Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis

Biochemical and Biophysical Research Communications

Volumn 415, Issue 1, 2011, Pages 30-35

  Cline, Gary W ^a,b   Pongratz, Rebecca L ^a   Zhao, Xiaojian ^a   Papas, Klearchos K ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Anaplerosis; ATP synthesis; Beta cells; Glucose stimulated insulin secretion; INS 1; Mitochondrial metabolism; Second messengers; Substrate cycling

Indexed keywords

ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; GLUCOSE; GLUTAMATE DEHYDROGENASE; GLUTAMINE; HUMAN INSULIN; LEUCINE; PYRUVATE CARBOXYLASE; TRICARBOXYLIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CITRIC ACID CYCLE; CONTROLLED STUDY; FLUOROMETER; GLUCOSE METABOLISM; HUMAN; INSULIN RELEASE; INSULINOMA; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; STIRRED REACTOR;

ADENOSINE TRIPHOSPHATE; CELL LINE; CITRIC ACID CYCLE; CULTURE MEDIA; GLUCOSE; HUMANS; INSULIN; OXYGEN CONSUMPTION;

EID: 80755175762     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.09.153     Document Type: Article

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