Down-regulation of DNMT3b in PC3 cells effects locus-specific DNA methylation, and represses cellular growth and migration

Cancer Cell International

Volumn 8, Issue , 2008, Pages

  Yaqinuddin, Ahmed ^a   Qureshi, Sohail A ^a   Qazi, Romena ^a   Abbas, Farhat ^a  

^a AGA KHAN UNIVERSITY   (Pakistan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; CYCLIN DEPENDENT KINASE 3; CYTOCHROME B5; DNA; DNA METHYLTRANSFERASE 3B; RETINOBLASTOMA PROTEIN; RETINOIC ACID RECEPTOR BETA;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL GROWTH; CELL MIGRATION; CONTROLLED STUDY; DNA METHYLATION; DOWN REGULATION; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MALE; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROSTATE CANCER; PROTEIN DEPLETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 53949094967     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-8-13     Document Type: Article

References (21)

1. Jones PA Baylin SB The fundamental role of epigenetic events in cancer Nat Rev Genet 2002, 3:415-428 12042769
2. Baylin SB Herman JG DNA hypermethylation in tumorigenesis: Epigenetics joins genetics Trends Genet 2000, 16:168-174 10729832
3. Buryanov YI Shevchuk TV DNA methyltransferases and structural-functional specificity of eukaryotic DNA modification Biochemistry (Mosc) 2005, 70:730-742 16097936
4. Jeltsch A Molecular enzymology of mammalian DNA methyltransferases Curr Top Microbiol Immunol 2006, 301:203-225 16570849
5. Bostick M Kim JK Esteve PO Clark A Pradhan S Jacobsen SE UHRF1 plays a role in maintaining DNA methylation in mammalian cells Science 2007, 317:1760-1764 17673620
6. Xie S Wang Z Okano M Nogami M Li Y He WW Okumura K Li E Cloning, expression and chromosome locations of the human DNMT3 gene family Gene 1999, 236:87-95 10433969
7. Chen T Ueda Y Dodge JE Wang Z Li E Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b Mol Cell Biol 2003, 23:5594-5605 166327 12897133
8. Kanai Y Ushijima S Kondo Y Nakanishi Y Hirohashi S DNA methyltransferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers Int J Cancer 2001, 91:205-212 11146446
9. Mizuno S Chijiwa T Okamura T Akashi K Fukumaki Y Niho Y Sasaki H Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia Blood 2001, 97:1172-1179 11222358
10. Saito Y Kanai Y Sakamoto M Saito H Ishii H Hirohashi S Expression of mRNA for DNA methyltransferases and methyl-CpG-binding proteins and DNA methylation status on CpG islands and pericentromeric satellite regions during human hepatocarcinogenesis Hepatology 2001, 33:561-568 11230735
11. Christoph F Weikert S Kempkensteffen C Krause H Schostak M Kollermann J Miller K Schrader M Promoter hypermethylation profile of kidney cancer with new proapoptotic p53 target genes and clinical implications Clin Cancer Res 2006, 12:5040-5046 16951219
12. Mino A Onoda N Yashiro M Aya M Fujiwara I Kubo N Sawada T Ohira M Kato Y Hirakawa K Frequent p16 CpG island hypermethylation in primary remnant gastric cancer suggesting an independent carcinogenic pathway Oncol Rep 2006, 15:615-620 16465421
13. Liu L Yoon JH Dammann R Pfeifer GP Frequent hypermethylation of the RASSF1A gene in prostate cancer Oncogene 2002, 21:6835-6840 12360410
14. Zhu YM Huang Q Lin J Hu Y Chen J Lai MD Expression of human DNA methyltransferase 1 in colorectal cancer tissues and their corresponding distant normal tissues Int J Colorectal Dis 2007, 22:661-666 17093909
15. Kim H Kwon YM Kim JS Han J Shim YM Park J Kim DH Elevated mRNA levels of DNA methyltransferase-1 as an independent prognostic factor in primary nonsmall cell lung cancer Cancer 2006, 107:1042-1049 16888795
16. Kassis ES Zhao M Hong JA Chen GA Nguyen DM Schrump DS Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells J Thorac Cardiovasc Surg 2006, 131:298-306 16434257
17. Rhee I Bachman KE Park BH Jair KW Yen RW Schuebel KE Cui H Feinberg AP Lengauer C Kinzler KW Baylin SB Vogelstein B DNMT1 and DNMT3b cooperate to silence genes in human cancer cells Nature 2002, 416:552-556 11932749
18. Beaulieu N Morin S Chute IC Robert MF Nguyen H MacLeod AR An essential role for DNA methyltransferase DNMT3B in cancer cell survival J Biol Chem 2002, 277:28176-28181 12015329
19. Robertson KD Uzvolgyi E Liang G Talmadge C Sumegi J Gonzales FA Jones PA The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors Nucleic Acids Res 1999, 27:2291-2298 148793 10325416
20. Arunkumar A Vijayababu MR Kanagaraj P Balasubramanian K Aruldhas MM Arunakaran J Growth suppressing effect of garlic compound diallyl disulfide on prostate cancer cell line (PC-3) in vitro Biol Pharm Bull 2005, 28:740-743 15802821
21. Albini A Benelli R Noonan DM Brigati C The "chemoinvasion assay": A tool to study tumor and endothelial cell invasion of basement membranes Int J Dev Biol 2004, 48:563-571 15349831