Analogues of σ receptor ligand 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4- tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) with added polar functionality and reduced lipophilicity for potential use as positron emission tomography radiotracers

Journal of Medicinal Chemistry

Volumn 54, Issue 4, 2011, Pages 1022-1032

  Abate, Carmen ^a   Niso, Mauro ^a   Lacivita, Enza ^a   Mosier, Philip D ^b   Toscano, Annamaria ^a   Perrone, Roberto ^a  

^a UNIVERSITY OF BARI   (Italy)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOHEXYL 4 [3 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)PROPYL]PIPERAZINE; ANTINEOPLASTIC AGENT; PB28; PIPERAZINE DERIVATIVE; PROPYLENE; TRACER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CELL PROLIFERATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HUMAN CELL; LIPOPHILICITY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

BINDING, COMPETITIVE; CELL LINE, TUMOR; CELL PROLIFERATION; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; OPTICAL ROTATION; P-GLYCOPROTEIN; PIPERAZINES; POSITRON-EMISSION TOMOGRAPHY; RECEPTORS, SIGMA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES; TETRAHYDRONAPHTHALENES;

EID: 79951840503     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm1013133     Document Type: Article

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