Nicholls, D.G.1
  • 25
    • 1242317666 scopus 로고    scopus 로고
    • The mitochondrial transporter family (SLC25): Physiological and pathological implications
    • Palmieri F (2004) The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch 447: 689-709
    • (2004) Pflugers Arch , vol.447 , pp. 689-709
    • Palmieri, F.1
  • 29
    • 0023654334 scopus 로고
    • Factors affecting the reactivation of the oligomycin-sensitive adenosine 50-triphosphatase and the release of ATPase inhibitor protein during the re-energization of intact mitochondria from ischemic cardiac muscle
    • Rouslin W (1987) Factors affecting the reactivation of the oligomycin-sensitive adenosine 50-triphosphatase and the release of ATPase inhibitor protein during the re-energization of intact mitochondria from ischemic cardiac muscle. J Biol Chem 262: 3472-3476
    • (1987) J Biol Chem , vol.262 , pp. 3472-3476
    • Rouslin, W.1
  • 30
    • 0030810982 scopus 로고    scopus 로고
    • Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells
    • Schuit F, De Vos A, Farfari S, Moens K, Pipeleers D, Brun T, Prentki M (1997) Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 272: 18572-18579
    • (1997) J Biol Chem , vol.272 , pp. 18572-18579
    • Schuit, F.1    De Vos, A.2    Farfari, S.3    Moens, K.4    Pipeleers, D.5    Brun, T.6    Prentki, M.7
  • 32
    • 0019454290 scopus 로고
    • The stimulus-secretion coupling of amino acid-induced insulin release. Biosynthetic and secretory responses of rat pancreatic islet to L-leucine and L-glutamine
    • Sener A, Somers G, Devis G, Malaisse WJ (1981) The stimulus-secretion coupling of amino acid-induced insulin release. Biosynthetic and secretory responses of rat pancreatic islet to L-leucine and L-glutamine. Diabetologia 21: 135-142
    • (1981) Diabetologia , vol.21 , pp. 135-142
    • Sener, A.1    Somers, G.2    Devis, G.3    Malaisse, W.J.4
  • 33
    • 0028904141 scopus 로고
    • The role of metabolism, cytoplasmic Ca2+, and pH-regulating exchangers in glucose-induced rise of cytoplasmic pH in normal mouse pancreatic islets
    • Shepherd RM, Henquin JC (1995) The role of metabolism, cytoplasmic Ca2+, and pH-regulating exchangers in glucose-induced rise of cytoplasmic pH in normal mouse pancreatic islets. J Biol Chem 270: 7915-7921
    • (1995) J Biol Chem , vol.270 , pp. 7915-7921
    • Shepherd, R.M.1    Henquin, J.C.2
  • 34
    • 17644434484 scopus 로고
    • Bicarbonate-carbon dioxide buffer system: A determinant of the mitochondrial pH gradient
    • Simpson DP, Hager SR (1984) Bicarbonate-carbon dioxide buffer system: a determinant of the mitochondrial pH gradient. Am J Physiol 247: F440-F446
    • (1984) Am J Physiol , vol.247
    • Simpson, D.P.1    Hager, S.R.2
  • 35
    • 34548337162 scopus 로고    scopus 로고
    • Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: Studies in islets lacking the Na+/H+ exchange R NHE1
    • Stiernet P, Nenquin M, Moulin P, Jonas JC, Henquin JC (2007) Glucose-induced cytosolic pH changes in beta-cells and insulin secretion are not causally related: studies in islets lacking the Na+/H+ exchange R NHE1. J Biol Chem 282: 24538-24546
    • (2007) J Biol Chem , vol.282 , pp. 24538-24546
    • Stiernet, P.1    Nenquin, M.2    Moulin, P.3    Jonas, J.C.4    Henquin, J.C.5
  • 36
    • 33646779855 scopus 로고    scopus 로고
    • Minireview: Implication of mitochondria in insulin secretion and action
    • Wiederkehr A, Wollheim CB (2006) Minireview: implication of mitochondria in insulin secretion and action. Endocrinology 147: 2643-2649
    • (2006) Endocrinology , vol.147 , pp. 2643-2649
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 37
    • 44949196953 scopus 로고    scopus 로고
    • Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell
    • Wiederkehr A, Wollheim CB (2008) Impact of mitochondrial calcium on the coupling of metabolism to insulin secretion in the pancreatic beta-cell. Cell Calcium 44: 64-76
    • (2008) Cell Calcium , vol.44 , pp. 64-76
    • Wiederkehr, A.1    Wollheim, C.B.2
  • 38
    • 0036311080 scopus 로고    scopus 로고
    • Beta-cell mitochondria and insulin secretion: Messenger role of nucleotides and metabolites
    • Wollheim CB, Maechler P (2002) Beta-cell mitochondria and insulin secretion: messenger role of nucleotides and metabolites. Diabetes 51(Suppl 1): S37-S42
    • (2002) Diabetes , vol.51 , Issue.SUPPL. 1
    • Wollheim, C.B.1    Maechler, P.2


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