-
1
-
-
0034047351
-
Characterization of an Atp-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline
-
Agus C., Ilett K.F., Kadlubar F.F., Minchin R.F. Characterization of an Atp-dependent pathway of activation for the heterocyclic amine carcinogen N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline. Carcinogenesis 2000, 21:1213-1219.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1213-1219
-
-
Agus, C.1
Ilett, K.F.2
Kadlubar, F.F.3
Minchin, R.F.4
-
2
-
-
0024402318
-
4-(2-Amino-1-methyl-imidazo[4,5-b]pyrid-6-yl)phenyl sulfate: a major metabolite of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat
-
Alexander J., Wallin H., Holme J.A., Becher G. 4-(2-Amino-1-methyl-imidazo[4,5-b]pyrid-6-yl)phenyl sulfate: a major metabolite of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in the rat. Carcinogenesis 1989, 10:1543-1547.
-
(1989)
Carcinogenesis
, vol.10
, pp. 1543-1547
-
-
Alexander, J.1
Wallin, H.2
Holme, J.A.3
Becher, G.4
-
3
-
-
0025934809
-
2-oxidized species of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat liver
-
2-oxidized species of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat liver. Carcinogenesis 1991, 12:2239-2245.
-
(1991)
Carcinogenesis
, vol.12
, pp. 2239-2245
-
-
Alexander, J.1
Wallin, H.2
Rossland, O.J.3
Solberg, K.E.4
Holme, J.A.5
Becher, G.6
Andersson, R.7
Grivas, S.8
-
4
-
-
0028150639
-
Metabolism of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in isolated liver cells from guinea pig, hamster, mouse, and rat
-
Alexander J., Fossum B.H., Holme J.A. Metabolism of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in isolated liver cells from guinea pig, hamster, mouse, and rat. Environ Health Perspect 1994, 102:109-114.
-
(1994)
Environ Health Perspect
, vol.102
, pp. 109-114
-
-
Alexander, J.1
Fossum, B.H.2
Holme, J.A.3
-
5
-
-
0025239384
-
Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary Dna-expressed human liver P450
-
Aoyama T., Gelboin H.V., Gonzalez F.J. Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline by complementary Dna-expressed human liver P450. Cancer Res 1990, 50:2060-2063.
-
(1990)
Cancer Res
, vol.50
, pp. 2060-2063
-
-
Aoyama, T.1
Gelboin, H.V.2
Gonzalez, F.J.3
-
6
-
-
0029936205
-
Glucuronide conjugates of 4-aminobiphenyl and its A-hydroxy metabolites: pH stability and synthesis by human and dog liver
-
Babu S.R., Lakshmi V.M., Huang G.P., Zenser T.V., Davis B.B. Glucuronide conjugates of 4-aminobiphenyl and its A-hydroxy metabolites: pH stability and synthesis by human and dog liver. Biochem Pharmacol 1996, 51:1679-1685.
-
(1996)
Biochem Pharmacol
, vol.51
, pp. 1679-1685
-
-
Babu, S.R.1
Lakshmi, V.M.2
Huang, G.P.3
Zenser, T.V.4
Davis, B.B.5
-
7
-
-
0023114183
-
Anaerobic metabolism of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) by human fecal flora
-
Bashirm Kingston D.G., Carman R.J., Van Tassell R.L., Wilkins T.D. Anaerobic metabolism of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline (IQ) by human fecal flora. Mutation Res 1987, 190:187-190.
-
(1987)
Mutation Res
, vol.190
, pp. 187-190
-
-
Bashirm, K.D.G.1
Carman, R.J.2
Van Tassell, R.L.3
Wilkins, T.D.4
-
8
-
-
0002364990
-
-
Sussex John Wiley & Sons, C. Ioannides (Ed.)
-
Bock K.W. Udp-glucuronosyltransferases 2002, 281-318. Sussex John Wiley & Sons. C. Ioannides (Ed.).
-
(2002)
Udp-glucuronosyltransferases
, pp. 281-318
-
-
Bock, K.W.1
-
9
-
-
26444618665
-
Arylamine A-acetyltransferases: what we learn from genes and genomes
-
Boukouvala S., Fakis G. Arylamine A-acetyltransferases: what we learn from genes and genomes. Drug Metab Rev 2005, 37:511-564.
-
(2005)
Drug Metab Rev
, vol.37
, pp. 511-564
-
-
Boukouvala, S.1
Fakis, G.2
-
10
-
-
0035339585
-
Synthesis and spectroscopic characterization of site-specific 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine oligodeoxyribo-nucleotide adducts
-
Brown K., Guenther E.A., Dingley K.H., Cosman M., Harvey C.A., Shields S.J., Turteltaub K.W. Synthesis and spectroscopic characterization of site-specific 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine oligodeoxyribo-nucleotide adducts. Aucl Acid Res 2001, 29:1951-1959.
-
(2001)
Aucl Acid Res
, vol.29
, pp. 1951-1959
-
-
Brown, K.1
Guenther, E.A.2
Dingley, K.H.3
Cosman, M.4
Harvey, C.A.5
Shields, S.J.6
Turteltaub, K.W.7
-
11
-
-
0024162363
-
Conversion of IQ, a dietary pyrolysis carcinogen to a direct-acting mutagen by normal intestinal bacteria of humans
-
Carman R.J., Van Tassell R.L., Kingston D.G., Bashir M., Wilkins T.D. Conversion of IQ, a dietary pyrolysis carcinogen to a direct-acting mutagen by normal intestinal bacteria of humans. Mutation Res 1988, 206:335-342.
-
(1988)
Mutation Res
, vol.206
, pp. 335-342
-
-
Carman, R.J.1
Van Tassell, R.L.2
Kingston, D.G.3
Bashir, M.4
Wilkins, T.D.5
-
12
-
-
25444456926
-
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for Cyp1A1 and Cyp1A2
-
Cheung C., Ma X., Krausz K.W., Kimura S., Feigenbaum L., Dalton T.P., Nebert D.W., Idle J.R., Gonzalez F.J. Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice humanized for Cyp1A1 and Cyp1A2. Chem Res Toxicol 2005, 18:1471-1478.
-
(2005)
Chem Res Toxicol
, vol.18
, pp. 1471-1478
-
-
Cheung, C.1
Ma, X.2
Krausz, K.W.3
Kimura, S.4
Feigenbaum, L.5
Dalton, T.P.6
Nebert, D.W.7
Idle, J.R.8
Gonzalez, F.J.9
-
13
-
-
0028952449
-
Metabolic activation of A-hydroxy arylamines and A-hydroxy heterocyclic amines by human sulfotransferase(s)
-
Chou H.-C., Lang N.P., Kadlubar F.F. Metabolic activation of A-hydroxy arylamines and A-hydroxy heterocyclic amines by human sulfotransferase(s). Cancer Res 1995, 55:525-529.
-
(1995)
Cancer Res
, vol.55
, pp. 525-529
-
-
Chou, H.-C.1
Lang, N.P.2
Kadlubar, F.F.3
-
14
-
-
0035479621
-
The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTAl on colorectal cancer risk
-
Coles B., Nowell S.A., Macleod S.L., Sweeney C., Lang N.P., Kadlubar F.F. The role of human glutathione S-transferases (hGSTs) in the detoxification of the food-derived carcinogen metabolite N-acetoxy-PhIP, and the effect of a polymorphism in hGSTAl on colorectal cancer risk. Mutation Res 2001, 482:3-10.
-
(2001)
Mutation Res
, vol.482
, pp. 3-10
-
-
Coles, B.1
Nowell, S.A.2
Macleod, S.L.3
Sweeney, C.4
Lang, N.P.5
Kadlubar, F.F.6
-
15
-
-
0031428285
-
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1
-
Crofts F.G., Strickland P.T., Hayes C.L., Sutter T.R. Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) by human cytochrome P4501B1. Carcinogenesis 1997, 18:1793-1798.
-
(1997)
Carcinogenesis
, vol.18
, pp. 1793-1798
-
-
Crofts, F.G.1
Strickland, P.T.2
Hayes, C.L.3
Sutter, T.R.4
-
16
-
-
0031721084
-
Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1
-
Crofts F.G., Sutter T.R., Strickland P.T. Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human cytochrome P4501A1, P4501A2 and P4501B1. Carcinogenesis 1998, 19:1969-1973.
-
(1998)
Carcinogenesis
, vol.19
, pp. 1969-1973
-
-
Crofts, F.G.1
Sutter, T.R.2
Strickland, P.T.3
-
17
-
-
0037867768
-
Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis
-
Dashwood R.H. Use of transgenic and mutant animal models in the study of heterocyclic amine-induced mutagenesis and carcinogenesis. JBiochem Mol Biol 2003, 36:35-42.
-
(2003)
JBiochem Mol Biol
, vol.36
, pp. 35-42
-
-
Dashwood, R.H.1
-
18
-
-
0027369714
-
Enzymatic phase-II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs ofmonkeys and rats
-
Davis C.D., SchutH A.J., Snyderwine E.G. Enzymatic phase-II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs ofmonkeys and rats. Carcinogenesis 1993, 14:2091-2096.
-
(1993)
Carcinogenesis
, vol.14
, pp. 2091-2096
-
-
Davis, C.D.1
SchutH, A.J.2
Snyderwine, E.G.3
-
19
-
-
0023872969
-
Synthesis and mutagenic activity of nitro-imidazoarenes: a study on the mechanism of the genotoxicity of heterocyclic arylamines and nitroarenes
-
Dirr A., Wild D. Synthesis and mutagenic activity of nitro-imidazoarenes: a study on the mechanism of the genotoxicity of heterocyclic arylamines and nitroarenes. Mutagenesis 1988, 3:147-152.
-
(1988)
Mutagenesis
, vol.3
, pp. 147-152
-
-
Dirr, A.1
Wild, D.2
-
20
-
-
0032968440
-
New O-acetyltransferase-deficient Ames Salmonella strains generated by specific gene disruption
-
Espinosa-Aguirre J.J., Yamada M., Matsui K., Watanabe M., Sofuni T., Nohmi T. New O-acetyltransferase-deficient Ames Salmonella strains generated by specific gene disruption. Mutation Res 1999, 439:159-169.
-
(1999)
Mutation Res
, vol.439
, pp. 159-169
-
-
Espinosa-Aguirre, J.J.1
Yamada, M.2
Matsui, K.3
Watanabe, M.4
Sofuni, T.5
Nohmi, T.6
-
21
-
-
0023017251
-
'The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)'
-
Felton J.S., Knize M.G., Shen N.H., Lewis P.R., Andresen B.D., Happe J., Hatch F.T. 'The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)'. Carcinogenesis 1986, 7:1081-1086.
-
(1986)
Carcinogenesis
, vol.7
, pp. 1081-1086
-
-
Felton, J.S.1
Knize, M.G.2
Shen, N.H.3
Lewis, P.R.4
Andresen, B.D.5
Happe, J.6
Hatch, F.T.7
-
22
-
-
0034044031
-
N-Acetyltransferase-dependent activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine: formation of2-amino-1-methyl-6-(5-hydroxy)phenylimidazo [4,5-b]pyridine, a possible biomarker for the reactive dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine
-
Frandsen H., Alexander J. N-Acetyltransferase-dependent activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine: formation of2-amino-1-methyl-6-(5-hydroxy)phenylimidazo [4,5-b]pyridine, a possible biomarker for the reactive dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Carcino-genesis 2000, 21:1197-1203.
-
(2000)
Carcino-genesis
, vol.21
, pp. 1197-1203
-
-
Frandsen, H.1
Alexander, J.2
-
23
-
-
0036218826
-
In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) in human and rat hepatic microsomes
-
Frederiksen H., Frandsen H. In vitro metabolism of two heterocyclic amines, 2-amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC) in human and rat hepatic microsomes. Pharmacol Toxicol 2002, 90:127-134.
-
(2002)
Pharmacol Toxicol
, vol.90
, pp. 127-134
-
-
Frederiksen, H.1
Frandsen, H.2
-
24
-
-
0037406247
-
Impact of five cytochrome P450 enzymes on the metabolism of two heterocyclic aromatic amines, 2-amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole(MeAαC)
-
Frederiksen H., Frandsen H. Impact of five cytochrome P450 enzymes on the metabolism of two heterocyclic aromatic amines, 2-amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole(MeAαC). Pharmacol Toxicol 2003, 92:246-248.
-
(2003)
Pharmacol Toxicol
, vol.92
, pp. 246-248
-
-
Frederiksen, H.1
Frandsen, H.2
-
25
-
-
1942534110
-
Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (AαC)
-
Frederiksen H., Frandsen H. Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (AαC). Food Chem Toxicol 2004, 42:879-885.
-
(2004)
Food Chem Toxicol
, vol.42
, pp. 879-885
-
-
Frederiksen, H.1
Frandsen, H.2
-
26
-
-
0023815101
-
Base-change analysis of revertants of the hisD3052 allele in Salmonella typhimurium
-
Fuscoe J.C., Wu R., Shen N.H., Healy S.K., Felton J.S. Base-change analysis of revertants of the hisD3052 allele in Salmonella typhimurium. Mutation Res 1988, 201:241-251.
-
(1988)
Mutation Res
, vol.201
, pp. 241-251
-
-
Fuscoe, J.C.1
Wu, R.2
Shen, N.H.3
Healy, S.K.4
Felton, J.S.5
-
27
-
-
0026828953
-
Regulation of two electro-phoretically distinct proteins recognized by antibody against rat liver cytochrome P4503A1
-
Gemzik B., Greenway D., Nevins C., Parkinson A,. Regulation of two electro-phoretically distinct proteins recognized by antibody against rat liver cytochrome P4503A1. JBiochem Toxicol 1992, 7:43-52.
-
(1992)
JBiochem Toxicol
, vol.7
, pp. 43-52
-
-
Gemzik, B.1
Greenway, D.2
Nevins, C.3
Parkinson, A.4
-
28
-
-
23044471764
-
UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver
-
Girard H., Thibaudeau J., Court M.H., Fortier L.C., Villeneuve L., Caron P., Hao Q., Von Moltke L.L., Greenblatt D.J., Guillemette C. UGT1A1 polymorphisms are important determinants of dietary carcinogen detoxification in the liver. Hepatology 2005, 42:448-457.
-
(2005)
Hepatology
, vol.42
, pp. 448-457
-
-
Girard, H.1
Thibaudeau, J.2
Court, M.H.3
Fortier, L.C.4
Villeneuve, L.5
Caron, P.6
Hao, Q.7
Von Moltke, L.L.8
Greenblatt, D.J.9
Guillemette, C.10
-
29
-
-
0034534841
-
Sulfotransferases in the bioactivation of xenobiotics
-
Glatt H.R. Sulfotransferases in the bioactivation of xenobiotics. Chem-Biol Interact 2000, 129:141-170.
-
(2000)
Chem-Biol Interact
, vol.129
, pp. 141-170
-
-
Glatt, H.R.1
-
33
-
-
30144438098
-
Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects
-
Glatt H.R., Meinl W. Sulfotransferases and acetyltransferases in mutagenicity testing: technical aspects. Meth enzymol 2005, 400:230-249.
-
(2005)
Meth enzymol
, vol.400
, pp. 230-249
-
-
Glatt, H.R.1
Meinl, W.2
-
34
-
-
2442575905
-
'Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAαC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes'
-
Glatt H.R., Pabel U., Meinl W., Frederiksen H., Frandsen H., Muckel E,. 'Bioactivation of the heterocyclic aromatic amine 2-amino-3-methyl-9H-pyrido [2,3-b]indole (MeAαC) in recombinant test systems expressing human xenobiotic-metabolizing enzymes'. Carcinogenesis 2004, 25:801-807.
-
(2004)
Carcinogenesis
, vol.25
, pp. 801-807
-
-
Glatt, H.R.1
Pabel, U.2
Meinl, W.3
Frederiksen, H.4
Frandsen, H.5
Muckel, E.6
-
35
-
-
10844236472
-
Lactoperoxidase-catalyzed activation of carcinogenic aromatic and heterocyclic amines
-
Gorlewska-Roberts K.M., Teitel C.H., Lay J.O., Roberts D.W., Kadlubar F.F,. Lactoperoxidase-catalyzed activation of carcinogenic aromatic and heterocyclic amines. Chem-Res Toxicol 2004, 17:1659-1666.
-
(2004)
Chem-Res Toxicol
, vol.17
, pp. 1659-1666
-
-
Gorlewska-Roberts, K.M.1
Teitel, C.H.2
Lay, J.O.3
Roberts, D.W.4
Kadlubar, F.F.5
-
36
-
-
0020434524
-
'Purification and characterization of liver microsomal cytochromes P450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or (β -naphthoflavone'
-
Guengerich F.P., Dannan G.A., Wright S.T., Martin M.V., Kaminsky L.S. 'Purification and characterization of liver microsomal cytochromes P450: electrophoretic, spectral, catalytic, and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or (β -naphthoflavone'. Biochemistry 1982, 21:6019-6030.
-
(1982)
Biochemistry
, vol.21
, pp. 6019-6030
-
-
Guengerich, F.P.1
Dannan, G.A.2
Wright, S.T.3
Martin, M.V.4
Kaminsky, L.S.5
-
37
-
-
0031417971
-
Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes
-
Hasmmons G.J., Milton D., Stepps K., Guengerich F.P., Tukey R.H., Kadlubar F.F. Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes. Carcinogenesis 1997, 8:851-854.
-
(1997)
Carcinogenesis
, vol.8
, pp. 851-854
-
-
Hasmmons, G.J.1
Milton, D.2
Stepps, K.3
Guengerich, F.P.4
Tukey, R.H.5
Kadlubar, F.F.6
-
38
-
-
0019164366
-
'Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole: identification of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and its reaction with Dna'
-
Hashimoto Y., Shudo K., Okamoto T. 'Activation of a mutagen, 3-amino-1-methyl-5H-pyrido[4,3-b]indole: identification of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole and its reaction with Dna'. Biochem Biophys Res Commun 1980, 96:355-362.
-
(1980)
Biochem Biophys Res Commun
, vol.96
, pp. 355-362
-
-
Hashimoto, Y.1
Shudo, K.2
Okamoto, T.3
-
39
-
-
0027935994
-
Genetic toxicity of 2-acetylaminofluorene, 2-amino fluorene and some of their metabolites and model metabolites
-
Heflich R.H., Neft R.E. Genetic toxicity of 2-acetylaminofluorene, 2-amino fluorene and some of their metabolites and model metabolites. Mutation Res 1994, 318:73-174.
-
(1994)
Mutation Res
, vol.318
, pp. 73-174
-
-
Heflich, R.H.1
Neft, R.E.2
-
40
-
-
0028040059
-
Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases
-
Hein D.W., Rustan T.D., Ferguson R.J., Doll M.A., Gray K. Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. Arch Toxicol 1994, 68:129133.
-
(1994)
Arch Toxicol
, vol.68
, pp. 129133
-
-
Hein, D.W.1
Rustan, T.D.2
Ferguson, R.J.3
Doll, M.A.4
Gray, K.5
-
41
-
-
84903657180
-
Bioaktivierung heterozyklischer aromatischer Amine in toxikologischen Modellsystemen - Beurteilung des kanzerogenen Potentials
-
Agrar- und Ernährungswissenschaftliche Fakultät der Christian-Albrechts-Universität Kiel, M. Huhn (Ed.)
-
Hollnagel H., Glatt H.R. Bioaktivierung heterozyklischer aromatischer Amine in toxikologischen Modellsystemen - Beurteilung des kanzerogenen Potentials. Potentiell kanzerogene Inhaltsstoffe in Lebensmitteln: Beiträge zum dritten Workshop der Arbeitsgruppe Lebensmittelqualität und - sicherheit 2003, 42-51. Agrar- und Ernährungswissenschaftliche Fakultät der Christian-Albrechts-Universität Kiel. M. Huhn (Ed.).
-
(2003)
Potentiell kanzerogene Inhaltsstoffe in Lebensmitteln: Beiträge zum dritten Workshop der Arbeitsgruppe Lebensmittelqualität und - sicherheit
, pp. 42-51
-
-
Hollnagel, H.1
Glatt, H.R.2
-
42
-
-
0343471515
-
Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa
-
Imaoka S., Yoneda Y., Matsuda T., Degawa M., Fukushima S., Funae Y. Mutagenic activation of urinary bladder carcinogens by CYP4B1 and the presence of CYP4B1 in bladder mucosa. Biochem Pharmacol 1997, 54:677-683.
-
(1997)
Biochem Pharmacol
, vol.54
, pp. 677-683
-
-
Imaoka, S.1
Yoneda, Y.2
Matsuda, T.3
Degawa, M.4
Fukushima, S.5
Funae, Y.6
-
43
-
-
0019868837
-
Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P450'
-
Ishii K., Yamazoe Y., Kamataki T., Kato R. Metabolic activation of glutamic acid pyrolysis products, 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2-amino-dipyrido[1,2-a:3',2'-d]imidazole, by purified cytochrome P450'. Chem-Biol Interact 1981, 38:1-13.
-
(1981)
Chem-Biol Interact
, vol.38
, pp. 1-13
-
-
Ishii, K.1
Yamazoe, Y.2
Kamataki, T.3
Kato, R.4
-
44
-
-
0025267863
-
Genotoxicity of heterocyclic amines in the hepatocyte/Dna repair assay using hepatocytes of rats or mice pretreated with 3-methylcholanthrene
-
Iwata H., Yoshimi N., Mori Y., Hara A., Mori H. Genotoxicity of heterocyclic amines in the hepatocyte/Dna repair assay using hepatocytes of rats or mice pretreated with 3-methylcholanthrene. Mutation Res 1990, 244:1-6.
-
(1990)
Mutation Res
, vol.244
, pp. 1-6
-
-
Iwata, H.1
Yoshimi, N.2
Mori, Y.3
Hara, A.4
Mori, H.5
-
45
-
-
0034892584
-
Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains
-
Josephy P.D., Batty S.M., Boverhof D.R. Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in Escherichia coli lacZ strains. Environ Mol Mutagen 2001, 38:12-18.
-
(2001)
Environ Mol Mutagen
, vol.38
, pp. 12-18
-
-
Josephy, P.D.1
Batty, S.M.2
Boverhof, D.R.3
-
46
-
-
0028108024
-
Metabolic activation pathway for the formation of Dna adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues
-
Kaderlik K.R., Minchin R.F., Mulder G.J., Ilett K.F., Daugaard-Jenson M., Teitel C.H., Kadlubar F.F. Metabolic activation pathway for the formation of Dna adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues. Carcinogenesis 1994, 15:1703-1709.
-
(1994)
Carcinogenesis
, vol.15
, pp. 1703-1709
-
-
Kaderlik, K.R.1
Minchin, R.F.2
Mulder, G.J.3
Ilett, K.F.4
Daugaard-Jenson, M.5
Teitel, C.H.6
Kadlubar, F.F.7
-
47
-
-
0028085519
-
Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) metabolism, PhIP-Dna adduct formation and unscheduled Dna synthesis in primary rat hepatocytes
-
Kaderlik K.R., Mulder G.J., Shaddock J.G., Casciano D.A., Teitel C.H., Kadlubar F.F. Effect of glutathione depletion and inhibition of glucuronidation and sulfation on 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine (PhIP) metabolism, PhIP-Dna adduct formation and unscheduled Dna synthesis in primary rat hepatocytes. Carcinogenesis 1994, 15:1711-1716.
-
(1994)
Carcinogenesis
, vol.15
, pp. 1711-1716
-
-
Kaderlik, K.R.1
Mulder, G.J.2
Shaddock, J.G.3
Casciano, D.A.4
Teitel, C.H.5
Kadlubar, F.F.6
-
48
-
-
0028092975
-
Glucuronidation of A-hydroxy heterocyclic amines by human and rat liver microsomes
-
Kaderlik K.R., Mulder G.J., Turesky R.J., Lang N.P., Teitel C.H., Chiarelli M.P., Kadlubar F.F. Glucuronidation of A-hydroxy heterocyclic amines by human and rat liver microsomes. Carcinogenesis 1994, 15:1695-1701.
-
(1994)
Carcinogenesis
, vol.15
, pp. 1695-1701
-
-
Kaderlik, K.R.1
Mulder, G.J.2
Turesky, R.J.3
Lang, N.P.4
Teitel, C.H.5
Chiarelli, M.P.6
Kadlubar, F.F.7
-
49
-
-
0024206540
-
In vitro and in vivo N-acetylation of carcinogenic glutamic acid pyrolysis products in humans
-
Kanai Y., Manabe S., Wada O. In vitro and in vivo N-acetylation of carcinogenic glutamic acid pyrolysis products in humans. Carcinogenesis 1988, 9:2179-2184.
-
(1988)
Carcinogenesis
, vol.9
, pp. 2179-2184
-
-
Kanai, Y.1
Manabe, S.2
Wada, O.3
-
50
-
-
0033376464
-
Comparison in metabolic activity of cytochrome P450 1A1 on heterocyclic amines between human and rat
-
Kanazawa K., Ashida H., Danno G. Comparison in metabolic activity of cytochrome P450 1A1 on heterocyclic amines between human and rat. JAgr Food Chem 1999, 47:4956-4961.
-
(1999)
JAgr Food Chem
, vol.47
, pp. 4956-4961
-
-
Kanazawa, K.1
Ashida, H.2
Danno, G.3
-
51
-
-
0034790149
-
Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)
-
Kassie F., Rabot S., Kundi M., Chabicovsky M., Qin H.M., Knasmuller S. Intestinal microflora plays a crucial role in the genotoxicity of the cooked food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Carcinogenesis 2001, 22:1721-1725.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1721-1725
-
-
Kassie, F.1
Rabot, S.2
Kundi, M.3
Chabicovsky, M.4
Qin, H.M.5
Knasmuller, S.6
-
52
-
-
0023254223
-
Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates
-
Kato R., Yamazoe Y. Metabolic activation and covalent binding to nucleic acids of carcinogenic heterocyclic amines from cooked foods and amino acid pyrolysates. Jpn J Cancer Res 1987, 78:297-311.
-
(1987)
Jpn J Cancer Res
, vol.78
, pp. 297-311
-
-
Kato, R.1
Yamazoe, Y.2
-
53
-
-
0020644886
-
N-Hydroxylation of carcinogenic and mutagenic aromatic amines
-
Kato R., Kamataki T., Yamazoe Y. N-Hydroxylation of carcinogenic and mutagenic aromatic amines. Environ Health Perspect 1983, 49:21-25.
-
(1983)
Environ Health Perspect
, vol.49
, pp. 21-25
-
-
Kato, R.1
Kamataki, T.2
Yamazoe, Y.3
-
54
-
-
0345700808
-
Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2
-
Kimura S., Kawabe M., Yu A.M., Morishima H., Fernandez-Salguero P., Hammons G.J., Ward J.M., Kadlubar F.F., Gonzalez F.J. Carcinogenesis of the food mutagen PhIP in mice is independent of CYP1A2. Carcinogenesis 2003, 24:583-587.
-
(2003)
Carcinogenesis
, vol.24
, pp. 583-587
-
-
Kimura, S.1
Kawabe, M.2
Yu, A.M.3
Morishima, H.4
Fernandez-Salguero, P.5
Hammons, G.J.6
Ward, J.M.7
Kadlubar, F.F.8
Gonzalez, F.J.9
-
55
-
-
0032783505
-
Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the A-hydroxy derivative
-
King R.S., Teitel C.H., Shaddock J.G., Casciano D.A., Kadlubar F.F. Detoxification of carcinogenic aromatic and heterocyclic amines by enzymatic reduction of the A-hydroxy derivative. Cancer Lett 1999, 143:167-171.
-
(1999)
Cancer Lett
, vol.143
, pp. 167-171
-
-
King, R.S.1
Teitel, C.H.2
Shaddock, J.G.3
Casciano, D.A.4
Kadlubar, F.F.5
-
56
-
-
0033920961
-
In vitro bioactivation of A-hydroxy-2-amino-a-carboline
-
King R.S., Teitel C.H., Kadlubar F.F. In vitro bioactivation of A-hydroxy-2-amino-a-carboline. Carcinogenesis 2000, 21:1347-1354.
-
(2000)
Carcinogenesis
, vol.21
, pp. 1347-1354
-
-
King, R.S.1
Teitel, C.H.2
Kadlubar, F.F.3
-
57
-
-
0017845046
-
Isolation and structure studies of mutagenic principles in amino acid pyrolysates
-
Kosuge T., Tsuji K., Wakabayashi K., Okamoto T., Shudo K., Iitaka Y., Itai A., Sugimura T., Kawachit Nagao M., Yahagit T., Seino Y. Isolation and structure studies of mutagenic principles in amino acid pyrolysates. Chem Pharm Bull (Tokyo) 1978, 26:611-619.
-
(1978)
Chem Pharm Bull (Tokyo)
, vol.26
, pp. 611-619
-
-
Kosuge, T.1
Tsuji, K.2
Wakabayashi, K.3
Okamoto, T.4
Shudo, K.5
Iitaka, Y.6
Itai, A.7
Sugimura, T.8
Kawachit, N.M.9
Yahagit, T.10
Seino, Y.11
-
58
-
-
0033747658
-
Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine following consumption of a single cooked chicken meal in humans
-
Kulp K.S., Knize M.G., Malfattim A., Salmon C.P., Felton J.S. Identification of urine metabolites of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine following consumption of a single cooked chicken meal in humans. Carcinogenesis 2000, 21:2065-2072.
-
(2000)
Carcinogenesis
, vol.21
, pp. 2065-2072
-
-
Kulp, K.S.1
Knize, M.G.2
Malfattim, A.3
Salmon, C.P.4
Felton, J.S.5
-
59
-
-
0030355238
-
Benzylic sulphuric acid esters react with diverse functional groups and often form secondary reactive species
-
Landsiedel R., Engst W., Scholtyssek M., Seidel A., Glatt H.R. Benzylic sulphuric acid esters react with diverse functional groups and often form secondary reactive species. Polycyclic Aromat Compds 1996, 11:341-348.
-
(1996)
Polycyclic Aromat Compds
, vol.11
, pp. 341-348
-
-
Landsiedel, R.1
Engst, W.2
Scholtyssek, M.3
Seidel, A.4
Glatt, H.R.5
-
60
-
-
0032775522
-
14c]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
-
14c]2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Cancer Lett 1999, 143:135-138.
-
(1999)
Cancer Lett
, vol.143
, pp. 135-138
-
-
Lang, N.P.1
Nowell, S.2
Malfatti, M.A.3
Kulp, K.S.4
Knize, M.G.5
Davis, C.6
Massengill, J.7
Williams, S.8
Mac Leod, S.9
Dingley, K.H.10
Felton, J.S.11
Turteltaub, K.W.12
-
61
-
-
0035102180
-
'Metabolism of 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxication pathway catalyzed by cytochrome P450 1A2'
-
Langouet S., Welti D.H., Kerriguy N., Fay L.B., Huynh-Ba T., Markovic J., Guengerich F.P., Guillouzo A., Turesky R.J. 'Metabolism of 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline in human hepatocytes: 2-amino-3-methylimidazo[4,5-f]quinoxaline-8-carboxylic acid is a major detoxication pathway catalyzed by cytochrome P450 1A2'. Chem Res Toxicol 2001, 14:211-221.
-
(2001)
Chem Res Toxicol
, vol.14
, pp. 211-221
-
-
Langouet, S.1
Welti, D.H.2
Kerriguy, N.3
Fay, L.B.4
Huynh-Ba, T.5
Markovic, J.6
Guengerich, F.P.7
Guillouzo, A.8
Turesky, R.J.9
-
62
-
-
0036197494
-
Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes
-
Langouet S., Paehler A., Welti D.H., Kerriguy N., Guillouzo A., Turesky R.J. Differential metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rat and human hepatocytes. Carcinogenesis 2002, 23:115-122.
-
(2002)
Carcinogenesis
, vol.23
, pp. 115-122
-
-
Langouet, S.1
Paehler, A.2
Welti, D.H.3
Kerriguy, N.4
Guillouzo, A.5
Turesky, R.J.6
-
63
-
-
0032967592
-
Prostate-specific human N-acetyltransferase 2 (Nat2) expression in the mouse
-
Leff M.A., Epstein P.N., Doll M.A., Fretland A.J., Devanaboyina U.S., Rustan T.D., Hein D.W. Prostate-specific human N-acetyltransferase 2 (Nat2) expression in the mouse. J Pharmacol Exp Ther 1999, 290:182-187.
-
(1999)
J Pharmacol Exp Ther
, vol.290
, pp. 182-187
-
-
Leff, M.A.1
Epstein, P.N.2
Doll, M.A.3
Fretland, A.J.4
Devanaboyina, U.S.5
Rustan, T.D.6
Hein, D.W.7
-
64
-
-
0031753391
-
Bioactivation of the cooked food mutagen A-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells
-
Lewis A.J., Walle U.K., King R.S., Kadlubar F.F., Falany C.N., Walle T. Bioactivation of the cooked food mutagen A-hydroxy-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by estrogen sulfotransferase in cultured human mammary epithelial cells. Carcinogenesis 1998, 19:2049-2053.
-
(1998)
Carcinogenesis
, vol.19
, pp. 2049-2053
-
-
Lewis, A.J.1
Walle, U.K.2
King, R.S.3
Kadlubar, F.F.4
Falany, C.N.5
Walle, T.6
-
65
-
-
0028095423
-
Effects of human and rat glutathione S-transferases on the covalent Dna binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro:apossible mechanism of organ specificity in their carcinogenesis
-
Lin D.X., Meyer D.J., Ketterer B., Lang N.P., Kadlubar F.F. Effects of human and rat glutathione S-transferases on the covalent Dna binding of the N-acetoxy derivatives of heterocyclic amine carcinogens in vitro:apossible mechanism of organ specificity in their carcinogenesis. Cancer Res 1994, 54:4920-4926.
-
(1994)
Cancer Res
, vol.54
, pp. 4920-4926
-
-
Lin, D.X.1
Meyer, D.J.2
Ketterer, B.3
Lang, N.P.4
Kadlubar, F.F.5
-
66
-
-
0028904047
-
Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from humans, rats, and mice
-
Lin D.X., Lang N.P., Kadlubarf F. Species differences in the biotransformation of the food-borne carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by hepatic microsomes and cytosols from humans, rats, and mice. Drug Metab Dispos 1995, 23:518-524.
-
(1995)
Drug Metab Dispos
, vol.23
, pp. 518-524
-
-
Lin, D.X.1
Lang, N.P.2
Kadlubarf, F.3
-
67
-
-
0034942927
-
A-Glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine (PhIP) and N-hydroxy-PhIP by specific human Udp-glucuronosyltransferases
-
Malfatti M.A., Felton J.S. A-Glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine (PhIP) and N-hydroxy-PhIP by specific human Udp-glucuronosyltransferases. Carcinogenesis 2001, 22:1087-1093.
-
(2001)
Carcinogenesis
, vol.22
, pp. 1087-1093
-
-
Malfatti, M.A.1
Felton, J.S.2
-
68
-
-
4243182634
-
Human Udp-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro
-
Malfatti M.A., Felton J.S. Human Udp-glucuronosyltransferase 1A1 is the primary enzyme responsible for the N-glucuronidation of N-hydroxy-PhIP in vitro. Chem Res Toxicol 2004, 17:1137-1144.
-
(2004)
Chem Res Toxicol
, vol.17
, pp. 1137-1144
-
-
Malfatti, M.A.1
Felton, J.S.2
-
69
-
-
0032586869
-
14c]2 -amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans
-
14c]2 -amino-1-methyl-6-phenylimidazo[4,5-b]pyridine metabolites in humans. Carcinogenesis 1999, 20:705-713.
-
(1999)
Carcinogenesis
, vol.20
, pp. 705-713
-
-
Malfatti, M.A.1
Kulp, K.S.2
Knize, M.G.3
Davis, C.4
Massengill, J.P.5
Williams, S.6
Nowell, S.7
Macleod, S.8
Dingley, K.H.9
Turteltaub, K.W.10
Lang, N.P.11
Felton, J.S.12
-
70
-
-
13544252575
-
The effect of Udp-glucuronosyltransferase 1a1 expression on the mutagenicity and metabolism of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Cho cells
-
Malfatti M.A., Wu R.W., Felton J.S. The effect of Udp-glucuronosyltransferase 1a1 expression on the mutagenicity and metabolism of the cooked-food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Cho cells. Mutation Res 2005, 570:205-214.
-
(2005)
Mutation Res
, vol.570
, pp. 205-214
-
-
Malfatti, M.A.1
Wu, R.W.2
Felton, J.S.3
-
71
-
-
0020533372
-
Revised methods for the Salmonella mutagenicity test',Mutation
-
Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test',Mutation. Res 1983, 113:73-215.
-
(1983)
Res
, vol.113
, pp. 73-215
-
-
Maron, D.M.1
Ames, B.N.2
-
73
-
-
0025296345
-
Metabolism of 2-acetylaminofluorene and benzo[a]pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P450
-
Mcmanus M.E., Burgess W.M., Veronese M.E., Huggett A., Quattrochil C., Tukey R.H. Metabolism of 2-acetylaminofluorene and benzo[a]pyrene and activation of food-derived heterocyclic amine mutagens by human cytochromes P450. Cancer Res 1990, 50:3367-3376.
-
(1990)
Cancer Res
, vol.50
, pp. 3367-3376
-
-
Mcmanus, M.E.1
Burgess, W.M.2
Veronese, M.E.3
Huggett, A.4
Quattrochil, C.5
Tukey, R.H.6
-
74
-
-
0018821137
-
Measurement of drug-metabolizing systems in Salmonella typhimurium strains G46, TA15135, TA100, TA1538 and TA98
-
Meijer J., Depierre J.W., Rannug U. Measurement of drug-metabolizing systems in Salmonella typhimurium strains G46, TA15135, TA100, TA1538 and TA98. Chem-Biol Interact 1980, 31:247-254.
-
(1980)
Chem-Biol Interact
, vol.31
, pp. 247-254
-
-
Meijer, J.1
Depierre, J.W.2
Rannug, U.3
-
75
-
-
12244310133
-
Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium
-
Meinl W., Meerman J.H., Glatt H.R. Differential activation of promutagens by alloenzymes of human sulfotransferase 1A2 expressed in Salmonella typhimurium. Pharmacogenetics 2002, 12:677-689.
-
(2002)
Pharmacogenetics
, vol.12
, pp. 677-689
-
-
Meinl, W.1
Meerman, J.H.2
Glatt, H.R.3
-
76
-
-
31844448260
-
Human sulfotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue
-
Meinl W., Pabel U., Osterloh-Quiroz M., Hengstler J.G., Glatt H.R. Human sulfotransferases are involved in the activation of aristolochic acids and are expressed in renal target tissue. Int J Cancer 2006, 118:1090-1097.
-
(2006)
Int J Cancer
, vol.118
, pp. 1090-1097
-
-
Meinl, W.1
Pabel, U.2
Osterloh-Quiroz, M.3
Hengstler, J.G.4
Glatt, H.R.5
-
77
-
-
0026650976
-
N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in Cos-1 cells
-
Minchin R.F., Reeves P.T., Teitel C.H., Mcmanus M.E., Mojarrabi B., Ilett K.F., Kadlubar F.F. N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in Cos-1 cells. Biochem Biophys Res Commun 1992, 185:839-844.
-
(1992)
Biochem Biophys Res Commun
, vol.185
, pp. 839-844
-
-
Minchin, R.F.1
Reeves, P.T.2
Teitel, C.H.3
Mcmanus, M.E.4
Mojarrabi, B.5
Ilett, K.F.6
Kadlubar, F.F.7
-
78
-
-
0036282074
-
Heterologous expression of human A-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines
-
Muckel E., Frandsen H., Glatt H.R. Heterologous expression of human A-acetyltransferases 1 and 2 and sulfotransferase 1A1 in Salmonella typhimurium for mutagenicity testing of heterocyclic amines. Food Chem Toxicol 2002, 40:1063-1068.
-
(2002)
Food Chem Toxicol
, vol.40
, pp. 1063-1068
-
-
Muckel, E.1
Frandsen, H.2
Glatt, H.R.3
-
79
-
-
0017412773
-
Role of sulfo-transferase from rat liver in the mutagenicity of N-hydroxy-2-acetylaminofluorene in Salmonella typhimurium
-
Mulder G.J., Hinson J.A., Nelson W.L., Thorgeirsson S.N. Role of sulfo-transferase from rat liver in the mutagenicity of N-hydroxy-2-acetylaminofluorene in Salmonella typhimurium. Biochem Pharmacol 1977, 26:1356-1358.
-
(1977)
Biochem Pharmacol
, vol.26
, pp. 1356-1358
-
-
Mulder, G.J.1
Hinson, J.A.2
Nelson, W.L.3
Thorgeirsson, S.N.4
-
80
-
-
0017335374
-
Mutagenicities of smoke condensates and the charred surface of fish and meat
-
Nagao M., Honda M., Seino Y., Yahagit T., Sugimura T. Mutagenicities of smoke condensates and the charred surface of fish and meat. Cancer Lett 1977, 2:221-226.
-
(1977)
Cancer Lett
, vol.2
, pp. 221-226
-
-
Nagao, M.1
Honda, M.2
Seino, Y.3
Yahagit, T.4
Sugimura, T.5
-
81
-
-
0019277863
-
Mutagenicities of Υ-carboline derivatives related to potent mutagens found in tryptophan pyrolysates
-
Nagao M., Takahashi Y., Yahagi T., Sugimura T., Takeda K., Shudo K., Okamoto T. Mutagenicities of Υ-carboline derivatives related to potent mutagens found in tryptophan pyrolysates. Carcinogenesis 1980, 1:451-454.
-
(1980)
Carcinogenesis
, vol.1
, pp. 451-454
-
-
Nagao, M.1
Takahashi, Y.2
Yahagi, T.3
Sugimura, T.4
Takeda, K.5
Shudo, K.6
Okamoto, T.7
-
82
-
-
0022998267
-
N-Acetyl derivative as the major active metabolite of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole in rat bile'
-
Negishic Umemoto A., Rafter J.J., Sato S., Sugimura T. N-Acetyl derivative as the major active metabolite of 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole in rat bile'. Mutation Res 1986, 175:23-28.
-
(1986)
Mutation Res
, vol.175
, pp. 23-28
-
-
Negishic, U.A.1
Rafter, J.J.2
Sato, S.3
Sugimura, T.4
-
83
-
-
0019991326
-
''Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes'
-
Niwa T., Yamazoe Y., Kato R. ''Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes'. Mutation Res 1982, 95:159-170.
-
(1982)
Mutation Res
, vol.95
, pp. 159-170
-
-
Niwa, T.1
Yamazoe, Y.2
Kato, R.3
-
84
-
-
0033059604
-
Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal Udp-glucuronosyltransferases: identification of specific Ugt1a family isoforms involved
-
Nowell S.A., Massengill J.S., Williams S., Radominska-Pandya A., Tephly T.R., Cheng Z.Q., Strassburg C.P., Tukey R.H., Macleod S.L., Lang N.P., Kadlubar F.F. Glucuronidation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by human microsomal Udp-glucuronosyltransferases: identification of specific Ugt1a family isoforms involved. Carcinogenesis 1999, 20:1107-1114.
-
(1999)
Carcinogenesis
, vol.20
, pp. 1107-1114
-
-
Nowell, S.A.1
Massengill, J.S.2
Williams, S.3
Radominska-Pandya, A.4
Tephly, T.R.5
Cheng, Z.Q.6
Strassburg, C.P.7
Tukey, R.H.8
Macleod, S.L.9
Lang, N.P.10
Kadlubar, F.F.11
-
85
-
-
0033027263
-
Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium Nm6001 andNM6002
-
Oda Y., Yamazakih H., Shimada T. Role of human N-acetyltransferases, NAT1 or NAT2, in genotoxicity of nitroarenes and aromatic amines in Salmonella typhimurium Nm6001 andNM6002. Carcinogenesis 1999, 20:1079-1083.
-
(1999)
Carcinogenesis
, vol.20
, pp. 1079-1083
-
-
Oda, Y.1
Yamazakih, H.2
Shimada, T.3
-
86
-
-
0035978747
-
'Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human Nadph-P450 reductase and bacterial O-acetyltransferase'
-
Oda Y., Aryal P., Terashita T., Gillam E.M.J., Guengerich F.P., Shimada T. 'Metabolic activation of heterocyclic amines and other procarcinogens in Salmonella typhimurium umu tester strains expressing human cytochrome P4501A1, 1A2, 1B1, 2C9, 2D6, 2E1, and 3A4 and human Nadph-P450 reductase and bacterial O-acetyltransferase'. Mutation Res 2001, 492:81-90.
-
(2001)
Mutation Res
, vol.492
, pp. 81-90
-
-
Oda, Y.1
Aryal, P.2
Terashita, T.3
Gillam, E.M.J.4
Guengerich, F.P.5
Shimada, T.6
-
87
-
-
0028607360
-
Activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by cDNA-expressed human and rat arylsulfotransferases
-
Ozawa S., Chou H.-C., Kadlubar F.F., Nagata K., Yamazoe Y., Kato R. Activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine by cDNA-expressed human and rat arylsulfotransferases. Jpn J Cancer Res 1994, 85:1220-1228.
-
(1994)
Jpn J Cancer Res
, vol.85
, pp. 1220-1228
-
-
Ozawa, S.1
Chou, H.-C.2
Kadlubar, F.F.3
Nagata, K.4
Yamazoe, Y.5
Kato, R.6
-
88
-
-
0031561408
-
Phenol sulfotransferase pharmacogenetics in humans: association of common Sult1a1 alleles with Ts Pst phenotype
-
Raftogianis R.B., Wood T.C., Otterness D.M., Van Loon J.A., Weinshilboum R.M. Phenol sulfotransferase pharmacogenetics in humans: association of common Sult1a1 alleles with Ts Pst phenotype. Biochem Biophys Res Commun 1997, 239.
-
(1997)
Biochem Biophys Res Commun
, vol.239
-
-
Raftogianis, R.B.1
Wood, T.C.2
Otterness, D.M.3
Van Loon, J.A.4
Weinshilboum, R.M.5
-
89
-
-
0029935767
-
Metabolism of 2-amino-α-carboline: a food-borne hetero-cyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2
-
Raza H., King R.S., Squires R.B., Guengerich F.P., Miller D.W., Freeman J.P., Lang N.P., Kadlubar F.F. Metabolism of 2-amino-α-carboline: a food-borne hetero-cyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2. Drug Metab Dispos 1996, 24:395-400.
-
(1996)
Drug Metab Dispos
, vol.24
, pp. 395-400
-
-
Raza, H.1
King, R.S.2
Squires, R.B.3
Guengerich, F.P.4
Miller, D.W.5
Freeman, J.P.6
Lang, N.P.7
Kadlubar, F.F.8
-
90
-
-
0020579803
-
Mutagenicity and genotoxicity of nitro-arenes: all nitro-containing chemicals were not created equal
-
Rosenkranz H.S., Mermelstein R. Mutagenicity and genotoxicity of nitro-arenes: all nitro-containing chemicals were not created equal. Mutation Res 1983, 114:217-267.
-
(1983)
Mutation Res
, vol.114
, pp. 217-267
-
-
Rosenkranz, H.S.1
Mermelstein, R.2
-
91
-
-
0021681695
-
'Glutathione conjugation of arylnitroso compound: detection and monitoring labile intermediates in situ inside a fast atom bombardment mass spectrometer'
-
Saito K., Kator R. 'Glutathione conjugation of arylnitroso compound: detection and monitoring labile intermediates in situ inside a fast atom bombardment mass spectrometer'. Biochem Biophys Res Commun 1984, 124:1-5.
-
(1984)
Biochem Biophys Res Commun
, vol.124
, pp. 1-5
-
-
Saito, K.1
Kator, R.2
-
92
-
-
0021088292
-
Activation and detoxication of A-hydroxy-Trp-P-2 by glutathione and glutathione transferases
-
Saito K., Yamazoe Y., Kamatakit K., Kato R. Activation and detoxication of A-hydroxy-Trp-P-2 by glutathione and glutathione transferases. Carcinogenesis 1983, 4:1551-1557.
-
(1983)
Carcinogenesis
, vol.4
, pp. 1551-1557
-
-
Saito, K.1
Yamazoe, Y.2
Kamatakit, K.3
Kato, R.4
-
93
-
-
0021068767
-
'Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA98 and TA98NR'
-
Saito K., Yamazoe Y., Kamataki T., Kato R. 'Syntheses of hydroxyamino, nitroso and nitro derivatives of Trp-P-2 and Glu-P-1, amino acid pyrolysate mutagens, and their direct mutagenicities towards Salmonella typhimurium TA98 and TA98NR'. Carcinogenesis 1983, 4:1547-1550.
-
(1983)
Carcinogenesis
, vol.4
, pp. 1547-1550
-
-
Saito, K.1
Yamazoe, Y.2
Kamataki, T.3
Kato, R.4
-
94
-
-
0021164049
-
Glutathione transferase-mediated and non-enzymatic activation and detoxication of the A-hydroxy derivative of Trp-P-2, a potent pyrolysate promutagen
-
Saito K., Yamazoe Y., Kamataki T., Kato R. Glutathione transferase-mediated and non-enzymatic activation and detoxication of the A-hydroxy derivative of Trp-P-2, a potent pyrolysate promutagen. Xenobiotica 1984, 14:545-548.
-
(1984)
Xenobiotica
, vol.14
, pp. 545-548
-
-
Saito, K.1
Yamazoe, Y.2
Kamataki, T.3
Kato, R.4
-
95
-
-
0021871782
-
Metabolic activation of mutagenic N-hydroxyarylamines by O-acetyltransferase in Salmonella typhimurium Ta98
-
Saito K., Shinohara A., Kamataki T., Kato R. Metabolic activation of mutagenic N-hydroxyarylamines by O-acetyltransferase in Salmonella typhimurium Ta98. Arch Biochem Biophys 1985, 239:286-295.
-
(1985)
Arch Biochem Biophys
, vol.239
, pp. 286-295
-
-
Saito, K.1
Shinohara, A.2
Kamataki, T.3
Kato, R.4
-
96
-
-
0022620360
-
A new assay for A-hydroxy-arylamine O-acetyltransferase: reduction of N-hydroxyarylamines through N-acetoxyarylamines
-
Saito K., Shinohara A., Kamataki T., Kato R. A new assay for A-hydroxy-arylamine O-acetyltransferase: reduction of N-hydroxyarylamines through N-acetoxyarylamines. Anal Biochem 1986, 152:226-231.
-
(1986)
Anal Biochem
, vol.152
, pp. 226-231
-
-
Saito, K.1
Shinohara, A.2
Kamataki, T.3
Kato, R.4
-
97
-
-
0028179768
-
High promutagen activating capacity of yeast microsomes containing human cytochrome P450 1A and human Nadph-cytochrome P450 reductase
-
Sengstag C., Eugsterh P., Wurgler F.E. High promutagen activating capacity of yeast microsomes containing human cytochrome P450 1A and human Nadph-cytochrome P450 reductase. Carcinogenesis 1994, 15:837-843.
-
(1994)
Carcinogenesis
, vol.15
, pp. 837-843
-
-
Sengstag, C.1
Eugsterh, P.2
Wurgler, F.E.3
-
99
-
-
0030008731
-
Activation of chemically diverse procarcinogens by human cytochrome P450 1B1
-
Shimada T., Hayes C.L., Yamazaki H., Amin S., Hecht S.S., Guengerich F.P., Sutter T.R. Activation of chemically diverse procarcinogens by human cytochrome P450 1B1. Cancer Res 1996, 56:2979-2984.
-
(1996)
Cancer Res
, vol.56
, pp. 2979-2984
-
-
Shimada, T.1
Hayes, C.L.2
Yamazaki, H.3
Amin, S.4
Hecht, S.S.5
Guengerich, F.P.6
Sutter, T.R.7
-
100
-
-
0021167699
-
Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates
-
Shinohara A., Yamazoe Y., Saito K., Kamataki T., Kato R. Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates. Carcinogenesis 1984, 5:683-686.
-
(1984)
Carcinogenesis
, vol.5
, pp. 683-686
-
-
Shinohara, A.1
Yamazoe, Y.2
Saito, K.3
Kamataki, T.4
Kato, R.5
-
101
-
-
0022484387
-
Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity
-
Shinohara A., Saito K., Yamazoe Y., Kamataki T., Kato R. Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity. Cancer Res 1986, 46:4362-4367.
-
(1986)
Cancer Res
, vol.46
, pp. 4362-4367
-
-
Shinohara, A.1
Saito, K.2
Yamazoe, Y.3
Kamataki, T.4
Kato, R.5
-
102
-
-
0022967785
-
Interaction of the synthetic ultimate carcinogens, N-sulfonoxy- and N-acetoxy-2-acetylaminofluorene, and of enzymatically activated N-hydroxy-2-acetylaminofluorene with nucleophiles
-
Smith B.A., Springfield J.R., Gutmann H.R. Interaction of the synthetic ultimate carcinogens, N-sulfonoxy- and N-acetoxy-2-acetylaminofluorene, and of enzymatically activated N-hydroxy-2-acetylaminofluorene with nucleophiles. Carcinogenesis 1986, 7:405-411.
-
(1986)
Carcinogenesis
, vol.7
, pp. 405-411
-
-
Smith, B.A.1
Springfield, J.R.2
Gutmann, H.R.3
-
103
-
-
0036775873
-
Effect of Cyp1a2 deficiency on heterocyclic amine Dna adduct levels in mice
-
Snyderwine E.G., Yu M.C., Schut H.A., Knigth-Jones J., Kimura S. Effect of Cyp1a2 deficiency on heterocyclic amine Dna adduct levels in mice. Food Chem Toxico 2002, 40:1529-1533.
-
(2002)
Food Chem Toxico
, vol.40
, pp. 1529-1533
-
-
Snyderwine, E.G.1
Yu, M.C.2
Schut, H.A.3
Knigth-Jones, J.4
Kimura, S.5
-
104
-
-
0032797354
-
Biomonitoring of heterocyclic aromatic amine metabolites in human urine
-
Stillwell W.G., Turesky R.J., Sinha R., Skipper P.L., Tannenbaum S.R. Biomonitoring of heterocyclic aromatic amine metabolites in human urine. Cancer Lett 1999, 143:145-148.
-
(1999)
Cancer Lett
, vol.143
, pp. 145-148
-
-
Stillwell, W.G.1
Turesky, R.J.2
Sinha, R.3
Skipper, P.L.4
Tannenbaum, S.R.5
-
105
-
-
0032502764
-
Expression of the Udp-glucuronosyltransferase 1a locus in human colon: identification and characterization of the novel extrahepatic UGT1A8
-
Strassburg C.P., Manns M.P., Tukey R.H. Expression of the Udp-glucuronosyltransferase 1a locus in human colon: identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem 1998, 273:719-8726.
-
(1998)
J Biol Chem
, vol.273
, pp. 719-8726
-
-
Strassburg, C.P.1
Manns, M.P.2
Tukey, R.H.3
-
106
-
-
0027380316
-
The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-f] pyridine (PhIP) by human and rabbit liver microsomes
-
Styczynski P.B., Blackmon R.C., Groopman J.D., Kensler T.W. The direct glucuronidation of 2-amino-1-methyl-6-phenylimidazo[4,5-f] pyridine (PhIP) by human and rabbit liver microsomes. Chem Res Toxicol 1993, 846-851.
-
(1993)
Chem Res Toxicol
, pp. 846-851
-
-
Styczynski, P.B.1
Blackmon, R.C.2
Groopman, J.D.3
Kensler, T.W.4
-
107
-
-
0037561531
-
Generation and functional characterization of arylamine N-acetyl-transferase Nat1/Nat2 double-knockout mice
-
Sugamori K.S., Wong S., Gaedigk A., Yu V., Abramovici H., Rozmahel R., Grant D.M. Generation and functional characterization of arylamine N-acetyl-transferase Nat1/Nat2 double-knockout mice. Mol Pharmacol 2003, 64:170-179.
-
(2003)
Mol Pharmacol
, vol.64
, pp. 170-179
-
-
Sugamori, K.S.1
Wong, S.2
Gaedigk, A.3
Yu, V.4
Abramovici, H.5
Rozmahel, R.6
Grant, D.M.7
-
108
-
-
0003025745
-
Mutagenic principle(s) in tryptophan and phenylalanine pyrolysis products
-
Sugimura T., Kawachi T., Nagao M., Yahagi T., Seino Y., Okamoto T., Shudo K., Kosuge T., Tsuji K., Wakabayashi K., Iitaka Y., Itai A. Mutagenic principle(s) in tryptophan and phenylalanine pyrolysis products. Proc Jap Acad 1977, 53:58-61.
-
(1977)
Proc Jap Acad
, vol.53
, pp. 58-61
-
-
Sugimura, T.1
Kawachi, T.2
Nagao, M.3
Yahagi, T.4
Seino, Y.5
Okamoto, T.6
Shudo, K.7
Kosuge, T.8
Tsuji, K.9
Wakabayashi, K.10
Iitaka, Y.11
Itai, A.12
-
109
-
-
1942504286
-
Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish
-
Sugimura T., Wakabayashi K., Nakagama H., Nagao M. Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci 2004, 95:290-299.
-
(2004)
Cancer Sci
, vol.95
, pp. 290-299
-
-
Sugimura, T.1
Wakabayashi, K.2
Nakagama, H.3
Nagao, M.4
-
110
-
-
0024829569
-
DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine in rats
-
Takayama K., Yamashita K., Wakabayashi K., Sugimura T., Nagao M. DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine in rats. Jpn J Cancer Res 1989, 80:1145-1148.
-
(1989)
Jpn J Cancer Res
, vol.80
, pp. 1145-1148
-
-
Takayama, K.1
Yamashita, K.2
Wakabayashi, K.3
Sugimura, T.4
Nagao, M.5
-
111
-
-
15044345102
-
Interspecies metabolism of heterocyclic aromatic amines and the uncertainties in extrapolation of animal toxicity data for human risk assessment
-
Turesky R.J. Interspecies metabolism of heterocyclic aromatic amines and the uncertainties in extrapolation of animal toxicity data for human risk assessment. Mol Autr Food Res 2005, 49:101-117.
-
(2005)
Mol Autr Food Res
, vol.49
, pp. 101-117
-
-
Turesky, R.J.1
-
112
-
-
0022778481
-
Sulfamate formation is a major route for detoxification of 2-amino-3-methylimidazo[4,5- f]quinoline in the rat
-
Turesky R.J., Skipper P.L., Tannenbaum S.R., Coles B., Ketterer B. Sulfamate formation is a major route for detoxification of 2-amino-3-methylimidazo[4,5- f]quinoline in the rat. Carcinogenesis 1986, 7:1483-1485.
-
(1986)
Carcinogenesis
, vol.7
, pp. 1483-1485
-
-
Turesky, R.J.1
Skipper, P.L.2
Tannenbaum, S.R.3
Coles, B.4
Ketterer, B.5
-
113
-
-
0026040316
-
Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon
-
Turesky R.J., Lang N.P., Butler M.A., Teitel C.H., Kadlubar F.F. Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis 1991, 12:1839-1845.
-
(1991)
Carcinogenesis
, vol.12
, pp. 1839-1845
-
-
Turesky, R.J.1
Lang, N.P.2
Butler, M.A.3
Teitel, C.H.4
Kadlubar, F.F.5
-
114
-
-
0031815379
-
Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2
-
Turesky R.J., Constable A., Richoz J., Varga N., Markovic J., Martin M.V., Guengerich F.P. Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. Chem Res Toxicol 1998, 11:925-936.
-
(1998)
Chem Res Toxicol
, vol.11
, pp. 925-936
-
-
Turesky, R.J.1
Constable, A.2
Richoz, J.3
Varga, N.4
Markovic, J.5
Martin, M.V.6
Guengerich, F.P.7
-
115
-
-
0034933767
-
8- andN-oxidation of 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2
-
8- andN-oxidation of 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline by human and rat liver microsomes and cytochromes P450 1A2. Chem Res Toxicol 2001, 14:901-911.
-
(2001)
Chem Res Toxicol
, vol.14
, pp. 901-911
-
-
Turesky, R.J.1
Parisod, V.2
Huynh-Ba, T.3
Langouet, S.4
Guengerich, F.P.5
-
116
-
-
0032782320
-
'Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses'
-
Turteltaub K.W., Dingley K.H., Curtis K.D., Malfatti M.A., Turesky R.J., Garner R.C., Felton J.S., Lang N.P. 'Macromolecular adduct formation and metabolism of heterocyclic amines in humans and rodents at low doses'. Cancer Lett 1999, 143:149-155.
-
(1999)
Cancer Lett
, vol.143
, pp. 149-155
-
-
Turteltaub, K.W.1
Dingley, K.H.2
Curtis, K.D.3
Malfatti, M.A.4
Turesky, R.J.5
Garner, R.C.6
Felton, J.S.7
Lang, N.P.8
-
118
-
-
0029420963
-
-
Princeton, Princeton Scientific Publishing Co., Princess Takamatsu symposium
-
Wakabayashi K., Kim I.S., Kurosaka R., Yamaizumi Z., Ushiyama H., Takahashi M., Koyota S., Tada A., Nukaya H., Goto S., Sugimura T., Nagao M. Identification of new mutagenic heterocyclic amines and quantification of known heterocyclic amines 1995, 39-49. Princeton, Princeton Scientific Publishing Co., Princess Takamatsu symposium.
-
(1995)
Identification of new mutagenic heterocyclic amines and quantification of known heterocyclic amines
, pp. 39-49
-
-
Wakabayashi, K.1
Kim, I.S.2
Kurosaka, R.3
Yamaizumi, Z.4
Ushiyama, H.5
Takahashi, M.6
Koyota, S.7
Tada, A.8
Nukaya, H.9
Goto, S.10
Sugimura, T.11
Nagao, M.12
-
119
-
-
0025019737
-
Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes
-
Wallin H., Mikalsen A., Guengerich F.P., Ingelman-Sundberg M., Solberg K.E., Rossland O.J., Alexander J. Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes. Carcinogenesis 1990, 11:489-492.
-
(1990)
Carcinogenesis
, vol.11
, pp. 489-492
-
-
Wallin, H.1
Mikalsen, A.2
Guengerich, F.P.3
Ingelman-Sundberg, M.4
Solberg, K.E.5
Rossland, O.J.6
Alexander, J.7
-
120
-
-
14044262238
-
Human cytochrome P450 2S1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine
-
Wang S.L., He X.Y., Hong J.Y. Human cytochrome P450 2S1: lack of activity in the metabolic activation of several cigarette smoke carcinogens and in the metabolism of nicotine. Drug Metab Dispos 2005, 33:336-340.
-
(2005)
Drug Metab Dispos
, vol.33
, pp. 336-340
-
-
Wang, S.L.1
He, X.Y.2
Hong, J.Y.3
-
121
-
-
0025076734
-
Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels
-
Watanabe M., Ishidate M., Nohmi T. Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels. Mutation Res 1990, 234:337-348.
-
(1990)
Mutation Res
, vol.234
, pp. 337-348
-
-
Watanabe, M.1
Ishidate, M.2
Nohmi, T.3
-
122
-
-
0028013265
-
Genotoxicity and carcinogenicity in rats and mice of 2-amino-3,6-dihydro-3-methyl-7H-imidazolo[4,5-f]quinolin-7-one: an intestinal bacterial metabolite of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline
-
Weisburger J.H., Rivenson A., Reinhardt J., Aliaga C., Braley J., Dolan L.M., Williams G.M., Zang E., Kingston D.G., Bashirm M. Genotoxicity and carcinogenicity in rats and mice of 2-amino-3,6-dihydro-3-methyl-7H-imidazolo[4,5-f]quinolin-7-one: an intestinal bacterial metabolite of 2-amino-3-methyl-3H-imidazo[4,5-f]quinoline. J Aatl Cancer Inst 1994, 86:25-30.
-
(1994)
J Aatl Cancer Inst
, vol.86
, pp. 25-30
-
-
Weisburger, J.H.1
Rivenson, A.2
Reinhardt, J.3
Aliaga, C.4
Braley, J.5
Dolan, L.M.6
Williams, G.M.7
Zang, E.8
Kingston, D.G.9
Bashirm, M.10
-
123
-
-
0035142384
-
Carcinogen substrate specificity of human COX-1 and COX-2
-
Wiese F.W., Thompson P.A., Kadlubar F.F. Carcinogen substrate specificity of human COX-1 and COX-2. Carcinogenesis 2001, 22:5-10.
-
(2001)
Carcinogenesis
, vol.22
, pp. 5-10
-
-
Wiese, F.W.1
Thompson, P.A.2
Kadlubar, F.F.3
-
124
-
-
0023260763
-
Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type
-
Wild D., Degen G.H. Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type. Carcinogenesis 1987, 8:541-545.
-
(1987)
Carcinogenesis
, vol.8
, pp. 541-545
-
-
Wild, D.1
Degen, G.H.2
-
125
-
-
0025812043
-
Azido-PhIP and nitro-PhIP, relatives of the heterocyclic arylamine and foodmutagen PhIP: mechanism of their mutagenicity in Salmonella
-
Wild D., Watkins B.E., Vanderlaan M. Azido-PhIP and nitro-PhIP, relatives of the heterocyclic arylamine and foodmutagen PhIP: mechanism of their mutagenicity in Salmonella. Carcinogenesis 1991, 12:1091-1096.
-
(1991)
Carcinogenesis
, vol.12
, pp. 1091-1096
-
-
Wild, D.1
Watkins, B.E.2
Vanderlaan, M.3
-
126
-
-
0028949369
-
Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium
-
Wild D., Feser W., Michel S., Lord H.L., Josephy P.D. Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium. Carcinogenesis 1995, 16:643-648.
-
(1995)
Carcinogenesis
, vol.16
, pp. 643-648
-
-
Wild, D.1
Feser, W.2
Michel, S.3
Lord, H.L.4
Josephy, P.D.5
-
127
-
-
0034061339
-
Pathways of heterocyclic amine activation in the breast: DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) formed by peroxidases and in human mammary epithelial cells and fibroblasts
-
Williams J.A., Stone E.M., Millar B.C., Hewer A., Phillips D.H. Pathways of heterocyclic amine activation in the breast: DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) formed by peroxidases and in human mammary epithelial cells and fibroblasts. Mutagenesis 2000, 15:149-154.
-
(2000)
Mutagenesis
, vol.15
, pp. 149-154
-
-
Williams, J.A.1
Stone, E.M.2
Millar, B.C.3
Hewer, A.4
Phillips, D.H.5
-
128
-
-
0026658465
-
'Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2'
-
Wölfel C., Heinrich-Hirsch B., Schulz-Schalge T., Seidel A., Frank H., Ramp U., WäCHTER F., Wiebel F.J., Gonzalez F., Greim H., Doehmer J. 'Genetically engineered V79 Chinese hamster cells for stable expression of human cytochrome P450IA2'. Eur J Pharmacol 1992, 228:95-102.
-
(1992)
Eur J Pharmacol
, vol.228
, pp. 95-102
-
-
Wölfel, C.1
Heinrich-Hirsch, B.2
Schulz-Schalge, T.3
Seidel, A.4
Frank, H.5
Ramp, U.6
Wächter, F.7
Wiebel, F.J.8
Gonzalez, F.9
Greim, H.10
Doehmer, J.11
-
129
-
-
0034068835
-
Bioactivation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by prostaglandin-H synthase and by monooxygenases: Dna adduct analysis
-
Wolz E., Pfau W., Degen G.H. Bioactivation of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) by prostaglandin-H synthase and by monooxygenases: Dna adduct analysis. Food Chem Toxicol 2000, 38:513-522.
-
(2000)
Food Chem Toxicol
, vol.38
, pp. 513-522
-
-
Wolz, E.1
Pfau, W.2
Degen, G.H.3
-
130
-
-
0019211719
-
'Myeloperoxidase-catalyzed binding of 3-amino-1-methyl-5H-pyrido[4,3-b]indole, a tryptophan pyrolysis product, to protein'
-
Yamada M., Mori M., Sugimura T. 'Myeloperoxidase-catalyzed binding of 3-amino-1-methyl-5H-pyrido[4,3-b]indole, a tryptophan pyrolysis product, to protein'. Chem-Biol Interact 1980, 33:19-33.
-
(1980)
Chem-Biol Interact
, vol.33
, pp. 19-33
-
-
Yamada, M.1
Mori, M.2
Sugimura, T.3
-
131
-
-
0025279740
-
DNA adducts formed by 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration
-
Yamashita K., Adachim Kato S., Nakagama H., Ochiaim Wakabayashi K., Sato S., Nagao M., Sugimura T. DNA adducts formed by 2-amino-3,8-dimethyl-imidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration. Jpn J Cancer Res 1990, 81:470-476.
-
(1990)
Jpn J Cancer Res
, vol.81
, pp. 470-476
-
-
Yamashita, K.1
Adachim, K.S.2
Nakagama, H.3
Ochiaim, W.K.4
Sato, S.5
Nagao, M.6
Sugimura, T.7
-
132
-
-
3342880303
-
'Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with Nadph-cytochrome P450 reductase sensitive to various promutagens'
-
Yamazakiy Fujita K., Nakayama K., Suzuki A., Nakamura K., Yamazaki H., Kamataki T. 'Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with Nadph-cytochrome P450 reductase sensitive to various promutagens'. Mutation Res 2004, 562:151-162.
-
(2004)
Mutation Res
, vol.562
, pp. 151-162
-
-
Yamazakiy, F.K.1
Nakayama, K.2
Suzuki, A.3
Nakamura, K.4
Yamazaki, H.5
Kamataki, T.6
-
133
-
-
0018842526
-
Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, Trp-P-2, formed by rat liver microsomes
-
Yamazoe Y., Ishii K., Kamataki T., Kato R., Sugimura T. Isolation and characterization of active metabolites of tryptophan-pyrolysate mutagen, Trp-P-2, formed by rat liver microsomes. Chem-Biol Interact 1980, 30:125-138.
-
(1980)
Chem-Biol Interact
, vol.30
, pp. 125-138
-
-
Yamazoe, Y.1
Ishii, K.2
Kamataki, T.3
Kato, R.4
Sugimura, T.5
-
134
-
-
0019882851
-
Enhancement of binding of A-hydroxy-Trp-P-2 to DNA by seryl-tRNA synthetase
-
Yamazoe Y., Tada M., Kamataki T., Kato R. Enhancement of binding of A-hydroxy-Trp-P-2 to DNA by seryl-tRNA synthetase. Biochem Biophys Res Commun 1981, 102:432-439.
-
(1981)
Biochem Biophys Res Commun
, vol.102
, pp. 432-439
-
-
Yamazoe, Y.1
Tada, M.2
Kamataki, T.3
Kato, R.4
-
135
-
-
0021810037
-
Catalysis of the covalent binding of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole to DNA by a L-proline- and adenosine triphosphate-dependent enzyme in rat hepatic cytosol
-
Yamazoe Y., Shimada M., Shinohara A., Saito K., Kamataki T., Kato R. Catalysis of the covalent binding of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole to DNA by a L-proline- and adenosine triphosphate-dependent enzyme in rat hepatic cytosol. Cancer Res 1985, 45:2495-2500.
-
(1985)
Cancer Res
, vol.45
, pp. 2495-2500
-
-
Yamazoe, Y.1
Shimada, M.2
Shinohara, A.3
Saito, K.4
Kamataki, T.5
Kato, R.6
-
136
-
-
0028290229
-
Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
-
Yanagawa H., Sawada M., Deguchi T., Gonzalez F.J., Kamataki T. Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Res 1994, 54:3422-3427.
-
(1994)
Cancer Res
, vol.54
, pp. 3422-3427
-
-
Yanagawa, H.1
Sawada, M.2
Deguchi, T.3
Gonzalez, F.J.4
Kamataki, T.5
|