Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Raza, Haider ^a   John, Annie ^a  

^a UNITED ARAB EMIRATES UNIVERSITY   (United Arab Emirates)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; ACONITATE HYDRATASE; ADENOSINE TRIPHOSPHATE; BUTHIONINE SULFOXIMINE; CELL DNA; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; BIOLOGICAL MARKER; CASPASE 3; GLUTATHIONE TRANSFERASE; LEUKOTRIENE C4 SYNTHASE; LEUKOTRIENE-C4 SYNTHASE; NONSTEROID ANTIINFLAMMATORY AGENT;

APOPTOSIS; ARTICLE; CELL STRAIN HEPG2; CELL STRESS; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA FRAGMENTATION; ENZYME ACTIVITY; ENZYME INHIBITION; GLUTATHIONE METABOLISM; HOMEOSTASIS; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PROTEIN DEPLETION; CELL RESPIRATION; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; LIPID PEROXIDATION; METABOLISM; MITOCHONDRION;

ACETYLCYSTEINE; ACONITATE HYDRATASE; ADENOSINE TRIPHOSPHATE; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; APOPTOSIS; ASPIRIN; BIOLOGICAL MARKERS; BUTHIONINE SULFOXIMINE; CASPASE 3; CELL RESPIRATION; DNA FRAGMENTATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUTATHIONE; GLUTATHIONE TRANSFERASE; HEP G2 CELLS; HUMANS; LIPID PEROXIDATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84860480140     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036325     Document Type: Article

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