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Volumn 13, Issue 1, 2011, Pages

A p53-independent role of Mdm2 in estrogen-mediated activation of breast cancer cell proliferation

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR ALPHA; PROTEIN MDM2; PROTEIN P53;

EID: 84860389938     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2804     Document Type: Article
Times cited : (64)

References (60)
  • 1
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • 10.1038/35042675, 11099028
    • Vogelstein B, Lane D, Levine AJ. Surfing the p53 network. Nature 2000, 408:307-310. 10.1038/35042675, 11099028.
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 2
    • 33745115304 scopus 로고    scopus 로고
    • P53 and breast cancer, an update
    • 10.1677/erc.1.01172, 16728565
    • Lacroix M, Toillon RA, Leclercq G. p53 and breast cancer, an update. Endocr Relat Cancer 2006, 13:293-325. 10.1677/erc.1.01172, 16728565.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 293-325
    • Lacroix, M.1    Toillon, R.A.2    Leclercq, G.3
  • 3
    • 0032814777 scopus 로고    scopus 로고
    • Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis
    • 10.1038/sj.bjc.6690628, 2363143, 10471047
    • Pharoah PD, Day NE, Caldas C. Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis. Br J Cancer 1999, 80:1968-1973. 10.1038/sj.bjc.6690628, 2363143, 10471047.
    • (1999) Br J Cancer , vol.80 , pp. 1968-1973
    • Pharoah, P.D.1    Day, N.E.2    Caldas, C.3
  • 4
    • 0031039955 scopus 로고    scopus 로고
    • The molecular epidemiology of p53 gene mutations in human breast cancer
    • 10.1016/S0168-9525(96)10043-3, 9009845
    • Hartmann A, Blaszyk H, Kovach JS, Sommer SS. The molecular epidemiology of p53 gene mutations in human breast cancer. Trends Genet 1997, 13:27-33. 10.1016/S0168-9525(96)10043-3, 9009845.
    • (1997) Trends Genet , vol.13 , pp. 27-33
    • Hartmann, A.1    Blaszyk, H.2    Kovach, J.S.3    Sommer, S.S.4
  • 5
    • 0032145989 scopus 로고    scopus 로고
    • The MDM2 gene amplification database
    • 10.1093/nar/26.15.3453, 147746, 9671804
    • Momand J, Jung D, Wilczynski S, Niland J. The MDM2 gene amplification database. Nucleic Acids Res 1998, 26:3453-3459. 10.1093/nar/26.15.3453, 147746, 9671804.
    • (1998) Nucleic Acids Res , vol.26 , pp. 3453-3459
    • Momand, J.1    Jung, D.2    Wilczynski, S.3    Niland, J.4
  • 7
    • 0027302563 scopus 로고
    • The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma
    • Sheikh MS, Shao Z, Hussain A, Fontana JA. The p53-binding protein MDM2 gene is differentially expressed in human breast carcinoma. Cancer Res 1993, 53:3226-3228.
    • (1993) Cancer Res , vol.53 , pp. 3226-3228
    • Sheikh, M.S.1    Shao, Z.2    Hussain, A.3    Fontana, J.A.4
  • 8
    • 0037505736 scopus 로고    scopus 로고
    • P53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells
    • Phelps M, Darley M, Primrose JN, Blaydes JP. p53-independent activation of the hdm2-P2 promoter through multiple transcription factor response elements results in elevated hdm2 expression in estrogen receptor alpha-positive breast cancer cells. Cancer Res 2003, 63:2616-2623.
    • (2003) Cancer Res , vol.63 , pp. 2616-2623
    • Phelps, M.1    Darley, M.2    Primrose, J.N.3    Blaydes, J.P.4
  • 9
    • 33646845960 scopus 로고    scopus 로고
    • Molecular biology of breast cancer
    • 10.1007/s12094-006-0089-6, 16632434
    • Martin M. Molecular biology of breast cancer. Clin Transl Oncol 2006, 8:7-14. 10.1007/s12094-006-0089-6, 16632434.
    • (2006) Clin Transl Oncol , vol.8 , pp. 7-14
    • Martin, M.1
  • 10
    • 8344275588 scopus 로고    scopus 로고
    • The biological role of estrogen receptors alpha and beta in cancer
    • 10.1016/j.critrevonc.2003.09.003, 15094156
    • Pearce ST, Jordan VC. The biological role of estrogen receptors alpha and beta in cancer. Crit Rev Oncol Hematol 2004, 50:3-22. 10.1016/j.critrevonc.2003.09.003, 15094156.
    • (2004) Crit Rev Oncol Hematol , vol.50 , pp. 3-22
    • Pearce, S.T.1    Jordan, V.C.2
  • 11
    • 23844465938 scopus 로고    scopus 로고
    • Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc
    • 10.1128/MCB.25.17.7917-7925.2005, 1190308, 16107734
    • Rodrik V, Zheng Y, Harrow F, Chen Y, Foster DA. Survival signals generated by estrogen and phospholipase D in MCF-7 breast cancer cells are dependent on Myc. Mol Cell Biol 2005, 25:7917-7925. 10.1128/MCB.25.17.7917-7925.2005, 1190308, 16107734.
    • (2005) Mol Cell Biol , vol.25 , pp. 7917-7925
    • Rodrik, V.1    Zheng, Y.2    Harrow, F.3    Chen, Y.4    Foster, D.A.5
  • 12
    • 0033621962 scopus 로고    scopus 로고
    • 17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence
    • 10.1128/MCB.20.8.2890-2901.2000, 85519, 10733592
    • Perillo B, Sasso A, Abbondanza C, Palumbo G. 17beta-estradiol inhibits apoptosis in MCF-7 cells, inducing bcl-2 expression via two estrogen-responsive elements present in the coding sequence. Mol Cell Biol 2000, 20:2890-2901. 10.1128/MCB.20.8.2890-2901.2000, 85519, 10733592.
    • (2000) Mol Cell Biol , vol.20 , pp. 2890-2901
    • Perillo, B.1    Sasso, A.2    Abbondanza, C.3    Palumbo, G.4
  • 14
    • 34548051074 scopus 로고    scopus 로고
    • Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis
    • 10.1158/0008-5472.CAN-06-3724, 17699779
    • Sayeed A, Konduri SD, Liu W, Bansal S, Li F, Das GM. Estrogen receptor alpha inhibits p53-mediated transcriptional repression: implications for the regulation of apoptosis. Cancer Res 2007, 67:7746-7755. 10.1158/0008-5472.CAN-06-3724, 17699779.
    • (2007) Cancer Res , vol.67 , pp. 7746-7755
    • Sayeed, A.1    Konduri, S.D.2    Liu, W.3    Bansal, S.4    Li, F.5    Das, G.M.6
  • 15
    • 34047247060 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells
    • 10.1158/0008-5472.CAN-06-2656, 17363597
    • Hu W, Feng Z, Ma L, Wagner J, Rice JJ, Stolovitzky G, Levine AJ. A single nucleotide polymorphism in the MDM2 gene disrupts the oscillation of p53 and MDM2 levels in cells. Cancer Res 2007, 67:2757-2765. 10.1158/0008-5472.CAN-06-2656, 17363597.
    • (2007) Cancer Res , vol.67 , pp. 2757-2765
    • Hu, W.1    Feng, Z.2    Ma, L.3    Wagner, J.4    Rice, J.J.5    Stolovitzky, G.6    Levine, A.J.7
  • 18
    • 0041630956 scopus 로고    scopus 로고
    • Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression
    • 10.1128/MCB.23.16.5867-5881.2003, 166332, 12897156
    • Kinyamu HK, Archer TK. Estrogen receptor-dependent proteasomal degradation of the glucocorticoid receptor is coupled to an increase in mdm2 protein expression. Mol Cell Biol 2003, 23:5867-5881. 10.1128/MCB.23.16.5867-5881.2003, 166332, 12897156.
    • (2003) Mol Cell Biol , vol.23 , pp. 5867-5881
    • Kinyamu, H.K.1    Archer, T.K.2
  • 21
    • 22844432020 scopus 로고    scopus 로고
    • A chromatin associated and transcriptionally inactive p53-MDM2 complex occurs in MDM2 SNP 309 homozygous cells
    • 10.1074/jbc.M505203200, 15908423
    • Arva NC, Gopen TR, Talbott KE, Campbell LE, Chicas A, White DE, Bond GL, Levine AJ, Bargonetti J. A chromatin associated and transcriptionally inactive p53-MDM2 complex occurs in MDM2 SNP 309 homozygous cells. J Biol Chem 2005, 280:26776-26787. 10.1074/jbc.M505203200, 15908423.
    • (2005) J Biol Chem , vol.280 , pp. 26776-26787
    • Arva, N.C.1    Gopen, T.R.2    Talbott, K.E.3    Campbell, L.E.4    Chicas, A.5    White, D.E.6    Bond, G.L.7    Levine, A.J.8    Bargonetti, J.9
  • 22
    • 0027501841 scopus 로고
    • Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene
    • Juven T, Barak Y, Zauberman A, George DL, Oren M. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 1993, 8:3411-3416.
    • (1993) Oncogene , vol.8 , pp. 3411-3416
    • Juven, T.1    Barak, Y.2    Zauberman, A.3    George, D.L.4    Oren, M.5
  • 24
    • 0346455771 scopus 로고    scopus 로고
    • The MDM2-p53 interaction
    • Moll UM, Petrenko O. The MDM2-p53 interaction. Mol Cancer Res 2003, 1:1001-1008.
    • (2003) Mol Cancer Res , vol.1 , pp. 1001-1008
    • Moll, U.M.1    Petrenko, O.2
  • 25
    • 0026649648 scopus 로고
    • The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation
    • 10.1016/0092-8674(92)90644-R, 1535557
    • Momand J, Zambetti GP, Olson DC, George D, Levine AJ. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation. Cell 1992, 69:1237-1245. 10.1016/0092-8674(92)90644-R, 1535557.
    • (1992) Cell , vol.69 , pp. 1237-1245
    • Momand, J.1    Zambetti, G.P.2    Olson, D.C.3    George, D.4    Levine, A.J.5
  • 26
    • 0027325132 scopus 로고
    • Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
    • 10.1038/362857a0, 8479525
    • Oliner JD, Pietenpol JA, Thiagalingam S, Gyuris J, Kinzler KW, Vogelstein B. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature 1993, 362:857-860. 10.1038/362857a0, 8479525.
    • (1993) Nature , vol.362 , pp. 857-860
    • Oliner, J.D.1    Pietenpol, J.A.2    Thiagalingam, S.3    Gyuris, J.4    Kinzler, K.W.5    Vogelstein, B.6
  • 27
    • 0027244853 scopus 로고
    • The p53-mdm-2 autoregulatory feedback loop
    • 10.1101/gad.7.7a.1126, 8319905
    • Wu X, Bayle JH, Olson D, Levine AJ. The p53-mdm-2 autoregulatory feedback loop. Genes Dev 1993, 7:1126-1132. 10.1101/gad.7.7a.1126, 8319905.
    • (1993) Genes Dev , vol.7 , pp. 1126-1132
    • Wu, X.1    Bayle, J.H.2    Olson, D.3    Levine, A.J.4
  • 28
    • 0030860911 scopus 로고    scopus 로고
    • Repression of p53-mediated transcription by MDM2: a dual mechanism
    • 10.1101/gad.11.15.1974, 316412, 9271120
    • Thut CJ, Goodrich JA, Tjian R. Repression of p53-mediated transcription by MDM2: a dual mechanism. Genes Dev 1997, 11:1974-1986. 10.1101/gad.11.15.1974, 316412, 9271120.
    • (1997) Genes Dev , vol.11 , pp. 1974-1986
    • Thut, C.J.1    Goodrich, J.A.2    Tjian, R.3
  • 29
    • 8844232663 scopus 로고    scopus 로고
    • The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression
    • 10.1016/j.molcel.2004.10.016, 15546622
    • Minsky N, Oren M. The RING domain of Mdm2 mediates histone ubiquitylation and transcriptional repression. Mol Cell 2004, 16:631-639. 10.1016/j.molcel.2004.10.016, 15546622.
    • (2004) Mol Cell , vol.16 , pp. 631-639
    • Minsky, N.1    Oren, M.2
  • 30
    • 0346243936 scopus 로고    scopus 로고
    • MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation
    • 10.1093/emboj/cdg600, 291841, 14633995
    • Jin Y, Lee H, Zeng SX, Dai MS, Lu H. MDM2 promotes p21waf1/cip1 proteasomal turnover independently of ubiquitylation. Embo J 2003, 22:6365-6377. 10.1093/emboj/cdg600, 291841, 14633995.
    • (2003) Embo J , vol.22 , pp. 6365-6377
    • Jin, Y.1    Lee, H.2    Zeng, S.X.3    Dai, M.S.4    Lu, H.5
  • 31
    • 57049114832 scopus 로고    scopus 로고
    • The genetics of the p53 pathway, apoptosis and cancer therapy
    • 10.1038/nrd2656, 19043449
    • Vazquez A, Bond EE, Levine AJ, Bond GL. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov 2008, 7:979-987. 10.1038/nrd2656, 19043449.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 979-987
    • Vazquez, A.1    Bond, E.E.2    Levine, A.J.3    Bond, G.L.4
  • 32
    • 33947534030 scopus 로고    scopus 로고
    • P53 in health and disease
    • 10.1038/nrm2147, 17380161
    • Vousden KH, Lane DP. p53 in health and disease. Nat Rev Mol Cell Biol 2007, 8:275-283. 10.1038/nrm2147, 17380161.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 275-283
    • Vousden, K.H.1    Lane, D.P.2
  • 33
    • 24644436766 scopus 로고    scopus 로고
    • PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
    • 10.1126/science.1114297, 16151013
    • Chipuk JE, Bouchier-Hayes L, Kuwana T, Newmeyer DD, Green DR. PUMA couples the nuclear and cytoplasmic proapoptotic function of p53. Science 2005, 309:1732-1735. 10.1126/science.1114297, 16151013.
    • (2005) Science , vol.309 , pp. 1732-1735
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Kuwana, T.3    Newmeyer, D.D.4    Green, D.R.5
  • 34
    • 37649007431 scopus 로고    scopus 로고
    • Selective estrogen-receptor modulators and antihormonal resistance in breast cancer
    • 10.1200/JCO.2007.11.3886, 17893378
    • Jordan VC, O'Malley BW. Selective estrogen-receptor modulators and antihormonal resistance in breast cancer. J Clin Oncol 2007, 25:5815-5824. 10.1200/JCO.2007.11.3886, 17893378.
    • (2007) J Clin Oncol , vol.25 , pp. 5815-5824
    • Jordan, V.C.1    O'Malley, B.W.2
  • 35
    • 0037039319 scopus 로고    scopus 로고
    • Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
    • 10.1073/pnas.012283399, 117520, 11756653
    • Kaeser MD, Iggo RD. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc Natl Acad Sci USA 2002, 99:95-100. 10.1073/pnas.012283399, 117520, 11756653.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 95-100
    • Kaeser, M.D.1    Iggo, R.D.2
  • 36
    • 0034633702 scopus 로고    scopus 로고
    • Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study
    • 10.1073/pnas.210171597, 17186, 11016968
    • Lev Bar-Or R, Maya R, Segel LA, Alon U, Levine AJ, Oren M. Generation of oscillations by the p53-Mdm2 feedback loop: a theoretical and experimental study. Proc Natl Acad Sci USA 2000, 97:11250-11255. 10.1073/pnas.210171597, 17186, 11016968.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11250-11255
    • Lev Bar-Or, R.1    Maya, R.2    Segel, L.A.3    Alon, U.4    Levine, A.J.5    Oren, M.6
  • 37
    • 33749337752 scopus 로고    scopus 로고
    • Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells
    • 10.1016/j.febslet.2006.09.013, 1876739, 16996503
    • Rodrik V, Gomes E, Hui L, Rockwell P, Foster DA. Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells. FEBS Lett 2006, 580:5647-5652. 10.1016/j.febslet.2006.09.013, 1876739, 16996503.
    • (2006) FEBS Lett , vol.580 , pp. 5647-5652
    • Rodrik, V.1    Gomes, E.2    Hui, L.3    Rockwell, P.4    Foster, D.A.5
  • 39
    • 0026694826 scopus 로고
    • Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion
    • 10.1073/pnas.89.15.7262, 49686, 1353891
    • Moll UM, Riou G, Levine AJ. Two distinct mechanisms alter p53 in breast cancer: mutation and nuclear exclusion. Proc Natl Acad Sci USA 1992, 89:7262-7266. 10.1073/pnas.89.15.7262, 49686, 1353891.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 7262-7266
    • Moll, U.M.1    Riou, G.2    Levine, A.J.3
  • 41
    • 0036990109 scopus 로고    scopus 로고
    • The organizing principle: microenvironmental influences in the normal and malignant breast
    • 10.1046/j.1432-0436.2002.700907.x, 2933198, 12492495
    • Bissell MJ, Radisky DC, Rizki A, Weaver VM, Petersen OW. The organizing principle: microenvironmental influences in the normal and malignant breast. Differentiation 2002, 70:537-546. 10.1046/j.1432-0436.2002.700907.x, 2933198, 12492495.
    • (2002) Differentiation , vol.70 , pp. 537-546
    • Bissell, M.J.1    Radisky, D.C.2    Rizki, A.3    Weaver, V.M.4    Petersen, O.W.5
  • 43
    • 0027977925 scopus 로고
    • Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells
    • Gudas JM, Oka M, Diella F, Trepel J, Cowan KH. Expression of wild-type p53 during the cell cycle in normal human mammary epithelial cells. Cell Growth Differ 1994, 5:295-304.
    • (1994) Cell Growth Differ , vol.5 , pp. 295-304
    • Gudas, J.M.1    Oka, M.2    Diella, F.3    Trepel, J.4    Cowan, K.H.5
  • 44
    • 0036159438 scopus 로고    scopus 로고
    • Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer
    • 10.1023/A:1013350419426, 11859876
    • Hori M, Shimazaki J, Inagawa S, Itabashi M. Overexpression of MDM2 oncoprotein correlates with possession of estrogen receptor alpha and lack of MDM2 mRNA splice variants in human breast cancer. Breast Cancer Res Treat 2002, 71:77-83. 10.1023/A:1013350419426, 11859876.
    • (2002) Breast Cancer Res Treat , vol.71 , pp. 77-83
    • Hori, M.1    Shimazaki, J.2    Inagawa, S.3    Itabashi, M.4
  • 45
    • 48849109488 scopus 로고    scopus 로고
    • Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation
    • 2926973, 18677110
    • Paris R, Henry RE, Stephens SJ, McBryde M, Espinosa JM. Multiple p53-independent gene silencing mechanisms define the cellular response to p53 activation. Cell Cycle 2008, 7:2427-2433. 2926973, 18677110.
    • (2008) Cell Cycle , vol.7 , pp. 2427-2433
    • Paris, R.1    Henry, R.E.2    Stephens, S.J.3    McBryde, M.4    Espinosa, J.M.5
  • 46
    • 46349100300 scopus 로고    scopus 로고
    • Mechanisms of regulatory diversity within the p53 transcriptional network
    • 10.1038/onc.2008.37, 2914794, 18278067
    • Espinosa JM. Mechanisms of regulatory diversity within the p53 transcriptional network. Oncogene 2008, 27:4013-4023. 10.1038/onc.2008.37, 2914794, 18278067.
    • (2008) Oncogene , vol.27 , pp. 4013-4023
    • Espinosa, J.M.1
  • 47
    • 33846815516 scopus 로고    scopus 로고
    • Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach
    • 10.1677/erc.1.01120, 17158757
    • Tozlu S, Girault I, Vacher S, Vendrell J, Andrieu C, Spyratos F, Cohen P, Lidereau R, Bieche I. Identification of novel genes that co-cluster with estrogen receptor alpha in breast tumor biopsy specimens, using a large-scale real-time reverse transcription-PCR approach. Endocr Relat Cancer 2006, 13:1109-1120. 10.1677/erc.1.01120, 17158757.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 1109-1120
    • Tozlu, S.1    Girault, I.2    Vacher, S.3    Vendrell, J.4    Andrieu, C.5    Spyratos, F.6    Cohen, P.7    Lidereau, R.8    Bieche, I.9
  • 48
    • 1642422891 scopus 로고    scopus 로고
    • Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer
    • 10.1093/carcin/bgg175, 14514655
    • Mobley JA, Brueggemeier RW. Estrogen receptor-mediated regulation of oxidative stress and DNA damage in breast cancer. Carcinogenesis 2004, 25:3-9. 10.1093/carcin/bgg175, 14514655.
    • (2004) Carcinogenesis , vol.25 , pp. 3-9
    • Mobley, J.A.1    Brueggemeier, R.W.2
  • 50
    • 0036020642 scopus 로고    scopus 로고
    • Genotoxic effects of oestrogens in breast cells detected by the micronucleus assay and the Comet assay
    • 10.1093/mutage/17.4.345, 12110632
    • Yared E, McMillan TJ, Martin FL. Genotoxic effects of oestrogens in breast cells detected by the micronucleus assay and the Comet assay. Mutagenesis 2002, 17:345-352. 10.1093/mutage/17.4.345, 12110632.
    • (2002) Mutagenesis , vol.17 , pp. 345-352
    • Yared, E.1    McMillan, T.J.2    Martin, F.L.3
  • 53
    • 3343022920 scopus 로고    scopus 로고
    • Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells
    • 10.1038/sj.bjc.6601902, 2364738, 15188005
    • Zhang S, Cao HJ, Davis FB, Tang HY, Davis PJ, Lin HY. Oestrogen inhibits resveratrol-induced post-translational modification of p53 and apoptosis in breast cancer cells. Br J Cancer 2004, 91:178-185. 10.1038/sj.bjc.6601902, 2364738, 15188005.
    • (2004) Br J Cancer , vol.91 , pp. 178-185
    • Zhang, S.1    Cao, H.J.2    Davis, F.B.3    Tang, H.Y.4    Davis, P.J.5    Lin, H.Y.6
  • 54
    • 0037163085 scopus 로고    scopus 로고
    • MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation
    • 10.1074/jbc.M204078200, 12068014
    • Jin Y, Zeng SX, Dai MS, Yang XJ, Lu H. MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation. J Biol Chem 2002, 277:30838-30843. 10.1074/jbc.M204078200, 12068014.
    • (2002) J Biol Chem , vol.277 , pp. 30838-30843
    • Jin, Y.1    Zeng, S.X.2    Dai, M.S.3    Yang, X.J.4    Lu, H.5
  • 55
    • 2442544457 scopus 로고    scopus 로고
    • MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation
    • 10.1074/jbc.M309916200, 14769800
    • Jin Y, Zeng SX, Lee H, Lu H. MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation. J Biol Chem 2004, 279:20035-20043. 10.1074/jbc.M309916200, 14769800.
    • (2004) J Biol Chem , vol.279 , pp. 20035-20043
    • Jin, Y.1    Zeng, S.X.2    Lee, H.3    Lu, H.4
  • 56
    • 2442548716 scopus 로고    scopus 로고
    • P300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels
    • 10.1073/pnas.0401002101, 409928, 15123817
    • Iyer NG, Chin SF, Ozdag H, Daigo Y, Hu DE, Cariati M, Brindle K, Aparicio S, Caldas C. p300 regulates p53-dependent apoptosis after DNA damage in colorectal cancer cells by modulation of PUMA/p21 levels. Proc Natl Acad Sci USA 2004, 101:7386-7391. 10.1073/pnas.0401002101, 409928, 15123817.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7386-7391
    • Iyer, N.G.1    Chin, S.F.2    Ozdag, H.3    Daigo, Y.4    Hu, D.E.5    Cariati, M.6    Brindle, K.7    Aparicio, S.8    Caldas, C.9
  • 57
    • 56149109528 scopus 로고    scopus 로고
    • A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis, and sensitizes lung cancer cells to chemotherapy
    • Sun SH, Zheng M, Ding K, Wang S, Sun Y. A small molecule that disrupts Mdm2-p53 binding activates p53, induces apoptosis, and sensitizes lung cancer cells to chemotherapy. Cancer Biol Ther 2008, 7.
    • (2008) Cancer Biol Ther , vol.7
    • Sun, S.H.1    Zheng, M.2    Ding, K.3    Wang, S.4    Sun, Y.5
  • 60
    • 0032545222 scopus 로고    scopus 로고
    • P53-independent role of MDM2 in TGF-beta1 resistance
    • 10.1126/science.282.5397.2270, 9856953
    • Sun P, Dong P, Dai K, Hannon GJ, Beach D. p53-independent role of MDM2 in TGF-beta1 resistance. Science 1998, 282:2270-2272. 10.1126/science.282.5397.2270, 9856953.
    • (1998) Science , vol.282 , pp. 2270-2272
    • Sun, P.1    Dong, P.2    Dai, K.3    Hannon, G.J.4    Beach, D.5


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