Drug-like Leads for Steric Discrimination between Substrate and Inhibitors of Human Acetylcholinesterase

Chemical Biology and Drug Design

Volumn 78, Issue 4, 2011, Pages 495-504

  Wildman, Scott A ^a   Zheng, Xiange ^a   Sept, David ^b   Auletta, Jeffrey T ^c   Rosenberry, Terrone L ^c   Marshall, Garland R ^a  

^a WASHINGTON UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c MAYO GRADUATE SCHOOL   (United States)

Author keywords

Acetylcholine; Acetylcholinesterase; AChE; Docking; Virtual screening

Indexed keywords

ACETYLCHOLINE; ACETYLTHIOCHOLINE; AFLATOXIN B1; CHOLINESTERASE INHIBITOR; DECIDIUM; EDROPHONIUM; METHYLENE BLUE; PROPIDIUM IODIDE; TACRINE; THIOFLAVINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING SITE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; DROSOPHILA; DRUG COMPETITION; DRUG DETERMINATION; DRUG SCREENING; ENZYME SUBSTRATE; HYDROLYSIS; MOLECULAR DOCKING; NONHUMAN; PRIORITY JOURNAL; STEREOSPECIFICITY; X RAY;

ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; BINDING SITES; CHOLINESTERASE INHIBITORS; DRUG DESIGN; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; SUBSTRATE SPECIFICITY;

EID: 84860416346     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2011.01157.x     Document Type: Article

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