-
1
-
-
77953388596
-
-
WHO. Diabetes. World Health Organization, 2008:Diabetes, Fact Sheet Number 312.
-
WHO. Diabetes. World Health Organization, 2008:Diabetes, Fact Sheet Number 312.
-
-
-
-
2
-
-
77953380371
-
-
Canadian Diabetes Association 2008 Clinical Practice Guidlines for the Prevention and Management of Diabetes in Canada. Canadian Journal of Diabetes 2008; 32:1.
-
Canadian Diabetes Association 2008 Clinical Practice Guidlines for the Prevention and Management of Diabetes in Canada. Canadian Journal of Diabetes 2008; 32:1.
-
-
-
-
3
-
-
0041828484
-
Inflammatory mediators and islet beta-cell failure: A link between type 1 and type 2 diabetes
-
Donath MY, Storling J, Maedler K, Mandrup-Poulsen T. Inflammatory mediators and islet beta-cell failure: a link between type 1 and type 2 diabetes. J Mol Med 2003; 81:455-70.
-
(2003)
J Mol Med
, vol.81
, pp. 455-470
-
-
Donath, M.Y.1
Storling, J.2
Maedler, K.3
Mandrup-Poulsen, T.4
-
4
-
-
0034853485
-
Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes
-
Kahn SE. Clinical review 135: The importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001; 86:4047-58.
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 4047-4058
-
-
Kahn, S.E.1
-
6
-
-
38949119419
-
Salsalate improves glycemia and inflammatory parameters in obese young adults
-
Fleischman A, Shoelson SE, Bernier R, Goldfine AB. Salsalate improves glycemia and inflammatory parameters in obese young adults. Diabetes Care 2008; 31:289-94.
-
(2008)
Diabetes Care
, vol.31
, pp. 289-294
-
-
Fleischman, A.1
Shoelson, S.E.2
Bernier, R.3
Goldfine, A.B.4
-
7
-
-
0035979775
-
Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
-
Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, Shoelson SE. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001; 293:1673-7.
-
(2001)
Science
, vol.293
, pp. 1673-1677
-
-
Yuan, M.1
Konstantopoulos, N.2
Lee, J.3
Hansen, L.4
Li, Z.W.5
Karin, M.6
Shoelson, S.E.7
-
8
-
-
67349117462
-
Emerging role of toll-like receptors in atherosclerosis
-
Curtiss LK, Tobias PS. Emerging role of toll-like receptors in atherosclerosis. J Lipid Res 2008.
-
(2008)
J Lipid Res
-
-
Curtiss, L.K.1
Tobias, P.S.2
-
9
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006; 116:3015-25.
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
10
-
-
44449110675
-
-
Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 2008; 16:1248-55.
-
Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 2008; 16:1248-55.
-
-
-
-
11
-
-
17644399470
-
Innate immunity and organ transplantation: The potential role of toll-like receptors
-
Andrade CF, Waddell TK, Keshavjee S, Liu M. Innate immunity and organ transplantation: the potential role of toll-like receptors. Am J Transplant 2005; 5:969-75.
-
(2005)
Am J Transplant
, vol.5
, pp. 969-975
-
-
Andrade, C.F.1
Waddell, T.K.2
Keshavjee, S.3
Liu, M.4
-
13
-
-
16244376480
-
Toll-like receptors, endogenous ligands and systemic autoimmune disease
-
Rifkin IR, Leadbetter EA, Busconi L, Viglianti G, Marshak-Rothstein A. Toll-like receptors, endogenous ligands and systemic autoimmune disease. Immunol Rev 2005; 204:27-42.
-
(2005)
Immunol Rev
, vol.204
, pp. 27-42
-
-
Rifkin, I.R.1
Leadbetter, E.A.2
Busconi, L.3
Viglianti, G.4
Marshak-Rothstein, A.5
-
14
-
-
1342302624
-
The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets
-
Wen L, Peng J, Li Z, Wong FS. The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol 2004; 172:3173-80.
-
(2004)
J Immunol
, vol.172
, pp. 3173-3180
-
-
Wen, L.1
Peng, J.2
Li, Z.3
Wong, F.S.4
-
15
-
-
58149333718
-
High glucose induces toll-like receptor expression in human monocytes: Mechanism of activation
-
Dasu MR, Devaraj S, Zhao L, Hwang DH, Jialal I. High glucose induces toll-like receptor expression in human monocytes: mechanism of activation. Diabetes 2008; 57:3090-8.
-
(2008)
Diabetes
, vol.57
, pp. 3090-3098
-
-
Dasu, M.R.1
Devaraj, S.2
Zhao, L.3
Hwang, D.H.4
Jialal, I.5
-
16
-
-
64249140045
-
The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury
-
Bollyky PL, Bice JB, Sweet IR, Falk BA, Gebe JA, Clark AE, et al. The toll-like receptor signaling molecule Myd88 contributes to pancreatic beta-cell homeostasis in response to injury. PLoS One 2009; 4:5063.
-
(2009)
PLoS One
, vol.4
, pp. 5063
-
-
Bollyky, P.L.1
Bice, J.B.2
Sweet, I.R.3
Falk, B.A.4
Gebe, J.A.5
Clark, A.E.6
-
17
-
-
0034075754
-
The IL-1 receptor/toll-like receptor superfamily: Crucial receptors for inflammation and host defense
-
O'Neill LA, Dinarello CA. The IL-1 receptor/toll-like receptor superfamily: crucial receptors for inflammation and host defense. Immunol Today 2000; 21:206-9.
-
(2000)
Immunol Today
, vol.21
, pp. 206-209
-
-
O'Neill, L.A.1
Dinarello, C.A.2
-
18
-
-
34547602916
-
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007; 56:1986-98.
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.3
Prada, P.O.4
Hirabara, S.M.5
Schenka, A.A.6
-
19
-
-
33845881411
-
Mechanisms linking obesity to insulin resistance and type 2 diabetes
-
Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature 2006; 444:840-6.
-
(2006)
Nature
, vol.444
, pp. 840-846
-
-
Kahn, S.E.1
Hull, R.L.2
Utzschneider, K.M.3
-
20
-
-
34249940441
-
Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs
-
Hasan UA, Caux C, Perrot I, Doffin AC, Menetrier-Caux C, Trinchieri G, et al. Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs. Proc Natl Acad Sci USA 2007; 104:8047-52.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8047-8052
-
-
Hasan, U.A.1
Caux, C.2
Perrot, I.3
Doffin, A.C.4
Menetrier-Caux, C.5
Trinchieri, G.6
-
21
-
-
20144382923
-
Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts
-
Hasan UA, Trinchieri G, Vlach J. Toll-like receptor signaling stimulates cell cycle entry and progression in fibroblasts. J Biol Chem 2005; 280:20620-7.
-
(2005)
J Biol Chem
, vol.280
, pp. 20620-20627
-
-
Hasan, U.A.1
Trinchieri, G.2
Vlach, J.3
-
22
-
-
0038393016
-
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
-
Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, et al. IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 2003; 4:491-6.
-
(2003)
Nat Immunol
, vol.4
, pp. 491-496
-
-
Fitzgerald, K.A.1
McWhirter, S.M.2
Faia, K.L.3
Rowe, D.C.4
Latz, E.5
Golenbock, D.T.6
-
23
-
-
33845513370
-
p27 Regulates the transition of beta-cells from quiescence to proliferation
-
Georgia S, Bhushan A. p27 Regulates the transition of beta-cells from quiescence to proliferation. Diabetes 2006; 55:2950-6.
-
(2006)
Diabetes
, vol.55
, pp. 2950-2956
-
-
Georgia, S.1
Bhushan, A.2
-
24
-
-
33846928411
-
NFkappaB prevents beta cell death and autoimmune diabetes in NOD mice
-
Kim S, Millet I, Kim HS, Kim JY, Han MS, Lee MK, et al. NFkappaB prevents beta cell death and autoimmune diabetes in NOD mice. Proc Natl Acad Sci USA 2007; 104:1913-8.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 1913-1918
-
-
Kim, S.1
Millet, I.2
Kim, H.S.3
Kim, J.Y.4
Han, M.S.5
Lee, M.K.6
-
25
-
-
44749083828
-
Induction of nuclear factor-kappaB and its downstream genes by TNFalpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells
-
Ortis F, Pirot P, Naamane N, Kreins AY, Rasschaert J, Moore F, et al. Induction of nuclear factor-kappaB and its downstream genes by TNFalpha and IL-1beta has a pro-apoptotic role in pancreatic beta cells. Diabetologia 2008; 51:1213-25.
-
(2008)
Diabetologia
, vol.51
, pp. 1213-1225
-
-
Ortis, F.1
Pirot, P.2
Naamane, N.3
Kreins, A.Y.4
Rasschaert, J.5
Moore, F.6
-
26
-
-
7544225495
-
Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling
-
Sarkar SN, Peters KL, Elco CP, Sakamoto S, Pal S, Sen GC. Novel roles of TLR3 tyrosine phosphorylation and PI3 kinase in double-stranded RNA signaling. Nat Struct Mol Biol 2004; 11:1060-7.
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 1060-1067
-
-
Sarkar, S.N.1
Peters, K.L.2
Elco, C.P.3
Sakamoto, S.4
Pal, S.5
Sen, G.C.6
-
27
-
-
9644270397
-
Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells
-
Bernal-Mizrachi E, Fatrai S, Johnson JD, Ohsugi M, Otani K, Han Z, et al. Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells. J Clin Invest 2004; 114:928-36.
-
(2004)
J Clin Invest
, vol.114
, pp. 928-936
-
-
Bernal-Mizrachi, E.1
Fatrai, S.2
Johnson, J.D.3
Ohsugi, M.4
Otani, K.5
Han, Z.6
-
28
-
-
58749093419
-
CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling
-
Schulthess FT, Paroni F, Sauter NS, Shu L, Ribaux P, Haataja L, et al. CXCL10 impairs beta cell function and viability in diabetes through TLR4 signaling. Cell Metab 2009; 9:125-39.
-
(2009)
Cell Metab
, vol.9
, pp. 125-139
-
-
Schulthess, F.T.1
Paroni, F.2
Sauter, N.S.3
Shu, L.4
Ribaux, P.5
Haataja, L.6
-
29
-
-
33644747390
-
Mechanisms of beta-cell death in type 2 diabetes
-
Donath MY, Ehses JA, Maedler K, Schumann DM, Ellingsgaard H, Eppler E, Reinecke M. Mechanisms of beta-cell death in type 2 diabetes. Diabetes 2005; 54:108-13.
-
(2005)
Diabetes
, vol.54
, pp. 108-113
-
-
Donath, M.Y.1
Ehses, J.A.2
Maedler, K.3
Schumann, D.M.4
Ellingsgaard, H.5
Eppler, E.6
Reinecke, M.7
-
30
-
-
67649373025
-
IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis
-
Schwarznau A, Hanson MS, Sperger JM, Schram BR, Danobeitia JS, Greenwood KK, et al. IL-1beta receptor blockade protects islets against pro-inflammatory cytokine induced necrosis and apoptosis. J Cell Physiol 2009; 220:341-7.
-
(2009)
J Cell Physiol
, vol.220
, pp. 341-347
-
-
Schwarznau, A.1
Hanson, M.S.2
Sperger, J.M.3
Schram, B.R.4
Danobeitia, J.S.5
Greenwood, K.K.6
-
31
-
-
33745187112
-
Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes
-
Song MJ, Kim KH, Yoon JM, Kim JB. Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes. Biochem Biophys Res Commun 2006; 346:739-45.
-
(2006)
Biochem Biophys Res Commun
, vol.346
, pp. 739-745
-
-
Song, M.J.1
Kim, K.H.2
Yoon, J.M.3
Kim, J.B.4
-
33
-
-
35848969322
-
Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells
-
Dror V, Nguyen V, Walia P, Kalynyak TB, Hill JA, Johnson JD. Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells. Diabetologia 2007; 50:2504-15.
-
(2007)
Diabetologia
, vol.50
, pp. 2504-2515
-
-
Dror, V.1
Nguyen, V.2
Walia, P.3
Kalynyak, T.B.4
Hill, J.A.5
Johnson, J.D.6
|