-
1
-
-
33747826874
-
Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology
-
Bentzen SM, (2006) Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology. Nat Rev Cancer 6: 702-713.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 702-713
-
-
Bentzen, S.M.1
-
2
-
-
58949092475
-
Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype
-
Barnett GC, West CM, Dunning AM, Elliott RM, Coles CE, et al. (2009) Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype. Nat Rev Cancer 9: 134-142.
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 134-142
-
-
Barnett, G.C.1
West, C.M.2
Dunning, A.M.3
Elliott, R.M.4
Coles, C.E.5
-
3
-
-
0036283219
-
The radiotherapeutic injury-a complex 'wound'
-
Denham JW, Hauer-Jensen M, (2002) The radiotherapeutic injury-a complex 'wound'. Radiother Oncol 63: 129-145.
-
(2002)
Radiother Oncol
, vol.63
, pp. 129-145
-
-
Denham, J.W.1
Hauer-Jensen, M.2
-
4
-
-
77951709927
-
Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy
-
Anscher MS, (2010) Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy. Oncologist 15: 350-359.
-
(2010)
Oncologist
, vol.15
, pp. 350-359
-
-
Anscher, M.S.1
-
5
-
-
0034178260
-
TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target?
-
Martin M, Lefaix J, Delanian S, (2000) TGF-beta1 and radiation fibrosis: a master switch and a specific therapeutic target? Int J Radiat Oncol Biol Phys 47: 277-290.
-
(2000)
Int J Radiat Oncol Biol Phys
, vol.47
, pp. 277-290
-
-
Martin, M.1
Lefaix, J.2
Delanian, S.3
-
6
-
-
0031926223
-
The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy
-
Anscher MS, Kong FM, Jirtle RL, (1998) The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy. Lung Cancer 19: 109-120.
-
(1998)
Lung Cancer
, vol.19
, pp. 109-120
-
-
Anscher, M.S.1
Kong, F.M.2
Jirtle, R.L.3
-
7
-
-
0035104799
-
The role of the tubulointerstitium in radiation-induced renal fibrosis
-
Robbins ME, O'Malley Y, Zhao W, Davis CS, Bonsib SM, (2001) The role of the tubulointerstitium in radiation-induced renal fibrosis. Radiat Res 155: 481-489.
-
(2001)
Radiat Res
, vol.155
, pp. 481-489
-
-
Robbins, M.E.1
O'Malley, Y.2
Zhao, W.3
Davis, C.S.4
Bonsib, S.M.5
-
8
-
-
0031737426
-
Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy
-
Wang J, Zheng H, Sung CC, Richter KK, Hauer-Jensen M, (1998) Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy. Am J Pathol 153: 1531-1540.
-
(1998)
Am J Pathol
, vol.153
, pp. 1531-1540
-
-
Wang, J.1
Zheng, H.2
Sung, C.C.3
Richter, K.K.4
Hauer-Jensen, M.5
-
9
-
-
0029838436
-
Long-term expression of transforming growth factor TGF beta 1 in mouse skin after localized beta-irradiation
-
Randall K, Coggle JE, (1996) Long-term expression of transforming growth factor TGF beta 1 in mouse skin after localized beta-irradiation. Int J Radiat Biol 70: 351-360.
-
(1996)
Int J Radiat Biol
, vol.70
, pp. 351-360
-
-
Randall, K.1
Coggle, J.E.2
-
10
-
-
0025342073
-
Transforming growth factor-beta 1 expression in irradiated liver
-
Anscher MS, Crocker IR, Jirtle RL, (1990) Transforming growth factor-beta 1 expression in irradiated liver. Radiat Res 122: 77-85.
-
(1990)
Radiat Res
, vol.122
, pp. 77-85
-
-
Anscher, M.S.1
Crocker, I.R.2
Jirtle, R.L.3
-
11
-
-
0029819980
-
Radiation-induced changes in transforming growth factor beta and collagen expression in the murine bladder wall and its correlation with bladder function
-
Kraft M, Oussoren Y, Stewart FA, Dorr W, Schultz-Hector S, (1996) Radiation-induced changes in transforming growth factor beta and collagen expression in the murine bladder wall and its correlation with bladder function. Radiat Res 146: 619-627.
-
(1996)
Radiat Res
, vol.146
, pp. 619-627
-
-
Kraft, M.1
Oussoren, Y.2
Stewart, F.A.3
Dorr, W.4
Schultz-Hector, S.5
-
12
-
-
34548389503
-
Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages
-
Milliat F, Francois A, Isoir M, Deutsch E, Tamarat R, et al. (2006) Influence of endothelial cells on vascular smooth muscle cells phenotype after irradiation: implication in radiation-induced vascular damages. Am J Pathol 169: 1484-1495.
-
(2006)
Am J Pathol
, vol.169
, pp. 1484-1495
-
-
Milliat, F.1
Francois, A.2
Isoir, M.3
Deutsch, E.4
Tamarat, R.5
-
13
-
-
59649090468
-
Radiation-induced activation of TGF-beta signaling pathways in relation to vascular damage in mouse kidneys
-
Kruse JJ, Floot BG, te Poele JA, Russell NS, Stewart FA, (2009) Radiation-induced activation of TGF-beta signaling pathways in relation to vascular damage in mouse kidneys. Radiat Res 171: 188-197.
-
(2009)
Radiat Res
, vol.171
, pp. 188-197
-
-
Kruse, J.J.1
Floot, B.G.2
te Poele, J.A.3
Russell, N.S.4
Stewart, F.A.5
-
14
-
-
40449100253
-
Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy
-
Milliat F, Sabourin JC, Tarlet G, Holler V, Deutsch E, et al. (2008) Essential role of plasminogen activator inhibitor type-1 in radiation enteropathy. Am J Pathol 172: 691-701.
-
(2008)
Am J Pathol
, vol.172
, pp. 691-701
-
-
Milliat, F.1
Sabourin, J.C.2
Tarlet, G.3
Holler, V.4
Deutsch, E.5
-
16
-
-
69949130912
-
Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys
-
Scharpfenecker M, Floot B, Russell NS, Ten Dijke P, Stewart FA, (2009) Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys. Radiother Oncol 92: 484-491.
-
(2009)
Radiother Oncol
, vol.92
, pp. 484-491
-
-
Scharpfenecker, M.1
Floot, B.2
Russell, N.S.3
Ten Dijke, P.4
Stewart, F.A.5
-
17
-
-
1942471106
-
Smad-3 and Smad-7 expression following anti-transforming growth factor beta 1 (TGFbeta1)-treatment in irradiated rat tissue
-
Schultze-Mosgau S, Blaese MA, Grabenbauer G, Wehrhan F, Kopp J, et al. (2004) Smad-3 and Smad-7 expression following anti-transforming growth factor beta 1 (TGFbeta1)-treatment in irradiated rat tissue. Radiother Oncol 70: 249-259.
-
(2004)
Radiother Oncol
, vol.70
, pp. 249-259
-
-
Schultze-Mosgau, S.1
Blaese, M.A.2
Grabenbauer, G.3
Wehrhan, F.4
Kopp, J.5
-
18
-
-
47249151503
-
Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1
-
Haydont V, Riser BL, Aigueperse J, Vozenin-Brotons MC, (2008) Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: a role for CCN2 and low concentration of TGF-beta1. Am J Physiol Cell Physiol 294: C1332-1341.
-
(2008)
Am J Physiol Cell Physiol
, vol.294
-
-
Haydont, V.1
Riser, B.L.2
Aigueperse, J.3
Vozenin-Brotons, M.C.4
-
19
-
-
10744233540
-
Interference with transforming growth factor-beta/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin
-
Flanders KC, Major CD, Arabshahi A, Aburime EE, Okada MH, et al. (2003) Interference with transforming growth factor-beta/Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol 163: 2247-2257.
-
(2003)
Am J Pathol
, vol.163
, pp. 2247-2257
-
-
Flanders, K.C.1
Major, C.D.2
Arabshahi, A.3
Aburime, E.E.4
Okada, M.H.5
-
20
-
-
0036124599
-
Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
-
Flanders KC, Sullivan CD, Fujii M, Sowers A, Anzano MA, et al. (2002) Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol 160: 1057-1068.
-
(2002)
Am J Pathol
, vol.160
, pp. 1057-1068
-
-
Flanders, K.C.1
Sullivan, C.D.2
Fujii, M.3
Sowers, A.4
Anzano, M.A.5
-
21
-
-
79251556820
-
Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling
-
Yan X, Chen YG, (2011) Smad7: not only a regulator, but also a cross-talk mediator of TGF-β signalling. Biochem J 434: 1-10.
-
(2011)
Biochem J
, vol.434
, pp. 1-10
-
-
Yan, X.1
Chen, Y.G.2
-
22
-
-
58149239731
-
Ski and SnoN, potent negative regulators of TGF-beta signaling
-
Deheuninck J, Luo K, (2009) Ski and SnoN, potent negative regulators of TGF-beta signaling. Cell Res 19: 47-57.
-
(2009)
Cell Res
, vol.19
, pp. 47-57
-
-
Deheuninck, J.1
Luo, K.2
-
23
-
-
0033515620
-
A Smad transcriptional corepressor
-
Wotton D, Lo RS, Lee S, Massague J, (1999) A Smad transcriptional corepressor. Cell 97: 29-39.
-
(1999)
Cell
, vol.97
, pp. 29-39
-
-
Wotton, D.1
Lo, R.S.2
Lee, S.3
Massague, J.4
-
24
-
-
33847716712
-
Negative regulation of TGF-beta receptor/Smad signal transduction
-
Itoh S, ten Dijke P, (2007) Negative regulation of TGF-beta receptor/Smad signal transduction. Curr Opin Cell Biol 19: 176-184.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 176-184
-
-
Itoh, S.1
ten Dijke, P.2
-
25
-
-
46049110090
-
Maternal Tgif is required for vascularization of the embryonic placenta
-
Bartholin L, Melhuish TA, Powers SE, Goddard-Leon S, Treilleux I, et al. (2008) Maternal Tgif is required for vascularization of the embryonic placenta. Dev Biol 319: 285-297.
-
(2008)
Dev Biol
, vol.319
, pp. 285-297
-
-
Bartholin, L.1
Melhuish, T.A.2
Powers, S.E.3
Goddard-Leon, S.4
Treilleux, I.5
-
26
-
-
0037318242
-
Molecular screening of the TGIF gene in holoprosencephaly: identification of two novel mutations
-
Aguilella C, Dubourg C, Attia-Sobol J, Vigneron J, Blayau M, et al. (2003) Molecular screening of the TGIF gene in holoprosencephaly: identification of two novel mutations. Hum Genet 112: 131-134.
-
(2003)
Hum Genet
, vol.112
, pp. 131-134
-
-
Aguilella, C.1
Dubourg, C.2
Attia-Sobol, J.3
Vigneron, J.4
Blayau, M.5
-
27
-
-
43449102813
-
Genomic structure, alternative splicing and expression of TG-interacting factor, in human myeloid leukemia blasts and cell lines
-
Hamid R, Patterson J, Brandt SJ, (2008) Genomic structure, alternative splicing and expression of TG-interacting factor, in human myeloid leukemia blasts and cell lines. Biochim Biophys Acta 1779: 347-355.
-
(2008)
Biochim Biophys Acta
, vol.1779
, pp. 347-355
-
-
Hamid, R.1
Patterson, J.2
Brandt, S.J.3
-
28
-
-
70350570381
-
Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells
-
Hamid R, Brandt SJ, (2009) Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells. Mol Oncol 3: 451-463.
-
(2009)
Mol Oncol
, vol.3
, pp. 451-463
-
-
Hamid, R.1
Brandt, S.J.2
-
29
-
-
31344465175
-
TGIF inhibits retinoid signaling
-
Bartholin L, Powers SE, Melhuish TA, Lasse S, Weinstein M, et al. (2006) TGIF inhibits retinoid signaling. Mol Cell Biol 26: 990-1001.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 990-1001
-
-
Bartholin, L.1
Powers, S.E.2
Melhuish, T.A.3
Lasse, S.4
Weinstein, M.5
-
30
-
-
0033601272
-
Multiple modes of repression by the Smad transcriptional corepressor TGIF
-
Wotton D, Lo RS, Swaby LA, Massague J, (1999) Multiple modes of repression by the Smad transcriptional corepressor TGIF. J Biol Chem 274: 37105-37110.
-
(1999)
J Biol Chem
, vol.274
, pp. 37105-37110
-
-
Wotton, D.1
Lo, R.S.2
Swaby, L.A.3
Massague, J.4
-
31
-
-
2942535966
-
Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
-
Fukasawa H, Yamamoto T, Togawa A, Ohashi N, Fujigaki Y, et al. (2004) Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice. Proc Natl Acad Sci U S A 101: 8687-8692.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 8687-8692
-
-
Fukasawa, H.1
Yamamoto, T.2
Togawa, A.3
Ohashi, N.4
Fujigaki, Y.5
-
32
-
-
33646709433
-
Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury
-
Fukasawa H, Yamamoto T, Togawa A, Ohashi N, Fujigaki Y, et al. (2006) Ubiquitin-dependent degradation of SnoN and Ski is increased in renal fibrosis induced by obstructive injury. Kidney Int 69: 1733-1740.
-
(2006)
Kidney Int
, vol.69
, pp. 1733-1740
-
-
Fukasawa, H.1
Yamamoto, T.2
Togawa, A.3
Ohashi, N.4
Fujigaki, Y.5
-
33
-
-
33646712129
-
Perspectives on blockade of TGFbeta overexpression
-
Huang Y, Border WA, Noble NA, (2006) Perspectives on blockade of TGFbeta overexpression. Kidney Int 69: 1713-1714.
-
(2006)
Kidney Int
, vol.69
, pp. 1713-1714
-
-
Huang, Y.1
Border, W.A.2
Noble, N.A.3
-
34
-
-
33749261981
-
Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation
-
Tan R, Zhang J, Tan X, Zhang X, Yang J, et al. (2006) Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am Soc Nephrol 17: 2781-2791.
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 2781-2791
-
-
Tan, R.1
Zhang, J.2
Tan, X.3
Zhang, X.4
Yang, J.5
-
35
-
-
33646883064
-
Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling
-
Mar L, Hoodless PA, (2006) Embryonic fibroblasts from mice lacking Tgif were defective in cell cycling. Mol Cell Biol 26: 4302-4310.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 4302-4310
-
-
Mar, L.1
Hoodless, P.A.2
-
36
-
-
36849026669
-
New rationales for using TGFbeta inhibitors in radiotherapy
-
Andarawewa KL, Paupert J, Pal A, Barcellos-Hoff MH, (2007) New rationales for using TGFbeta inhibitors in radiotherapy. Int J Radiat Biol 83: 803-811.
-
(2007)
Int J Radiat Biol
, vol.83
, pp. 803-811
-
-
Andarawewa, K.L.1
Paupert, J.2
Pal, A.3
Barcellos-Hoff, M.H.4
-
37
-
-
0028177037
-
Transforming growth factor-beta activation in irradiated murine mammary gland
-
Barcellos-Hoff MH, Derynck R, Tsang ML, Weatherbee JA, (1994) Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest 93: 892-899.
-
(1994)
J Clin Invest
, vol.93
, pp. 892-899
-
-
Barcellos-Hoff, M.H.1
Derynck, R.2
Tsang, M.L.3
Weatherbee, J.A.4
-
38
-
-
58149357077
-
Ionizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cells
-
Scharpfenecker M, Kruse JJ, Sprong D, Russell NS, Ten Dijke P, et al. (2009) Ionizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cells. Int J Radiat Oncol Biol Phys 73: 506-513.
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.73
, pp. 506-513
-
-
Scharpfenecker, M.1
Kruse, J.J.2
Sprong, D.3
Russell, N.S.4
Ten Dijke, P.5
-
39
-
-
0030770411
-
Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation
-
Ehrhart EJ, Segarini P, Tsang ML, Carroll AG, Barcellos-Hoff MH, (1997) Latent transforming growth factor beta1 activation in situ: quantitative and functional evidence after low-dose gamma-irradiation. Faseb J 11: 991-1002.
-
(1997)
Faseb J
, vol.11
, pp. 991-1002
-
-
Ehrhart, E.J.1
Segarini, P.2
Tsang, M.L.3
Carroll, A.G.4
Barcellos-Hoff, M.H.5
-
40
-
-
33845358508
-
Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species
-
Jobling MF, Mott JD, Finnegan MT, Jurukovski V, Erickson AC, et al. (2006) Isoform-specific activation of latent transforming growth factor beta (LTGF-beta) by reactive oxygen species. Radiat Res 166: 839-848.
-
(2006)
Radiat Res
, vol.166
, pp. 839-848
-
-
Jobling, M.F.1
Mott, J.D.2
Finnegan, M.T.3
Jurukovski, V.4
Erickson, A.C.5
-
41
-
-
80051704370
-
Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells
-
Liu ZM, Tseng JT, Hong DY, Huang HS, (2011) Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells. Biochem J 438: 349-358.
-
(2011)
Biochem J
, vol.438
, pp. 349-358
-
-
Liu, Z.M.1
Tseng, J.T.2
Hong, D.Y.3
Huang, H.S.4
-
42
-
-
6344260070
-
The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
-
Seo SR, Lallemand F, Ferrand N, Pessah M, L'Hoste S, et al. (2004) The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. Embo J 23: 3780-3792.
-
(2004)
Embo J
, vol.23
, pp. 3780-3792
-
-
Seo, S.R.1
Lallemand, F.2
Ferrand, N.3
Pessah, M.4
L'Hoste, S.5
-
43
-
-
0034671905
-
The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
-
Melhuish TA, Wotton D, (2000) The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J Biol Chem 275: 39762-39766.
-
(2000)
J Biol Chem
, vol.275
, pp. 39762-39766
-
-
Melhuish, T.A.1
Wotton, D.2
-
44
-
-
2542433088
-
Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF
-
Dai C, Liu Y, (2004) Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF. J Am Soc Nephrol 15: 1402-1412.
-
(2004)
J Am Soc Nephrol
, vol.15
, pp. 1402-1412
-
-
Dai, C.1
Liu, Y.2
-
45
-
-
72149101537
-
A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicity
-
Demange C, Ferrand N, Prunier C, Bourgeade MF, Atfi A, (2009) A model of partnership co-opted by the homeodomain protein TGIF and the Itch/AIP4 ubiquitin ligase for effective execution of TNF-alpha cytotoxicity. Mol Cell 36: 1073-1085.
-
(2009)
Mol Cell
, vol.36
, pp. 1073-1085
-
-
Demange, C.1
Ferrand, N.2
Prunier, C.3
Bourgeade, M.F.4
Atfi, A.5
-
46
-
-
0035863208
-
Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF
-
Lo RS, Wotton D, Massague J, (2001) Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. Embo J 20: 128-136.
-
(2001)
Embo J
, vol.20
, pp. 128-136
-
-
Lo, R.S.1
Wotton, D.2
Massague, J.3
-
47
-
-
71649107564
-
Radiation-induced interleukin-6 expression through MAPK/p38/NF-kappaB signaling pathway and the resultant antiapoptotic effect on endothelial cells through Mcl-1 expression with sIL6-Ralpha
-
Chou CH, Chen SU, Cheng JC, (2009) Radiation-induced interleukin-6 expression through MAPK/p38/NF-kappaB signaling pathway and the resultant antiapoptotic effect on endothelial cells through Mcl-1 expression with sIL6-Ralpha. Int J Radiat Oncol Biol Phys 75: 1553-1561.
-
(2009)
Int J Radiat Oncol Biol Phys
, vol.75
, pp. 1553-1561
-
-
Chou, C.H.1
Chen, S.U.2
Cheng, J.C.3
-
48
-
-
0141757460
-
MAPK pathways in radiation responses
-
Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S, (2003) MAPK pathways in radiation responses. Oncogene 22: 5885-5896.
-
(2003)
Oncogene
, vol.22
, pp. 5885-5896
-
-
Dent, P.1
Yacoub, A.2
Fisher, P.B.3
Hagan, M.P.4
Grant, S.5
|