Radiation-Induced Interleukin-6 Expression Through MAPK/p38/NF-κB Signaling Pathway and the Resultant Antiapoptotic Effect on Endothelial Cells Through Mcl-1 Expression With sIL6-Rα

International Journal of Radiation Oncology Biology Physics

Volumn 75, Issue 5, 2009, Pages 1553-1561

  Chou, Chia Hung ^a   Chen, Shee Uan ^b   Cheng, Jason Chia Hsien ^a,b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Endothelial cell; Interleukin 6; Radiation; Resistance

Indexed keywords

ANTI-APOPTOTIC EFFECTS; BIOLOGIC FUNCTIONS; CHEMICAL INHIBITORS; IL-6 EXPRESSION; INTERLEUKIN-6; MITOGEN-ACTIVATED PROTEINS; NUCLEAR FACTORS; OLIGODEOXYNUCLEOTIDES; RADIATION RESISTANCE; RADIATION-INDUCED; REVERSE TRANSCRIPTASE- POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION PATHWAYS; SIGNALING PATHWAYS; SMALL INTERFERING RNA; TRANSCRIPTIONAL REGULATION; TRANSLATIONAL REGULATION; VASCULAR ENDOTHELIAL CELLS; WESTERN BLOTTING;

BLOOD VESSEL PROSTHESES; IONIZING RADIATION; NUCLEIC ACIDS; PROTEINS; RNA; SELF ASSEMBLY; SIGNAL TRANSDUCTION;

ENDOTHELIAL CELLS;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE P38; OLIGODEOXYNUCLEOTIDE; PROTEIN MCL 1; SMALL INTERFERING RNA; TRYPAN BLUE;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; ENDOTHELIUM CELL; ENZYME IMMUNOASSAY; HUMAN; HUMAN CELL; HUMAN UMBILICAL VASCULAR ENDOTHELIAL CELL; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION DOSE; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; WESTERN BLOTTING;

APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; GENE EXPRESSION; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; IMIDAZOLES; INTERLEUKIN-6; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; RECEPTORS, INTERLEUKIN-6; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 71649107564     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2009.08.034     Document Type: Article

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