Impact of five cytochrome P450 enzymes on the metabolism of two heterocyclic aromatic amines, 2-amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3-methyl-9H-pyrido[2,3-b]indole (MeAαC)

Pharmacology and Toxicology

Volumn 92, Issue 5, 2003, Pages 246-248

  Frederiksen, Hanne ^a   Frandsen, Henrik ^a  

^a DANISH VETERINARY AND FOOD ADMINISTRATION   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 METHYL ALPHA CARBOLINE; 2 AMINO ALPHA CARBOLINE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; HETEROCYCLIC AMINE; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DETOXIFICATION; ENZYME METABOLISM; FOOD SAFETY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CARBOLINES; CARCINOGENS; CYTOCHROME P-450 CYP1A1; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; MUTAGENS; RATS; TIME FACTORS;

EID: 0037406247     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-0773.2003.920508.x     Document Type: Article

References (5)

1. Felton, J. S., M. Jagerstad, M. G. Knize, K. Skog & K. Wakabayashi: Contents in foods, beverages and tobacco. In: Food borne carcinogens; Heterocyclic amines. Eds.: M. Nagao & T. Sugimura. John Wiley & Sons Ltd, West Sussex, England 2002, pp. 31-72.
2. Frandsen, H., S. Damkjær, S. Grivas, R. Andersson, M. L. Binderup & J. C. Larsen: Microsomal metabolism and activation of the environmental carcinogen 2-amino-3-methyl-9H-pyrido[2,3-b]indole. Mutagenesis 1998, 13, 181-185.
3. Frederiksen, H. & H. Frandsen: In vitro metabolism of two heterocyclic amines, 2- amino-9H-pyrido[2,3-b]indole (AαC) and 2-amino-3-methyl-9H-pyridol2,3-b]indole (MeAαC) in human and rat hepatic microsomes. Pharmacology & Toxicology 2002, 90, 127-134.
4. Shimada, T. & F. P. Guengerich: Activation of amino-alpha-carboline, 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes. Cancer Res. 1991, 51, 5284-5291.
5. Turesky, R. J., A. Constable, J. Richoz, N. Varga, J. Markovic, M. V. Martin & F. P. Guengerich: Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2. Chem. Res. Toxicol. 1998, 11, 925-936.