Molecular basis of inhibition of substrate hydrolysis by a ligand bound to the peripheral site of acetylcholinesterase

Chemico-Biological Interactions

Volumn 187, Issue 1-3, 2010, Pages 135-141

  Auletta, Jeffrey T ^a   Johnson, Joseph L ^a   Rosenberry, Terrone L ^a  

^a MAYO CLINIC   (United States)

Author keywords

Acetylcholinesterase; Carbamoylation; Enzyme mechanism; Peripheral site; Substrate analogs; Thioflavin T

Indexed keywords

3 (ACETAMIDO) N,N,N TRIMETHYLANILINIUM; ACETYLCHOLINESTERASE; ACETYLTHIOCHOLINE; ANILINIUM DERIVATIVE; CARBACHOL; LIGAND; THIOFLAVINE; UNCLASSIFIED DRUG;

ACYLATION; ANIMAL CELL; ARTICLE; BINDING SITE; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; HUMAN; HYDROLYSIS; LIGAND BINDING; NONHUMAN;

EID: 77955553053     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2010.05.009     Document Type: Article

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