메뉴 건너뛰기




Volumn 7, Issue 5, 2012, Pages

Antiproliferative effects of DNA methyltransferase 3b depletion are not associated with DNA demethylation

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3B; DNA (CYTOSINE 5) METHYLTRANSFERASE;

EID: 84860432500     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036125     Document Type: Article
Times cited : (16)

References (44)
  • 1
    • 33847065486 scopus 로고    scopus 로고
    • The epigenomics of cancer
    • Jones PA, Baylin SB, (2007) The epigenomics of cancer. Cell 128: 683-692.
    • (2007) Cell , vol.128 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 2
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB, (2002) The fundamental role of epigenetic events in cancer. Nat Rev Genet 3: 415-428.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 5
    • 48549101423 scopus 로고    scopus 로고
    • CpG island methylator phenotype (CIMP) in cancer: causes and implications
    • Teodoridis JM, Hardie C, Brown R, (2008) CpG island methylator phenotype (CIMP) in cancer: causes and implications. Cancer Lett 268: 177-186.
    • (2008) Cancer Lett , vol.268 , pp. 177-186
    • Teodoridis, J.M.1    Hardie, C.2    Brown, R.3
  • 6
    • 33846649587 scopus 로고    scopus 로고
    • Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer
    • Schlesinger Y, Straussman R, Keshet I, Farkash S, Hecht M, et al. (2007) Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer. Nat Genet 39: 232-236.
    • (2007) Nat Genet , vol.39 , pp. 232-236
    • Schlesinger, Y.1    Straussman, R.2    Keshet, I.3    Farkash, S.4    Hecht, M.5
  • 8
    • 33846569960 scopus 로고    scopus 로고
    • A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing
    • Ohm JE, McGarvey KM, Yu X, Cheng L, Schuebel KE, et al. (2007) A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing. Nat Genet 39: 237-242.
    • (2007) Nat Genet , vol.39 , pp. 237-242
    • Ohm, J.E.1    McGarvey, K.M.2    Yu, X.3    Cheng, L.4    Schuebel, K.E.5
  • 9
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll MG, Bestor TH, (2005) Eukaryotic cytosine methyltransferases. Annu Rev Biochem 74: 481-514.
    • (2005) Annu Rev Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 10
    • 0032722062 scopus 로고    scopus 로고
    • Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation
    • Pradhan S, Bacolla A, Wells RD, Roberts RJ, (1999) Recombinant human DNA (cytosine-5) methyltransferase. I. Expression, purification, and comparison of de novo and maintenance methylation. J Biol Chem 274: 33002-33010.
    • (1999) J Biol Chem , vol.274 , pp. 33002-33010
    • Pradhan, S.1    Bacolla, A.2    Wells, R.D.3    Roberts, R.J.4
  • 11
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M, Bell DW, Haber DA, Li E, (1999) DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99: 247-257.
    • (1999) Cell , vol.99 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 12
    • 78651314191 scopus 로고    scopus 로고
    • Identification of preferential target sites for human DNA methyltransferases
    • Choi SH, Heo K, Byun HM, An W, Lu W, et al. (2011) Identification of preferential target sites for human DNA methyltransferases. Nucleic Acids Res 39: 104-118.
    • (2011) Nucleic Acids Res , vol.39 , pp. 104-118
    • Choi, S.H.1    Heo, K.2    Byun, H.M.3    An, W.4    Lu, W.5
  • 13
    • 36849004469 scopus 로고    scopus 로고
    • Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing
    • Linhart HG, Lin H, Yamada Y, Moran E, Steine EJ, et al. (2007) Dnmt3b promotes tumorigenesis in vivo by gene-specific de novo methylation and transcriptional silencing. Genes Dev 21: 3110-3122.
    • (2007) Genes Dev , vol.21 , pp. 3110-3122
    • Linhart, H.G.1    Lin, H.2    Yamada, Y.3    Moran, E.4    Steine, E.J.5
  • 14
    • 79955510962 scopus 로고    scopus 로고
    • Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer
    • Steine EJ, Ehrich M, Bell GW, Raj A, Reddy S, et al. (2011) Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer. J Clin Invest 121: 1748-1752.
    • (2011) J Clin Invest , vol.121 , pp. 1748-1752
    • Steine, E.J.1    Ehrich, M.2    Bell, G.W.3    Raj, A.4    Reddy, S.5
  • 15
    • 66649097032 scopus 로고    scopus 로고
    • DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer
    • Nosho K, Shima K, Irahara N, Kure S, Baba Y, et al. (2009) DNMT3B expression might contribute to CpG island methylator phenotype in colorectal cancer. Clin Cancer Res 15: 3663-3671.
    • (2009) Clin Cancer Res , vol.15 , pp. 3663-3671
    • Nosho, K.1    Shima, K.2    Irahara, N.3    Kure, S.4    Baba, Y.5
  • 16
    • 79952539026 scopus 로고    scopus 로고
    • Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression
    • Ibrahim AE, Arends MJ, Silva AL, Wyllie AH, Greger L, et al. (2011) Sequential DNA methylation changes are associated with DNMT3B overexpression in colorectal neoplastic progression. Gut 60: 499-508.
    • (2011) Gut , vol.60 , pp. 499-508
    • Ibrahim, A.E.1    Arends, M.J.2    Silva, A.L.3    Wyllie, A.H.4    Greger, L.5
  • 17
    • 79955648677 scopus 로고    scopus 로고
    • DNMT3B gene amplification predicts resistance to DNA demethylating drugs
    • Simo-Riudalbas L, Melo SA, Esteller M, (2011) DNMT3B gene amplification predicts resistance to DNA demethylating drugs. Genes Chromosomes Cancer 50: 527-534.
    • (2011) Genes Chromosomes Cancer , vol.50 , pp. 527-534
    • Simo-Riudalbas, L.1    Melo, S.A.2    Esteller, M.3
  • 18
    • 18344390653 scopus 로고    scopus 로고
    • DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    • Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, et al. (2002) DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416: 552-556.
    • (2002) Nature , vol.416 , pp. 552-556
    • Rhee, I.1    Bachman, K.E.2    Park, B.H.3    Jair, K.W.4    Yen, R.W.5
  • 19
    • 0037008775 scopus 로고    scopus 로고
    • An essential role for DNA methyltransferase DNMT3B in cancer cell survival
    • Beaulieu N, Morin S, Chute IC, Robert MF, Nguyen H, et al. (2002) An essential role for DNA methyltransferase DNMT3B in cancer cell survival. J Biol Chem 277: 28176-28181.
    • (2002) J Biol Chem , vol.277 , pp. 28176-28181
    • Beaulieu, N.1    Morin, S.2    Chute, I.C.3    Robert, M.F.4    Nguyen, H.5
  • 20
    • 53949094967 scopus 로고    scopus 로고
    • Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration
    • Yaqinuddin A, Qureshi SA, Qazi R, Abbas F, (2008) Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration. Cancer Cell Int 8: 13.
    • (2008) Cancer Cell Int , vol.8 , pp. 13
    • Yaqinuddin, A.1    Qureshi, S.A.2    Qazi, R.3    Abbas, F.4
  • 21
    • 79251557812 scopus 로고    scopus 로고
    • Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors
    • Chik F, Szyf M, (2011) Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis 32: 224-232.
    • (2011) Carcinogenesis , vol.32 , pp. 224-232
    • Chik, F.1    Szyf, M.2
  • 23
    • 0345308734 scopus 로고    scopus 로고
    • ImageJ, U. S. National Institutes of Health, Bethesda, Maryland, USA
    • Image Processing and Analysis in Java website:. Accessed 2012 April 1
    • Rasband WS, (1997-2011) ImageJ, U. S. National Institutes of Health, Bethesda, Maryland, USA. Image Processing and Analysis in Java website: http://imagej.nih.gov/ij. Accessed 2012 April 1.
    • (1997)
    • Rasband, W.S.1
  • 25
    • 84909943667 scopus 로고    scopus 로고
    • R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria
    • Team RDC
    • Team RDC (2011) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0.
    • (2011) ISBN 3-900051-07-0
  • 27
    • 77249141762 scopus 로고    scopus 로고
    • Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling
    • Hinoue T, Weisenberger DJ, Pan F, Campan M, Kim M, et al. (2009) Analysis of the association between CIMP and BRAF in colorectal cancer by DNA methylation profiling. PLoS One 4: e8357.
    • (2009) PLoS One , vol.4
    • Hinoue, T.1    Weisenberger, D.J.2    Pan, F.3    Campan, M.4    Kim, M.5
  • 28
    • 80053304450 scopus 로고    scopus 로고
    • High density DNA methylation array with single CpG site resolution
    • Bibikova M, Barnes B, Tsan C, Ho V, Klotzle B, et al. (2011) High density DNA methylation array with single CpG site resolution. Genomics 98: 288-295.
    • (2011) Genomics , vol.98 , pp. 288-295
    • Bibikova, M.1    Barnes, B.2    Tsan, C.3    Ho, V.4    Klotzle, B.5
  • 29
    • 0141988726 scopus 로고    scopus 로고
    • Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation
    • Leu YW, Rahmatpanah F, Shi H, Wei SH, Liu JC, et al. (2003) Double RNA interference of DNMT3b and DNMT1 enhances DNA demethylation and gene reactivation. Cancer Res 63: 6110-6115.
    • (2003) Cancer Res , vol.63 , pp. 6110-6115
    • Leu, Y.W.1    Rahmatpanah, F.2    Shi, H.3    Wei, S.H.4    Liu, J.C.5
  • 30
    • 33748998743 scopus 로고    scopus 로고
    • Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival
    • Egger G, Jeong S, Escobar SG, Cortez CC, Li TW, et al. (2006) Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc Natl Acad Sci U S A 103: 14080-14085.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14080-14085
    • Egger, G.1    Jeong, S.2    Escobar, S.G.3    Cortez, C.C.4    Li, T.W.5
  • 31
    • 33847348016 scopus 로고    scopus 로고
    • DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells
    • Spada F, Haemmer A, Kuch D, Rothbauer U, Schermelleh L, et al. (2007) DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells. J Cell Biol 176: 565-571.
    • (2007) J Cell Biol , vol.176 , pp. 565-571
    • Spada, F.1    Haemmer, A.2    Kuch, D.3    Rothbauer, U.4    Schermelleh, L.5
  • 33
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E, Bestor TH, Jaenisch R, (1992) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69: 915-926.
    • (1992) Cell , vol.69 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 34
    • 33749594205 scopus 로고    scopus 로고
    • DNA methyltransferase 1 knockdown activates a replication stress checkpoint
    • Unterberger A, Andrews SD, Weaver IC, Szyf M, (2006) DNA methyltransferase 1 knockdown activates a replication stress checkpoint. Mol Cell Biol 26: 7575-7586.
    • (2006) Mol Cell Biol , vol.26 , pp. 7575-7586
    • Unterberger, A.1    Andrews, S.D.2    Weaver, I.C.3    Szyf, M.4
  • 35
    • 0031860739 scopus 로고    scopus 로고
    • Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases
    • Okano M, Xie S, Li E, (1998) Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 19: 219-220.
    • (1998) Nat Genet , vol.19 , pp. 219-220
    • Okano, M.1    Xie, S.2    Li, E.3
  • 36
    • 77649267695 scopus 로고    scopus 로고
    • Dynamic changes in the human methylome during differentiation
    • Laurent L, Wong E, Li G, Huynh T, Tsirigos A, et al. (2010) Dynamic changes in the human methylome during differentiation. Genome Res 20: 320-331.
    • (2010) Genome Res , vol.20 , pp. 320-331
    • Laurent, L.1    Wong, E.2    Li, G.3    Huynh, T.4    Tsirigos, A.5
  • 37
    • 77955038710 scopus 로고    scopus 로고
    • DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis
    • Shah MY, Vasanthakumar A, Barnes NY, Figueroa ME, Kamo A, et al. (2010) DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis. Cancer Res 70: 5840-5850.
    • (2010) Cancer Res , vol.70 , pp. 5840-5850
    • Shah, M.Y.1    Vasanthakumar, A.2    Barnes, N.Y.3    Figueroa, M.E.4    Kamo, A.5
  • 38
    • 84855433323 scopus 로고    scopus 로고
    • Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis
    • Hlady RA, Novakova S, Opavska J, Klinkebiel D, Peters SL, et al. (2012) Loss of Dnmt3b function upregulates the tumor modifier Ment and accelerates mouse lymphomagenesis. J Clin Invest 122: 163-177.
    • (2012) J Clin Invest , vol.122 , pp. 163-177
    • Hlady, R.A.1    Novakova, S.2    Opavska, J.3    Klinkebiel, D.4    Peters, S.L.5
  • 39
    • 2542583103 scopus 로고    scopus 로고
    • Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery
    • Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, et al. (2004) Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery. Nucleic Acids Res 32: 2716-2729.
    • (2004) Nucleic Acids Res , vol.32 , pp. 2716-2729
    • Geiman, T.M.1    Sankpal, U.T.2    Robertson, A.K.3    Chen, Y.4    Mazumdar, M.5
  • 40
    • 0035861938 scopus 로고    scopus 로고
    • Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1
    • Kang ES, Park CW, Chung JH, (2001) Dnmt3b, de novo DNA methyltransferase, interacts with SUMO-1 and Ubc9 through its N-terminal region and is subject to modification by SUMO-1. Biochem Biophys Res Commun 289: 862-868.
    • (2001) Biochem Biophys Res Commun , vol.289 , pp. 862-868
    • Kang, E.S.1    Park, C.W.2    Chung, J.H.3
  • 41
    • 33646157746 scopus 로고    scopus 로고
    • Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b
    • Suzuki M, Yamada T, Kihara-Negishi F, Sakurai T, Hara E, et al. (2006) Site-specific DNA methylation by a complex of PU.1 and Dnmt3a/b. Oncogene 25: 2477-2488.
    • (2006) Oncogene , vol.25 , pp. 2477-2488
    • Suzuki, M.1    Yamada, T.2    Kihara-Negishi, F.3    Sakurai, T.4    Hara, E.5
  • 42
    • 68749117667 scopus 로고    scopus 로고
    • DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions
    • Gopalakrishnan S, Sullivan BA, Trazzi S, Della Valle G, Robertson KD, (2009) DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. Hum Mol Genet 18: 3178-3193.
    • (2009) Hum Mol Genet , vol.18 , pp. 3178-3193
    • Gopalakrishnan, S.1    Sullivan, B.A.2    Trazzi, S.3    Della Valle, G.4    Robertson, K.D.5
  • 43
    • 3142543806 scopus 로고    scopus 로고
    • DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation
    • Milutinovic S, Brown SE, Zhuang Q, Szyf M, (2004) DNA methyltransferase 1 knock down induces gene expression by a mechanism independent of DNA methylation and histone deacetylation. J Biol Chem 279: 27915-27927.
    • (2004) J Biol Chem , vol.279 , pp. 27915-27927
    • Milutinovic, S.1    Brown, S.E.2    Zhuang, Q.3    Szyf, M.4
  • 44
    • 0038341137 scopus 로고    scopus 로고
    • Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes
    • Milutinovic S, Zhuang Q, Niveleau A, Szyf M, (2003) Epigenomic stress response. Knockdown of DNA methyltransferase 1 triggers an intra-S-phase arrest of DNA replication and induction of stress response genes. J Biol Chem 278: 14985-14995.
    • (2003) J Biol Chem , vol.278 , pp. 14985-14995
    • Milutinovic, S.1    Zhuang, Q.2    Niveleau, A.3    Szyf, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.