Fluorescent derivatives of σ Receptor ligand 1-cyclohexyl-4-[3-(5- methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) as a tool for uptake and cellular localization studies in pancreatic tumor cells

Journal of Medicinal Chemistry

Volumn 54, Issue 16, 2011, Pages 5858-5867

  Abate, Carmen ^a   Hornick, John R ^b   Spitzer, Dirk ^b   Hawkins, William G ^b   Niso, Mauro ^a   Perrone, Roberto ^a   Berardi, Francesco ^a  

^a UNIVERSITY OF BARI   (Italy)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 CYCLOHEXYL 4 [3 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)PROPYL]PIPERAZINE; 6 [4 [4 [3 (5 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALEN 1 YL)PROPYL]PIPERAZIN 1 YL]PIPERIDINO] N (7 NITRO 2,1,3 BENZOXADIAZOL 4 YL)HEXANAMINE; ANTINEOPLASTIC AGENT; METHYL GROUP; PB 28; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CELL ORGANELLE; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; DRUG TUMOR LEVEL; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; FLUORESCENCE; HUMAN; HUMAN CELL; LYSOSOME; PANCREAS TUMOR; RECEPTOR AFFINITY;

BINDING, COMPETITIVE; CELL LINE, TUMOR; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; FLOW CYTOMETRY; FLUORESCENCE; HUMANS; LIGANDS; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PANCREATIC NEOPLASMS; PIPERAZINES; PROTEIN BINDING; PROTEIN ISOFORMS; RADIOLIGAND ASSAY; RECEPTORS, SIGMA;

EID: 80051862694     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200591t     Document Type: Article

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