Inhibition of protein geranylgeranylation induces apoptosis in synovial fibroblasts

Arthritis Research and Therapy

Volumn 8, Issue 4, 2006, Pages

  Connor, Alison M ^a   Berger, Stuart ^a   Narendran, Aru ^b   Keystone, Edward C ^c  

^a The Wellesley Toronto Arthritis and Immune Disorder Research Centre   (Canada)

^b ALBERTA CHILDREN'S HOSPITAL   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DITERPENE; GERANYLGERANIOL; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID PHOSPHATE; MEMBRANE PROTEIN; PROTEIN KINASE B; RAC1 PROTEIN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA;

ANTAGONISTS AND INHIBITORS; APOPTOSIS; CELL CULTURE; CELL SURVIVAL; CYTOPLASM; DRUG EFFECTS; FIBROBLAST; GENETICS; HUMAN; METABOLISM; OSTEOARTHRITIS; PATHOLOGY; PATHOPHYSIOLOGY; RHEUMATOID ARTHRITIS; SYNOVIUM; TISSUE DISTRIBUTION; TRANSPORT AT THE CELLULAR LEVEL;

APOPTOSIS; ARTHRITIS, RHEUMATOID; BIOLOGICAL TRANSPORT; CELL SURVIVAL; CELLS, CULTURED; CYTOPLASM; DITERPENES; FIBROBLASTS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEMBRANE PROTEINS; OSTEOARTHRITIS; POLYISOPRENYL PHOSPHATES; PROTO-ONCOGENE PROTEINS C-AKT; RAC1 GTP-BINDING PROTEIN; RNA, SMALL INTERFERING; SYNOVIAL MEMBRANE; TISSUE DISTRIBUTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 70350593596     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar1968     Document Type: Article

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